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Aliases for SLC26A10 Gene

Aliases for SLC26A10 Gene

  • Solute Carrier Family 26 Member 10 2 3 5
  • Solute Carrier Family 26, Member 10 2

External Ids for SLC26A10 Gene

Previous GeneCards Identifiers for SLC26A10 Gene

  • GC12P057605
  • GC12P058147
  • GC12P057721
  • GC12P056290
  • GC12P056301
  • GC12P058013
  • GC12P055051

Summaries for SLC26A10 Gene

GeneCards Summary for SLC26A10 Gene

SLC26A10 (Solute Carrier Family 26 Member 10) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include antiporter activity and sulfate transmembrane transporter activity. An important paralog of this gene is SLC26A5.

UniProtKB/Swiss-Prot for SLC26A10 Gene

  • Chloride/bicarbonate exchanger.

Additional gene information for SLC26A10 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLC26A10 Gene

Genomics for SLC26A10 Gene

GeneHancer (GH) Regulatory Elements for SLC26A10 Gene

Promoters and enhancers for SLC26A10 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH12I057619 Enhancer 1.1 Ensembl ENCODE 550.8 +1.2 1231 3.2 HDGF ARID4B SIN3A ZNF2 ZNF48 GLIS2 ARID2 ZNF143 RUNX3 MXD4 ENSG00000224713 SLC26A10 LOC101927583 EEF1AKMT3 ARHGEF25
GH12I057109 Promoter/Enhancer 2.4 EPDnew Ensembl ENCODE dbSUPER 58.8 -508.3 -508273 3.8 CLOCK FEZF1 DMAP1 IRF4 YY1 ZNF213 ZNF416 ZNF143 ZNF548 MCM3 STAT6 NEMP1 EEF1AKMT3 ENSG00000257740 BAZ2A PAN2 SMARCC2 ANKRD52 CDK4 CTDSP2
GH12I056631 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 21.4 -984.6 -984608 6.9 MLX ZFP64 FEZF1 IRF4 YY1 ZNF213 E2F8 ZNF143 SP3 NFYC BAZ2A IKZF4 ENSG00000257740 SMARCC2 SLC26A10 ANKRD52 ENSG00000224713 DTX3 ARHGEF25 PAN2
GH12I057590 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 22.3 -28.1 -28106 1.9 HDGF SMAD1 FOXA2 ARID4B SIN3A ZNF2 YY1 ZNF766 E2F8 ZNF207 PIP4K2C ENSG00000224713 NEMP1 SLC26A10 LOC283387 TSPAN31 TSFM EEF1AKMT3 ARHGEF25 CDK4
GH12I057782 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 19.2 +163.5 163491 1.9 FEZF1 DMAP1 YY1 SLC30A9 ZNF213 E2F8 ZNF416 ZNF143 SP3 NFYC TSFM NEMP1 MBD6 CDK4 EEF1AKMT3 CTDSP2 NAB2 ENSG00000224713 SLC26A10 ZBTB39
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around SLC26A10 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the SLC26A10 gene promoter:

Genomic Locations for SLC26A10 Gene

Genomic Locations for SLC26A10 Gene
chr12:57,619,527-57,626,151
(GRCh38/hg38)
Size:
6,625 bases
Orientation:
Plus strand
chr12:58,013,310-58,019,934
(GRCh37/hg19)

Genomic View for SLC26A10 Gene

Genes around SLC26A10 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SLC26A10 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SLC26A10 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC26A10 Gene

Proteins for SLC26A10 Gene

  • Protein details for SLC26A10 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NG04-S2610_HUMAN
    Recommended name:
    Solute carrier family 26 member 10
    Protein Accession:
    Q8NG04
    Secondary Accessions:
    • A6NMJ2
    • B6ZDQ3
    • Q6ZWI7

    Protein attributes for SLC26A10 Gene

    Size:
    563 amino acids
    Molecular mass:
    60059 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAC85515.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for SLC26A10 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SLC26A10 Gene

