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This gene is a member of the mitochondrial carrier subfamily of solute carrier protein genes. The product of this gene functions as a gated pore that translocates ADP from the cytoplasm into the mitochondrial matrix and ATP from the mitochondrial matrix into the cytoplasm. The protein is implicated in the function of the permability transition pore complex (PTPC), which regulat... See more...
Aliases for SLC25A6 Gene
Aliases for SLC25A6 Gene
External Ids for SLC25A6 Gene
Previous HGNC Symbols for SLC25A6 Gene
- ANT3
Previous GeneCards Identifiers for SLC25A6 Gene
- GC0XM000980
- GC0XM000821
- GC0XM001081
- GC0XM001150
- GC0YM001548
- GC0XM001548
- GC0XM001465
- GC0XM001505
Summaries for SLC25A6 Gene
-
This gene is a member of the mitochondrial carrier subfamily of solute carrier protein genes. The product of this gene functions as a gated pore that translocates ADP from the cytoplasm into the mitochondrial matrix and ATP from the mitochondrial matrix into the cytoplasm. The protein is implicated in the function of the permability transition pore complex (PTPC), which regulates the release of mitochondrial products that induce apoptosis. The human genome contains several non-transcribed pseudogenes of this gene. [provided by RefSeq, Jun 2013]
GeneCards Summary for SLC25A6 Gene
SLC25A6 (Solute Carrier Family 25 Member 6) is a Protein Coding gene. Diseases associated with SLC25A6 include Influenza and Bubonic Plague. Among its related pathways are Apoptosis and survival_Regulation of Apoptosis by Mitochondrial Proteins and HIV Life Cycle. Gene Ontology (GO) annotations related to this gene include transporter activity and ATP:ADP antiporter activity. An important paralog of this gene is SLC25A5.
UniProtKB/Swiss-Prot Summary for SLC25A6 Gene
-
Catalyzes the exchange of cytoplasmic ADP with mitochondrial ATP across the mitochondrial inner membrane. May participate in the formation of the permeability transition pore complex (PTPC) responsible for the release of mitochondrial products that triggers apoptosis.
Additional gene information for SLC25A6 Gene
- HGNC (10992)
- NCBI Entrez Gene (293)
- Ensembl (ENSG00000169100)
- OMIM® (300151)
- OMIM® (403000)
- UniProtKB/Swiss-Prot (P12236)
- Open Targets Platform(ENSG00000169100)
- Search for SLC25A6 at DataMed
- Search for SLC25A6 at HumanCyc
No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for SLC25A6 Gene
Genomics for SLC25A6 Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for SLC25A6 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around SLC25A6 on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for SLC25A6
- Top Transcription factor binding sites by QIAGEN in the SLC25A6 gene promoter:
-
- GCNF
- GCNF-1
- Pax-5
- PPAR-gamma1
- PPAR-gamma2
Genomic Locations for SLC25A6 Gene
Latest Assembly
- chrX:1,386,152-1,392,113
- (GRCh38/hg38)
- Size:
- 5,962 bases
- Orientation:
- Minus strand
Previous Assembly
- chrX:1,505,045-1,511,006
- (GRCh37/hg19 by Entrez Gene)
- Size:
- 5,962 bases
- Orientation:
- Minus strand
- chrX:1,505,045-1,511,617
- (GRCh37/hg19 by Ensembl)
- Size:
- 6,573 bases
- Orientation:
- Minus strand
Genomic View for SLC25A6 Gene
Genes around SLC25A6 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- Xp22.32 and Yp11.3 by HGNC
- X;Y by Entrez Gene
- Xp22.33 by Ensembl
SLC25A6 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for SLC25A6 Gene
Proteins for SLC25A6 Gene
-
Protein details for SLC25A6 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P12236-ADT3_HUMAN
- Recommended name:
- ADP/ATP translocase 3
- Protein Accession:
- P12236
- Q96C49
Protein attributes for SLC25A6 Gene
- Size:
- 298 amino acids
- Molecular mass:
- 32866 Da
- Quaternary structure:
-
- Homodimer (By similarity). Found in a complex with ARL2, ARL2BP and SLC25A6 (By similarity).
