The protein encoded by this gene is a member of the ADP/ATP carrier family of proteins that exchange cytosolic ADP for matrix ATP in the mitochondria. Cells over-expressing this gene have been shown to display an anti-apoptotic phenotype. This protein is also thought to play a role in spermatogenesis, where it is believed to associate with a part of the flagellar cytoskeleton a... See more...

Aliases for SLC25A31 Gene

Aliases for SLC25A31 Gene

  • Solute Carrier Family 25 Member 31 2 3 4 5
  • ANT4 2 3 4
  • Solute Carrier Family 25 (Mitochondrial Carrier; Adenine Nucleotide Translocator), Member 31 2 3
  • Sperm Flagellar Energy Carrier Protein 3 4
  • Adenine Nucleotide Translocator 4 3 4
  • ADP,ATP Carrier Protein 4 3 4
  • ADP/ATP Translocase 4 3 4
  • ANT 4 3 4
  • AAC4 3 4
  • Adenine Nucleotide Translocase 4 3
  • DKFZP434N1235 2
  • SFEC35kDa 3
  • SLC25A31 5
  • SFEC 4

External Ids for SLC25A31 Gene

Previous GeneCards Identifiers for SLC25A31 Gene

  • GC04P129010
  • GC04P128871
  • GC04P128651
  • GC04P124379

Summaries for SLC25A31 Gene

Entrez Gene Summary for SLC25A31 Gene

  • The protein encoded by this gene is a member of the ADP/ATP carrier family of proteins that exchange cytosolic ADP for matrix ATP in the mitochondria. Cells over-expressing this gene have been shown to display an anti-apoptotic phenotype. This protein is also thought to play a role in spermatogenesis, where it is believed to associate with a part of the flagellar cytoskeleton and with glycolytic enzymes. Male mice with mutations in the mouse ortholog of this gene are sterile and spermatocytes display an early meiotic arrest phenotype. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jan 2016]

GeneCards Summary for SLC25A31 Gene

SLC25A31 (Solute Carrier Family 25 Member 31) is a Protein Coding gene. Diseases associated with SLC25A31 include Acute Laryngitis and Huntington Disease. Among its related pathways are Calcium signaling pathway and Human T-cell leukemia virus 1 infection. Gene Ontology (GO) annotations related to this gene include transporter activity. An important paralog of this gene is SLC25A4.

UniProtKB/Swiss-Prot Summary for SLC25A31 Gene

  • Catalyzes the exchange of cytoplasmic ADP with mitochondrial ATP across the mitochondrial inner membrane. May serve to mediate energy generating and energy consuming processes in the distal flagellum, possibly as a nucleotide shuttle between flagellar glycolysis, protein phosphorylation and mechanisms of motility.

Gene Wiki entry for SLC25A31 Gene

Additional gene information for SLC25A31 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for SLC25A31 Gene

Genomics for SLC25A31 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for SLC25A31 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH04J127730 Promoter 0.6 EPDnew 600.7 0.0 0 0.1 MNT ZBTB33 RAD51 CHAMP1 SLC25A31 piR-56341-172 INTU
GH04J127781 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 10.2 +52.9 52873 4.3 ARHGAP35 HNRNPL CREB1 GATAD2A TEAD4 PRDM10 REST ZNF629 NFKBIZ ZNF692 HSPA4L SLC25A31 INTU ABHD18 ENSG00000282855 PLK4
GH04J127632 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE CraniofacialAtlas 10.7 -97.2 -97171 2.8 GATAD2A PRDM10 TFE3 RFX1 IKZF1 NFKBIZ NFRKB FOXA1 PRDM1 RXRB INTU LOC105377413 SLC25A31 MFSD8 piR-61532-230
GH04J127622 Promoter/Enhancer 1.5 Ensembl ENCODE CraniofacialAtlas 10.3 -106.4 -106371 3.2 CTCF PRDM10 KDM1A ZNF692 PRDM1 PATZ1 EZH2 ZNF600 ZNF341 SCRT2 INTU ENSG00000287021 LINC02615 SLC25A31 MFSD8 LOC105377413
GH04J127698 Enhancer 0.9 Ensembl ENCODE 11.3 -31.5 -31471 3 BACH1 JUND RELA TCF12 IKZF2 TRIM22 PKNOX1 CEBPB ARID3A ZSCAN29 INTU SLC25A31 piR-56341-172
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around SLC25A31 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for SLC25A31

Top Transcription factor binding sites by QIAGEN in the SLC25A31 gene promoter:
  • AREB6
  • CUTL1
  • E4BP4
  • GR
  • GR-alpha
  • GR-beta
  • HFH-1
  • Lhx3a
  • LHX3b
  • Nkx6-1

