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Aliases for SLC25A43 Gene

Aliases for SLC25A43 Gene

  • Solute Carrier Family 25 Member 43 2 3 5
  • Solute Carrier Family 25, Member 43 2

External Ids for SLC25A43 Gene

Previous GeneCards Identifiers for SLC25A43 Gene

  • GC0XP118398
  • GC0XP118533
  • GC0XP108026

Summaries for SLC25A43 Gene

Entrez Gene Summary for SLC25A43 Gene

  • This gene encodes a member of the mitochondrial carrier family of proteins.[provided by RefSeq, Dec 2009]

GeneCards Summary for SLC25A43 Gene

SLC25A43 (Solute Carrier Family 25 Member 43) is a Protein Coding gene. An important paralog of this gene is SLC25A16.

Additional gene information for SLC25A43 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLC25A43 Gene

Genomics for SLC25A43 Gene

GeneHancer (GH) Regulatory Elements for SLC25A43 Gene

Promoters and enhancers for SLC25A43 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH0XI119398 Promoter/Enhancer 1.8 EPDnew Ensembl ENCODE 568.7 +0.4 416 2.3 ATF1 SIN3A ZNF48 ATF7 SP5 MXD4 CEBPB REST ELF1 ZNF592 SLC25A43 LOC159007 ENSG00000237903
GH0XI119466 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE dbSUPER 30.9 +70.1 70149 4.6 PKNOX1 SMAD1 ARID4B SIN3A DMAP1 ZNF2 YY1 POLR2B ZNF143 SP3 SLC25A5-AS1 SLC25A5 PIR58034 SLC25A43 CXorf56 ENSG00000237903 RNU1-67P EEF1A1P30 NKAP NKAPP1
GH0XI119493 Enhancer 1.2 Ensembl ENCODE dbSUPER 21.7 +96.4 96438 4.3 SOX13 TFAP4 FOXA2 SAP130 MAX ZNF384 DMAP1 ZNF644 ZNF48 RARA SLC25A43 CXorf56 SLC25A5 SLC25A5-AS1 ENSG00000226661 GC0XM119476 GC0XM119539
GH0XI119512 Enhancer 1.1 Ensembl ENCODE dbSUPER 20.5 +113.4 113432 0.6 CTCF ZNF654 RB1 ZNF449 ARID4B ZNF384 REST RAD21 SP1 ZNF121 CXorf56 SLC25A43 SLC25A5 SLC25A5-AS1 RNU1-67P ENSG00000237903 ENSG00000226661 GC0XM119539 GC0XM119476
GH0XI119454 Enhancer 0.9 ENCODE dbSUPER 20.5 +56.7 56745 2.3 SOX5 SOX13 GATAD2A FOXA2 FOXA3 ZNF384 ZSCAN21 PRDM6 ZNF316 ZNF366 GC0XP119457 RNY3P16 SLC25A43 ENSG00000226661 SLC25A5 RN7SL118P
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around SLC25A43 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the SLC25A43 gene promoter:

Genomic Locations for SLC25A43 Gene

Genomic Locations for SLC25A43 Gene
chrX:119,399,060-119,454,478
(GRCh38/hg38)
Size:
55,419 bases
Orientation:
Plus strand
chrX:118,533,023-118,588,441
(GRCh37/hg19)

Genomic View for SLC25A43 Gene

Genes around SLC25A43 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SLC25A43 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SLC25A43 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC25A43 Gene

Proteins for SLC25A43 Gene

  • Protein details for SLC25A43 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8WUT9-S2543_HUMAN
    Recommended name:
    Solute carrier family 25 member 43
    Protein Accession:
    Q8WUT9
    Secondary Accessions:
    • O75854
    • Q8N9L5

    Protein attributes for SLC25A43 Gene

    Size:
    341 amino acids
    Molecular mass:
    37718 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAC62432.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for SLC25A43 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SLC25A43 Gene

Post-translational modifications for SLC25A43 Gene

No Post-translational modifications

Other Protein References for SLC25A43 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SLC25A43 Gene

Domains & Families for SLC25A43 Gene

Gene Families for SLC25A43 Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • Predicted membrane proteins
  • Transporters

Suggested Antigen Peptide Sequences for SLC25A43 Gene

Graphical View of Domain Structure for InterPro Entry

Q8WUT9

UniProtKB/Swiss-Prot:

S2543_HUMAN :
  • Belongs to the mitochondrial carrier (TC 2.A.29) family.
Family:
  • Belongs to the mitochondrial carrier (TC 2.A.29) family.
genes like me logo Genes that share domains with SLC25A43: view

Function for SLC25A43 Gene

Phenotypes From GWAS Catalog for SLC25A43 Gene

Gene Ontology (GO) - Molecular Function for SLC25A43 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0022857 transmembrane transporter activity IBA --
genes like me logo Genes that share ontologies with SLC25A43: view

Phenotypes for SLC25A43 Gene

GenomeRNAi human phenotypes for SLC25A43:
genes like me logo Genes that share phenotypes with SLC25A43: view

Animal Model Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SLC25A43 Gene

Localization for SLC25A43 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC25A43 Gene

Mitochondrion inner membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SLC25A43 gene
Compartment Confidence
mitochondrion 4
nucleus 2
extracellular 1
peroxisome 1
endoplasmic reticulum 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for SLC25A43 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005743 mitochondrial inner membrane IBA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IBA --
genes like me logo Genes that share ontologies with SLC25A43: view

