This gene is a member of the mitochondrial carrier subfamily of solute carrier protein genes. The product of this gene functions as a gated pore that translocates ADP from the cytoplasm into the mitochondrial matrix and ATP from the mitochondrial matrix into the cytoplasm. The protein is implicated in the function of the permability transition pore complex (PTPC), which regulat... See more...

Aliases for SLC25A6 Gene

Aliases for SLC25A6 Gene

  • Solute Carrier Family 25 Member 6 2 3 4 5
  • Solute Carrier Family 25 (Mitochondrial Carrier; Adenine Nucleotide Translocator), Member 6 2 3
  • Adenine Nucleotide Translocator 3 3 4
  • ADP,ATP Carrier Protein 3 3 4
  • ADP/ATP Translocase 3 3 4
  • ANT 2 3 4
  • ANT 3 3 4
  • ANT3Y 2 3
  • ANT3 3 4
  • Epididymis Secretory Sperm Binding Protein 3
  • ADP,ATP Carrier Protein, Isoform T2 4
  • ADP,ATP Carrier Protein, Liver 3
  • ADP/ATP Translocator Of Liver 3
  • ADP,ATP Carrier Protein 3
  • MGC17525 2
  • SLC25A6 5
  • AAC3 3
  • ANT 3

External Ids for SLC25A6 Gene

Previous HGNC Symbols for SLC25A6 Gene

  • ANT3

Previous GeneCards Identifiers for SLC25A6 Gene

  • GC0XM000980
  • GC0XM000821
  • GC0XM001081
  • GC0XM001150
  • GC0YM001548
  • GC0XM001548
  • GC0XM001465
  • GC0XM001505

Summaries for SLC25A6 Gene

Entrez Gene Summary for SLC25A6 Gene

  • This gene is a member of the mitochondrial carrier subfamily of solute carrier protein genes. The product of this gene functions as a gated pore that translocates ADP from the cytoplasm into the mitochondrial matrix and ATP from the mitochondrial matrix into the cytoplasm. The protein is implicated in the function of the permability transition pore complex (PTPC), which regulates the release of mitochondrial products that induce apoptosis. The human genome contains several non-transcribed pseudogenes of this gene. [provided by RefSeq, Jun 2013]

GeneCards Summary for SLC25A6 Gene

SLC25A6 (Solute Carrier Family 25 Member 6) is a Protein Coding gene. Diseases associated with SLC25A6 include Influenza and Bubonic Plague. Among its related pathways are Integration of energy metabolism and Apoptosis and survival_Regulation of Apoptosis by Mitochondrial Proteins. Gene Ontology (GO) annotations related to this gene include transporter activity and ATP:ADP antiporter activity. An important paralog of this gene is SLC25A5.

UniProtKB/Swiss-Prot Summary for SLC25A6 Gene

  • Catalyzes the exchange of cytoplasmic ADP with mitochondrial ATP across the mitochondrial inner membrane. May participate in the formation of the permeability transition pore complex (PTPC) responsible for the release of mitochondrial products that triggers apoptosis.

Gene Wiki entry for SLC25A6 Gene

Additional gene information for SLC25A6 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for SLC25A6 Gene

Genomics for SLC25A6 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for SLC25A6 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around SLC25A6 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for SLC25A6

Top Transcription factor binding sites by QIAGEN in the SLC25A6 gene promoter:
  • GCNF
  • GCNF-1
  • Pax-5
  • PPAR-gamma1
  • PPAR-gamma2

Genomic Locations for SLC25A6 Gene

Genomic Locations for SLC25A6 Gene
chrX:1,386,152-1,392,113
(GRCh38/hg38)
Size:
5,962 bases
Orientation:
Minus strand
chrX:1,505,045-1,511,617
(GRCh37/hg19)
Size:
6,573 bases
Orientation:
Minus strand

Genomic View for SLC25A6 Gene

Genes around SLC25A6 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SLC25A6 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SLC25A6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC25A6 Gene

Proteins for SLC25A6 Gene

  • Protein details for SLC25A6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P12236-ADT3_HUMAN
    Recommended name:
    ADP/ATP translocase 3
    Protein Accession:
    P12236
    Secondary Accessions:
    • Q96C49