Genomic Locations for SLC25A31 Gene

Genomic Locations for SLC25A31 Gene
chr4:127,730,372-127,774,299
(GRCh38/hg38)
Size:
43,928 bases
Orientation:
Plus strand
chr4:128,651,533-128,695,448
(GRCh37/hg19)
Size:
43,916 bases
Orientation:
Plus strand

Genomic View for SLC25A31 Gene

Genes around SLC25A31 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SLC25A31 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SLC25A31 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC25A31 Gene

Proteins for SLC25A31 Gene

  • Protein details for SLC25A31 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H0C2-ADT4_HUMAN
    Recommended name:
    ADP/ATP translocase 4
    Protein Accession:
    Q9H0C2

    Protein attributes for SLC25A31 Gene

    Size:
    315 amino acids
    Molecular mass:
    35022 Da
    Quaternary structure:
    No Data Available

neXtProt entry for SLC25A31 Gene

Post-translational modifications for SLC25A31 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SLC25A31 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SLC25A31 Gene

Domains & Families for SLC25A31 Gene

Gene Families for SLC25A31 Gene

Protein Domains for SLC25A31 Gene

InterPro:
Blocks:
  • Mitochondrial carrier protein signature
  • Adenine nucleotide translocator 1 signature
ProtoNet:

Suggested Antigen Peptide Sequences for SLC25A31 Gene

GenScript: Design optimal peptide antigens:
  • Sperm flagellar energy carrier protein (ADT4_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q9H0C2

UniProtKB/Swiss-Prot:

ADT4_HUMAN :
  • The transmembrane helices are not perpendicular to the plane of the membrane, but cross the membrane at an angle. Odd-numbered transmembrane helices exhibit a sharp kink, due to the presence of a conserved proline residue.
  • Belongs to the mitochondrial carrier (TC 2.A.29) family.
Domain:
  • The transmembrane helices are not perpendicular to the plane of the membrane, but cross the membrane at an angle. Odd-numbered transmembrane helices exhibit a sharp kink, due to the presence of a conserved proline residue.
Family:
  • Belongs to the mitochondrial carrier (TC 2.A.29) family.
genes like me logo Genes that share domains with SLC25A31: view

Function for SLC25A31 Gene

Molecular function for SLC25A31 Gene

UniProtKB/Swiss-Prot Function:
Catalyzes the exchange of cytoplasmic ADP with mitochondrial ATP across the mitochondrial inner membrane. May serve to mediate energy generating and energy consuming processes in the distal flagellum, possibly as a nucleotide shuttle between flagellar glycolysis, protein phosphorylation and mechanisms of motility.

Phenotypes From GWAS Catalog for SLC25A31 Gene

Gene Ontology (GO) - Molecular Function for SLC25A31 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005471 ATP:ADP antiporter activity IBA --
GO:0022857 transmembrane transporter activity IEA --
genes like me logo Genes that share ontologies with SLC25A31: view
genes like me logo Genes that share phenotypes with SLC25A31: view

Animal Models for SLC25A31 Gene

MGI Knock Outs for SLC25A31:

Animal Model Products

  • Taconic Biosciences Mouse Models for SLC25A31

CRISPR Products

miRNA for SLC25A31 Gene

miRTarBase miRNAs that target SLC25A31

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SLC25A31

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for SLC25A31 Gene

Localization for SLC25A31 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC25A31 Gene

Mitochondrion inner membrane. Multi-pass membrane protein. Cell projection, cilium, flagellum. Note=In sperm flagellum this protein is located in the fibrous sheath, a non-mitochondrial region.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SLC25A31 gene
Compartment Confidence
mitochondrion 5
nucleus 4
cytosol 2
plasma membrane 1
extracellular 1
cytoskeleton 1
peroxisome 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for SLC25A31 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus HDA 21630459
GO:0005739 mitochondrion IEA,IDA --
GO:0005743 mitochondrial inner membrane IEA --
GO:0005929 cilium IEA --
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with SLC25A31: view

Pathways & Interactions for SLC25A31 Gene

genes like me logo Genes that share pathways with SLC25A31: view

Gene Ontology (GO) - Biological Process for SLC25A31 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0015866 ADP transport IEA --
GO:0015867 ATP transport IEA --
GO:0055085 transmembrane transport IEA --
genes like me logo Genes that share ontologies with SLC25A31: view

No data available for SIGNOR curated interactions for SLC25A31 Gene

Drugs & Compounds for SLC25A31 Gene

(3) Drugs for SLC25A31 Gene - From: PharmGKB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Atenolol Approved Pharma Antagonist 114
Hydrochlorothiazide Approved, Vet_approved Pharma Inhibitor, Inhibition 453
Metoprolol Approved, Investigational Pharma Antagonist 255
genes like me logo Genes that share compounds with SLC25A31: view

Transcripts for SLC25A31 Gene

mRNA/cDNA for SLC25A31 Gene

2 REFSEQ mRNAs :
9 NCBI additional mRNA sequence :
1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SLC25A31

Alternative Splicing Database (ASD) splice patterns (SP) for SLC25A31 Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6a · 6b
SP1:
SP2: - -

Relevant External Links for SLC25A31 Gene

GeneLoc Exon Structure for
SLC25A31

Expression for SLC25A31 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for SLC25A31 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SLC25A31 Gene

This gene is overexpressed in Testis (x49.9).

