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Aliases for SLC25A34 Gene

Aliases for SLC25A34 Gene

  • Solute Carrier Family 25 Member 34 2 3 5
  • Solute Carrier Family 25, Member 34 2

External Ids for SLC25A34 Gene

Previous GeneCards Identifiers for SLC25A34 Gene

  • GC01P015809
  • GC01P015935
  • GC01P016062
  • GC01P014581

Summaries for SLC25A34 Gene

Entrez Gene Summary for SLC25A34 Gene

  • SLC25A34 belongs to the SLC25 family of mitochondrial carrier proteins (Haitina et al., 2006 [PubMed 16949250]).[supplied by OMIM, Mar 2008]

GeneCards Summary for SLC25A34 Gene

SLC25A34 (Solute Carrier Family 25 Member 34) is a Protein Coding gene. An important paralog of this gene is SLC25A35.

Additional gene information for SLC25A34 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLC25A34 Gene

Genomics for SLC25A34 Gene

GeneHancer (GH) Regulatory Elements for SLC25A34 Gene

Promoters and enhancers for SLC25A34 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01I015734 Promoter/Enhancer 1.7 EPDnew Ensembl ENCODE dbSUPER 585.9 +1.1 1133 3 CTCF TFAP4 KLF1 FOXA2 SAP130 ARID4B MAX SIN3A RAD21 BCL11B SLC25A34 ENSG00000237938 AGMAT PLEKHM2
GH01I015678 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 13.8 -52.7 -52731 8 PKNOX1 YBX1 POLR2B GLIS2 ZNF143 FOS ATF7 RUNX3 JUNB MEF2D PLEKHM2 ENSG00000271742 SPEN CROCCP3 CASP9 SLC25A34 LINC01772 CROCCP2 ZBTB17 RPL22P3
GH01I015740 Promoter/Enhancer 1.6 EPDnew Ensembl ENCODE 21.3 +7.1 7072 2.6 MLX ARID4B SIN3A DMAP1 ZNF2 ZNF48 YY1 ARID2 ZNF143 KLF7 TMEM82 SLC25A34 PLEKHM2 SLC25A34-AS1 ENSG00000237938
GH01I015755 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 11 +23.8 23793 6.4 PKNOX1 SIN3A FEZF1 DMAP1 ZNF48 TCF12 GLIS2 GATA2 SMARCA4 GLIS1 FBLIM1 CROCC CROCCP2 SLC25A34 CROCCP3 SPEN PLEKHM2 CASP9 EPHA2 RPL12P14
GH01I015615 Promoter/Enhancer 2.5 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 10.3 -116.7 -116725 5.4 HDGF PKNOX1 CLOCK FOXA2 MLX ARNT ARID4B SIN3A FEZF1 DMAP1 DDI2 CROCCP3 NBPF1 LINC01772 PLEKHM2 ZBTB17 AGMAT SLC25A34 ENSG00000237938 EFHD2
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around SLC25A34 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the SLC25A34 gene promoter:

Genomic Locations for SLC25A34 Gene

Genomic Locations for SLC25A34 Gene
chr1:15,735,088-15,741,396
(GRCh38/hg38)
Size:
6,309 bases
Orientation:
Plus strand
chr1:16,062,809-16,067,891
(GRCh37/hg19)

Genomic View for SLC25A34 Gene

Genes around SLC25A34 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SLC25A34 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SLC25A34 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC25A34 Gene

Proteins for SLC25A34 Gene

  • Protein details for SLC25A34 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6PIV7-S2534_HUMAN
    Recommended name:
    Solute carrier family 25 member 34
    Protein Accession:
    Q6PIV7
    Secondary Accessions:
    • Q68DV0

    Protein attributes for SLC25A34 Gene

    Size:
    304 amino acids
    Molecular mass:
    32224 Da
    Quaternary structure:
    No Data Available

neXtProt entry for SLC25A34 Gene

Post-translational modifications for SLC25A34 Gene

No Post-translational modifications

Other Protein References for SLC25A34 Gene

No data available for DME Specific Peptides for SLC25A34 Gene

Domains & Families for SLC25A34 Gene

Gene Families for SLC25A34 Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • Predicted membrane proteins
  • Transporters

Protein Domains for SLC25A34 Gene

Suggested Antigen Peptide Sequences for SLC25A34 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q6PIV7

UniProtKB/Swiss-Prot:

S2534_HUMAN :
  • Belongs to the mitochondrial carrier (TC 2.A.29) family.
Family:
  • Belongs to the mitochondrial carrier (TC 2.A.29) family.
genes like me logo Genes that share domains with SLC25A34: view

Function for SLC25A34 Gene

Phenotypes From GWAS Catalog for SLC25A34 Gene

Gene Ontology (GO) - Molecular Function for SLC25A34 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0022857 transmembrane transporter activity IBA --
genes like me logo Genes that share ontologies with SLC25A34: view
genes like me logo Genes that share phenotypes with SLC25A34: view

Animal Model Products

miRNA for SLC25A34 Gene

miRTarBase miRNAs that target SLC25A34

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SLC25A34 Gene

Localization for SLC25A34 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC25A34 Gene

Mitochondrion inner membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SLC25A34 gene
Compartment Confidence
mitochondrion 4
plasma membrane 3
extracellular 1
peroxisome 1
lysosome 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for SLC25A34 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005743 mitochondrial inner membrane IBA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IBA --
genes like me logo Genes that share ontologies with SLC25A34: view

