This gene is a member of the mitochondrial carrier subfamily of solute carrier protein genes. The product of this gene functions as a gated pore that translocates ADP from the cytoplasm into the mitochondrial matrix and ATP from the mitochondrial matrix into the cytoplasm. The protein forms a homodimer embedded in the inner mitochondria membrane. Suppressed expression of this g... See more...

Aliases for SLC25A5 Gene

Aliases for SLC25A5 Gene

  • Solute Carrier Family 25 Member 5 2 3 4 5
  • Solute Carrier Family 25 (Mitochondrial Carrier; Adenine Nucleotide Translocator), Member 5 2 3
  • ADP,ATP Carrier Protein, Fibroblast Isoform 3 4
  • ADP/ATP Translocase 2 3 4
  • ANT2 3 4
  • Adenine Nucleotide Translocator 2 (Fibroblast) 3
  • Adenine Nucleotide Translocator 2 4
  • ADP,ATP Carrier Protein 2 4
  • ANT 2 4
  • AAC2 3
  • 2F1 3
  • T2 3
  • T3 3

External Ids for SLC25A5 Gene

Previous HGNC Symbols for SLC25A5 Gene

  • ANT2

Previous GeneCards Identifiers for SLC25A5 Gene

  • GC0XP113420
  • GC0XP115588
  • GC0XP116577
  • GC0XP117356
  • GC0XP118384
  • GC0XP118486
  • GC0XP118602
  • GC0XP108095

Summaries for SLC25A5 Gene

Entrez Gene Summary for SLC25A5 Gene

  • This gene is a member of the mitochondrial carrier subfamily of solute carrier protein genes. The product of this gene functions as a gated pore that translocates ADP from the cytoplasm into the mitochondrial matrix and ATP from the mitochondrial matrix into the cytoplasm. The protein forms a homodimer embedded in the inner mitochondria membrane. Suppressed expression of this gene has been shown to induce apoptosis and inhibit tumor growth. The human genome contains several non-transcribed pseudogenes of this gene.[provided by RefSeq, Jun 2013]

GeneCards Summary for SLC25A5 Gene

SLC25A5 (Solute Carrier Family 25 Member 5) is a Protein Coding gene. Diseases associated with SLC25A5 include Non-Syndromic Intellectual Disability and Oncocytoma. Among its related pathways are HIV Life Cycle and Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.. Gene Ontology (GO) annotations related to this gene include adenine transmembrane transporter activity. An important paralog of this gene is SLC25A6.

UniProtKB/Swiss-Prot Summary for SLC25A5 Gene

  • Catalyzes the exchange of cytoplasmic ADP with mitochondrial ATP across the mitochondrial inner membrane. As part of the mitotic spindle-associated MMXD complex it may play a role in chromosome segregation.

Additional gene information for SLC25A5 Gene

No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for SLC25A5 Gene

Genomics for SLC25A5 Gene

GeneHancer (GH) Regulatory Elements for SLC25A5 Gene

Promoters and enhancers for SLC25A5 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around SLC25A5 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for SLC25A5

Top Transcription factor binding sites by QIAGEN in the SLC25A5 gene promoter:
  • AP-1
  • ATF-2
  • c-Jun
  • MyoD
  • PPAR-alpha
  • STAT3

Genomic Locations for SLC25A5 Gene

Genomic Locations for SLC25A5 Gene
chrX:119,468,400-119,471,396
(GRCh38/hg38)
Size:
2,997 bases
Orientation:
Plus strand
chrX:118,602,363-118,605,359
(GRCh37/hg19)
Size:
2,997 bases
Orientation:
Plus strand

Genomic View for SLC25A5 Gene

Genes around SLC25A5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SLC25A5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SLC25A5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC25A5 Gene

Proteins for SLC25A5 Gene

  • Protein details for SLC25A5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P05141-ADT2_HUMAN
    Recommended name:
    ADP/ATP translocase 2
    Protein Accession:
    P05141
    Secondary Accessions:
    • B2RCV1
    • O43350

