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Aliases for SLC26A11 Gene

Aliases for SLC26A11 Gene

  • Solute Carrier Family 26 Member 11 2 3 4 5
  • Solute Carrier Family 26 (Anion Exchanger), Member 11 2
  • Solute Carrier Family 26, Member 11 2

External Ids for SLC26A11 Gene

Previous GeneCards Identifiers for SLC26A11 Gene

  • GC17U990215
  • GC17P078757
  • GC17P078894
  • GC17P075808
  • GC17P078194
  • GC17P073635

Summaries for SLC26A11 Gene

Entrez Gene Summary for SLC26A11 Gene

  • This gene encodes a member of the solute linked carrier 26 family of anion exchangers. Members of this family of proteins are essential for numerous cellular functions including homeostasis and intracellular electrolyte balance. The encoded protein is a sodium independent sulfate transporter that is sensitive to the anion exchanger inhibitor 4,4'-diisothiocyanostilbene-2,2'-disulfonic acid. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Oct 2009]

GeneCards Summary for SLC26A11 Gene

SLC26A11 (Solute Carrier Family 26 Member 11) is a Protein Coding gene. Diseases associated with SLC26A11 include Deafness, Autosomal Dominant 20. Among its related pathways are Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds. Gene Ontology (GO) annotations related to this gene include secondary active sulfate transmembrane transporter activity and sulfate transmembrane transporter activity.

UniProtKB/Swiss-Prot for SLC26A11 Gene

  • Exhibits sodium-independent sulfate anion transporter activity that may cooperate with SLC26A2 to mediate DIDS-sensitive sulfate uptake into high endothelial venules endothelial cells (HEVEC).

Additional gene information for SLC26A11 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLC26A11 Gene

Genomics for SLC26A11 Gene

GeneHancer (GH) Regulatory Elements for SLC26A11 Gene

Promoters and enhancers for SLC26A11 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH17I080218 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 571.2 +0.8 842 4.5 HDGF PKNOX1 SMAD1 MLX ARNT ZFP64 ARID4B SIN3A ZNF2 POLR2B SLC26A11 SGSH ENSG00000262580 CARD14 CBX8 GC17P080181
GH17I080252 Promoter/Enhancer 2.9 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 5.5 +40.0 40000 14.2 CLOCK MLX ZFP64 DMAP1 YBX1 IRF4 YY1 SLC30A9 ZNF143 MEF2D RNF213 GC17M080259 EIF4A3 CHMP6 ENSG00000262580 CARD14 CEP131 RPL12P37 SLC26A11 RBFOX3
GH17I081056 Enhancer 1.4 Ensembl ENCODE dbSUPER 4.7 +838.0 838040 2.8 HDGF PKNOX1 CLOCK ATF1 SIN3A GLIS2 CBX5 ATF7 ZNF263 REST RAC3 SLC26A11 BAIAP2 GC17M081121
GH17I080453 Promoter/Enhancer 2 FANTOM5 Ensembl ENCODE 1.2 +236.1 236095 5 HDGF PKNOX1 ZFP64 ARID4B SIN3A DMAP1 ZNF2 SLC30A9 POLR2B ZNF766 ENSG00000260369 CEP131 TEPSIN TBC1D16 LOC105371925 CBX8 NPTX1 EIF4A3 SGSH GAA
GH17I080224 Enhancer 0.8 FANTOM5 0.8 +4.8 4760 0.4 HDAC1 HDGF NFIB ZSCAN4 IRF9 ZFHX2 EGR1 ZNF366 NFATC1 ZNF207 EIF4A3 ENSG00000262580 SGSH SLC26A11 GC17M080259 GC17P080181
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around SLC26A11 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the SLC26A11 gene promoter:

Genomic Locations for SLC26A11 Gene

Genomic Locations for SLC26A11 Gene
33,811 bases
Plus strand

Genomic View for SLC26A11 Gene

Genes around SLC26A11 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SLC26A11 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SLC26A11 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC26A11 Gene

Proteins for SLC26A11 Gene

  • Protein details for SLC26A11 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Sodium-independent sulfate anion transporter
    Protein Accession:
    Secondary Accessions:
    • B2RCI7
    • Q86VX1
    • Q86YX7
    • Q8IV11
    • Q8N2I1
    • Q8NG03

    Protein attributes for SLC26A11 Gene

    606 amino acids
    Molecular mass:
    65299 Da
    Quaternary structure:
    No Data Available

neXtProt entry for SLC26A11 Gene

Post-translational modifications for SLC26A11 Gene

  • Ubiquitination at posLast=578578 and isoforms=600
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for SLC26A11 Gene