- (Microbial infection) Interacts with influenza A virus PB1-F2 protein.
- (Microbial infection) Interacts with HIV-1 Vpr.
- Miscellaneous:
-
- The gene coding for this protein is located in the pseudoautosomal region 1 (PAR1) of X and Y chromosomes.
Protein Expression for SLC25A6 Gene
Post-translational modifications for SLC25A6 Gene
- Trimethylated by ANTKMT at Lys-52.
-
Ubiquitination at Lys43, Lys105, Lys147, Lys163, and Lys166
- NX_P12236 (NX_P12236-1)
- Modification sites at PhosphoSitePlus
Other Protein References for SLC25A6 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibodies for research
- LifeSpan BioSciences SLC25A6 / ANT3 Antibody
- G Biosciences Immunotag™ ANT3 Polyclonal Antibody and Immunotag™ SLC25A6 Antibody
- Novus Biologicals Antibodies for SLC25A6
-
Abcam antibodies for SLC25A6
- Invitrogen Antibodies for SLC25A6 (AFLGC-Slc25a6)
-
Santa Cruz Biotechnology (SCBT) Antibodies for SLC25A6
Protein products for research
-
OriGene Purified Proteins for SLC25A6
- Search Origene for MassSpec and Protein Over-expression Lysates for SLC25A6
- Origene Custom Protein Services for SLC25A6
- antibodies-online: Show 5 available SLC25A6 Proteins ranked by validation data
- Compare Top SLC25A6 Proteins
-
Quality Products:
-
Abcam proteins for SLC25A6
Assay products for research
- antibodies-online: Show 7 available SLC25A6 Elisa Kits ranked by validation data
- Compare Top SLC25A6 Elisa Kits
-
Quality Products:
No data available for DME Specific Peptides for SLC25A6 Gene
Domains & Families for SLC25A6 Gene
Gene Families for SLC25A6 Gene
- HGNC:
- IUPHAR :
- Human Protein Atlas (HPA):
-
- FDA approved drug targets
- Plasma proteins
- Predicted membrane proteins
- Transporters
Protein Domains for SLC25A6 Gene
- InterPro:
- Blocks:
-
- Mitochondrial carrier protein signature
- Adenine nucleotide translocator 1 signature
- ProtoNet:
Suggested Antigen Peptide Sequences for SLC25A6 Gene
- GenScript: Design optimal peptide antigens:
-
- Solute carrier family 25 member 6 (ADT3_HUMAN)
- cDNA, FLJ92654, highly similar to Homo sapiens solute carrier family 25 (mitochondrial carrier (Q6I9V5_HUMAN)
Graphical View of Domain Structure for InterPro Entry
P12236UniProtKB/Swiss-Prot:
ADT3_HUMAN :- The transmembrane helices are not perpendicular to the plane of the membrane, but cross the membrane at an angle. Odd-numbered transmembrane helices exhibit a sharp kink, due to the presence of a conserved proline residue.
- Belongs to the mitochondrial carrier (TC 2.A.29) family.
- Domain:
-
- The transmembrane helices are not perpendicular to the plane of the membrane, but cross the membrane at an angle. Odd-numbered transmembrane helices exhibit a sharp kink, due to the presence of a conserved proline residue.
- Family:
-
- Belongs to the mitochondrial carrier (TC 2.A.29) family.
Function for SLC25A6 Gene
Molecular function for SLC25A6 Gene
- UniProtKB/Swiss-Prot Function:
- Catalyzes the exchange of cytoplasmic ADP with mitochondrial ATP across the mitochondrial inner membrane. May participate in the formation of the permeability transition pore complex (PTPC) responsible for the release of mitochondrial products that triggers apoptosis.
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005347 | ATP transmembrane transporter activity | IEA | -- |
| GO:0005471 | ATP:ADP antiporter activity | NAS | 2541251 |
| GO:0005515 | protein binding | IPI | 16201016 |
| GO:0022857 | transmembrane transporter activity | IEA | -- |
Phenotypes for SLC25A6 Gene
- GenomeRNAi human phenotypes for SLC25A6:
Animal Models for research
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR products for research
- Applied Biological Materials (abm): CRISPR Clones for SLC25A6 - Starting at $85 >
- * SLC25A6 CRISPR as ready-to-use vector or virus: Non-viral | Lenti- | Adeno- | AAV- | siRNA - Browse All
- * Cas9 Nucleases, Nickases, Null Mutants, and GFP tag also available.
