Aliases for SLC26A10 Gene

Aliases for SLC26A10 Gene

  • Solute Carrier Family 26 Member 10 2 3 4 5
  • Solute Carrier Family 26, Member 10 2
  • SLC26A10 5

External Ids for SLC26A10 Gene

Previous GeneCards Identifiers for SLC26A10 Gene

  • GC12P057605
  • GC12P058147
  • GC12P057721
  • GC12P056290
  • GC12P056301
  • GC12P058013
  • GC12P055051

Summaries for SLC26A10 Gene

GeneCards Summary for SLC26A10 Gene

SLC26A10 (Solute Carrier Family 26 Member 10) is a Pseudogene. Diseases associated with SLC26A10 include Sialolithiasis and Pendred Syndrome. Gene Ontology (GO) annotations related to this gene include antiporter activity and sulfate transmembrane transporter activity. An important paralog of this gene is SLC26A6.

UniProtKB/Swiss-Prot Summary for SLC26A10 Gene

Additional gene information for SLC26A10 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for SLC26A10 Gene

Genomics for SLC26A10 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for SLC26A10 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around SLC26A10 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for SLC26A10

Top Transcription factor binding sites by QIAGEN in the SLC26A10 gene promoter:
  • AhR
  • AP-4
  • Arnt
  • E47
  • GATA-2
  • ITF-2
  • Pax-3
  • Pax-4a
  • Tal-1
  • Tal-1beta

Genomic Locations for SLC26A10 Gene

Genomic Locations for SLC26A10 Gene
chr12:57,619,527-57,626,151
(GRCh38/hg38)
Size:
6,625 bases
Orientation:
Plus strand
chr12:58,013,310-58,019,934
(GRCh37/hg19)
Size:
6,625 bases
Orientation:
Plus strand

Genomic View for SLC26A10 Gene

Genes around SLC26A10 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SLC26A10 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SLC26A10 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC26A10 Gene

Proteins for SLC26A10 Gene

  • Protein details for SLC26A10 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NG04-S2610_HUMAN
    Recommended name:
    Solute carrier family 26 member 10
    Protein Accession:
    Q8NG04
    Secondary Accessions:
    • A6NMJ2
    • B6ZDQ3
    • Q6ZWI7

    Protein attributes for SLC26A10 Gene

    Size:
    563 amino acids
    Molecular mass:
    60059 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAC85515.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for SLC26A10 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SLC26A10 Gene

Post-translational modifications for SLC26A10 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SLC26A10 Gene

ENSEMBL proteins:

No data available for DME Specific Peptides for SLC26A10 Gene

Domains & Families for SLC26A10 Gene

Gene Families for SLC26A10 Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • Predicted membrane proteins
  • Transporters

Protein Domains for SLC26A10 Gene

InterPro:
Blocks:
  • Helix-turn-helix, AraC type
ProtoNet:

Suggested Antigen Peptide Sequences for SLC26A10 Gene

GenScript: Design optimal peptide antigens:
  • Solute carrier family 26 member 10 (S2610_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q8NG04

UniProtKB/Swiss-Prot:

S2610_HUMAN :
  • Belongs to the SLC26A/SulP transporter (TC 2.A.53) family.
Family:
  • Belongs to the SLC26A/SulP transporter (TC 2.A.53) family.
genes like me logo Genes that share domains with SLC26A10: view

Function for SLC26A10 Gene

Molecular function for SLC26A10 Gene

UniProtKB/Swiss-Prot Function:
Chloride/bicarbonate exchanger.