Post-translational modifications for SLC26A10 Gene

No Post-translational modifications

Other Protein References for SLC26A10 Gene

No data available for DME Specific Peptides for SLC26A10 Gene

Domains & Families for SLC26A10 Gene

Gene Families for SLC26A10 Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • Predicted membrane proteins
  • Transporters

Protein Domains for SLC26A10 Gene

Suggested Antigen Peptide Sequences for SLC26A10 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8NG04

UniProtKB/Swiss-Prot:

S2610_HUMAN :
  • Belongs to the SLC26A/SulP transporter (TC 2.A.53) family.
Family:
  • Belongs to the SLC26A/SulP transporter (TC 2.A.53) family.
genes like me logo Genes that share domains with SLC26A10: view

Function for SLC26A10 Gene

Molecular function for SLC26A10 Gene

UniProtKB/Swiss-Prot Function:
Chloride/bicarbonate exchanger.

Phenotypes From GWAS Catalog for SLC26A10 Gene

Gene Ontology (GO) - Molecular Function for SLC26A10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005254 chloride channel activity IBA --
GO:0008271 secondary active sulfate transmembrane transporter activity IEA --
GO:0015106 bicarbonate transmembrane transporter activity IBA --
GO:0015116 sulfate transmembrane transporter activity IEA,IBA --
GO:0015297 antiporter activity IEA --
genes like me logo Genes that share ontologies with SLC26A10: view
genes like me logo Genes that share phenotypes with SLC26A10: view

Animal Model Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for SLC26A10 Gene

Localization for SLC26A10 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC26A10 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SLC26A10 gene
Compartment Confidence
plasma membrane 3

Gene Ontology (GO) - Cellular Components for SLC26A10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005887 integral component of plasma membrane IBA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with SLC26A10: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for SLC26A10 Gene

Pathways & Interactions for SLC26A10 Gene

SuperPathways for SLC26A10 Gene

No Data Available

Interacting Proteins for SLC26A10 Gene

Gene Ontology (GO) - Biological Process for SLC26A10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport IEA --
GO:0008272 sulfate transport IEA --
GO:0015701 bicarbonate transport IBA --
GO:0019532 oxalate transport IEA --
GO:0042391 regulation of membrane potential IBA --
genes like me logo Genes that share ontologies with SLC26A10: view

No data available for Pathways by source and SIGNOR curated interactions for SLC26A10 Gene

Drugs & Compounds for SLC26A10 Gene

(2) Additional Compounds for SLC26A10 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Chloride ion
  • Bertholite
  • Chloor
  • Chlor
  • Chlore
  • Chloride
16887-00-6
Hydrogen carbonate
  • Bicarbonate
  • Bicarbonate (HCO3-)
  • Bicarbonate anion
  • Bicarbonate ion
  • Bicarbonate ion (HCO31-)
71-52-3
genes like me logo Genes that share compounds with SLC26A10: view

Transcripts for SLC26A10 Gene

Unigene Clusters for SLC26A10 Gene

Solute carrier family 26, member 10:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for SLC26A10 Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8a · 8b ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13a · 13b ^ 14 ^ 15 ^ 16a · 16b ^ 17a · 17b ^ 18 ^ 19 ^
SP1: - -
SP2: - -
SP3:
SP4: -
SP5:
SP6: - - - - - - -
SP7: - - -
SP8: -
SP9:
SP10:
SP11:
SP12:

ExUns: 20a · 20b · 20c ^ 21a · 21b ^ 22 ^ 23 ^ 24 ^ 25 ^ 26 ^ 27 ^ 28a · 28b ^ 29 ^ 30 ^ 31 ^ 32a · 32b ^ 33
SP1:
SP2:
SP3: - -
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:

Relevant External Links for SLC26A10 Gene

GeneLoc Exon Structure for
SLC26A10
ECgene alternative splicing isoforms for
SLC26A10

Expression for SLC26A10 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SLC26A10 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SLC26A10 Gene

This gene is overexpressed in Brain - Cerebellum (x5.8) and Brain - Cerebellar Hemisphere (x4.7).

