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Aliases for SLC25A42 Gene

Aliases for SLC25A42 Gene

  • Solute Carrier Family 25 Member 42 2 3 4 5
  • Mitochondrial Coenzyme A Transporter SLC25A42 3
  • Solute Carrier Family 25, Member 42 2

External Ids for SLC25A42 Gene

Previous GeneCards Identifiers for SLC25A42 Gene

  • GC19P019036
  • GC19P019174
  • GC19P018738

Summaries for SLC25A42 Gene

Entrez Gene Summary for SLC25A42 Gene

  • This gene encodes a solute carrier family 25 protein. Solute carrier family 25 proteins are localized to mitochondria and play critical roles in the transport of molecules across the inner mitochondrial membrane. The encoded protein is a mitochondrial transporter for coenzyme A (CoA) and adenosine 3',5'-diphosphate. [provided by RefSeq, Feb 2012]

GeneCards Summary for SLC25A42 Gene

SLC25A42 (Solute Carrier Family 25 Member 42) is a Protein Coding gene. Diseases associated with SLC25A42 include Mitochondrial Myopathy. Gene Ontology (GO) annotations related to this gene include ATP transmembrane transporter activity and coenzyme A transmembrane transporter activity. An important paralog of this gene is SLC25A25.

UniProtKB/Swiss-Prot for SLC25A42 Gene

  • Mitochondrial carrier mediating the transport of coenzyme A (CoA) in mitochondria in exchange for intramitochondrial (deoxy)adenine nucleotides and adenosine 3,5-diphosphate.

Additional gene information for SLC25A42 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLC25A42 Gene

Genomics for SLC25A42 Gene

GeneHancer (GH) Regulatory Elements for SLC25A42 Gene

Promoters and enhancers for SLC25A42 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19J019058 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 659.3 -1.4 -1439 7.3 HDGF HNRNPUL1 PKNOX1 SMAD1 ARNT ARID4B NEUROD1 SIN3A DMAP1 ZBTB7B SLC25A42 UPF1 IQCN MAU2 ENSG00000268030 ENSG00000268938 ATP13A1 ENSG00000269191 NR2C2AP ELL
GH19J019078 Promoter 0.7 EPDnew 650.4 +14.8 14764 0.1 ZNF341 PRDM10 SLC25A42 GC19P020576
GH19J019031 Promoter/Enhancer 2.4 EPDnew FANTOM5 Ensembl ENCODE 8.8 -30.6 -30590 3.1 HDGF PKNOX1 ARNT ARID4B SIN3A DMAP1 YY1 SLC30A9 POLR2B E2F8 ARMC6 SUGP2 ATP13A1 TMEM161A MEF2B ENSG00000268030 NR2C2AP ENSG00000268938 UPF1 ENSG00000269191
GH19J019094 Enhancer 0.9 ENCODE 20.8 +32.0 32037 3.7 FOXA2 MLX ARID4B DMAP1 ZNF48 ETS1 YY1 TCF12 SLC30A9 ATF7 SLC25A42 TMEM161A MEF2B BORCS8 BORCS8-MEF2B RFXANK ARMC6 GC19P020576
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around SLC25A42 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the SLC25A42 gene promoter:
  • Sox9
  • CUTL1
  • COMP1
  • STAT1beta
  • STAT1alpha
  • STAT1
  • NF-E2 p45
  • NF-E2
  • IRF-7A
  • CBF(2)

Genomic Locations for SLC25A42 Gene

Genomic Locations for SLC25A42 Gene
49,065 bases
Plus strand
48,902 bases
Plus strand

Genomic View for SLC25A42 Gene

Genes around SLC25A42 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SLC25A42 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SLC25A42 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC25A42 Gene

Proteins for SLC25A42 Gene

  • Protein details for SLC25A42 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Mitochondrial coenzyme A transporter SLC25A42
    Protein Accession:
    Secondary Accessions:
    • D2T2J5
    • O14553
    • O43378