Domains & Families for SLC26A11 Gene

Gene Families for SLC26A11 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted membrane proteins
  • Transporters

Suggested Antigen Peptide Sequences for SLC26A11 Gene

Graphical View of Domain Structure for InterPro Entry



S2611_HUMAN :
  • Belongs to the SLC26A/SulP transporter (TC 2.A.53) family.
  • Belongs to the SLC26A/SulP transporter (TC 2.A.53) family.
genes like me logo Genes that share domains with SLC26A11: view

Function for SLC26A11 Gene

Molecular function for SLC26A11 Gene

UniProtKB/Swiss-Prot Function:
Exhibits sodium-independent sulfate anion transporter activity that may cooperate with SLC26A2 to mediate DIDS-sensitive sulfate uptake into high endothelial venules endothelial cells (HEVEC).

Phenotypes From GWAS Catalog for SLC26A11 Gene

Gene Ontology (GO) - Molecular Function for SLC26A11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005254 chloride channel activity IBA --
GO:0008271 secondary active sulfate transmembrane transporter activity IEA --
GO:0008509 anion transmembrane transporter activity IDA 12626430
GO:0015106 bicarbonate transmembrane transporter activity IBA --
GO:0015116 sulfate transmembrane transporter activity IEA,TAS --
genes like me logo Genes that share ontologies with SLC26A11: view
genes like me logo Genes that share phenotypes with SLC26A11: view

Animal Model Products

  • Taconic Biosciences Mouse Models for SLC26A11

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for SLC26A11 Gene

Localization for SLC26A11 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC26A11 Gene

Cell membrane; Multi-pass membrane protein. Lysosome membrane; Multi-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SLC26A11 gene
Compartment Confidence
plasma membrane 5
extracellular 5
endoplasmic reticulum 5
lysosome 5
golgi apparatus 5
nucleus 4

Subcellular locations from the

Human Protein Atlas (HPA)
  • Vesicles (3)
  • Golgi apparatus (2)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for SLC26A11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005654 nucleoplasm IDA --
GO:0005764 lysosome IEA --
GO:0005765 lysosomal membrane IDA,IEA 20957757
GO:0005783 endoplasmic reticulum IDA 12626430
GO:0005794 Golgi apparatus IDA 12626430
genes like me logo Genes that share ontologies with SLC26A11: view

Pathways & Interactions for SLC26A11 Gene

genes like me logo Genes that share pathways with SLC26A11: view

Interacting Proteins for SLC26A11 Gene

Gene Ontology (GO) - Biological Process for SLC26A11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport IEA --
GO:0006811 ion transport TAS --
GO:0008272 sulfate transport IEA,IDA 12626430
GO:0015701 bicarbonate transport IBA --
GO:0019532 oxalate transport IEA --
genes like me logo Genes that share ontologies with SLC26A11: view

No data available for SIGNOR curated interactions for SLC26A11 Gene

Drugs & Compounds for SLC26A11 Gene

(2) Additional Compounds for SLC26A11 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
  • Sodium
  • Sodium ion
  • Sulfate (ion 2-)
  • Sulfate anion
  • Sulfate anion(2-)
  • Sulfate dianion
  • Sulfate ion
genes like me logo Genes that share compounds with SLC26A11: view

Transcripts for SLC26A11 Gene

Unigene Clusters for SLC26A11 Gene

Solute carrier family 26, member 11:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for SLC26A11 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b · 3c ^ 4 ^ 5a · 5b · 5c ^ 6a · 6b ^ 7a · 7b ^ 8a · 8b · 8c ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13 ^ 14 ^ 15a · 15b ^
SP1: - - - - -
SP2: - - - - -
SP3: -
SP4: - - -
SP6: - - - - -
SP7: - - - -
SP9: -

ExUns: 16 ^ 17 ^ 18 ^ 19a · 19b
SP5: -

Relevant External Links for SLC26A11 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SLC26A11 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SLC26A11 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for SLC26A11 Gene

This gene is overexpressed in Retina (37.9) and Fetal Liver (31.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for SLC26A11 Gene

Protein tissue co-expression partners for SLC26A11 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of SLC26A11 Gene:


SOURCE GeneReport for Unigene cluster for SLC26A11 Gene:


mRNA Expression by UniProt/SwissProt for SLC26A11 Gene:

Tissue specificity: Detected in all tissues tested with highest expression observed in brain, kidney, HEVEC and placenta and lowest in pancreas, skeletal muscle, liver, lung and heart.

