SLC25A35 belongs to the SLC25 family of mitochondrial carrier proteins (Haitina et al., 2006 [PubMed 16949250]).[supplied by OMIM, Mar 2008] See more...

Aliases for SLC25A35 Gene

Aliases for SLC25A35 Gene

  • Solute Carrier Family 25 Member 35 2 3 4 5
  • Solute Carrier Family 25, Member 35 2

External Ids for SLC25A35 Gene

Previous GeneCards Identifiers for SLC25A35 Gene

  • GC17M008133
  • GC17M008086
  • GC17M008191

Summaries for SLC25A35 Gene

Entrez Gene Summary for SLC25A35 Gene

  • SLC25A35 belongs to the SLC25 family of mitochondrial carrier proteins (Haitina et al., 2006 [PubMed 16949250]).[supplied by OMIM, Mar 2008]

GeneCards Summary for SLC25A35 Gene

SLC25A35 (Solute Carrier Family 25 Member 35) is a Protein Coding gene. Diseases associated with SLC25A35 include Cardiac Arrhythmia. An important paralog of this gene is SLC25A34.

Additional gene information for SLC25A35 Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for SLC25A35 Gene

Genomics for SLC25A35 Gene

GeneHancer (GH) Regulatory Elements for SLC25A35 Gene

Promoters and enhancers for SLC25A35 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around SLC25A35 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for SLC25A35

Top Transcription factor binding sites by QIAGEN in the SLC25A35 gene promoter:
  • C/EBPbeta
  • Chx10
  • FOXO4
  • MyoD
  • Pax-4a
  • RP58
  • SEF-1 (1)
  • SREBP-1a
  • SREBP-1b
  • SREBP-1c

Genomic Locations for SLC25A35 Gene

Genomic Locations for SLC25A35 Gene
chr17:8,287,763-8,295,400
(GRCh38/hg38)
Size:
7,638 bases
Orientation:
Minus strand
chr17:8,191,081-8,198,661
(GRCh37/hg19)
Size:
7,581 bases
Orientation:
Minus strand

Genomic View for SLC25A35 Gene

Genes around SLC25A35 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SLC25A35 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SLC25A35 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC25A35 Gene

Proteins for SLC25A35 Gene

  • Protein details for SLC25A35 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q3KQZ1-S2535_HUMAN
    Recommended name:
    Solute carrier family 25 member 35
    Protein Accession:
    Q3KQZ1
    Secondary Accessions:
    • Q494X5
    • Q6RGS3
    • Q8N7Y5

    Protein attributes for SLC25A35 Gene

    Size:
    300 amino acids
    Molecular mass:
    32438 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for SLC25A35 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SLC25A35 Gene

Post-translational modifications for SLC25A35 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for SLC25A35 Gene

Domains & Families for SLC25A35 Gene

Gene Families for SLC25A35 Gene

Protein Domains for SLC25A35 Gene

Suggested Antigen Peptide Sequences for SLC25A35 Gene

GenScript: Design optimal peptide antigens:
  • Solute carrier family 25 member 35 (S2535_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q3KQZ1

UniProtKB/Swiss-Prot:

S2535_HUMAN :
  • Belongs to the mitochondrial carrier (TC 2.A.29) family.
Family:
  • Belongs to the mitochondrial carrier (TC 2.A.29) family.
genes like me logo Genes that share domains with SLC25A35: view

Function for SLC25A35 Gene

Phenotypes From GWAS Catalog for SLC25A35 Gene

genes like me logo Genes that share phenotypes with SLC25A35: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SLC25A35

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for SLC25A35 Gene

Localization for SLC25A35 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC25A35 Gene

Mitochondrion inner membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SLC25A35 gene
Compartment Confidence
mitochondrion 4
plasma membrane 1
extracellular 1
peroxisome 1
endoplasmic reticulum 1
nucleus 0

Subcellular locations from the

Human Protein Atlas (HPA)
  • Mitochondria (2)
  • Vesicles (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for SLC25A35 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005743 mitochondrial inner membrane IEA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with SLC25A35: view

Pathways & Interactions for SLC25A35 Gene

PathCards logo

SuperPathways for SLC25A35 Gene

No Data Available

Gene Ontology (GO) - Biological Process for SLC25A35 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for SLC25A35 Gene

Drugs & Compounds for SLC25A35 Gene

No Compound Related Data Available

Transcripts for SLC25A35 Gene

mRNA/cDNA for SLC25A35 Gene

5 REFSEQ mRNAs :
9 NCBI additional mRNA sequence :
7 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SLC25A35

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for SLC25A35 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5
SP1: - -
SP2:
SP3:

Relevant External Links for SLC25A35 Gene

GeneLoc Exon Structure for
SLC25A35

Expression for SLC25A35 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for SLC25A35 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SLC25A35 Gene

This gene is overexpressed in Testis (x4.1).