    Protein attributes for SLC25A6 Gene

    Size:
    298 amino acids
    Molecular mass:
    32866 Da
    Quaternary structure:
    • Found in a complex with ARL2, ARL2BP and SLC25A6 (By similarity). Homodimer.
    • (Microbial infection) Interacts with influenza A virus PB1-F2 protein.
    • (Microbial infection) Interacts with HIV-1 Vpr.
    Miscellaneous:
    • The gene coding for this protein is located in the pseudoautosomal region 1 (PAR1) of X and Y chromosomes.

neXtProt entry for SLC25A6 Gene

Post-translational modifications for SLC25A6 Gene

  • Trimethylated by ANTKMT at Lys-52.
  • Ubiquitination at Lys43, Lys105, Lys147, Lys163, and Lys166
  • Modification sites at PhosphoSitePlus

Other Protein References for SLC25A6 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SLC25A6 Gene

Domains & Families for SLC25A6 Gene

Gene Families for SLC25A6 Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • FDA approved drug targets
  • Plasma proteins
  • Predicted membrane proteins
  • Transporters

Protein Domains for SLC25A6 Gene

InterPro:
Blocks:
  • Mitochondrial carrier protein signature
  • Adenine nucleotide translocator 1 signature
ProtoNet:

Suggested Antigen Peptide Sequences for SLC25A6 Gene

GenScript: Design optimal peptide antigens:
  • Solute carrier family 25 member 6 (ADT3_HUMAN)
  • cDNA, FLJ92654, highly similar to Homo sapiens solute carrier family 25 (mitochondrial carrier (Q6I9V5_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P12236

UniProtKB/Swiss-Prot:

ADT3_HUMAN :
  • The transmembrane helices are not perpendicular to the plane of the membrane, but cross the membrane at an angle. Odd-numbered transmembrane helices exhibit a sharp kink, due to the presence of a conserved proline residue.
  • Belongs to the mitochondrial carrier (TC 2.A.29) family.
Domain:
  • The transmembrane helices are not perpendicular to the plane of the membrane, but cross the membrane at an angle. Odd-numbered transmembrane helices exhibit a sharp kink, due to the presence of a conserved proline residue.
Family:
  • Belongs to the mitochondrial carrier (TC 2.A.29) family.
genes like me logo Genes that share domains with SLC25A6: view

Function for SLC25A6 Gene

Molecular function for SLC25A6 Gene

UniProtKB/Swiss-Prot Function:
Catalyzes the exchange of cytoplasmic ADP with mitochondrial ATP across the mitochondrial inner membrane. May participate in the formation of the permeability transition pore complex (PTPC) responsible for the release of mitochondrial products that triggers apoptosis.

Gene Ontology (GO) - Molecular Function for SLC25A6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005471 ATP:ADP antiporter activity NAS 2541251
GO:0005515 protein binding IPI 16201016
GO:0022857 transmembrane transporter activity IEA --
genes like me logo Genes that share ontologies with SLC25A6: view
genes like me logo Genes that share phenotypes with SLC25A6: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SLC25A6

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SLC25A6 Gene

Localization for SLC25A6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC25A6 Gene

Mitochondrion inner membrane. Multi-pass membrane protein. Note=The complex formed with ARL2BP, ARL2 and SLC25A6 is expressed in mitochondria. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SLC25A6 gene
Compartment Confidence
mitochondrion 5
nucleus 4
cytosol 3
plasma membrane 2
extracellular 2
cytoskeleton 2
peroxisome 1
endoplasmic reticulum 1
endosome 1
lysosome 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for SLC25A6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus HDA 21630459
GO:0005739 mitochondrion IEA,IDA --
GO:0005743 mitochondrial inner membrane TAS --
GO:0005744 TIM23 mitochondrial import inner membrane translocase complex TAS 2541251
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with SLC25A6: view

Pathways & Interactions for SLC25A6 Gene

genes like me logo Genes that share pathways with SLC25A6: view

Pathways by source for SLC25A6 Gene

1 GeneGo (Thomson Reuters) pathway for SLC25A6 Gene
  • Apoptosis and survival_Regulation of Apoptosis by Mitochondrial Proteins
2 Qiagen pathways for SLC25A6 Gene
  • Cellular Apoptosis Pathway
  • Mitochondrial Apoptosis

