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Aliases for SLC25A47 Gene

Aliases for SLC25A47 Gene

  • Solute Carrier Family 25 Member 47 2 3 5
  • Hepatocellular Carcinoma Down-Regulated Mitochondrial Carrier Protein 3 4
  • C14orf68 3 4
  • HDMCP 3 4
  • Hepatocellular Carcinoma-Downregulated Mitochondrial Carrier Protein 3
  • HCC-Down-Regulated Mitochondrial Carrier Protein 3
  • Chromosome 14 Open Reading Frame 68 2
  • Solute Carrier Family 25, Member 47 2
  • HMFN1655 3

External Ids for SLC25A47 Gene

Previous HGNC Symbols for SLC25A47 Gene

  • C14orf68

Previous GeneCards Identifiers for SLC25A47 Gene

  • GC14P101010
  • GC14P080971
  • GC14P101022
  • GC14P101033
  • GC14P101047
  • GC14P101077
  • GC14P101114
  • GC14P101163
  • GC14P101225

Summaries for SLC25A47 Gene

Entrez Gene Summary for SLC25A47 Gene

  • This gene encodes a member of a large family of mitochondrial transporters. The nuclear-encoded carrier protein is embedded in the inner mitochondrial membrane. This member of the family is thought to be an uncoupling protein that uncouples mitochondrial respiration from ATP synthesis by dissipating the transmembrane proton gradient. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2017]

GeneCards Summary for SLC25A47 Gene

SLC25A47 (Solute Carrier Family 25 Member 47) is a Protein Coding gene. An important paralog of this gene is SLC25A45.

UniProtKB/Swiss-Prot for SLC25A47 Gene

  • Uncoupling protein which may catalyze the physiological proton leak in liver. Overexpression induces the dissipation of mitochondrial membrane potential.

Additional gene information for SLC25A47 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLC25A47 Gene

Genomics for SLC25A47 Gene

GeneHancer (GH) Regulatory Elements for SLC25A47 Gene

Promoters and enhancers for SLC25A47 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH14I100323 Promoter 1.1 EPDnew 550.8 0.0 -17 0.1 DRAP1 TFAP4 FOXA2 TAF1 SAP130 MLX MAX RAD21 THRB ZNF48 SLC25A47 RN7SL523P GC14M100323
GH14I100284 Enhancer 1.7 FANTOM5 Ensembl ENCODE dbSUPER 11.2 -38.1 -38060 2.5 HDGF CLOCK ARNT ZFP64 ARID4B SIN3A DMAP1 ZNF2 ZBTB7B POLR2B WARS CCNK WDR25 SLC25A47 PIR46113 ENSG00000259052 GC14P100279 SLC25A29
GH14I100405 Enhancer 1.7 FANTOM5 Ensembl ENCODE dbSUPER 9.9 +85.1 85054 5.8 PKNOX1 MLX ARID4B DMAP1 SLC30A9 FOS REST ZNF592 MIER3 SMARCA4 LOC105370664 WDR25 WARS SLC25A47 GC14P100409 HMGN1P25
GH14I100383 Enhancer 1.3 Ensembl ENCODE dbSUPER 10.8 +65.9 65859 11.2 PKNOX1 FOXA2 SIN3A ZNF2 YY1 GLIS2 ZNF143 DEK RXRA REST WARS WDR25 SLC25A47 BEGAIN MIR493 MIR337 MIR136 RTL1 MIR127 MIR431
GH14I100397 Enhancer 1.2 Ensembl ENCODE dbSUPER 10.4 +75.1 75122 1.9 ELF3 SOX13 MXI1 SAP130 ARID4B CEBPG DMAP1 ZNF644 RARA TEAD3 WARS WDR25 SLC25A47 GC14P100409
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around SLC25A47 on UCSC Golden Path with GeneCards custom track

Genomic Locations for SLC25A47 Gene

Genomic Locations for SLC25A47 Gene
7,042 bases
Plus strand

Genomic View for SLC25A47 Gene

Genes around SLC25A47 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SLC25A47 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SLC25A47 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC25A47 Gene

