SLC25A34 belongs to the SLC25 family of mitochondrial carrier proteins (Haitina et al., 2006 [PubMed 16949250]).[supplied by OMIM, Mar 2008] See more...

Aliases for SLC25A34 Gene

Aliases for SLC25A34 Gene

  • Solute Carrier Family 25 Member 34 2 3 4 5
  • Solute Carrier Family 25, Member 34 2

External Ids for SLC25A34 Gene

Previous GeneCards Identifiers for SLC25A34 Gene

  • GC01P015809
  • GC01P015935
  • GC01P016062
  • GC01P014581

Summaries for SLC25A34 Gene

Entrez Gene Summary for SLC25A34 Gene

  • SLC25A34 belongs to the SLC25 family of mitochondrial carrier proteins (Haitina et al., 2006 [PubMed 16949250]).[supplied by OMIM, Mar 2008]

GeneCards Summary for SLC25A34 Gene

SLC25A34 (Solute Carrier Family 25 Member 34) is a Protein Coding gene. An important paralog of this gene is SLC25A35.

Additional gene information for SLC25A34 Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for SLC25A34 Gene

Genomics for SLC25A34 Gene

GeneHancer (GH) Regulatory Elements for SLC25A34 Gene

Promoters and enhancers for SLC25A34 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around SLC25A34 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the SLC25A34 gene promoter:
  • CP2
  • HOXA5
  • ITF-2
  • Nkx2-5
  • Tal-1beta

Genomic Locations for SLC25A34 Gene

Genomic Locations for SLC25A34 Gene
chr1:15,735,088-15,741,392
(GRCh38/hg38)
Size:
6,305 bases
Orientation:
Plus strand
chr1:16,062,809-16,067,891
(GRCh37/hg19)
Size:
5,083 bases
Orientation:
Plus strand

Genomic View for SLC25A34 Gene

Genes around SLC25A34 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SLC25A34 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SLC25A34 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC25A34 Gene

Proteins for SLC25A34 Gene

  • Protein details for SLC25A34 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6PIV7-S2534_HUMAN
    Recommended name:
    Solute carrier family 25 member 34
    Protein Accession:
    Q6PIV7
    Secondary Accessions:
    • Q68DV0

    Protein attributes for SLC25A34 Gene

    Size:
    304 amino acids
    Molecular mass:
    32224 Da
    Quaternary structure:
    No Data Available

neXtProt entry for SLC25A34 Gene

Post-translational modifications for SLC25A34 Gene

No Post-translational modifications

Other Protein References for SLC25A34 Gene

No data available for DME Specific Peptides for SLC25A34 Gene

Domains & Families for SLC25A34 Gene

Gene Families for SLC25A34 Gene

Protein Domains for SLC25A34 Gene

Suggested Antigen Peptide Sequences for SLC25A34 Gene

GenScript: Design optimal peptide antigens:
  • Solute carrier family 25 member 34 (S2534_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q6PIV7

UniProtKB/Swiss-Prot:

S2534_HUMAN :
  • Belongs to the mitochondrial carrier (TC 2.A.29) family.
Family:
  • Belongs to the mitochondrial carrier (TC 2.A.29) family.
genes like me logo Genes that share domains with SLC25A34: view

Function for SLC25A34 Gene

Phenotypes From GWAS Catalog for SLC25A34 Gene

genes like me logo Genes that share phenotypes with SLC25A34: view

Animal Model Products

CRISPR Products

miRNA for SLC25A34 Gene

miRTarBase miRNAs that target SLC25A34

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SLC25A34 Gene

Localization for SLC25A34 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC25A34 Gene

Mitochondrion inner membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SLC25A34 gene
Compartment Confidence
mitochondrion 3
plasma membrane 2
extracellular 0
peroxisome 0
lysosome 0

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for SLC25A34 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion IEA --
GO:0005743 mitochondrial inner membrane IEA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with SLC25A34: view

Pathways & Interactions for SLC25A34 Gene

PathCards logo

SuperPathways for SLC25A34 Gene

No Data Available

Interacting Proteins for SLC25A34 Gene

Gene Ontology (GO) - Biological Process for SLC25A34 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001835 blastocyst hatching IEA --
genes like me logo Genes that share ontologies with SLC25A34: view

No data available for Pathways by source and SIGNOR curated interactions for SLC25A34 Gene

Drugs & Compounds for SLC25A34 Gene

No Compound Related Data Available

Transcripts for SLC25A34 Gene

mRNA/cDNA for SLC25A34 Gene

(1) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(370) Selected AceView cDNA sequences:
(3) Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for SLC25A34 Gene

No ASD Table

Relevant External Links for SLC25A34 Gene

GeneLoc Exon Structure for
SLC25A34
ECgene alternative splicing isoforms for
SLC25A34

Expression for SLC25A34 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SLC25A34 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SLC25A34 Gene

This gene is overexpressed in Muscle - Skeletal (x7.6).