Gene Ontology (GO) - Biological Process for SLC25A6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006626 protein targeting to mitochondrion TAS --
GO:0006915 apoptotic process IEA --
GO:0015866 ADP transport IEA --
GO:0015867 ATP transport IEA --
GO:0016032 viral process IEA --
genes like me logo Genes that share ontologies with SLC25A6: view

No data available for SIGNOR curated interactions for SLC25A6 Gene

Drugs & Compounds for SLC25A6 Gene

(5) Drugs for SLC25A6 Gene - From: DrugBank, ApexBio, DGIdb, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Clodronate Approved, Investigational, Vet_approved Pharma Target, inhibitor 12
Etidronic acid Approved Pharma Target, inhibitor 37
Atractyloside Dipotassium Salt Pharma ANT inhibitor 0

(1) Additional Compounds for SLC25A6 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs

(1) ApexBio Compounds for SLC25A6 Gene

Compound Action Cas Number
Atractyloside Dipotassium Salt ANT inhibitor 102130-43-8
genes like me logo Genes that share compounds with SLC25A6: view

Drug Products

Transcripts for SLC25A6 Gene

mRNA/cDNA for SLC25A6 Gene

1 REFSEQ mRNAs :
18 NCBI additional mRNA sequence :
3 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SLC25A6

Alternative Splicing Database (ASD) splice patterns (SP) for SLC25A6 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b · 3c ^ 4a · 4b · 4c · 4d · 4e · 4f ^ 5a · 5b ^ 6a · 6b
SP1: - - - - - -
SP2: - - -
SP3: - - -
SP4: - -
SP5: - -
SP6: - - - -
SP7: -
SP8: - - -
SP9:

Relevant External Links for SLC25A6 Gene

GeneLoc Exon Structure for
SLC25A6

Expression for SLC25A6 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for SLC25A6 Gene

Protein differential expression in normal tissues from HIPED for SLC25A6 Gene

This gene is overexpressed in Nasal epithelium (13.2), Brain (7.6), and Frontal cortex (6.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for SLC25A6 Gene



Protein tissue co-expression partners for SLC25A6 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for SLC25A6

SOURCE GeneReport for Unigene cluster for SLC25A6 Gene:

Hs.350927

Evidence on tissue expression from TISSUES for SLC25A6 Gene

  • Nervous system(5)
  • Lung(5)
  • Liver(5)
  • Eye(4.9)
  • Blood(4.8)
  • Intestine(4.6)
  • Skin(4.6)
  • Muscle(4.4)
  • Pancreas(4.3)
  • Stomach(4.2)
  • Kidney(4)
  • Heart(3.5)
  • Spleen(3)
  • Thyroid gland(2.9)
  • Bone(2.8)
  • Lymph node(2.7)
  • Bone marrow(2.7)
  • Adrenal gland(2.5)
genes like me logo Genes that share expression patterns with SLC25A6: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for SLC25A6 Gene

Orthologs for SLC25A6 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for SLC25A6 Gene

Organism Taxonomy Gene Similarity Type Details
Oppossum
(Monodelphis domestica)
Mammalia -- 31
  • 97 (a)
ManyToMany
Cow
(Bos Taurus)
Mammalia SLC25A6 30 31
  • 91.61 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia SLC25A6 30 31
  • 91.14 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Slc25a6 30
  • 78.49 (n)
Platypus
(Ornithorhynchus anatinus)
Mammalia SLC25A6 31
  • 74 (a)
OneToOne
Chicken
(Gallus gallus)
Aves -- 31
  • 94 (a)
ManyToMany
SLC25A6 30
  • 79.19 (n)
Lizard
(Anolis carolinensis)
Reptilia SLC25A6 31
  • 88 (a)
OneToOne
Zebrafish
(Danio rerio)
Actinopterygii slc25a6 30 31
  • 77.07 (n)
ManyToMany
Fruit Fly
(Drosophila melanogaster)
Insecta sesB 31 32
  • 76 (a)
ManyToMany
Ant2 30 31 32
  • 71.51 (n)
ManyToMany
African malaria mosquito
(Anopheles gambiae)
Insecta ADT1_ANOGA 30
  • 72.93 (n)
Worm
(Caenorhabditis elegans)
Secernentea K01H12.2 32
  • 70 (a)
T01B11.4 32
  • 70 (a)
ant-1.3 30
  • 66.55 (n)
W02D3.6 32
  • 66 (a)
ant-1.2 31
  • 65 (a)
ManyToMany
C47E12.2 32
  • 50 (a)
F25B4.7 32
  • 48 (a)
R07E3.4 32
  • 45 (a)
Baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes AAC3 31
  • 52 (a)
ManyToMany
AAC1 31
  • 50 (a)
ManyToMany
PET9 31
  • 50 (a)
ManyToMany
Sea Squirt
(Ciona savignyi)
Ascidiacea CSA.2354 31
  • 54 (a)
ManyToMany
Species where no ortholog for SLC25A6 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Mouse (Mus musculus)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)

