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Aliases for SLC25A28 Gene

Aliases for SLC25A28 Gene

  • Solute Carrier Family 25 Member 28 2 3 4 5
  • Solute Carrier Family 25 (Mitochondrial Iron Transporter), Member 28 2 3
  • Mitochondrial RNA-Splicing Protein 3/4 Homolog 3 4
  • Mitochondrial Iron Transporter 2 3 4
  • HMRS3/4 3 4
  • MRS3/4 3 4
  • MFRN2 3 4
  • Mitochondrial RNA Splicing Protein 3/4 3
  • Putative Mitochondrial Solute Carrier 3
  • Solute Carrier Family 25, Member 28 2
  • Mitoferrin 2 2
  • Mitoferrin-2 3
  • NPD016 3
  • MRS4L 3

External Ids for SLC25A28 Gene

Previous GeneCards Identifiers for SLC25A28 Gene

  • GC10M101034
  • GC10M101360
  • GC10M094997

Summaries for SLC25A28 Gene

GeneCards Summary for SLC25A28 Gene

SLC25A28 (Solute Carrier Family 25 Member 28) is a Protein Coding gene. Among its related pathways are Metabolism and Mitochondrial iron-sulfur cluster biogenesis. An important paralog of this gene is SLC25A37.

UniProtKB/Swiss-Prot for SLC25A28 Gene

  • Mitochondrial iron transporter that mediates iron uptake. Probably required for heme synthesis of hemoproteins and Fe-S cluster assembly in non-erythroid cells. The iron delivered into the mitochondria, presumably as Fe(2+), is then probably delivered to ferrochelatase to catalyze Fe(2+) incorporation into protoprophyrin IX to make heme (By similarity).

Additional gene information for SLC25A28 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLC25A28 Gene

Genomics for SLC25A28 Gene

GeneHancer (GH) Regulatory Elements for SLC25A28 Gene

Promoters and enhancers for SLC25A28 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH10I099617 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 561.7 +39.4 39405 5.6 HDGF PKNOX1 FOXA2 SMAD1 ARNT ZFP64 ARID4B SIN3A DMAP1 ZNF2 SLC25A28 ENSG00000260475 CWF19L1 PHBP9 CHUK DNMBP EBAG9P1 ENSG00000236308 NKX2-3 CUTC
GH10I099658 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE dbSUPER 562.2 -1.7 -1745 5.8 HDGF PKNOX1 ARNT ARID4B SIN3A DMAP1 ZNF2 YY1 POLR2B FOS SLC25A28 ENTPD7 PIR56896 CWF19L1 CUTC CHUK EBAG9P1 ABCC2
GH10I100228 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 20 -570.2 -570154 1.8 HDGF PKNOX1 ARNT ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 POLR2B CHUK ENSG00000227492 BLOC1S2 EBAG9P1 MRPL43 CWF19L1 SLC25A28 PHBP9 LZTS2 ENSG00000236308
GH10I100535 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 12.1 -876.6 -876598 1.6 HDGF PKNOX1 ARID4B SIN3A DMAP1 ZNF2 ZBTB7B YY1 POLR2B E2F8 HIF1AN SEC31B PHBP9 CWF19L1 SLC25A28 MRPL43 SLF2 SEMA4G NDUFB8 ENSG00000274660
GH10I099429 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 11.5 +228.7 228710 3.2 PKNOX1 SMAD1 ARID4B SIN3A DMAP1 YY1 SLC30A9 POLR2B ZNF143 FOS LOC101927300 GC10P099431 GOT1 CWF19L1 CHUK HPS1 PHBP9 SLC25A28 DNMBP PIR44588
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around SLC25A28 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the SLC25A28 gene promoter:

Genomic Locations for SLC25A28 Gene

Genomic Locations for SLC25A28 Gene
chr10:99,610,518-99,659,339
(GRCh38/hg38)
Size:
48,822 bases
Orientation:
Minus strand
chr10:101,370,275-101,380,366
(GRCh37/hg19)

Genomic View for SLC25A28 Gene

Genes around SLC25A28 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SLC25A28 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SLC25A28 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC25A28 Gene

Proteins for SLC25A28 Gene

  • Protein details for SLC25A28 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96A46-MFRN2_HUMAN
    Recommended name:
    Mitoferrin-2
    Protein Accession:
    Q96A46
    Secondary Accessions:
    • Q4VBZ0
    • Q5T777
    • Q86VX5
    • Q969G8
    • Q9H2J3