Protein differential expression in normal tissues from HIPED for SLC25A35 Gene

This gene is overexpressed in Placenta (11.5), Bone (11.0), Peripheral blood mononuclear cells (10.1), and Adipocyte (9.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for SLC25A35 Gene



Transcriptomic regulation report from SPP (The Signaling Pathways Project) for SLC25A35

SOURCE GeneReport for Unigene cluster for SLC25A35 Gene:

Hs.118918

Evidence on tissue expression from TISSUES for SLC25A35 Gene

  • Skin(4)
genes like me logo Genes that share expression patterns with SLC25A35: view

No data available for Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for SLC25A35 Gene

Orthologs for SLC25A35 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for SLC25A35 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SLC25A35 31
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SLC25A35 31 30
  • 91.5 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Slc25a35 30
  • 89.99 (n)
cow
(Bos Taurus)
Mammalia SLC25A35 31 30
  • 89.76 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Slc25a35 17 31 30
  • 88.48 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia SLC25A35 31
  • 73 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SLC25A35 31
  • 69 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SLC25A35 31
  • 56 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii slc25a35 31 30
  • 63.09 (n)
ManyToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP005239 30
  • 53.31 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG18324 31
  • 40 (a)
ManyToMany
CG18327 31
  • 38 (a)
ManyToMany
CG8323 31
  • 38 (a)
ManyToMany
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ABL023W 30
  • 51.93 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes OAC1 31
  • 29 (a)
OneToMany
Species where no ortholog for SLC25A35 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SLC25A35 Gene

ENSEMBL:
Gene Tree for SLC25A35 (if available)
TreeFam:
Gene Tree for SLC25A35 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for SLC25A35: view image

Paralogs for SLC25A35 Gene

Variants for SLC25A35 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for SLC25A35 Gene

SNP ID Clinical significance and condition Chr 17 pos Variation AA Info Type
646452 Uncertain Significance: Cardiac arrhythmia 8,289,540(-) G/A MISSENSE_VARIANT,SYNONYMOUS_VARIANT,THREE_PRIME_UTR_VARIANT,INTRON_VARIANT
652025 Uncertain Significance: Cardiac arrhythmia 8,289,591(-) A/G NON_CODING_TRANSCRIPT_VARIANT,SYNONYMOUS_VARIANT,THREE_PRIME_UTR_VARIANT,INTRON_VARIANT
664423 Uncertain Significance: Cardiac arrhythmia 8,288,846(-) A/T MISSENSE_VARIANT,THREE_PRIME_UTR_VARIANT,INTRON_VARIANT
rs138959557 Benign: Cardiac arrhythmia; not specified 8,289,331(-) T/C NON_CODING_TRANSCRIPT_VARIANT,SYNONYMOUS_VARIANT,THREE_PRIME_UTR_VARIANT,INTRON_VARIANT
rs140704891 Benign/Likely Benign: Cardiac arrhythmia; not specified; not provided 8,289,059(-) G/T NONSENSE,NON_CODING_TRANSCRIPT_VARIANT,THREE_PRIME_UTR_VARIANT,INTRON_VARIANT

Additional dbSNP identifiers (rs#s) for SLC25A35 Gene

Structural Variations from Database of Genomic Variants (DGV) for SLC25A35 Gene

Variant ID Type Subtype PubMed ID
esv3554096 CNV deletion 23714750
nsv833353 CNV loss 17160897

Variation tolerance for SLC25A35 Gene

Residual Variation Intolerance Score: 48.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.18; 23.84% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SLC25A35 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SLC25A35

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SLC25A35 Gene

Disorders for SLC25A35 Gene

MalaCards: The human disease database

(1) MalaCards diseases for SLC25A35 Gene - From: GeneCards

Disorder Aliases PubMed IDs
cardiac arrhythmia
  • extrasystoles
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for SLC25A35

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with SLC25A35: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SLC25A35 Gene

Publications for SLC25A35 Gene

  1. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson SL … O'Brien SJ (PloS one 2010) 3 41 54
  2. Fourteen novel human members of mitochondrial solute carrier family 25 (SLC25) widely expressed in the central nervous system. (PMID: 16949250) Haitina T … Fredriksson R (Genomics 2006) 3 4 54
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 54
  4. Quantitative mapping of RNA-mediated nuclear estrogen receptor β interactome in human breast cancer cells. (PMID: 29509190) Giurato G … Tarallo R (Scientific data 2018) 3 54
  5. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 54

Products for SLC25A35 Gene

  • Biorbyt antibodies for SLC25A35

Sources for SLC25A35 Gene