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Aliases for SLC25A45 Gene

Aliases for SLC25A45 Gene

  • Solute Carrier Family 25 Member 45 2 3 5
  • Solute Carrier Family 25, Member 45 2

External Ids for SLC25A45 Gene

Previous GeneCards Identifiers for SLC25A45 Gene

  • GC11M064900
  • GC11M065142
  • GC11M061469

Summaries for SLC25A45 Gene

Entrez Gene Summary for SLC25A45 Gene

  • SLC25A45 belongs to the SLC25 family of mitochondrial carrier proteins (Haitina et al., 2006 [PubMed 16949250]).[supplied by OMIM, Mar 2008]

GeneCards Summary for SLC25A45 Gene

SLC25A45 (Solute Carrier Family 25 Member 45) is a Protein Coding gene. An important paralog of this gene is SLC25A47.

Additional gene information for SLC25A45 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLC25A45 Gene

Genomics for SLC25A45 Gene

GeneHancer (GH) Regulatory Elements for SLC25A45 Gene

Promoters and enhancers for SLC25A45 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH11I065377 Promoter/Enhancer 2.8 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 550.8 +1.2 1219 10.3 MLX FEZF1 DMAP1 IRF4 YY1 SLC30A9 ZNF213 ZNF143 ZNF263 SP3 FRMD8 SLC25A45 SF1 PCNX3 POLA2 MUS81 NEAT1 SART1 EIF1AD RELA
GH11I065470 Promoter/Enhancer 2.9 VISTA FANTOM5 Ensembl ENCODE dbSUPER 14 -106.4 -106383 40 CLOCK MLX ZFP64 FEZF1 DMAP1 YBX1 IRF4 YY1 SLC30A9 ZNF213 LOC105369346 SF1 PCNX3 POLA2 ZFPL1 EIF1AD SART1 MUS81 LOC105369352 KAT5
GH11I065288 Enhancer 1.7 FANTOM5 Ensembl ENCODE dbSUPER 13 +87.9 87904 14.5 PKNOX1 FOXA2 ARID4B SIN3A DMAP1 BRCA1 ZNF48 ETS1 ZNF766 FOS POLA2 EHD1 LOC728975 SLC25A45 DPF2 FRMD8 ENSG00000255478 SPDYC CAPN1 PGAM1P8
GH11I065452 Promoter/Enhancer 1.7 Ensembl ENCODE dbSUPER 12.6 -71.3 -71326 5.2 ATF1 SMAD1 ARNT ARID4B SIN3A ZNF48 TCF12 POLR2B ZNF143 ATF7 LOC101927789 NEAT1 FRMD8 ZFPL1 EIF1AD SART1 PCNX3 SLC25A45 MALAT1 SF1
GH11I065438 Enhancer 1.4 Ensembl ENCODE dbSUPER 12.6 -60.5 -60530 10.7 PKNOX1 CLOCK SMAD1 IRF4 YY1 TCF12 ZNF121 POLR2B GLIS2 E2F8 ENSG00000275948 GC11P065523 GC11P065530 GC11P065531 MIR612 NEAT1 SF1 RELA VPS51 EIF1AD
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around SLC25A45 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the SLC25A45 gene promoter:

Genomic Locations for SLC25A45 Gene

Genomic Locations for SLC25A45 Gene
chr11:65,373,053-65,383,701
(GRCh38/hg38)
Size:
10,649 bases
Orientation:
Minus strand
chr11:65,142,663-65,151,172
(GRCh37/hg19)

Genomic View for SLC25A45 Gene

Genes around SLC25A45 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SLC25A45 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SLC25A45 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC25A45 Gene

Proteins for SLC25A45 Gene

  • Protein details for SLC25A45 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N413-S2545_HUMAN
    Recommended name:
    Solute carrier family 25 member 45
    Protein Accession:
    Q8N413
    Secondary Accessions:
    • Q6PL49
    • Q8IW29

    Protein attributes for SLC25A45 Gene

    Size:
    288 amino acids
    Molecular mass:
    31906 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for SLC25A45 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SLC25A45 Gene

Post-translational modifications for SLC25A45 Gene

No Post-translational modifications

No data available for DME Specific Peptides for SLC25A45 Gene

Domains & Families for SLC25A45 Gene

Gene Families for SLC25A45 Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted membrane proteins
  • Transporters

Protein Domains for SLC25A45 Gene

Suggested Antigen Peptide Sequences for SLC25A45 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8N413

UniProtKB/Swiss-Prot:

S2545_HUMAN :
  • Belongs to the mitochondrial carrier (TC 2.A.29) family.
Family:
  • Belongs to the mitochondrial carrier (TC 2.A.29) family.
genes like me logo Genes that share domains with SLC25A45: view

Function for SLC25A45 Gene

Phenotypes From GWAS Catalog for SLC25A45 Gene

Gene Ontology (GO) - Molecular Function for SLC25A45 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000064 NOT L-ornithine transmembrane transporter activity IBA --
GO:0022857 transmembrane transporter activity IBA --
genes like me logo Genes that share ontologies with SLC25A45: view

Phenotypes for SLC25A45 Gene

genes like me logo Genes that share phenotypes with SLC25A45: view

Animal Model Products

miRNA for SLC25A45 Gene

miRTarBase miRNAs that target SLC25A45

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SLC25A45 Gene

Localization for SLC25A45 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC25A45 Gene

Mitochondrion inner membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SLC25A45 gene
Compartment Confidence
mitochondrion 4
extracellular 2
nucleus 2
cytosol 2
plasma membrane 1
peroxisome 1
endoplasmic reticulum 1
lysosome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for SLC25A45 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005743 mitochondrial inner membrane IBA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IBA --
genes like me logo Genes that share ontologies with SLC25A45: view