    Protein attributes for SLC25A28 Gene

    Size:
    364 amino acids
    Molecular mass:
    39272 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH47312.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAI16900.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for SLC25A28 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SLC25A28 Gene

Post-translational modifications for SLC25A28 Gene

No Post-translational modifications

No data available for DME Specific Peptides for SLC25A28 Gene

Domains & Families for SLC25A28 Gene

Gene Families for SLC25A28 Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transporters

Protein Domains for SLC25A28 Gene

Suggested Antigen Peptide Sequences for SLC25A28 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q96A46

UniProtKB/Swiss-Prot:

MFRN2_HUMAN :
  • Belongs to the mitochondrial carrier (TC 2.A.29) family.
Family:
  • Belongs to the mitochondrial carrier (TC 2.A.29) family.
genes like me logo Genes that share domains with SLC25A28: view

Function for SLC25A28 Gene

Molecular function for SLC25A28 Gene

UniProtKB/Swiss-Prot Function:
Mitochondrial iron transporter that mediates iron uptake. Probably required for heme synthesis of hemoproteins and Fe-S cluster assembly in non-erythroid cells. The iron delivered into the mitochondria, presumably as Fe(2+), is then probably delivered to ferrochelatase to catalyze Fe(2+) incorporation into protoprophyrin IX to make heme (By similarity).

Phenotypes From GWAS Catalog for SLC25A28 Gene

Gene Ontology (GO) - Molecular Function for SLC25A28 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005381 iron ion transmembrane transporter activity IBA --
genes like me logo Genes that share ontologies with SLC25A28: view
genes like me logo Genes that share phenotypes with SLC25A28: view

Animal Models for SLC25A28 Gene

MGI Knock Outs for SLC25A28:

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for SLC25A28 Gene

Localization for SLC25A28 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC25A28 Gene

Mitochondrion inner membrane; Multi-pass membrane protein. Note=Isoform 1 and isoform 2 are both localized in the mitochondrion.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SLC25A28 gene
Compartment Confidence
mitochondrion 4
nucleus 2
cytosol 2
peroxisome 1

Gene Ontology (GO) - Cellular Components for SLC25A28 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion IEA --
GO:0005743 mitochondrial inner membrane IBA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IBA --
genes like me logo Genes that share ontologies with SLC25A28: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for SLC25A28 Gene

Pathways & Interactions for SLC25A28 Gene

genes like me logo Genes that share pathways with SLC25A28: view

Pathways by source for SLC25A28 Gene

2 Reactome pathways for SLC25A28 Gene

Interacting Proteins for SLC25A28 Gene

Gene Ontology (GO) - Biological Process for SLC25A28 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport IEA --
GO:0006811 ion transport IEA --
GO:0006839 mitochondrial transport IBA --
GO:0034755 iron ion transmembrane transport IEA --
GO:0048250 mitochondrial iron ion transport IBA --
genes like me logo Genes that share ontologies with SLC25A28: view

No data available for SIGNOR curated interactions for SLC25A28 Gene

Drugs & Compounds for SLC25A28 Gene

(1) Drugs for SLC25A28 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
heme Pharma Agonist 0

(1) Additional Compounds for SLC25A28 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Fe2+
  • Armco iron
  • Carbonyl iron
  • FE
  • Ferrovac e
  • Hematite
15438-31-0
genes like me logo Genes that share compounds with SLC25A28: view

Transcripts for SLC25A28 Gene

Unigene Clusters for SLC25A28 Gene

Solute carrier family 25 (mitochondrial iron transporter), member 28:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for SLC25A28 Gene

ExUns: 1 ^ 2 ^ 3a · 3b · 3c · 3d ^ 4a · 4b ^ 5a · 5b · 5c · 5d
SP1: - - - -
SP2: - - - -
SP3: - - -
SP4: -
SP5: -

Relevant External Links for SLC25A28 Gene

GeneLoc Exon Structure for
SLC25A28
ECgene alternative splicing isoforms for
SLC25A28

Expression for SLC25A28 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SLC25A28 Gene

Protein differential expression in normal tissues from HIPED for SLC25A28 Gene

This gene is overexpressed in Heart (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for SLC25A28 Gene



Protein tissue co-expression partners for SLC25A28 Gene

NURSA nuclear receptor signaling pathways regulating expression of SLC25A28 Gene:

SLC25A28

SOURCE GeneReport for Unigene cluster for SLC25A28 Gene:

Hs.403790

mRNA Expression by UniProt/SwissProt for SLC25A28 Gene:

Q96A46-MFRN2_HUMAN
Tissue specificity: Ubiquitous. Expressed in placenta, lung, kidney, pancreas, liver, brain, skeletal muscle and heart.