    Protein attributes for SLC25A42 Gene

    318 amino acids
    Molecular mass:
    35409 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAC02758.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

neXtProt entry for SLC25A42 Gene

Post-translational modifications for SLC25A42 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SLC25A42 Gene

No data available for DME Specific Peptides for SLC25A42 Gene

Domains & Families for SLC25A42 Gene

Gene Families for SLC25A42 Gene

Human Protein Atlas (HPA):
  • Predicted membrane proteins
  • Transporters

Suggested Antigen Peptide Sequences for SLC25A42 Gene

Graphical View of Domain Structure for InterPro Entry



S2542_HUMAN :
  • Belongs to the mitochondrial carrier (TC 2.A.29) family.
  • Belongs to the mitochondrial carrier (TC 2.A.29) family.
genes like me logo Genes that share domains with SLC25A42: view

Function for SLC25A42 Gene

Molecular function for SLC25A42 Gene

UniProtKB/Swiss-Prot Function:
Mitochondrial carrier mediating the transport of coenzyme A (CoA) in mitochondria in exchange for intramitochondrial (deoxy)adenine nucleotides and adenosine 3,5-diphosphate.

Gene Ontology (GO) - Molecular Function for SLC25A42 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005347 ATP transmembrane transporter activity IDA 19429682
GO:0015217 ADP transmembrane transporter activity IDA 19429682
GO:0015228 coenzyme A transmembrane transporter activity IDA 19429682
GO:0022857 transmembrane transporter activity IBA --
GO:0043262 adenosine-diphosphatase activity IDA 19429682
genes like me logo Genes that share ontologies with SLC25A42: view
genes like me logo Genes that share phenotypes with SLC25A42: view

Animal Model Products

  • Taconic Biosciences Mouse Models for SLC25A42

Clone Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SLC25A42 Gene

Localization for SLC25A42 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC25A42 Gene

Mitochondrion inner membrane; Multi-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SLC25A42 gene
Compartment Confidence
mitochondrion 5
nucleus 5
peroxisome 2
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for SLC25A42 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus HDA 21630459
GO:0005739 mitochondrion IEA,IDA 19429682
GO:0005743 mitochondrial inner membrane IBA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IBA --
genes like me logo Genes that share ontologies with SLC25A42: view

Pathways & Interactions for SLC25A42 Gene

SuperPathways for SLC25A42 Gene

No Data Available

Interacting Proteins for SLC25A42 Gene

Gene Ontology (GO) - Biological Process for SLC25A42 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006839 mitochondrial transport IBA --
GO:0015866 ADP transport IDA 19429682
GO:0015867 ATP transport IDA 19429682
GO:0035349 coenzyme A transmembrane transport IDA 19429682
GO:0055085 transmembrane transport IEA --
genes like me logo Genes that share ontologies with SLC25A42: view

No data available for Pathways by source and SIGNOR curated interactions for SLC25A42 Gene

Drugs & Compounds for SLC25A42 Gene

No Compound Related Data Available

Transcripts for SLC25A42 Gene

Unigene Clusters for SLC25A42 Gene

Solute carrier family 25, member 42:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for SLC25A42 Gene

No ASD Table

Relevant External Links for SLC25A42 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SLC25A42 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SLC25A42 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SLC25A42 Gene

This gene is overexpressed in Liver (x5.2).

Protein differential expression in normal tissues from HIPED for SLC25A42 Gene

This gene is overexpressed in Brain (19.5), Liver (12.4), and Gallbladder (12.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for SLC25A42 Gene

NURSA nuclear receptor signaling pathways regulating expression of SLC25A42 Gene:


SOURCE GeneReport for Unigene cluster for SLC25A42 Gene:


Evidence on tissue expression from TISSUES for SLC25A42 Gene

  • Nervous system(4.4)
genes like me logo Genes that share expression patterns with SLC25A42: view

No data available for Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for SLC25A42 Gene