Proteins for SLC25A47 Gene

  • Protein details for SLC25A47 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Solute carrier family 25 member 47
    Protein Accession:
    Secondary Accessions:
    • B2RP39
    • Q68CL2
    • Q6PZD8
    • Q86U14

    Protein attributes for SLC25A47 Gene

    308 amino acids
    Molecular mass:
    33435 Da
    Quaternary structure:
    No Data Available
    • Sequence=BAD38636.1; Type=Erroneous translation; Note=Wrong choice of frame.; Evidence={ECO:0000305}; Sequence=CAD62588.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Alternative splice isoforms for SLC25A47 Gene


neXtProt entry for SLC25A47 Gene

Post-translational modifications for SLC25A47 Gene

No Post-translational modifications

Other Protein References for SLC25A47 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SLC25A47 Gene

Domains & Families for SLC25A47 Gene

Gene Families for SLC25A47 Gene

Human Protein Atlas (HPA):
  • Predicted membrane proteins
  • Transporters

Protein Domains for SLC25A47 Gene

Suggested Antigen Peptide Sequences for SLC25A47 Gene

Graphical View of Domain Structure for InterPro Entry



S2547_HUMAN :
  • Belongs to the mitochondrial carrier (TC 2.A.29) family.
  • Belongs to the mitochondrial carrier (TC 2.A.29) family.
genes like me logo Genes that share domains with SLC25A47: view

Function for SLC25A47 Gene

Molecular function for SLC25A47 Gene

UniProtKB/Swiss-Prot Function:
Uncoupling protein which may catalyze the physiological proton leak in liver. Overexpression induces the dissipation of mitochondrial membrane potential.
UniProtKB/Swiss-Prot Induction:
Down-regulated in hepatocarcinoma.

Gene Ontology (GO) - Molecular Function for SLC25A47 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005476 NOT carnitine:acyl carnitine antiporter activity IBA --
GO:0015226 NOT carnitine transmembrane transporter activity IBA --
GO:0022857 transmembrane transporter activity IBA --
genes like me logo Genes that share ontologies with SLC25A47: view
genes like me logo Genes that share phenotypes with SLC25A47: view

Animal Model Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for SLC25A47 Gene

Localization for SLC25A47 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC25A47 Gene

Mitochondrion inner membrane; Multi-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SLC25A47 gene
Compartment Confidence
mitochondrion 4
plasma membrane 2
extracellular 2
peroxisome 1
endoplasmic reticulum 1
cytosol 1

Gene Ontology (GO) - Cellular Components for SLC25A47 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005743 mitochondrial inner membrane IBA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IBA,IEA --
genes like me logo Genes that share ontologies with SLC25A47: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for SLC25A47 Gene

Pathways & Interactions for SLC25A47 Gene

SuperPathways for SLC25A47 Gene

No Data Available

Interacting Proteins for SLC25A47 Gene

Selected Interacting proteins: Q6Q0C1-S2547_HUMAN for SLC25A47 Gene via IID

Symbol External ID(s) Details

Gene Ontology (GO) - Biological Process for SLC25A47 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport IEA --
GO:0006839 mitochondrial transport IBA --
GO:0015879 NOT carnitine transport IBA --
GO:0055085 transmembrane transport IEA --
genes like me logo Genes that share ontologies with SLC25A47: view

No data available for Pathways by source and SIGNOR curated interactions for SLC25A47 Gene

Drugs & Compounds for SLC25A47 Gene

No Compound Related Data Available

Transcripts for SLC25A47 Gene

mRNA/cDNA for SLC25A47 Gene

Unigene Clusters for SLC25A47 Gene

Solute carrier family 25, member 47:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for SLC25A47 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6
SP1: -

Relevant External Links for SLC25A47 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SLC25A47 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SLC25A47 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SLC25A47 Gene

This gene is overexpressed in Liver (x52.1).

Protein differential expression in normal tissues from HIPED for SLC25A47 Gene

This gene is overexpressed in Spleen (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for SLC25A47 Gene

Protein tissue co-expression partners for SLC25A47 Gene

NURSA nuclear receptor signaling pathways regulating expression of SLC25A47 Gene:


SOURCE GeneReport for Unigene cluster for SLC25A47 Gene:


mRNA Expression by UniProt/SwissProt for SLC25A47 Gene:

Tissue specificity: Specifically expressed in liver.

