Aliases for SLC25A37 Gene
External Ids for SLC25A37 Gene
Previous GeneCards Identifiers for SLC25A37 Gene
SLC25A37 is a solute carrier localized in the mitochondrial inner membrane. It functions as an essential iron importer for the synthesis of mitochondrial heme and iron-sulfur clusters (summary by Chen et al., 2009 [PubMed 19805291]).[supplied by OMIM, Jan 2011]
GeneCards Summary for SLC25A37 Gene
SLC25A37 (Solute Carrier Family 25 Member 37) is a Protein Coding gene. Diseases associated with SLC25A37 include Anemia, Sideroblastic, 1 and Protoporphyria, Erythropoietic, 1. Among its related pathways are Mitochondrial iron-sulfur cluster biogenesis and Metabolism. Gene Ontology (GO) annotations related to this gene include iron ion transmembrane transporter activity. An important paralog of this gene is SLC25A28.
UniProtKB/Swiss-Prot Summary for SLC25A37 Gene
Mitochondrial iron transporter that specifically mediates iron uptake in developing erythroid cells, thereby playing an essential role in heme biosynthesis. The iron delivered into the mitochondria, presumably as Fe(2+), is then probably delivered to ferrochelatase to catalyze Fe(2+) incorporation into protoprophyrin IX to make heme (By similarity).