This gene encodes a member of the solute linked carrier 26 family of anion exchangers. Members of this family of proteins are essential for numerous cellular functions including homeostasis and intracellular electrolyte balance. The encoded protein is a sodium independent sulfate transporter that is sensitive to the anion exchanger inhibitor 4,4'-diisothiocyanostilbene-2,2'-dis... See more...

Aliases for SLC26A11 Gene

Aliases for SLC26A11 Gene

  • Solute Carrier Family 26 Member 11 2 3 4 5
  • Solute Carrier Family 26 (Anion Exchanger), Member 11 2 3
  • Sodium-Independent Sulfate Anion Transporter 3 4
  • Solute Carrier Family 26, Member 11 2
  • SLC26A11 5

External Ids for SLC26A11 Gene

Previous GeneCards Identifiers for SLC26A11 Gene

  • GC17U990215
  • GC17P078757
  • GC17P078894
  • GC17P075808
  • GC17P078194
  • GC17P073635

Summaries for SLC26A11 Gene

Entrez Gene Summary for SLC26A11 Gene

  • This gene encodes a member of the solute linked carrier 26 family of anion exchangers. Members of this family of proteins are essential for numerous cellular functions including homeostasis and intracellular electrolyte balance. The encoded protein is a sodium independent sulfate transporter that is sensitive to the anion exchanger inhibitor 4,4'-diisothiocyanostilbene-2,2'-disulfonic acid. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Oct 2009]

GeneCards Summary for SLC26A11 Gene

SLC26A11 (Solute Carrier Family 26 Member 11) is a Protein Coding gene. Diseases associated with SLC26A11 include Mucopolysaccharidosis, Type Iiia and Mucopolysaccharidosis Iii. Among its related pathways are Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds. Gene Ontology (GO) annotations related to this gene include secondary active sulfate transmembrane transporter activity and sulfate transmembrane transporter activity. An important paralog of this gene is SLC26A1.

UniProtKB/Swiss-Prot Summary for SLC26A11 Gene

  • Exhibits sodium-independent sulfate anion transporter activity that may cooperate with SLC26A2 to mediate DIDS-sensitive sulfate uptake into high endothelial venules endothelial cells (HEVEC).

No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for SLC26A11 Gene

Genomics for SLC26A11 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for SLC26A11 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around SLC26A11 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for SLC26A11

Top Transcription factor binding sites by QIAGEN in the SLC26A11 gene promoter:
  • Lmo2

Genomic Locations for SLC26A11 Gene

Latest Assembly
chr17:80,219,699-80,253,502
(GRCh38/hg38)
Size:
33,804 bases
Orientation:
Plus strand

Previous Assembly
chr17:78,194,226-78,227,299
(GRCh37/hg19 by Entrez Gene)
Size:
33,074 bases
Orientation:
Plus strand

chr17:78,193,498-78,227,299
(GRCh37/hg19 by Ensembl)
Size:
33,802 bases
Orientation:
Plus strand

Genomic View for SLC26A11 Gene

Genes around SLC26A11 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SLC26A11 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SLC26A11 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC26A11 Gene

Proteins for SLC26A11 Gene

  • Protein details for SLC26A11 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q86WA9-S2611_HUMAN
    Recommended name:
    Sodium-independent sulfate anion transporter
    Protein Accession:
    Q86WA9
    Secondary Accessions:
    • B2RCI7
    • Q86VX1
    • Q86YX7
    • Q8IV11
    • Q8N2I1
    • Q8NG03

    Protein attributes for SLC26A11 Gene

    Size:
    606 amino acids
    Molecular mass:
    65299 Da
    Quaternary structure:
    No Data Available

neXtProt entry for SLC26A11 Gene

Post-translational modifications for SLC26A11 Gene

  • Ubiquitination at Lys578 and Lys600
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for SLC26A11 Gene

Domains & Families for SLC26A11 Gene

Gene Families for SLC26A11 Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted membrane proteins
  • Transporters