Phenotypes From GWAS Catalog for SLC26A10 Gene

Gene Ontology (GO) - Molecular Function for SLC26A10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008271 secondary active sulfate transmembrane transporter activity IEA --
GO:0015106 bicarbonate transmembrane transporter activity IBA 21873635
GO:0015108 chloride transmembrane transporter activity IBA 21873635
GO:0015116 sulfate transmembrane transporter activity IBA 21873635
GO:0015297 antiporter activity IEA --
genes like me logo Genes that share ontologies with SLC26A10: view
genes like me logo Genes that share phenotypes with SLC26A10: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SLC26A10

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for SLC26A10 Gene

Localization for SLC26A10 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC26A10 Gene

Membrane. Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SLC26A10 gene
Compartment Confidence
plasma membrane 3
extracellular 1
cytoskeleton 1
nucleus 1
lysosome 1

Gene Ontology (GO) - Cellular Components for SLC26A10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005887 integral component of plasma membrane IBA 21873635
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0016323 basolateral plasma membrane IBA 21873635
genes like me logo Genes that share ontologies with SLC26A10: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for SLC26A10 Gene

Pathways & Interactions for SLC26A10 Gene

PathCards logo

SuperPathways for SLC26A10 Gene

No Data Available

Interacting Proteins for SLC26A10 Gene

STRING Interaction Network Preview (showing top 5 STRING interactants - click image to see top 25)
STRING Interaction Network
Selected Interacting proteins: ENSP00000320217 Q8NG04-S2610_HUMAN for SLC26A10 Gene via STRING IID

Gene Ontology (GO) - Biological Process for SLC26A10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008272 sulfate transport IEA --
GO:0015701 bicarbonate transport IEA --
GO:0019532 oxalate transport IEA --
GO:0055085 transmembrane transport IEA --
GO:0098656 anion transmembrane transport IEA --
genes like me logo Genes that share ontologies with SLC26A10: view

No data available for Pathways by source and SIGNOR curated interactions for SLC26A10 Gene

Drugs & Compounds for SLC26A10 Gene

(1) Drugs for SLC26A10 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Chloride ion Experimental Pharma 0

(1) Additional Compounds for SLC26A10 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Carbonic acid
  • [co(OH)2]
  • Dihydrogen carbonate
  • H2CO3
  • Koehlensaeure
  • Carbonate
71-52-3, 463-79-6
genes like me logo Genes that share compounds with SLC26A10: view

Transcripts for SLC26A10 Gene

mRNA/cDNA for SLC26A10 Gene

2 REFSEQ mRNAs :
5 NCBI additional mRNA sequence :
11 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SLC26A10

Alternative Splicing Database (ASD) splice patterns (SP) for SLC26A10 Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8a · 8b ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13a · 13b ^ 14 ^ 15 ^ 16a · 16b ^ 17a · 17b ^ 18 ^ 19 ^
SP1: - -
SP2: - -
SP3:
SP4: -
SP5:
SP6: - - - - - - -
SP7: - - -
SP8: -
SP9:
SP10:
SP11:
SP12:

ExUns: 20a · 20b · 20c ^ 21a · 21b ^ 22 ^ 23 ^ 24 ^ 25 ^ 26 ^ 27 ^ 28a · 28b ^ 29 ^ 30 ^ 31 ^ 32a · 32b ^ 33
SP1:
SP2:
SP3: - -
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:

Relevant External Links for SLC26A10 Gene

GeneLoc Exon Structure for
SLC26A10

Expression for SLC26A10 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for SLC26A10 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SLC26A10 Gene

This gene is overexpressed in Brain - Cerebellum (x5.8) and Brain - Cerebellar Hemisphere (x4.7).

Protein differential expression in normal tissues from HIPED for SLC26A10 Gene

This gene is overexpressed in Heart (42.6) and Ovary (26.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for SLC26A10 Gene



Protein tissue co-expression partners for SLC26A10 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for SLC26A10

SOURCE GeneReport for Unigene cluster for SLC26A10 Gene:

Hs.727726

Evidence on tissue expression from TISSUES for SLC26A10 Gene

  • Nervous system(4.3)
genes like me logo Genes that share expression patterns with SLC26A10: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for SLC26A10 Gene