Orthologs for SLC25A42 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for SLC25A42 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia SLC25A42 34 33
  • 99.69 (n)
(Bos Taurus)
Mammalia SLC25A42 34 33
  • 91.3 (n)
(Canis familiaris)
Mammalia SLC25A42 34 33
  • 89.94 (n)
(Mus musculus)
Mammalia Slc25a42 16 34 33
  • 85.85 (n)
(Rattus norvegicus)
Mammalia Slc25a42 33
  • 85.12 (n)
(Monodelphis domestica)
Mammalia SLC25A42 34
  • 82 (a)
(Ornithorhynchus anatinus)
Mammalia SLC25A42 34
  • 79 (a)
(Gallus gallus)
Aves SLC25A42 34 33
  • 72.87 (n)
tropical clawed frog
(Silurana tropicalis)
Amphibia slc25a42 33
  • 68.87 (n)
(Danio rerio)
Actinopterygii slc25a42 34 33
  • 70.14 (n)
fruit fly
(Drosophila melanogaster)
Insecta att-ORFA 34 33
  • 61.82 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP000097 33
  • 60.37 (n)
(Caenorhabditis elegans)
Secernentea F43G9.3 34 33
  • 52.16 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes LEU5 34
  • 28 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT4G26180 33
  • 49.39 (n)
Species where no ortholog for SLC25A42 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SLC25A42 Gene

Gene Tree for SLC25A42 (if available)
Gene Tree for SLC25A42 (if available)
Evolutionary constrained regions (ECRs) for SLC25A42: view image

Paralogs for SLC25A42 Gene

Paralogs for SLC25A42 Gene

(7) SIMAP similar genes for SLC25A42 Gene using alignment to 1 proteins:

  • S2542_HUMAN
genes like me logo Genes that share paralogs with SLC25A42: view

Variants for SLC25A42 Gene

Sequence variations from dbSNP and Humsavar for SLC25A42 Gene

SNP ID Clin Chr 19 pos Variation AA Info Type
rs864321624 likely-pathogenic, uncertain-significance, Mitochondrial myopathy, not provided 19,110,790(+) A/G coding_sequence_variant, missense_variant
rs1000027315 -- 19,102,845(+) G/C intron_variant
rs1000108975 -- 19,110,410(+) G/A intron_variant
rs1000180716 -- 19,097,586(+) C/T intron_variant
rs1000188639 -- 19,104,046(+) G/C intron_variant

Structural Variations from Database of Genomic Variants (DGV) for SLC25A42 Gene

Variant ID Type Subtype PubMed ID
nsv952424 CNV deletion 24416366
nsv833779 CNV loss 17160897
nsv833778 CNV loss 17160897
nsv472790 CNV novel sequence insertion 20440878
nsv1151217 CNV deletion 26484159
nsv1059305 CNV loss 25217958
esv3556143 CNV deletion 23714750
esv28513 CNV loss 19812545

Variation tolerance for SLC25A42 Gene

Residual Variation Intolerance Score: 55.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.80; 16.81% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SLC25A42 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SLC25A42 Gene

Disorders for SLC25A42 Gene

MalaCards: The human disease database

(1) MalaCards diseases for SLC25A42 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
mitochondrial myopathy
  • mitochondrial cytopathy
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for SLC25A42

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with SLC25A42: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SLC25A42 Gene

Publications for SLC25A42 Gene

  1. A novel member of solute carrier family 25 (SLC25A42) is a transporter of coenzyme A and adenosine 3',5'-diphosphate in human mitochondria. (PMID: 19429682) Fiermonte G … Palmieri F (The Journal of biological chemistry 2009) 2 3 4 58
  2. Fourteen novel human members of mitochondrial solute carrier family 25 (SLC25) widely expressed in the central nervous system. (PMID: 16949250) Haitina T … Fredriksson R (Genomics 2006) 2 3 4 58
  3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 44 58
  4. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson SL … O'Brien SJ (PloS one 2010) 3 44 58
  5. The mitochondrial transporter family SLC25: identification, properties and physiopathology. (PMID: 23266187) Palmieri F (Molecular aspects of medicine 2013) 3 58

Products for SLC25A42 Gene

Sources for SLC25A42 Gene

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