Evolution for SLC25A6 Gene

ENSEMBL:
Gene Tree for SLC25A6 (if available)
TreeFam:
Gene Tree for SLC25A6 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for SLC25A6: view image

Paralogs for SLC25A6 Gene

(8) SIMAP similar genes for SLC25A6 Gene using alignment to 3 proteins:

  • ADT3_HUMAN
  • I7HJJ0_HUMAN
  • Q6I9V5_HUMAN
genes like me logo Genes that share paralogs with SLC25A6: view

Variants for SLC25A6 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for SLC25A6 Gene

SNP ID Clinical significance and condition Chr 0X pos Variation AA Info Type
709133 Likely Benign: not provided 1,389,614(-) A/C SYNONYMOUS_VARIANT
717418 Benign: not provided 1,386,740(-) G/A SYNONYMOUS_VARIANT
733296 Likely Benign: not provided 1,389,254(-) G/A SYNONYMOUS_VARIANT
741178 Likely Benign: not provided 1,389,386(-) C/T SYNONYMOUS_VARIANT
774972 Likely Benign: not provided 1,386,737(-) G/A SYNONYMOUS_VARIANT

Additional dbSNP identifiers (rs#s) for SLC25A6 Gene

Structural Variations from Database of Genomic Variants (DGV) for SLC25A6 Gene

Variant ID Type Subtype PubMed ID
dgv1299e201 CNV deletion 23290073
esv21933 CNV gain+loss 19812545
esv2666429 CNV deletion 23128226
esv29996 CNV loss 17803354
nsv1115920 CNV duplication 24896259

Variation tolerance for SLC25A6 Gene

Residual Variation Intolerance Score: 2.37% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.01; 60.28% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SLC25A6 Gene

Human Gene Mutation Database (HGMD)
SLC25A6
SNPedia medical, phenotypic, and genealogical associations of SNPs for
SLC25A6

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SLC25A6 Gene

Disorders for SLC25A6 Gene

MalaCards: The human disease database

(8) MalaCards diseases for SLC25A6 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
influenza
  • flu
bubonic plague
  • black death
autosomal dominant progressive external ophthalmoplegia
  • adpeo
cataract 4, multiple types
  • ctrct4
plague
  • yersiniosis
- elite association - COSMIC cancer census association via MalaCards
genes like me logo Genes that share disorders with SLC25A6: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SLC25A6 Gene

Publications for SLC25A6 Gene

  1. Molecular interactions between mitochondrial membrane proteins and the C-terminal domain of PB1-F2: an in silico approach. (PMID: 19669810) Danishuddin M … Khan AU (Journal of molecular modeling 2010) 3 23
  2. Adenine nucleotide (ADP/ATP) translocase 3 participates in the tumor necrosis factor induced apoptosis of MCF-7 cells. (PMID: 17855512) Yang Z … Gu J (Molecular biology of the cell 2007) 3 23
  3. IL-4-induced upregulation of adenine nucleotide translocase 3 and its role in Th cell survival from apoptosis. (PMID: 16930576) Jang JY … Lee CE (Cellular immunology 2006) 3 23
  4. Influenza virus PB1-F2 protein induces cell death through mitochondrial ANT3 and VDAC1. (PMID: 16201016) Zamarin D … Palese P (PLoS pathogens 2005) 3 4
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4

Products for SLC25A6 Gene

  • Signalway ELISA kits for SLC25A6
  • Signalway Proteins for SLC25A6

Sources for SLC25A6 Gene