Pathways & Interactions for SLC25A43 Gene

SuperPathways for SLC25A43 Gene

No Data Available

Interacting Proteins for SLC25A43 Gene

STRING Interaction Network Preview (showing 5 interactants - click image to see details)
http://version10.5.string-db.org/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000217909%0d%0a9606.ENSP00000324127%0d%0a9606.ENSP00000360163%0d%0a9606.ENSP00000406157%0d%0a9606.ENSP00000215882%0d%0a9606.ENSP00000362186%0d%0a
Selected Interacting proteins: Q8WUT9-S2543_HUMAN ENSP00000217909 for SLC25A43 Gene via IID STRING

Gene Ontology (GO) - Biological Process for SLC25A43 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport IEA --
GO:0006839 mitochondrial transport IBA --
GO:0055085 transmembrane transport IEA --
genes like me logo Genes that share ontologies with SLC25A43: view

No data available for Pathways by source and SIGNOR curated interactions for SLC25A43 Gene

Drugs & Compounds for SLC25A43 Gene

No Compound Related Data Available

Transcripts for SLC25A43 Gene

Unigene Clusters for SLC25A43 Gene

Solute carrier family 25, member 43:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for SLC25A43 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b · 3c ^ 4 ^ 5a · 5b ^ 6
SP1: - - -
SP2: -
SP3:

Relevant External Links for SLC25A43 Gene

GeneLoc Exon Structure for
SLC25A43
ECgene alternative splicing isoforms for
SLC25A43

Expression for SLC25A43 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SLC25A43 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for SLC25A43 Gene

This gene is overexpressed in Heart (64.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for SLC25A43 Gene



Protein tissue co-expression partners for SLC25A43 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of SLC25A43 Gene:

SLC25A43

SOURCE GeneReport for Unigene cluster for SLC25A43 Gene:

Hs.496658

Evidence on tissue expression from TISSUES for SLC25A43 Gene

  • Lung(4.2)
  • Nervous system(4)
genes like me logo Genes that share expression patterns with SLC25A43: view

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for SLC25A43 Gene

Orthologs for SLC25A43 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for SLC25A43 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SLC25A43 33 34
  • 99.7 (n)
cow
(Bos Taurus)
Mammalia SLC25A43 33 34
  • 90.91 (n)
dog
(Canis familiaris)
Mammalia SLC25A43 33 34
  • 88.86 (n)
mouse
(Mus musculus)
Mammalia Slc25a43 33 16 34
  • 85.84 (n)
rat
(Rattus norvegicus)
Mammalia Slc25a43 33
  • 84.36 (n)
oppossum
(Monodelphis domestica)
Mammalia SLC25A43 34
  • 78 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SLC25A43 34
  • 71 (a)
OneToOne
chicken
(Gallus gallus)
Aves SLC25A43 33 34
  • 72.88 (n)
lizard
(Anolis carolinensis)
Reptilia SLC25A43 34
  • 76 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia slc25a43 33
  • 64.44 (n)
zebrafish
(Danio rerio)
Actinopterygii slc25a43 33 34
  • 61.83 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes LEU5 34
  • 21 (a)
OneToMany
Species where no ortholog for SLC25A43 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SLC25A43 Gene

ENSEMBL:
Gene Tree for SLC25A43 (if available)
TreeFam:
Gene Tree for SLC25A43 (if available)

Paralogs for SLC25A43 Gene

Paralogs for SLC25A43 Gene

(3) SIMAP similar genes for SLC25A43 Gene using alignment to 2 proteins:

Pseudogenes.org Pseudogenes for SLC25A43 Gene

genes like me logo Genes that share paralogs with SLC25A43: view

Variants for SLC25A43 Gene

Sequence variations from dbSNP and Humsavar for SLC25A43 Gene

SNP ID Clin Chr 0X pos Variation AA Info Type
rs1000007124 -- 119,420,726(+) A/T genic_downstream_transcript_variant, intron_variant
rs1000019219 -- 119,405,958(+) G/A intron_variant
rs1000038278 -- 119,450,581(+) T/G genic_downstream_transcript_variant, intron_variant
rs1000085996 -- 119,433,344(+) T/C genic_downstream_transcript_variant, intron_variant
rs1000127506 -- 119,419,413(+) C/T genic_downstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for SLC25A43 Gene

Variant ID Type Subtype PubMed ID
nsv518389 CNV loss 19592680
nsv476428 CNV novel sequence insertion 20440878

Variation tolerance for SLC25A43 Gene

Residual Variation Intolerance Score: 40.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.39; 8.65% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SLC25A43 Gene

Human Gene Mutation Database (HGMD)
SLC25A43
SNPedia medical, phenotypic, and genealogical associations of SNPs for
SLC25A43

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SLC25A43 Gene

Disorders for SLC25A43 Gene

Additional Disease Information for SLC25A43

No disorders were found for SLC25A43 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SLC25A43 Gene

Publications for SLC25A43 Gene

  1. Fourteen novel human members of mitochondrial solute carrier family 25 (SLC25) widely expressed in the central nervous system. (PMID: 16949250) Haitina T … Fredriksson R (Genomics 2006) 2 3 4 58
  2. Genome-wide association identifies three new susceptibility loci for Paget's disease of bone. (PMID: 21623375) Albagha OM … Genetic Determinants of Paget's Disease (GDPD) Consortium (Nature genetics 2011) 3 44 58
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  4. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  5. Mitochondrial regulation of cell cycle progression through SLC25A43. (PMID: 26721434) Gabrielson M … Tina E (Biochemical and biophysical research communications 2016) 3 58

Products for SLC25A43 Gene

Sources for SLC25A43 Gene

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