Protein Domains for SLC26A11 Gene

InterPro:
Blocks:
  • Sulphate transporter

Suggested Antigen Peptide Sequences for SLC26A11 Gene

GenScript: Design optimal peptide antigens:
  • SLC26A11 protein (Q96BU7_HUMAN)
  • Solute carrier family 26 member 11 (S2611_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q86WA9

UniProtKB/Swiss-Prot:

S2611_HUMAN :
  • Belongs to the SLC26A/SulP transporter (TC 2.A.53) family.
Family:
  • Belongs to the SLC26A/SulP transporter (TC 2.A.53) family.
genes like me logo Genes that share domains with SLC26A11: view

Function for SLC26A11 Gene

Molecular function for SLC26A11 Gene

UniProtKB/Swiss-Prot Function:
Exhibits sodium-independent sulfate anion transporter activity that may cooperate with SLC26A2 to mediate DIDS-sensitive sulfate uptake into high endothelial venules endothelial cells (HEVEC).

Phenotypes From GWAS Catalog for SLC26A11 Gene

Gene Ontology (GO) - Molecular Function for SLC26A11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 32296183
GO:0008271 secondary active sulfate transmembrane transporter activity IEA --
GO:0008509 anion transmembrane transporter activity IDA 12626430
GO:0015116 sulfate transmembrane transporter activity IEA,TAS --
GO:0015301 anion:anion antiporter activity IEA,IBA 21873635
genes like me logo Genes that share ontologies with SLC26A11: view
genes like me logo Genes that share phenotypes with SLC26A11: view

Animal Models for research

  • Taconic Biosciences Mouse Models for SLC26A11

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SLC26A11

Clone products for research

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for SLC26A11 Gene

Localization for SLC26A11 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC26A11 Gene

Cell membrane. Multi-pass membrane protein. Lysosome membrane. Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SLC26A11 gene
Compartment Confidence
plasma membrane 5
endoplasmic reticulum 5
lysosome 5
golgi apparatus 5
extracellular 4
nucleus 4
mitochondrion 1
endosome 1
cytosol 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Vesicles (3)
  • Golgi apparatus (2)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for SLC26A11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005654 nucleoplasm IDA --
GO:0005764 lysosome IEA --
GO:0005765 lysosomal membrane IEA,IDA 20957757
GO:0005783 endoplasmic reticulum IDA 12626430
GO:0005794 Golgi apparatus IDA 12626430
genes like me logo Genes that share ontologies with SLC26A11: view

Pathways & Interactions for SLC26A11 Gene

genes like me logo Genes that share pathways with SLC26A11: view

Interacting Proteins for SLC26A11 Gene

Gene Ontology (GO) - Biological Process for SLC26A11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006811 ion transport TAS --
GO:0008272 sulfate transport IEA,IDA 12626430
GO:0055085 transmembrane transport IEA --
GO:0098656 anion transmembrane transport IEA --
GO:1902358 sulfate transmembrane transport IEA --
genes like me logo Genes that share ontologies with SLC26A11: view

No data available for SIGNOR curated interactions for SLC26A11 Gene

Drugs & Compounds for SLC26A11 Gene

(1) Drugs for SLC26A11 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Sulfate Experimental, Investigational Pharma 0

(1) Additional Compounds for SLC26A11 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
sodium
  • Na(+)
  • Na+
  • SODIUM ion
  • Sodium(1+)
7440-23-5
genes like me logo Genes that share compounds with SLC26A11: view

Transcripts for SLC26A11 Gene

mRNA/cDNA for SLC26A11 Gene

4 REFSEQ mRNAs :
12 NCBI additional mRNA sequence :
17 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SLC26A11

Clone products for research

Alternative Splicing Database (ASD) splice patterns (SP) for SLC26A11 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b · 3c ^ 4 ^ 5a · 5b · 5c ^ 6a · 6b ^ 7a · 7b ^ 8a · 8b · 8c ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13 ^ 14 ^ 15a · 15b ^
SP1: - - - - -
SP2: - - - - -
SP3: -
SP4: - - -
SP5:
SP6: - - - - -
SP7: - - - -
SP8:
SP9: -