-
OriGene CRISPR knockouts for SLC25A6
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for SLC25A6
miRNA for SLC25A6 Gene
- miRTarBase miRNAs that target SLC25A6
-
- hsa-miR-16-5p (MIRT031609)
- hsa-miR-421 (MIRT039389)
- hsa-miR-423-3p (MIRT042493)
- hsa-miR-204-3p (MIRT738832)
- hsa-miR-3148 (MIRT740246)
- hsa-miR-3153 (MIRT740399)
- hsa-miR-4438 (MIRT744505)
- hsa-miR-4505 (MIRT745541)
- hsa-miR-4514 (MIRT745726)
- hsa-miR-4646-5p (MIRT746442)
- hsa-miR-4668-5p (MIRT746830)
- hsa-miR-4692 (MIRT747132)
- hsa-miR-5095 (MIRT749699)
- hsa-miR-549a (MIRT750845)
- hsa-miR-5787 (MIRT751490)
- hsa-miR-6733-5p (MIRT754123)
- hsa-miR-6739-5p (MIRT754320)
- hsa-miR-6808-5p (MIRT756601)
- hsa-miR-6893-5p (MIRT758746)
- hsa-miR-7151-3p (MIRT759182)
- hsa-miR-940 (MIRT760842)
- hsa-miR-139-5p (MIRT762612)
miRNA products for research
Inhibitory RNAs for research
- Origene shrna, sirna, and RNAi products in human, mouse, rat for SLC25A6
- Browse OriGene Inhibitory RNA Products For SLC25A6
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SLC25A6
Clone products for research
- Applied Biological Materials (abm): Clones for SLC25A6 - Starting at $45 >
- * SLC25A6 as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Retro- | Protein Vector - Browse All
- * Viral Packaging Services and High Titer Production Services also available.
- Sino Biological Human cDNA Clone for SLC25A6
- Addgene plasmids for SLC25A6
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for SLC25A6
Cell Lines for research
-
Horizon Cell Lines for SLC25A6
No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SLC25A6 Gene
Localization for SLC25A6 Gene
Subcellular locations from UniProtKB/Swiss-Prot for SLC25A6 Gene
- Mitochondrion inner membrane. Multi-pass membrane protein. Membrane. Note=The complex formed with ARL2BP, ARL2 and SLC25A6 is expressed in mitochondria (By similarity). May localize to non-mitochondrial membranes (By similarity). {ECO:0000250 UniProtKB:P12235, ECO:0000250 UniProtKB:P32007}.
| Compartment | Confidence |
|---|---|
| mitochondrion | 5 |
| nucleus | 4 |
| cytosol | 3 |
| extracellular | 2 |
| peroxisome | 2 |
| plasma membrane | 1 |
| cytoskeleton | 1 |
| endoplasmic reticulum | 1 |
| endosome | 1 |
| lysosome | 1 |
| golgi apparatus | 1 |
- Mitochondria (3)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005634 | nucleus | HDA | 21630459 |
| GO:0005739 | mitochondrion | IEA,IDA | -- |
| GO:0005743 | mitochondrial inner membrane | TAS | -- |
| GO:0005744 | TIM23 mitochondrial import inner membrane translocase complex | TAS | 2541251 |
| GO:0016020 | membrane | IEA,IDA | 27641616 |
Pathways & Interactions for SLC25A6 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | HIV Life Cycle |
.64
|
.45
|
| 2 | Pathways of neurodegeneration - multiple diseases | ||
| 3 | Transport of the SLBP independent Mature mRNA | ||
| 4 | Prion disease |
.55
|
|
| 5 | Apoptotic Pathways in Synovial Fibroblasts |
Cellular Apoptosis Pathway
.85
|
Mitochondrial Apoptosis
.85
|
Pathways by source for SLC25A6 Gene
1 BioSystems pathway for SLC25A6 Gene
14 Reactome pathways for SLC25A6 Gene
13 KEGG pathways for SLC25A6 Gene
1 GeneGo (Thomson Reuters) pathway for SLC25A6 Gene
- Apoptosis and survival_Regulation of Apoptosis by Mitochondrial Proteins
2 Qiagen pathways for SLC25A6 Gene
- Cellular Apoptosis Pathway
- Mitochondrial Apoptosis