Evidence on tissue expression from TISSUES for SLC26A11 Gene

  • Nervous system(4)
genes like me logo Genes that share expression patterns with SLC26A11: view

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for SLC26A11 Gene

Orthologs for SLC26A11 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for SLC26A11 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia SLC26A11 33 34
  • 99.35 (n)
(Canis familiaris)
Mammalia SLC26A11 33 34
  • 86.91 (n)
(Bos Taurus)
Mammalia SLC26A11 33 34
  • 84.63 (n)
(Mus musculus)
Mammalia Slc26a11 33 16 34
  • 82.8 (n)
(Rattus norvegicus)
Mammalia Slc26a11 33
  • 81.29 (n)
(Monodelphis domestica)
Mammalia SLC26A11 34
  • 73 (a)
(Ornithorhynchus anatinus)
Mammalia SLC26A11 34
  • 67 (a)
(Gallus gallus)
Aves SLC26A11 33 34
  • 72.26 (n)
(Anolis carolinensis)
Reptilia SLC26A11 34
  • 70 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia slc26a11 33
  • 61.26 (n)
(Danio rerio)
Actinopterygii slc26a11 33 34
  • 62.56 (n)
wufd14d06 33
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP012302 33
  • 52.19 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG5002 34
  • 40 (a)
CG7912 34
  • 40 (a)
CG6928 34
  • 36 (a)
CG9717 34
  • 35 (a)
Esp 34
  • 34 (a)
CG5404 34
  • 32 (a)
CG9702 34
  • 32 (a)
CG6125 34
  • 31 (a)
(Caenorhabditis elegans)
Secernentea sulp-1 34
  • 14 (a)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AGR077C 33
  • 47.93 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SUL1 33 34 36
  • 44.18 (n)
SUL2 34
  • 21 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0F19338g 33
  • 43.36 (n)
bread mold
(Neurospora crassa)
Ascomycetes NCU04433 33
  • 50.77 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 47 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPAC869.05c 33
  • 46.05 (n)
Species where no ortholog for SLC26A11 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SLC26A11 Gene

Gene Tree for SLC26A11 (if available)
Gene Tree for SLC26A11 (if available)

Paralogs for SLC26A11 Gene

genes like me logo Genes that share paralogs with SLC26A11: view

No data available for Paralogs for SLC26A11 Gene

Variants for SLC26A11 Gene

Sequence variations from dbSNP and Humsavar for SLC26A11 Gene

SNP ID Clin Chr 17 pos Variation AA Info Type
rs533566888 uncertain-significance, Sanfilippo syndrome 80,220,336(+) G/A/C/T coding_sequence_variant, genic_upstream_transcript_variant, missense_variant, non_coding_transcript_variant, upstream_transcript_variant
rs75720127 uncertain-significance, Sanfilippo syndrome 80,220,218(+) G/A upstream_transcript_variant
rs786200990 uncertain-significance, not provided 80,220,231(+) AGCAGCAG/AGCAGCAGCAG upstream_transcript_variant
rs1000020158 -- 80,235,214(+) T/G intron_variant
rs1000114468 -- 80,253,409(+) C/T 3_prime_UTR_variant, genic_downstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for SLC26A11 Gene

Variant ID Type Subtype PubMed ID
esv3554852 CNV deletion 23714750
nsv1066606 CNV gain 25217958
nsv457968 CNV loss 19166990
nsv469591 CNV loss 16826518
nsv576131 CNV loss 21841781
nsv828123 CNV gain 20364138
nsv833562 CNV loss 17160897

Variation tolerance for SLC26A11 Gene

Residual Variation Intolerance Score: 98% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.60; 72.45% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SLC26A11 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SLC26A11 Gene

Disorders for SLC26A11 Gene

MalaCards: The human disease database

(1) MalaCards diseases for SLC26A11 Gene - From: DISEASES

Disorder Aliases PubMed IDs
deafness, autosomal dominant 20
  • dfna20
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for SLC26A11

genes like me logo Genes that share disorders with SLC26A11: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SLC26A11 Gene

Publications for SLC26A11 Gene

  1. The proteome of lysosomes. (PMID: 20957757) Schröder BA … Saftig P (Proteomics 2010) 3 4 58
  2. Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries. (PMID: 16303743) Otsuki T … Isogai T (DNA research : an international journal for rapid publication of reports on genes and genomes 2005) 3 4 58
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  4. Molecular and functional characterization of SLC26A11, a sodium-independent sulfate transporter from high endothelial venules. (PMID: 12626430) Vincourt JB … Girard JP (FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2003) 3 4 58
  5. N-glycosylation and topology of the human SLC26 family of anion transport membrane proteins. (PMID: 24647542) Li J … Reithmeier RA (American journal of physiology. Cell physiology 2014) 3 58

Products for SLC26A11 Gene

Sources for SLC26A11 Gene

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