ExUns: 16 ^ 17 ^ 18 ^ 19a · 19b
SP1:
SP2:
SP3:
SP4:
SP5: -
SP6:
SP7:
SP8:
SP9:

Relevant External Links for SLC26A11 Gene

GeneLoc Exon Structure for
SLC26A11

Expression for SLC26A11 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for SLC26A11 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for SLC26A11 Gene

This gene is overexpressed in Retina (37.9) and Fetal Liver (31.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for SLC26A11 Gene



Protein tissue co-expression partners for SLC26A11 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for SLC26A11

SOURCE GeneReport for Unigene cluster for SLC26A11 Gene:

Hs.4866

mRNA Expression by UniProt/SwissProt for SLC26A11 Gene:

Q86WA9-S2611_HUMAN
Tissue specificity: Detected in all tissues tested with highest expression observed in brain, kidney, HEVEC and placenta and lowest in pancreas, skeletal muscle, liver, lung and heart.

Evidence on tissue expression from TISSUES for SLC26A11 Gene

  • Nervous system(4.2)
genes like me logo Genes that share expression patterns with SLC26A11: view

Primer products for research

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for SLC26A11 Gene

Orthologs for SLC26A11 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for SLC26A11 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia SLC26A11 29 30
  • 99.35 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia SLC26A11 29 30
  • 86.91 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia SLC26A11 29 30
  • 84.63 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Slc26a11 29 16 30
  • 82.8 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Slc26a11 29
  • 81.29 (n)
Oppossum
(Monodelphis domestica)
Mammalia SLC26A11 30
  • 73 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia SLC26A11 30
  • 67 (a)
OneToOne
Chicken
(Gallus gallus)
Aves SLC26A11 29 30
  • 72.26 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia SLC26A11 30
  • 70 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia slc26a11 29
  • 61.26 (n)
Zebrafish
(Danio rerio)
Actinopterygii slc26a11 29 30
  • 62.56 (n)
OneToOne
wufd14d06 29
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP012302 29
  • 52.19 (n)
Fruit Fly
(Drosophila melanogaster)
Insecta CG5002 30
  • 40 (a)
OneToMany
CG7912 30
  • 40 (a)
OneToMany
CG6928 30
  • 36 (a)
OneToMany
CG9717 30
  • 35 (a)
OneToMany
Esp 30
  • 34 (a)
OneToMany
CG5404 30
  • 32 (a)
OneToMany
CG9702 30
  • 32 (a)
OneToMany
CG6125 30
  • 31 (a)
OneToMany
Worm
(Caenorhabditis elegans)
Secernentea sulp-1 30
  • 14 (a)
ManyToMany
A. gosspyii yeast
(Eremothecium gossypii)
Saccharomycetes AGOS_AGR077C 29
  • 47.93 (n)
Baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SUL1 29 30 32
  • 44.18 (n)
ManyToMany
SUL2 30
  • 21 (a)
ManyToMany
K. Lactis Yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0F19338g 29
  • 43.36 (n)
Bread mold
(Neurospora crassa)
Ascomycetes NCU04433 29
  • 50.77 (n)
Sea Squirt
(Ciona savignyi)
Ascidiacea -- 30
  • 47 (a)
OneToOne
Fission Yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPAC869.05c 29
  • 46.05 (n)
Species where no ortholog for SLC26A11 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for SLC26A11 Gene

ENSEMBL:
Gene Tree for SLC26A11 (if available)
TreeFam:
Gene Tree for SLC26A11 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for SLC26A11: view image
Alliance of Genome Resources:
Additional Orthologs for SLC26A11

Paralogs for SLC26A11 Gene

(5) SIMAP similar genes for SLC26A11 Gene using alignment to 9 proteins:

  • S2611_HUMAN
  • I3L0N9_HUMAN
  • I3L124_HUMAN
  • I3L1H1_HUMAN
  • I3L250_HUMAN
  • I3L266_HUMAN
  • I3L2J9_HUMAN
  • I3L3K8_HUMAN
  • Q96BU7_HUMAN
genes like me logo Genes that share paralogs with SLC26A11: view

Variants for SLC26A11 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for SLC26A11 Gene

SNP ID Clinical significance and condition Chr 17 pos Variation AA Info Type
889289 Uncertain Significance: Mucopolysaccharidosis, MPS-III-A 80,220,325(+) C/T
NM_000199.5(SGSH):c.-12G>A
NON_CODING_TRANSCRIPT_VARIANT,FIVE_PRIME_UTR
rs1043643087 Likely Benign: Mucopolysaccharidosis, MPS-III-A 80,220,308(+) G/A
NM_000199.5(SGSH):c.6C>T (p.Ser2=)
NON_CODING_TRANSCRIPT_VARIANT,SYNONYMOUS
rs117854297 Benign: not provided 80,220,458(+) C/T
NM_001166347.2(SLC26A11):c.-252C>T
FIVE_PRIME_UTR
rs1250300189 Pathogenic/Likely Pathogenic: Mucopolysaccharidosis, MPS-III-A. Pathogenic: Mucopolysaccharidosis, MPS-III-A 80,220,313(+) T/CT/G
NM_000199.5(SGSH):c.1A>G (p.Met1Val)
INITIATIOR_CODON_VARIANT,MISSENSE_VARIANT,NON_CODING_TRANSCRIPT
rs1488660868 Pathogenic: Mucopolysaccharidosis, MPS-III-A; not provided 80,220,312(+) A/G
NM_000199.5(SGSH):c.2T>C (p.Met1Thr)
INITIATIOR_CODON_VARIANT,MISSENSE_VARIANT,NON_CODING_TRANSCRIPT

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for SLC26A11 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for SLC26A11 Gene

Variant ID Type Subtype PubMed ID
esv3554852 CNV deletion 23714750
nsv1066606 CNV gain 25217958
nsv457968 CNV loss 19166990
nsv469591 CNV loss 16826518
nsv576131 CNV loss 21841781
nsv828123 CNV gain 20364138
nsv833562 CNV loss 17160897

Variation tolerance for SLC26A11 Gene

Residual Variation Intolerance Score: 98% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.60; 72.45% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SLC26A11 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SLC26A11
Leiden Open Variation Database (LOVD)
SLC26A11

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SLC26A11 Gene

Disorders for SLC26A11 Gene

MalaCards: The human disease database

(8) MalaCards diseases for SLC26A11 Gene - From: CVR and COP

Disorder Aliases PubMed IDs
mucopolysaccharidosis, type iiia
  • mps3a
mucopolysaccharidosis iii
  • heparan sulfate sulfatase deficiency
sialolithiasis
  • salivary gland stone
diastrophic dysplasia
  • dtd
pendred syndrome
  • pds
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for SLC26A11

genes like me logo Genes that share disorders with SLC26A11: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SLC26A11 Gene

Publications for SLC26A11 Gene

  1. The proteome of lysosomes. (PMID: 20957757) Schröder BA … Saftig P (Proteomics 2010) 3 4
  2. Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries. (PMID: 16303743) Otsuki T … Isogai T (DNA research : an international journal for rapid publication of reports on genes and genomes 2005) 3 4
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4
  4. Molecular and functional characterization of SLC26A11, a sodium-independent sulfate transporter from high endothelial venules. (PMID: 12626430) Vincourt JB … Girard JP (FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2003) 3 4
  5. A reference map of the human binary protein interactome. (PMID: 32296183) Luck K … Calderwood MA (Nature 2020) 3

Products for SLC26A11 Gene

Sources for SLC26A11 Gene