Interacting Proteins for SLC25A6 Gene
Selected Interacting proteins:
P12236-ADT3_HUMAN
ENSP00000370808
for SLC25A6 Gene via
UniProtKB
MINT
STRING
IID
GPS-Prot Interaction Network for SLC25A6
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006626 | protein targeting to mitochondrion | TAS | -- |
| GO:0006915 | apoptotic process | IEA | -- |
| GO:0016032 | viral process | IEA | -- |
| GO:0050796 | regulation of insulin secretion | TAS | -- |
| GO:0055085 | transmembrane transport | IEA | -- |
No data available for SIGNOR curated interactions for SLC25A6 Gene
Drugs & Compounds for SLC25A6 Gene
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs |
|---|
(1) ApexBio Compounds for SLC25A6 Gene
| Compound | Action | Cas Number |
|---|---|---|
| Atractyloside Dipotassium Salt | ANT inhibitor | 102130-43-8 |
Transcripts for SLC25A6 Gene
mRNA/cDNA for SLC25A6 Gene
- 1 REFSEQ mRNAs :
- 18 NCBI additional mRNA sequence :
- 3 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000381401 1451 nts (view in UCSC)
- ENST00000475167 900 nts (view in UCSC)
- ENST00000484026 854 nts (view in UCSC)
CRISPR products for research
- Applied Biological Materials (abm): CRISPR Clones for SLC25A6 - Starting at $85 >
- * SLC25A6 CRISPR as ready-to-use vector or virus: Non-viral | Lenti- | Adeno- | AAV- | siRNA - Browse All
- * Cas9 Nucleases, Nickases, Null Mutants, and GFP tag also available.
-
OriGene CRISPR knockouts for SLC25A6
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for SLC25A6
miRNA products for research
Inhibitory RNAs for research
- Origene shrna, sirna, and RNAi products in human, mouse, rat for SLC25A6
- Browse OriGene Inhibitory RNA Products For SLC25A6
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SLC25A6
Clone products for research
- Applied Biological Materials (abm): Clones for SLC25A6 - Starting at $45 >
- * SLC25A6 as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Retro- | Protein Vector - Browse All
- * Viral Packaging Services and High Titer Production Services also available.
- Sino Biological Human cDNA Clone for SLC25A6
- Addgene plasmids for SLC25A6
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for SLC25A6
| ExUns: | 1a | · | 1b | · | 1c | ^ | 2 | ^ | 3a | · | 3b | · | 3c | ^ | 4a | · | 4b | · | 4c | · | 4d | · | 4e | · | 4f | ^ | 5a | · | 5b | ^ | 6a | · | 6b |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | - | - | - | |||||||||||||||||||||||||||
| SP2: | - | - | - | ||||||||||||||||||||||||||||||
| SP3: | - | - | - | ||||||||||||||||||||||||||||||
| SP4: | - | - | |||||||||||||||||||||||||||||||
| SP5: | - | - | |||||||||||||||||||||||||||||||
| SP6: | - | - | - | - | |||||||||||||||||||||||||||||
| SP7: | - | ||||||||||||||||||||||||||||||||
| SP8: | - | - | - | ||||||||||||||||||||||||||||||
| SP9: |
Relevant External Links for SLC25A6 Gene
- GeneLoc Exon Structure for
- SLC25A6
Expression for SLC25A6 Gene
This gene is overexpressed in Nasal epithelium (13.2), Brain (7.6), and Frontal cortex (6.6).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for SLC25A6 Gene
- Elite partner
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for SLC25A6
SOURCE GeneReport for Unigene cluster for SLC25A6 Gene:
Hs.350927mRNA Expression by UniProt/SwissProt for SLC25A6 Gene:
P12236-ADT3_HUMAN
Tissue specificity:
Expressed in erythrocytes (at protein level).