Protein differential expression in normal tissues from HIPED for SLC26A10 Gene

This gene is overexpressed in Heart (42.6) and Ovary (26.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for SLC26A10 Gene



Protein tissue co-expression partners for SLC26A10 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of SLC26A10 Gene:

SLC26A10

SOURCE GeneReport for Unigene cluster for SLC26A10 Gene:

Hs.727726

Evidence on tissue expression from TISSUES for SLC26A10 Gene

  • Nervous system(4.3)
genes like me logo Genes that share expression patterns with SLC26A10: view

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for SLC26A10 Gene

Orthologs for SLC26A10 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for SLC26A10 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SLC26A10 33
  • 98.4 (n)
dog
(Canis familiaris)
Mammalia SLC26A10 34
  • 84 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SLC26A10 34
  • 71 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Slc26a10 34
  • 63 (a)
OneToOne
chicken
(Gallus gallus)
Aves -- 34
  • 24 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia SLC26A10 34
  • 53 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii slc26a10 34
  • 41 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Prestin 34
  • 22 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea sulp-7 34
  • 26 (a)
ManyToMany
sulp-8 34
  • 26 (a)
ManyToMany
sulp-2 34
  • 23 (a)
ManyToMany
sulp-4 34
  • 23 (a)
ManyToMany
sulp-5 34
  • 23 (a)
ManyToMany
sulp-3 34
  • 19 (a)
ManyToMany
sulp-6 34
  • 18 (a)
ManyToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SUL1 34
  • 12 (a)
ManyToMany
SUL2 34
  • 11 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 29 (a)
OneToMany
Species where no ortholog for SLC26A10 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for SLC26A10 Gene

ENSEMBL:
Gene Tree for SLC26A10 (if available)
TreeFam:
Gene Tree for SLC26A10 (if available)

Paralogs for SLC26A10 Gene

(11) SIMAP similar genes for SLC26A10 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with SLC26A10: view

Variants for SLC26A10 Gene

Sequence variations from dbSNP and Humsavar for SLC26A10 Gene

SNP ID Clin Chr 12 pos Variation AA Info Type
VAR_045678 A colorectal cancer sample p.Leu270Ser
rs1000249907 -- 57,622,016(+) C/T intron_variant
rs1000603740 -- 57,620,582(+) G/T intron_variant
rs1001302779 -- 57,624,035(+) G/A coding_sequence_variant, missense_variant
rs1001508563 -- 57,618,453(+) C/T upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for SLC26A10 Gene

Variant ID Type Subtype PubMed ID
nsv482992 CNV gain+loss 15286789

Variation tolerance for SLC26A10 Gene

Residual Variation Intolerance Score: 91.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 10.31; 90.69% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SLC26A10 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SLC26A10

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SLC26A10 Gene

Disorders for SLC26A10 Gene

Additional Disease Information for SLC26A10

No disorders were found for SLC26A10 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SLC26A10 Gene

Publications for SLC26A10 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  2. A whole genome screen for HIV restriction factors. (PMID: 22082156) Liu L … McKnight A (Retrovirology 2011) 3 58
  3. The finished DNA sequence of human chromosome 12. (PMID: 16541075) Scherer SE … Baylor College of Medicine Human Genome Sequencing Center Sequence Production Team (Nature 2006) 4 58
  4. The consensus coding sequences of human breast and colorectal cancers. (PMID: 16959974) Sjöblom T … Velculescu VE (Science (New York, N.Y.) 2006) 4 58
  5. The SLC26 gene family of multifunctional anion exchangers. (PMID: 12759755) Mount DB … Romero MF (Pflugers Archiv : European journal of physiology 2004) 4 58

Products for SLC26A10 Gene

Sources for SLC26A10 Gene

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