Orthologs for SLC26A10 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for SLC26A10 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia SLC26A10 30
  • 98.4 (n)
Dog
(Canis familiaris)
Mammalia SLC26A10 31
  • 84 (a)
OneToOne
Cow
(Bos Taurus)
Mammalia SLC26A10 31
  • 71 (a)
OneToOne
Mouse
(Mus musculus)
Mammalia Slc26a10 31
  • 63 (a)
OneToOne
Chicken
(Gallus gallus)
Aves -- 31
  • 24 (a)
ManyToMany
Lizard
(Anolis carolinensis)
Reptilia SLC26A10 31
  • 53 (a)
OneToOne
Zebrafish
(Danio rerio)
Actinopterygii slc26a10 31
  • 41 (a)
OneToOne
Fruit Fly
(Drosophila melanogaster)
Insecta Prestin 31
  • 22 (a)
OneToMany
Worm
(Caenorhabditis elegans)
Secernentea sulp-7 31
  • 26 (a)
ManyToMany
sulp-8 31
  • 26 (a)
ManyToMany
sulp-2 31
  • 23 (a)
ManyToMany
sulp-5 31
  • 23 (a)
ManyToMany
sulp-4 31
  • 23 (a)
ManyToMany
sulp-3 31
  • 19 (a)
ManyToMany
sulp-6 31
  • 18 (a)
ManyToMany
Baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SUL1 31
  • 12 (a)
ManyToMany
SUL2 31
  • 11 (a)
ManyToMany
Sea Squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 29 (a)
OneToMany
Species where no ortholog for SLC26A10 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Oppossum (Monodelphis domestica)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)

Evolution for SLC26A10 Gene

ENSEMBL:
Gene Tree for SLC26A10 (if available)
TreeFam:
Gene Tree for SLC26A10 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for SLC26A10: view image

Paralogs for SLC26A10 Gene

(11) SIMAP similar genes for SLC26A10 Gene using alignment to 3 proteins:

  • S2610_HUMAN
  • E9PIH7_HUMAN
  • H0Y683_HUMAN
genes like me logo Genes that share paralogs with SLC26A10: view

Variants for SLC26A10 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for SLC26A10 Gene

SNP ID Clinical significance and condition Chr 12 pos Variation AA Info Type
VAR_045678 A colorectal cancer sample p.Leu270Ser
rs774895 - p.Leu546Val
rs923828 - p.Ala193Thr
rs971209 - p.Met130Thr

Additional dbSNP identifiers (rs#s) for SLC26A10 Gene

Structural Variations from Database of Genomic Variants (DGV) for SLC26A10 Gene

Variant ID Type Subtype PubMed ID
nsv482992 CNV gain+loss 15286789

Variation tolerance for SLC26A10 Gene

Residual Variation Intolerance Score: 91.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 10.31; 90.69% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SLC26A10 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SLC26A10

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SLC26A10 Gene

Disorders for SLC26A10 Gene

MalaCards: The human disease database

(3) MalaCards diseases for SLC26A10 Gene - From: DISEASES

Disorder Aliases PubMed IDs
sialolithiasis
  • salivary gland stone
pendred syndrome
  • pds
fetal akinesia deformation sequence 1
  • fads1
- elite association - COSMIC cancer census association via MalaCards
genes like me logo Genes that share disorders with SLC26A10: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SLC26A10 Gene

Publications for SLC26A10 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4
  2. RNA-binding activity of TRIM25 is mediated by its PRY/SPRY domain and is required for ubiquitination. (PMID: 29117863) Choudhury NR … Michlewski G (BMC biology 2017) 3
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. (PMID: 21873635) Gaudet P … Thomas PD (Briefings in bioinformatics 2011) 3
  4. A whole genome screen for HIV restriction factors. (PMID: 22082156) Liu L … McKnight A (Retrovirology 2011) 3
  5. The consensus coding sequences of human breast and colorectal cancers. (PMID: 16959974) Sjöblom T … Velculescu VE (Science (New York, N.Y.) 2006) 4

Products for SLC26A10 Gene

Sources for SLC26A10 Gene