Protein differential expression in normal tissues from HIPED for SLC25A31 Gene

This gene is overexpressed in Brain (38.7), Heart (11.3), and Testis (10.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for SLC25A31 Gene



Protein tissue co-expression partners for SLC25A31 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for SLC25A31

SOURCE GeneReport for Unigene cluster for SLC25A31 Gene:

Hs.149030

mRNA Expression by UniProt/SwissProt for SLC25A31 Gene:

Q9H0C2-ADT4_HUMAN
Tissue specificity: Expressed in brain, liver, sperm and testis.

Evidence on tissue expression from TISSUES for SLC25A31 Gene

  • Liver(4.4)
  • Heart(2.1)
genes like me logo Genes that share expression patterns with SLC25A31: view

Primer Products

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for SLC25A31 Gene

Orthologs for SLC25A31 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for SLC25A31 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia SLC25A31 30 31
  • 99.58 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia SLC25A31 30 31
  • 91.72 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia SLC25A31 30 31
  • 91.72 (n)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia SLC25A31 31
  • 87 (a)
OneToOne
Mouse
(Mus musculus)
Mammalia Slc25a31 30 17 31
  • 85.46 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Slc25a31 30
  • 83.97 (n)
Lizard
(Anolis carolinensis)
Reptilia SLC25A31 31
  • 80 (a)
OneToOne
Fruit Fly
(Drosophila melanogaster)
Insecta sesB 31
  • 69 (a)
ManyToMany
Ant2 31
  • 67 (a)
ManyToMany
Worm
(Caenorhabditis elegans)
Secernentea R07E3.4 31
  • 43 (a)
ManyToMany
Baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes AAC1 31
  • 50 (a)
ManyToMany
PET9 31 33
  • 50 (a)
ManyToMany
AAC3 31
  • 50 (a)
ManyToMany
Thale Cress
(Arabidopsis thaliana)
eudicotyledons AT5G56450 30
  • 55.59 (n)
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.1260 30
Sea Squirt
(Ciona savignyi)
Ascidiacea CSA.10315 31
  • 70 (a)
OneToMany
-- 31
  • 70 (a)
OneToMany
CSA.11146 31
  • 68 (a)
OneToMany
-- 31
  • 58 (a)
OneToMany
Species where no ortholog for SLC25A31 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Zebrafish (Danio rerio)

Evolution for SLC25A31 Gene

ENSEMBL:
Gene Tree for SLC25A31 (if available)
TreeFam:
Gene Tree for SLC25A31 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for SLC25A31: view image

Paralogs for SLC25A31 Gene

Variants for SLC25A31 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for SLC25A31 Gene

SNP ID Clinical significance and condition Chr 04 pos Variation AA Info Type
VAR_074177 - p.Lys303Glu

Additional dbSNP identifiers (rs#s) for SLC25A31 Gene

Structural Variations from Database of Genomic Variants (DGV) for SLC25A31 Gene

Variant ID Type Subtype PubMed ID
nsv290569 CNV deletion 16902084
nsv437935 CNV loss 16468122
nsv830056 CNV loss 17160897
nsv830057 CNV loss 17160897

Variation tolerance for SLC25A31 Gene

Residual Variation Intolerance Score: 75.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.01; 37.04% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SLC25A31 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SLC25A31

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SLC25A31 Gene

Disorders for SLC25A31 Gene

MalaCards: The human disease database

(2) MalaCards diseases for SLC25A31 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
acute laryngitis
huntington disease
  • hd
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for SLC25A31

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
genes like me logo Genes that share disorders with SLC25A31: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SLC25A31 Gene

Publications for SLC25A31 Gene

  1. A fourth ADP/ATP carrier isoform in man: identification, bacterial expression, functional characterization and tissue distribution. (PMID: 15670820) Dolce V … Palmieri F (FEBS letters 2005) 2 3 4
  2. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson SL … O'Brien SJ (PloS one 2010) 3 41
  3. Compartmentalization of a unique ADP/ATP carrier protein SFEC (Sperm Flagellar Energy Carrier, AAC4) with glycolytic enzymes in the fibrous sheath of the human sperm flagellar principal piece. (PMID: 17137571) Kim YH … Herr JC (Developmental biology 2007) 3 4
  4. Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PMID: 11230166) Wiemann S … Poustka A (Genome research 2001) 3 4
  5. A reference map of the human binary protein interactome. (PMID: 32296183) Luck K … Calderwood MA (Nature 2020) 3

Products for SLC25A31 Gene

Sources for SLC25A31 Gene