    Protein attributes for SLC25A5 Gene

    Size:
    298 amino acids
    Molecular mass:
    32852 Da
    Quaternary structure:
    • Homodimer. Component of the MMXD complex, which includes CIAO1, ERCC2, CIAO2B, MMS19 and SLC25A5 (PubMed:20797633). Interacts with AK4 (PubMed:19130895).
    • (Microbial infection) Interacts with HIV-1 Vpr.

neXtProt entry for SLC25A5 Gene

Post-translational modifications for SLC25A5 Gene

  • Trimethylated by ANTKMT at Lys-52.
  • Ubiquitination at Lys43, Lys105, Lys147, Lys163, Lys166, and Lys245
  • Modification sites at PhosphoSitePlus

Other Protein References for SLC25A5 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SLC25A5 Gene

Domains & Families for SLC25A5 Gene

Gene Families for SLC25A5 Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • FDA approved drug targets
  • Plasma proteins
  • Predicted membrane proteins
  • Transporters

Protein Domains for SLC25A5 Gene

Blocks:
  • Mitochondrial carrier protein signature
  • Adenine nucleotide translocator 1 signature
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for SLC25A5 Gene

GenScript: Design optimal peptide antigens:
  • Solute carrier family 25 member 5 (ADT2_HUMAN)
  • SLC25A5 protein (Q6NVC0_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P05141

UniProtKB/Swiss-Prot:

ADT2_HUMAN :
  • The transmembrane helices are not perpendicular to the plane of the membrane, but cross the membrane at an angle. Odd-numbered transmembrane helices exhibit a sharp kink, due to the presence of a conserved proline residue.
  • Belongs to the mitochondrial carrier (TC 2.A.29) family.
Domain:
  • The transmembrane helices are not perpendicular to the plane of the membrane, but cross the membrane at an angle. Odd-numbered transmembrane helices exhibit a sharp kink, due to the presence of a conserved proline residue.
Family:
  • Belongs to the mitochondrial carrier (TC 2.A.29) family.
genes like me logo Genes that share domains with SLC25A5: view

Function for SLC25A5 Gene

Molecular function for SLC25A5 Gene

UniProtKB/Swiss-Prot Function:
Catalyzes the exchange of cytoplasmic ADP with mitochondrial ATP across the mitochondrial inner membrane. As part of the mitotic spindle-associated MMXD complex it may play a role in chromosome segregation.

Phenotypes From GWAS Catalog for SLC25A5 Gene

Gene Ontology (GO) - Molecular Function for SLC25A5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding HDA 22658674
GO:0005471 ATP:ADP antiporter activity IBA 21873635
GO:0005515 protein binding IPI 17715127
GO:0015207 adenine transmembrane transporter activity TAS 2168878
GO:0022857 transmembrane transporter activity IEA --
genes like me logo Genes that share ontologies with SLC25A5: view
genes like me logo Genes that share phenotypes with SLC25A5: view

Animal Model Products

CRISPR Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SLC25A5 Gene

Localization for SLC25A5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC25A5 Gene

Mitochondrion inner membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SLC25A5 gene
Compartment Confidence
cytoskeleton 5
mitochondrion 5
plasma membrane 4
cytosol 3
extracellular 2
nucleus 2
peroxisome 1
endoplasmic reticulum 1
lysosome 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for SLC25A5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus HDA 21630459
GO:0005739 mitochondrion IEA,IDA --
GO:0005743 mitochondrial inner membrane TAS --
GO:0005887 integral component of plasma membrane TAS 2168878
GO:0016020 membrane IEA,HDA 19946888
genes like me logo Genes that share ontologies with SLC25A5: view