NURSA nuclear receptor signaling pathways regulating expression of SLC25A34 Gene:

SLC25A34

SOURCE GeneReport for Unigene cluster for SLC25A34 Gene:

Hs.631867

Evidence on tissue expression from TISSUES for SLC25A34 Gene

  • Intestine(4.1)
  • Nervous system(4)
genes like me logo Genes that share expression patterns with SLC25A34: view

No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for SLC25A34 Gene

Orthologs for SLC25A34 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for SLC25A34 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SLC25A34 33 32
  • 99.23 (n)
OneToOne
cow
(Bos Taurus)
Mammalia SLC25A34 33 32
  • 88.71 (n)
OneToOne
dog
(Canis familiaris)
Mammalia SLC25A34 33 32
  • 88.23 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Slc25a34 32
  • 86.27 (n)
mouse
(Mus musculus)
Mammalia Slc25a34 17 33 32
  • 86.03 (n)
oppossum
(Monodelphis domestica)
Mammalia SLC25A34 33
  • 77 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SLC25A34 33
  • 71 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SLC25A34 33
  • 72 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia slc25a34 32
  • 70.12 (n)
zebrafish
(Danio rerio)
Actinopterygii slc25a34 32
  • 66.55 (n)
CABZ01052268.1 33
  • 42 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG8323 33 32
  • 54.77 (n)
ManyToMany
CG18327 33
  • 42 (a)
ManyToMany
CG18324 33
  • 42 (a)
ManyToMany
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0B12826g 32
  • 48.12 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes OAC1 35 33 32
  • 42.96 (n)
bread mold
(Neurospora crassa)
Ascomycetes NCU07884 32
  • 51.58 (n)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes oac1 32
  • 44.64 (n)
Species where no ortholog for SLC25A34 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SLC25A34 Gene

ENSEMBL:
Gene Tree for SLC25A34 (if available)
TreeFam:
Gene Tree for SLC25A34 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for SLC25A34: view image

Paralogs for SLC25A34 Gene

Variants for SLC25A34 Gene

Sequence variations from dbSNP and Humsavar for SLC25A34 Gene

SNP ID Clin Chr 01 pos Variation AA Info Type
rs199904231 uncertain-significance, Dilated Cardiomyopathy, Recessive 15,733,918(+) G/A upstream_transcript_variant
rs201091991 uncertain-significance, Dilated Cardiomyopathy, Recessive 15,733,845(+) T/C upstream_transcript_variant
rs369250576 uncertain-significance, Dilated Cardiomyopathy, Recessive 15,733,848(+) G/A upstream_transcript_variant
rs533946132 uncertain-significance, Dilated Cardiomyopathy, Recessive 15,733,909(+) G/A upstream_transcript_variant
rs933542967 uncertain-significance, Dilated Cardiomyopathy, Recessive 15,733,894(+) G/A upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for SLC25A34 Gene

Variant ID Type Subtype PubMed ID
dgv11n27 CNV gain 19166990
dgv151n54 CNV gain 21841781
esv3585317 CNV gain 21293372
esv3585319 CNV gain 21293372
nsv508925 CNV insertion 20534489
nsv524044 CNV loss 19592680
nsv545617 CNV loss 21841781
nsv954825 CNV deletion 24416366

Variation tolerance for SLC25A34 Gene

Residual Variation Intolerance Score: 71.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.51; 43.88% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SLC25A34 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SLC25A34

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SLC25A34 Gene

Disorders for SLC25A34 Gene

Additional Disease Information for SLC25A34

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for SLC25A34 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SLC25A34 Gene

Publications for SLC25A34 Gene

  1. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson SL … O'Brien SJ (PloS one 2010) 3 43 56
  2. Fourteen novel human members of mitochondrial solute carrier family 25 (SLC25) widely expressed in the central nervous system. (PMID: 16949250) Haitina T … Fredriksson R (Genomics 2006) 3 4 56
  3. Single-cell transcriptomes identify human islet cell signatures and reveal cell-type-specific expression changes in type 2 diabetes. (PMID: 27864352) Lawlor N … Stitzel ML (Genome research 2017) 3 56
  4. The mitochondrial transporter family SLC25: identification, properties and physiopathology. (PMID: 23266187) Palmieri F (Molecular aspects of medicine 2013) 3 56
  5. The full-ORF clone resource of the German cDNA Consortium. (PMID: 17974005) Bechtel S … Schupp I (BMC genomics 2007) 4 56

Products for SLC25A34 Gene

Sources for SLC25A34 Gene