Evidence on tissue expression from TISSUES for SLC25A6 Gene
- Nervous system(5)
- Lung(5)
- Liver(4.9)
- Eye(4.9)
- Blood(4.7)
- Intestine(4.5)
- Skin(4.5)
- Muscle(4.4)
- Pancreas(4.2)
- Stomach(4.1)
- Kidney(3.9)
- Heart(3.3)
- Thyroid gland(2.7)
- Spleen(2.7)
- Bone(2.6)
- Lymph node(2.4)
- Bone marrow(2)
Primer products for research
-
OriGene qPCR primer pairs for SLC25A6
-
OriGene qPCR primer pairs and template standards for SLC25A6
Gene Expression Assays for research
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for SLC25A6 Gene
Orthologs for SLC25A6 Gene
This gene was present in the common ancestor of animals and fungi.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Oppossum (Monodelphis domestica) |
Mammalia | -- 31 |
|
ManyToMany | |
| Cow (Bos Taurus) |
Mammalia | SLC25A6 30 31 |
|
OneToOne | |
| Dog (Canis familiaris) |
Mammalia | SLC25A6 30 31 |
|
OneToOne | |
| Rat (Rattus norvegicus) |
Mammalia | Slc25a6 30 |
|
||
| Platypus (Ornithorhynchus anatinus) |
Mammalia | SLC25A6 31 |
|
OneToOne | |
| Chicken (Gallus gallus) |
Aves | -- 31 |
|
ManyToMany | |
| SLC25A6 30 |
|
||||
| Lizard (Anolis carolinensis) |
Reptilia | SLC25A6 31 |
|
OneToOne | |
| Zebrafish (Danio rerio) |
Actinopterygii | slc25a6 30 31 |
|
ManyToMany | |
| Fruit Fly (Drosophila melanogaster) |
Insecta | sesB 31 32 |
|
ManyToMany | |
| Ant2 30 31 32 |
|
ManyToMany | |||
| African malaria mosquito (Anopheles gambiae) |
Insecta | ADT1_ANOGA 30 |
|
||
| Worm (Caenorhabditis elegans) |
Secernentea | K01H12.2 32 |
|
|
|
| T01B11.4 32 |
|
|
|||
| ant-1.3 30 |
|
||||
| W02D3.6 32 |
|
|
|||
| ant-1.2 31 |
|
ManyToMany | |||
| C47E12.2 32 |
|
|
|||
| F25B4.7 32 |
|
|
|||
| R07E3.4 32 |
|
|
|||
| Baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | AAC3 31 |
|
ManyToMany | |
| AAC1 31 |
|
ManyToMany | |||
| PET9 31 |
|
ManyToMany | |||
| Sea Squirt (Ciona savignyi) |
Ascidiacea | CSA.2354 31 |
|
ManyToMany |
- Species where no ortholog for SLC25A6 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chimpanzee (Pan troglodytes)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Mouse (Mus musculus)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rainbow Trout (Oncorhynchus mykiss)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Tropical Clawed Frog (Silurana tropicalis)
- Wheat (Triticum aestivum)
Evolution for SLC25A6 Gene
- ENSEMBL:
- Gene Tree for SLC25A6 (if available)
- TreeFam:
- Gene Tree for SLC25A6 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for SLC25A6: view image
Paralogs for SLC25A6 Gene
Paralogs for SLC25A6 Gene
- SLC25A5 5
- SLC25A4 5
- SLC25A31 5
- SLC25A16 5
- SLC25A12 5
- SLC25A43 5
- SLC25A13 5
- SLC25A1 5
- SLC25A23 5
- SLC25A21 5
- SLC25A42 5
- SLC25A29 5
- SLC25A24 5
- SLC25A30 5
- SLC25A22 5
- SLC25A41 5
- SLC25A14 5
- SLC25A25 5
- SLC25A20 5
- SLC25A32 5
- SLC25A18 5
- SLC25A47 5
- SLC25A39 5
- UCP2 5
- SLC25A27 5
- SLC25A45 5
- UCP3 5
- SLC25A19 5
- SLC25A38 5
- SLC25A34 5
- ENSG00000285982 5
- SLC25A40 5
- SLC25A48 5
- SLC25A2 5
- SLC25A36 5
- SLC25A15 5
- SLC25A51 5
- SLC25A52 5
- SLC25A33 5
- UCP1 5
- SLC25A3 5
- SLC25A35 5
- SLC25A17 5
- SLC25A11 5
- SLC25A37 5
- SLC25A53 5
- SLC25A28 5
- SLC25A26 5