Pathways & Interactions for SLC25A45 Gene

SuperPathways for SLC25A45 Gene

No Data Available

Interacting Proteins for SLC25A45 Gene

Gene Ontology (GO) - Biological Process for SLC25A45 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000066 NOT mitochondrial ornithine transport IBA --
GO:0006810 transport IEA --
GO:0006839 mitochondrial transport IBA --
GO:0055085 transmembrane transport IEA --
genes like me logo Genes that share ontologies with SLC25A45: view

No data available for Pathways by source and SIGNOR curated interactions for SLC25A45 Gene

Drugs & Compounds for SLC25A45 Gene

No Compound Related Data Available

Transcripts for SLC25A45 Gene

Unigene Clusters for SLC25A45 Gene

Solute carrier family 25, member 45:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for SLC25A45 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c · 2d · 2e · 2f ^ 3a · 3b · 3c ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8a · 8b ^ 9a · 9b
SP1: - - - - - -
SP2: - - - -
SP3: - - - - -
SP4: - - - - - - - - - -
SP5: - - - - - - -
SP6: - - - - -
SP7: - - - -
SP8: - - - - - - -
SP9:
SP10: - - - - -

Relevant External Links for SLC25A45 Gene

GeneLoc Exon Structure for
SLC25A45
ECgene alternative splicing isoforms for
SLC25A45

Expression for SLC25A45 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SLC25A45 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SLC25A45 Gene

This gene is overexpressed in Pancreas (x5.2).

Protein differential expression in normal tissues from HIPED for SLC25A45 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (66.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for SLC25A45 Gene



Protein tissue co-expression partners for SLC25A45 Gene

NURSA nuclear receptor signaling pathways regulating expression of SLC25A45 Gene:

SLC25A45

SOURCE GeneReport for Unigene cluster for SLC25A45 Gene:

Hs.661604

Evidence on tissue expression from TISSUES for SLC25A45 Gene

  • Pancreas(4.3)
genes like me logo Genes that share expression patterns with SLC25A45: view

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for SLC25A45 Gene

Orthologs for SLC25A45 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for SLC25A45 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SLC25A45 33 34
  • 99.42 (n)
cow
(Bos Taurus)
Mammalia SLC25A45 33 34
  • 88.54 (n)
dog
(Canis familiaris)
Mammalia SLC25A45 33 34
  • 87.85 (n)
rat
(Rattus norvegicus)
Mammalia Slc25a45 33
  • 84.2 (n)
mouse
(Mus musculus)
Mammalia Slc25a45 33 16 34
  • 83.16 (n)
oppossum
(Monodelphis domestica)
Mammalia SLC25A45 34
  • 77 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SLC25A45 34
  • 55 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SLC25A45 34
  • 62 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia slc25a45 33
  • 58.39 (n)
zebrafish
(Danio rerio)
Actinopterygii LOC100329446 33
  • 56.55 (n)
si:dkey-150i13.2 34
  • 33 (a)
ManyToMany
fruit fly
(Drosophila melanogaster)
Insecta CG5646 34
  • 34 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea R07B7.10 33 34
  • 44.73 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes YMC1 34
  • 27 (a)
ManyToMany
YMC2 34
  • 25 (a)
ManyToMany
Species where no ortholog for SLC25A45 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SLC25A45 Gene

ENSEMBL:
Gene Tree for SLC25A45 (if available)
TreeFam:
Gene Tree for SLC25A45 (if available)

Paralogs for SLC25A45 Gene

Paralogs for SLC25A45 Gene

genes like me logo Genes that share paralogs with SLC25A45: view

Variants for SLC25A45 Gene

Sequence variations from dbSNP and Humsavar for SLC25A45 Gene

SNP ID Clin Chr 11 pos Variation AA Info Type
rs1000078572 -- 65,378,634(-) G/T intron_variant
rs1000584157 -- 65,374,717(-) C/T downstream_transcript_variant
rs1000820805 -- 65,377,755(-) T/A intron_variant
rs1000869584 -- 65,383,411(-) G/A 5_prime_UTR_variant, genic_upstream_transcript_variant, upstream_transcript_variant
rs1000885325 -- 65,378,852(-) C/T intron_variant

Structural Variations from Database of Genomic Variants (DGV) for SLC25A45 Gene

Variant ID Type Subtype PubMed ID
esv2422285 CNV deletion 17116639
nsv526181 CNV gain 19592680
nsv951016 CNV deletion 24416366

Variation tolerance for SLC25A45 Gene

Residual Variation Intolerance Score: 88.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.85; 58.77% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SLC25A45 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SLC25A45

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SLC25A45 Gene

Disorders for SLC25A45 Gene

Additional Disease Information for SLC25A45

No disorders were found for SLC25A45 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SLC25A45 Gene

Publications for SLC25A45 Gene

  1. Fourteen novel human members of mitochondrial solute carrier family 25 (SLC25) widely expressed in the central nervous system. (PMID: 16949250) Haitina T … Fredriksson R (Genomics 2006) 2 3 4 58
  2. Genome-wide association study on dimethylarginines reveals novel AGXT2 variants associated with heart rate variability but not with overall mortality. (PMID: 24159190) Seppälä I … AtheroRemo Consortium (European heart journal 2014) 3 58
  3. The mitochondrial transporter family SLC25: identification, properties and physiopathology. (PMID: 23266187) Palmieri F (Molecular aspects of medicine 2013) 3 58
  4. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PMID: 17207965) Lamesch P … Vidal M (Genomics 2007) 3 58
  5. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K … Sugano S (Genome research 2006) 3 58

Products for SLC25A45 Gene

Sources for SLC25A45 Gene

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