Evidence on tissue expression from TISSUES for SLC25A28 Gene

  • Nervous system(4.3)
  • Eye(4.1)
genes like me logo Genes that share expression patterns with SLC25A28: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for SLC25A28 Gene

Orthologs for SLC25A28 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for SLC25A28 Gene

Organism Taxonomy Gene Similarity Type Details
dog
(Canis familiaris)
Mammalia -- 34
  • 100 (a)
OneToMany
SLC25A28 33
  • 94.87 (n)
-- 34
  • 83 (a)
OneToMany
chimpanzee
(Pan troglodytes)
Mammalia SLC25A28 34
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SLC25A28 33 34
  • 95.42 (n)
oppossum
(Monodelphis domestica)
Mammalia SLC25A28 34
  • 95 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Slc25a28 33
  • 92.86 (n)
mouse
(Mus musculus)
Mammalia Slc25a28 33 16 34
  • 92.4 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia SLC25A28 34
  • 92 (a)
OneToOne
chicken
(Gallus gallus)
Aves SLC25A28 33 34
  • 81.84 (n)
lizard
(Anolis carolinensis)
Reptilia SLC25A28 34
  • 84 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia slc25a28 33
  • 79.85 (n)
Str.17759 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.28756 33
zebrafish
(Danio rerio)
Actinopterygii LOC100535877 33
  • 73.27 (n)
slc25a28 34 34
  • 66 (a)
OneToMany
wufc48b02 33
fruit fly
(Drosophila melanogaster)
Insecta mfrn 34
  • 42 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea mfn-1 34
  • 51 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes MRS4 34 36
  • 39 (a)
ManyToMany
MRS3 34
  • 38 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 45 (a)
OneToMany
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.3760 33
Species where no ortholog for SLC25A28 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SLC25A28 Gene

ENSEMBL:
Gene Tree for SLC25A28 (if available)
TreeFam:
Gene Tree for SLC25A28 (if available)

Paralogs for SLC25A28 Gene

Paralogs for SLC25A28 Gene

(1) SIMAP similar genes for SLC25A28 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with SLC25A28: view

Variants for SLC25A28 Gene

Sequence variations from dbSNP and Humsavar for SLC25A28 Gene

SNP ID Clin Chr 10 pos Variation AA Info Type
rs1000008686 -- 99,621,989(-) G/T genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1000122077 -- 99,632,335(-) C/T genic_upstream_transcript_variant, intron_variant
rs1000200706 -- 99,640,979(-) G/T genic_upstream_transcript_variant, intron_variant
rs1000204129 -- 99,634,223(-) A/G genic_upstream_transcript_variant, intron_variant
rs1000279297 -- 99,615,286(-) G/A intron_variant

Structural Variations from Database of Genomic Variants (DGV) for SLC25A28 Gene

Variant ID Type Subtype PubMed ID
nsv7515 CNV insertion 18451855
nsv831958 CNV gain 17160897

Variation tolerance for SLC25A28 Gene

Residual Variation Intolerance Score: 28.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.41; 9.11% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SLC25A28 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SLC25A28

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SLC25A28 Gene

Disorders for SLC25A28 Gene

Additional Disease Information for SLC25A28

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for SLC25A28 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SLC25A28 Gene

Publications for SLC25A28 Gene

  1. Characterization of a novel human putative mitochondrial transporter homologous to the yeast mitochondrial RNA splicing proteins 3 and 4. (PMID: 11297739) Li FY … Suomalainen A (FEBS letters 2001) 2 3 4 58
  2. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson SL … O'Brien SJ (PloS one 2010) 3 44 58
  3. A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease. (PMID: 16385451) Grupe A … Goate A (American journal of human genetics 2006) 3 44 58
  4. The DNA sequence and comparative analysis of human chromosome 10. (PMID: 15164054) Deloukas P … Rogers J (Nature 2004) 3 4 58
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58

Products for SLC25A28 Gene

Sources for SLC25A28 Gene

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