Pathways & Interactions for SLC25A34 Gene

SuperPathways for SLC25A34 Gene

No Data Available

Interacting Proteins for SLC25A34 Gene

Gene Ontology (GO) - Biological Process for SLC25A34 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport IEA --
GO:0006839 mitochondrial transport IBA --
GO:0055085 transmembrane transport IEA --
genes like me logo Genes that share ontologies with SLC25A34: view

No data available for Pathways by source and SIGNOR curated interactions for SLC25A34 Gene

Drugs & Compounds for SLC25A34 Gene

No Compound Related Data Available

Transcripts for SLC25A34 Gene

Unigene Clusters for SLC25A34 Gene

Solute carrier family 25, member 34:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for SLC25A34 Gene

No ASD Table

Relevant External Links for SLC25A34 Gene

GeneLoc Exon Structure for
SLC25A34
ECgene alternative splicing isoforms for
SLC25A34

Expression for SLC25A34 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SLC25A34 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SLC25A34 Gene

This gene is overexpressed in Muscle - Skeletal (x7.6).

NURSA nuclear receptor signaling pathways regulating expression of SLC25A34 Gene:

SLC25A34

SOURCE GeneReport for Unigene cluster for SLC25A34 Gene:

Hs.631867

Evidence on tissue expression from TISSUES for SLC25A34 Gene

  • Intestine(4.1)
  • Nervous system(4)
genes like me logo Genes that share expression patterns with SLC25A34: view

No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for SLC25A34 Gene

Orthologs for SLC25A34 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for SLC25A34 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SLC25A34 33 34
  • 99.23 (n)
cow
(Bos Taurus)
Mammalia SLC25A34 33 34
  • 88.71 (n)
dog
(Canis familiaris)
Mammalia SLC25A34 33 34
  • 88.23 (n)
rat
(Rattus norvegicus)
Mammalia Slc25a34 33
  • 86.27 (n)
mouse
(Mus musculus)
Mammalia Slc25a34 33 16 34
  • 86.03 (n)
oppossum
(Monodelphis domestica)
Mammalia SLC25A34 34
  • 77 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SLC25A34 34
  • 71 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SLC25A34 34
  • 72 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia slc25a34 33
  • 70.12 (n)
zebrafish
(Danio rerio)
Actinopterygii slc25a34 33
  • 66.55 (n)
CABZ01052268.1 34
  • 42 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG8323 33 34
  • 54.77 (n)
CG18324 34
  • 42 (a)
ManyToMany
CG18327 34
  • 42 (a)
ManyToMany
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0B12826g 33
  • 48.12 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes OAC1 33 34 36
  • 42.96 (n)
bread mold
(Neurospora crassa)
Ascomycetes NCU07884 33
  • 51.58 (n)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes oac1 33
  • 44.64 (n)
Species where no ortholog for SLC25A34 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SLC25A34 Gene

ENSEMBL:
Gene Tree for SLC25A34 (if available)
TreeFam:
Gene Tree for SLC25A34 (if available)

Paralogs for SLC25A34 Gene

Paralogs for SLC25A34 Gene

(8) SIMAP similar genes for SLC25A34 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with SLC25A34: view

Variants for SLC25A34 Gene

Sequence variations from dbSNP and Humsavar for SLC25A34 Gene

SNP ID Clin Chr 01 pos Variation AA Info Type
rs933542967 uncertain-significance, Dilated Cardiomyopathy, Recessive 15,733,894(+) G/A upstream_transcript_variant
rs1000642160 -- 15,737,768(+) G/C intron_variant
rs1000902757 -- 15,733,138(+) C/T upstream_transcript_variant
rs1000915865 -- 15,740,775(+) C/T 3_prime_UTR_variant, genic_downstream_transcript_variant
rs1000988714 -- 15,735,957(+) G/A 5_prime_UTR_variant, genic_upstream_transcript_variant, non_coding_transcript_variant, upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for SLC25A34 Gene

Variant ID Type Subtype PubMed ID
nsv954825 CNV deletion 24416366
nsv545617 CNV loss 21841781
nsv524044 CNV loss 19592680
nsv508925 CNV insertion 20534489
esv3585319 CNV gain 21293372
esv3585317 CNV gain 21293372
dgv151n54 CNV gain 21841781
dgv11n27 CNV gain 19166990

Variation tolerance for SLC25A34 Gene

Residual Variation Intolerance Score: 71.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.51; 43.88% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SLC25A34 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SLC25A34

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SLC25A34 Gene

Disorders for SLC25A34 Gene

Additional Disease Information for SLC25A34

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for SLC25A34 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SLC25A34 Gene

Publications for SLC25A34 Gene

  1. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson SL … O'Brien SJ (PloS one 2010) 3 44 58
  2. Fourteen novel human members of mitochondrial solute carrier family 25 (SLC25) widely expressed in the central nervous system. (PMID: 16949250) Haitina T … Fredriksson R (Genomics 2006) 3 4 58
  3. The mitochondrial transporter family SLC25: identification, properties and physiopathology. (PMID: 23266187) Palmieri F (Molecular aspects of medicine 2013) 3 58
  4. The full-ORF clone resource of the German cDNA Consortium. (PMID: 17974005) Bechtel S … Schupp I (BMC genomics 2007) 4 58
  5. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory SG … Prigmore E (Nature 2006) 4 58

Products for SLC25A34 Gene

Sources for SLC25A34 Gene

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