Evidence on tissue expression from TISSUES for SLC25A47 Gene

  • Liver(4.5)
genes like me logo Genes that share expression patterns with SLC25A47: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for SLC25A47 Gene

Orthologs for SLC25A47 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for SLC25A47 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia SLC25A47 33 34
  • 98.59 (n)
(Canis familiaris)
Mammalia SLC25A47 33 34
  • 87.83 (n)
(Bos Taurus)
Mammalia SLC25A47 33 34
  • 86.1 (n)
(Mus musculus)
Mammalia Slc25a47 33 16 34
  • 83.33 (n)
(Rattus norvegicus)
Mammalia Slc25a47 33
  • 83.23 (n)
(Monodelphis domestica)
Mammalia SLC25A47 34
  • 73 (a)
(Ornithorhynchus anatinus)
Mammalia SLC25A47 34
  • 66 (a)
(Gallus gallus)
Aves SLC25A47 33 34
  • 64.58 (n)
(Anolis carolinensis)
Reptilia SLC25A47 34
  • 58 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia slc25a47 33
  • 57.55 (n)
(Danio rerio)
Actinopterygii slc25a47b 33 34
  • 58.45 (n)
slc25a47a 34
  • 54 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG5646 34
  • 31 (a)
(Caenorhabditis elegans)
Secernentea R07B7.10 34
  • 34 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes YMC1 34
  • 28 (a)
YMC2 34
  • 26 (a)
Species where no ortholog for SLC25A47 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SLC25A47 Gene

Gene Tree for SLC25A47 (if available)
Gene Tree for SLC25A47 (if available)

Paralogs for SLC25A47 Gene

Paralogs for SLC25A47 Gene

(10) SIMAP similar genes for SLC25A47 Gene using alignment to 2 proteins: Pseudogenes for SLC25A47 Gene

genes like me logo Genes that share paralogs with SLC25A47: view

Variants for SLC25A47 Gene

Sequence variations from dbSNP and Humsavar for SLC25A47 Gene

SNP ID Clin Chr 14 pos Variation AA Info Type
rs193920797 uncertain-significance, Malignant tumor of prostate 100,325,815(+) C/T coding_sequence_variant, missense_variant
rs1000164580 -- 100,329,984(+) T/A 3_prime_UTR_variant
rs1000621284 -- 100,329,823(+) C/T 3_prime_UTR_variant
rs1000881128 -- 100,321,711(+) G/A upstream_transcript_variant
rs1000904537 -- 100,326,227(+) G/A coding_sequence_variant, missense_variant

Structural Variations from Database of Genomic Variants (DGV) for SLC25A47 Gene

Variant ID Type Subtype PubMed ID
nsv832875 CNV loss 17160897

Variation tolerance for SLC25A47 Gene

Residual Variation Intolerance Score: 67.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.59; 56.22% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SLC25A47 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SLC25A47 Gene

Disorders for SLC25A47 Gene

Additional Disease Information for SLC25A47

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for SLC25A47 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SLC25A47 Gene

Publications for SLC25A47 Gene

  1. Cloning and identification of hepatocellular carcinoma down-regulated mitochondrial carrier protein, a novel liver-specific uncoupling protein. (PMID: 15322095) Tan MG … Hui KM (The Journal of biological chemistry 2004) 3 4 22 58
  2. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson SL … O'Brien SJ (PloS one 2010) 3 44 58
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  4. Expression profiling and differential screening between hepatoblastomas and the corresponding normal livers: identification of high expression of the PLK1 oncogene as a poor-prognostic indicator of hepatoblastomas. (PMID: 15221005) Yamada S … Nakagawara A (Oncogene 2004) 3 4 58
  5. The mitochondrial transporter family SLC25: identification, properties and physiopathology. (PMID: 23266187) Palmieri F (Molecular aspects of medicine 2013) 3 58

Products for SLC25A47 Gene

Sources for SLC25A47 Gene

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