Pathways & Interactions for SLC25A5 Gene

genes like me logo Genes that share pathways with SLC25A5: view

Pathways by source for SLC25A5 Gene

1 GeneGo (Thomson Reuters) pathway for SLC25A5 Gene
  • Apoptosis and survival_Regulation of Apoptosis by Mitochondrial Proteins
2 Qiagen pathways for SLC25A5 Gene
  • Cellular Apoptosis Pathway
  • Mitochondrial Apoptosis
1 Cell Signaling Technology pathway for SLC25A5 Gene

Gene Ontology (GO) - Biological Process for SLC25A5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007059 chromosome segregation IEA --
GO:0008284 positive regulation of cell proliferation IMP 19154410
GO:0015853 adenine transport IEA --
GO:0015866 ADP transport IEA --
GO:0015867 ATP transport IEA --
genes like me logo Genes that share ontologies with SLC25A5: view

No data available for SIGNOR curated interactions for SLC25A5 Gene

Drugs & Compounds for SLC25A5 Gene

(6) Drugs for SLC25A5 Gene - From: DrugBank, ApexBio, DGIdb, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Clodronate Approved, Investigational, Vet_approved Pharma Target, inhibitor 12
Atractyloside Dipotassium Salt Pharma ANT inhibitor 0

(1) Additional Compounds for SLC25A5 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs

(1) ApexBio Compounds for SLC25A5 Gene

Compound Action Cas Number
Atractyloside Dipotassium Salt ANT inhibitor 102130-43-8
genes like me logo Genes that share compounds with SLC25A5: view

Drug Products

Transcripts for SLC25A5 Gene

mRNA/cDNA for SLC25A5 Gene

1 REFSEQ mRNAs :
8 NCBI additional mRNA sequence :
4 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for SLC25A5 Gene

No ASD Table

Relevant External Links for SLC25A5 Gene

GeneLoc Exon Structure for
SLC25A5

Expression for SLC25A5 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for SLC25A5 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for SLC25A5 Gene

This gene is overexpressed in Nasal epithelium (23.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for SLC25A5 Gene



Protein tissue co-expression partners for SLC25A5 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for SLC25A5

SOURCE GeneReport for Unigene cluster for SLC25A5 Gene:

Hs.632282

Evidence on tissue expression from TISSUES for SLC25A5 Gene

  • Nervous system(4.9)
  • Eye(4.6)
  • Liver(4.6)
  • Skin(4.3)
  • Blood(4.2)
  • Lung(4.1)
  • Pancreas(3.7)
  • Intestine(3.6)
  • Kidney(3.6)
  • Muscle(2.6)
  • Stomach(2.6)
  • Heart(2.5)
  • Thyroid gland(2.4)
  • Lymph node(2.2)
  • Bone marrow(2)
  • Spleen(2)
genes like me logo Genes that share expression patterns with SLC25A5: view

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for SLC25A5 Gene

Orthologs for SLC25A5 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for SLC25A5 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SLC25A5 31
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SLC25A5 31 30
  • 94.18 (n)
OneToOne
cow
(Bos Taurus)
Mammalia SLC25A5 31 30
  • 93.18 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Slc25a5 30
  • 93.06 (n)
mouse
(Mus musculus)
Mammalia Slc25a5 17 31 30
  • 92.62 (n)
oppossum
(Monodelphis domestica)
Mammalia -- 31
  • 91 (a)
OneToMany
-- 31
  • 91 (a)
OneToMany
-- 31
  • 91 (a)
OneToMany
-- 31
  • 91 (a)
OneToMany
-- 31
  • 78 (a)
OneToMany
-- 31
  • 70 (a)
OneToMany
chicken
(Gallus gallus)
Aves SLC25A6 31
  • 88 (a)
OneToOne
SLC25A5 30
  • 81.32 (n)
lizard
(Anolis carolinensis)
Reptilia -- 31
  • 91 (a)
OneToMany
-- 31
  • 91 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia MGC75700 30
  • 80.81 (n)
zebrafish
(Danio rerio)
Actinopterygii SLC25A5 (1 of 2) 31
  • 84 (a)
OneToMany
slc25a5 31 30
  • 81.98 (n)
OneToMany
-- 30
fruit fly
(Drosophila melanogaster)
Insecta sesB 31 32
  • 77 (a)
ManyToMany
Ant2 31 32
  • 71 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea K01H12.2 32
  • 71 (a)
T01B11.4 32
  • 71 (a)
ant-1.1 31
  • 68 (a)
ManyToMany
ant-1.3 31
  • 67 (a)
ManyToMany
W02D3.6 32
  • 67 (a)
C47E12.2 31 32
  • 49 (a)
ManyToMany
F25B4.7 31 32
  • 47 (a)
ManyToMany
R07E3.4 32
  • 44 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes AAC3 31
  • 52 (a)
ManyToMany
AAC1 31
  • 50 (a)
ManyToMany
PET9 31
  • 50 (a)
ManyToMany
rice
(Oryza sativa)
Liliopsida Os.23386 30
sea squirt
(Ciona savignyi)
Ascidiacea CSA.2354 31
  • 53 (a)
ManyToMany
Species where no ortholog for SLC25A5 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SLC25A5 Gene

