Free for academic non-profit institutions. Other users need a Commercial license
This gene is a member of the mitochondrial carrier subfamily of solute carrier protein genes. The product of this gene functions as a gated pore that translocates ADP from the cytoplasm into the mitochondrial matrix and ATP from the mitochondrial matrix into the cytoplasm. The protein is implicated in the function of the permability transition pore complex (PTPC), which regulates the release of mitochondrial products that induce apoptosis. The human genome contains several non-transcribed pseudogenes of this gene. [provided by RefSeq, Jun 2013]
SLC25A6 (Solute Carrier Family 25 Member 6) is a Protein Coding gene. Diseases associated with SLC25A6 include Influenza and Bubonic Plague. Among its related pathways are Apoptosis and survival_Regulation of Apoptosis by Mitochondrial Proteins and HIV Life Cycle. Gene Ontology (GO) annotations related to this gene include transporter activity and ATP:ADP antiporter activity. An important paralog of this gene is SLC25A5.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005347 | ATP transmembrane transporter activity | IEA | -- |
GO:0005471 | ATP:ADP antiporter activity | NAS | 2541251 |
GO:0005515 | protein binding | IPI | 16201016 |
GO:0022857 | transmembrane transporter activity | IEA | -- |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005634 | nucleus | HDA | 21630459 |
GO:0005739 | mitochondrion | IEA,IDA | -- |
GO:0005743 | mitochondrial inner membrane | TAS | -- |
GO:0005744 | TIM23 mitochondrial import inner membrane translocase complex | TAS | 2541251 |
GO:0016020 | membrane | IEA,IDA | 27641616 |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | HIV Life Cycle |
.64
|
.45
|
2 | Pathways of neurodegeneration - multiple diseases | ||
3 | Transport of the SLBP independent Mature mRNA | ||
4 | Prion disease |
.55
|
|
5 | Apoptotic Pathways in Synovial Fibroblasts |
Cellular Apoptosis Pathway
.85
|
Mitochondrial Apoptosis
.85
|
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0006626 | protein targeting to mitochondrion | TAS | -- |
GO:0006915 | apoptotic process | IEA | -- |
GO:0016032 | viral process | IEA | -- |
GO:0050796 | regulation of insulin secretion | TAS | -- |
GO:0055085 | transmembrane transport | IEA | -- |
Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs |
---|
Compound | Action | Cas Number |
---|---|---|
Atractyloside Dipotassium Salt | ANT inhibitor | 102130-43-8 |
ExUns: | 1a | · | 1b | · | 1c | ^ | 2 | ^ | 3a | · | 3b | · | 3c | ^ | 4a | · | 4b | · | 4c | · | 4d | · | 4e | · | 4f | ^ | 5a | · | 5b | ^ | 6a | · | 6b |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | - | - | - | - | - | - | |||||||||||||||||||||||||||
SP2: | - | - | - | ||||||||||||||||||||||||||||||
SP3: | - | - | - | ||||||||||||||||||||||||||||||
SP4: | - | - | |||||||||||||||||||||||||||||||
SP5: | - | - | |||||||||||||||||||||||||||||||
SP6: | - | - | - | - | |||||||||||||||||||||||||||||
SP7: | - | ||||||||||||||||||||||||||||||||
SP8: | - | - | - | ||||||||||||||||||||||||||||||
SP9: |
This gene was present in the common ancestor of animals and fungi.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Oppossum (Monodelphis domestica) |
Mammalia | -- 31 |
|
ManyToMany | |
Cow (Bos Taurus) |
Mammalia | SLC25A6 30 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | SLC25A6 30 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Slc25a6 30 |
|
||
Platypus (Ornithorhynchus anatinus) |
Mammalia | SLC25A6 31 |
|
OneToOne | |
Chicken (Gallus gallus) |
Aves | -- 31 |
|
ManyToMany | |
SLC25A6 30 |
|
||||
Lizard (Anolis carolinensis) |
Reptilia | SLC25A6 31 |
|
OneToOne | |
Zebrafish (Danio rerio) |
Actinopterygii | slc25a6 30 31 |
|
ManyToMany | |
Fruit Fly (Drosophila melanogaster) |
Insecta | sesB 31 32 |
|
ManyToMany | |
Ant2 30 31 32 |
|
ManyToMany | |||
African malaria mosquito (Anopheles gambiae) |
Insecta | ADT1_ANOGA 30 |
|
||
Worm (Caenorhabditis elegans) |
Secernentea | K01H12.2 32 |
|
|
|
T01B11.4 32 |
|
|
|||
ant-1.3 30 |
|
||||
W02D3.6 32 |
|
|
|||
ant-1.2 31 |
|
ManyToMany | |||
C47E12.2 32 |
|
|
|||
F25B4.7 32 |
|
|
|||
R07E3.4 32 |
|
|
|||
Baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | AAC3 31 |
|
ManyToMany | |
AAC1 31 |
|
ManyToMany | |||
PET9 31 |
|
ManyToMany | |||
Sea Squirt (Ciona savignyi) |
Ascidiacea | CSA.2354 31 |
|
ManyToMany |
SNP ID | Clinical significance and condition | Chr 0X pos | Variation | AA Info | Type |
---|---|---|---|---|---|
rs1143655 | Benign: not provided | 1,389,572(-) |
G/A NM_001636.4(SLC25A6):c.267C>T (p.Phe89=) |
SYNONYMOUS | |
rs11550233 | Likely Benign: not provided | 1,389,614(-) |
A/C NM_001636.4(SLC25A6):c.225T>G (p.Leu75=) |
SYNONYMOUS | |
rs138672404 | Benign: not provided | 1,389,533(-) |
G/A NM_001636.4(SLC25A6):c.306C>T (p.Gly102=) |
SYNONYMOUS | |
rs143216483 | Likely Benign: not provided | 1,389,410(-) |
C/T NM_001636.4(SLC25A6):c.429G>A (p.Ala143=) |
SYNONYMOUS | |
rs149117617 | Likely Benign: not provided | 1,386,737(-) |
G/A NM_001636.4(SLC25A6):c.762C>T (p.Thr254=) |
SYNONYMOUS |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
dgv1299e201 | CNV | deletion | 23290073 |
esv21933 | CNV | gain+loss | 19812545 |
esv2666429 | CNV | deletion | 23128226 |
esv29996 | CNV | loss | 17803354 |
nsv1115920 | CNV | duplication | 24896259 |
Disorder | Aliases | PubMed IDs |
---|---|---|
influenza |
|
|
bubonic plague |
|
|
autosomal dominant progressive external ophthalmoplegia |
|
|
plague |
|
|
amyotrophic lateral sclerosis 1 |
|
|