- SLC25A44 5
- ENSG00000262660 5
- SLC25A10 5
(8) SIMAP similar genes for SLC25A6 Gene using alignment to 3 proteins:
- ADT3_HUMAN
- I7HJJ0_HUMAN
- Q6I9V5_HUMAN
Pseudogenes.org Pseudogenes for SLC25A6 Gene
Variants for SLC25A6 Gene
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for SLC25A6 Gene
| SNP ID | Clinical significance and condition | Chr 0X pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1143655 | Benign: not provided | 1,389,572(-) |
G/A NM_001636.4(SLC25A6):c.267C>T (p.Phe89=) |
SYNONYMOUS | |
| rs11550233 | Likely Benign: not provided | 1,389,614(-) |
A/C NM_001636.4(SLC25A6):c.225T>G (p.Leu75=) |
SYNONYMOUS | |
| rs138672404 | Benign: not provided | 1,389,533(-) |
G/A NM_001636.4(SLC25A6):c.306C>T (p.Gly102=) |
SYNONYMOUS | |
| rs143216483 | Likely Benign: not provided | 1,389,410(-) |
C/T NM_001636.4(SLC25A6):c.429G>A (p.Ala143=) |
SYNONYMOUS | |
| rs149117617 | Likely Benign: not provided | 1,386,737(-) |
G/A NM_001636.4(SLC25A6):c.762C>T (p.Thr254=) |
SYNONYMOUS |
All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| dgv1299e201 | CNV | deletion | 23290073 |
| esv21933 | CNV | gain+loss | 19812545 |
| esv2666429 | CNV | deletion | 23128226 |
| esv29996 | CNV | loss | 17803354 |
| nsv1115920 | CNV | duplication | 24896259 |
Residual Variation Intolerance Score:
2.37% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
4.01;
60.28% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for SLC25A6 Gene
SNP Genotyping and Copy Number Assays for research
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SLC25A6 Gene
Disorders for SLC25A6 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| influenza |
|
|
| bubonic plague |
|
|
| autosomal dominant progressive external ophthalmoplegia |
|
|
| plague |
|
|
| amyotrophic lateral sclerosis 1 |
|
|
Search SLC25A6 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for SLC25A6
- Atlas
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
- Open Targets Platform
No data available for UniProtKB/Swiss-Prot and Genatlas for SLC25A6 Gene
Publications for SLC25A6 Gene
- TSPO ligands stimulate ZnPPIX transport and ROS accumulation leading to the inhibition of P. falciparum growth in human blood. (PMID: 27641616) Marginedas-Freixa I … Ostuni MA (Scientific reports 2016) 3 4
- Molecular interactions between mitochondrial membrane proteins and the C-terminal domain of PB1-F2: an in silico approach. (PMID: 19669810) Danishuddin M … Khan AU (Journal of molecular modeling 2010) 3 23
- Adenine nucleotide (ADP/ATP) translocase 3 participates in the tumor necrosis factor induced apoptosis of MCF-7 cells. (PMID: 17855512) Yang Z … Gu J (Molecular biology of the cell 2007) 3 23
- IL-4-induced upregulation of adenine nucleotide translocase 3 and its role in Th cell survival from apoptosis. (PMID: 16930576) Jang JY … Lee CE (Cellular immunology 2006) 3 23
- Influenza virus PB1-F2 protein induces cell death through mitochondrial ANT3 and VDAC1. (PMID: 16201016) Zamarin D … Palese P (PLoS pathogens 2005) 3 4
ExternalLinks
Products for SLC25A6 Gene
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Sources for SLC25A6 Gene
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