ENSEMBL:
Gene Tree for SLC25A5 (if available)
TreeFam:
Gene Tree for SLC25A5 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for SLC25A5: view image

Paralogs for SLC25A5 Gene

(5) SIMAP similar genes for SLC25A5 Gene using alignment to 2 proteins:

  • ADT2_HUMAN
  • Q6NVC0_HUMAN
genes like me logo Genes that share paralogs with SLC25A5: view

Variants for SLC25A5 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for SLC25A5 Gene

SNP ID Clinical significance and condition Chr 0X pos Variation AA Info Type
rs371749 - p.Leu111Arg

Additional dbSNP identifiers (rs#s) for SLC25A5 Gene

Structural Variations from Database of Genomic Variants (DGV) for SLC25A5 Gene

Variant ID Type Subtype PubMed ID
esv2740427 CNV deletion 23290073
esv2740429 CNV deletion 23290073

Variation tolerance for SLC25A5 Gene

Residual Variation Intolerance Score: 62.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.17; 3.76% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SLC25A5 Gene

Human Gene Mutation Database (HGMD)
SLC25A5
SNPedia medical, phenotypic, and genealogical associations of SNPs for
SLC25A5

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SLC25A5 Gene

Disorders for SLC25A5 Gene

MalaCards: The human disease database

(3) MalaCards diseases for SLC25A5 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
non-syndromic intellectual disability
  • intellectual disability, non syndromic
oncocytoma
  • oxyphilic adenoma
dilated cardiomyopathy
  • cardiomyopathy, familial idiopathic
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for SLC25A5

genes like me logo Genes that share disorders with SLC25A5: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SLC25A5 Gene

Publications for SLC25A5 Gene

  1. Ordered shotgun sequencing of a 135 kb Xq25 YAC containing ANT2 and four possible genes, including three confirmed by EST matches. (PMID: 8918809) Chen CN … Chen E (Nucleic acids research 1996) 3 4 23 54
  2. The human fibroblast adenine nucleotide translocator gene. Molecular cloning and sequence. (PMID: 2168878) Ku DH … Wurzel J (The Journal of biological chemistry 1990) 2 3 4 54
  3. Two distinct genes for ADP/ATP translocase are expressed at the mRNA level in adult human liver. (PMID: 2829183) Houldsworth J … Attardi G (Proceedings of the National Academy of Sciences of the United States of America 1988) 2 3 4 54
  4. MMXD, a TFIIH-independent XPD-MMS19 protein complex involved in chromosome segregation. (PMID: 20797633) Ito S … Tanaka K (Molecular cell 2010) 3 4 54
  5. Enzymatically inactive adenylate kinase 4 interacts with mitochondrial ADP/ATP translocase. (PMID: 19130895) Liu R … Zhu H (The international journal of biochemistry & cell biology 2009) 3 4 54

Products for SLC25A5 Gene

Sources for SLC25A5 Gene