Mitochondrial uncoupling proteins (UCP) are members of the larger family of mitochondrial anion carrier proteins (MACP). UCPs separate oxidative phosphorylation from ATP synthesis with energy dissipated as heat, also referred to as the mitochondrial proton leak. UCPs facilitate the transfer of anions from the inner to the outer mitochondrial membrane and the return transfer of ... See more...

Aliases for SLC25A27 Gene

Aliases for SLC25A27 Gene

  • Solute Carrier Family 25 Member 27 2 3 4 5
  • Mitochondrial Uncoupling Protein 4 3 4
  • UCP 4 3 4
  • UCP4 3 4
  • Solute Carrier Family 25, Member 27 2
  • Uncoupling Protein 4 3

External Ids for SLC25A27 Gene

Previous GeneCards Identifiers for SLC25A27 Gene

  • GC00U912988
  • GC06P046667
  • GC06P046728
  • GC06P046620
  • GC06P046343

Summaries for SLC25A27 Gene

Entrez Gene Summary for SLC25A27 Gene

  • Mitochondrial uncoupling proteins (UCP) are members of the larger family of mitochondrial anion carrier proteins (MACP). UCPs separate oxidative phosphorylation from ATP synthesis with energy dissipated as heat, also referred to as the mitochondrial proton leak. UCPs facilitate the transfer of anions from the inner to the outer mitochondrial membrane and the return transfer of protons from the outer to the inner mitochondrial membrane. They also reduce the mitochondrial membrane potential in mammalian cells. Tissue specificity occurs for the different UCPs and the exact methods of how UCPs transfer H+/OH- are not known. UCPs contain the three homologous protein domains of MACPs. Transcripts of this gene are only detected in brain tissue and are specifically modulated by various environmental conditions. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Feb 2011]

GeneCards Summary for SLC25A27 Gene

SLC25A27 (Solute Carrier Family 25 Member 27) is a Protein Coding gene. Diseases associated with SLC25A27 include Hepatocellular Carcinoma. Among its related pathways are Mitochondrial Uncoupling Proteins and Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.. An important paralog of this gene is SLC25A14.

UniProtKB/Swiss-Prot Summary for SLC25A27 Gene

  • UCP are mitochondrial transporter proteins that create proton leaks across the inner mitochondrial membrane, thus uncoupling oxidative phosphorylation from ATP synthesis. As a result, energy is dissipated in the form of heat. May play a role in thermoregulatory heat production and metabolism in brain.

Gene Wiki entry for SLC25A27 Gene

Additional gene information for SLC25A27 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for SLC25A27 Gene

Genomics for SLC25A27 Gene

GeneHancer (GH) Regulatory Elements for SLC25A27 Gene

Promoters and enhancers for SLC25A27 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around SLC25A27 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for SLC25A27

Top Transcription factor binding sites by QIAGEN in the SLC25A27 gene promoter:
  • Brachyury
  • Cart-1
  • FAC1
  • HOXA3
  • Ik-2
  • ISGF-3
  • LyF-1
  • MIF-1
  • Pax-4a
  • PPAR-alpha

Genomic Locations for SLC25A27 Gene

Genomic Locations for SLC25A27 Gene
chr6:46,652,915-46,678,190
(GRCh38/hg38)
Size:
25,276 bases
Orientation:
Plus strand
chr6:46,620,652-46,645,930
(GRCh37/hg19)
Size:
25,279 bases
Orientation:
Plus strand

Genomic View for SLC25A27 Gene

Genes around SLC25A27 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SLC25A27 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SLC25A27 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC25A27 Gene

Proteins for SLC25A27 Gene

  • Protein details for SLC25A27 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O95847-UCP4_HUMAN
    Recommended name:
    Mitochondrial uncoupling protein 4
    Protein Accession:
    O95847
    Secondary Accessions:
    • F5GWR4
    • Q5VTS9
    • Q8N518

    Protein attributes for SLC25A27 Gene

    Size:
    323 amino acids
    Molecular mass:
    36064 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for SLC25A27 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SLC25A27 Gene

Post-translational modifications for SLC25A27 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

  • Abcam antibodies for SLC25A27
  • Boster Bio Antibodies for SLC25A27
  • Santa Cruz Biotechnology (SCBT) Antibodies for SLC25A27

No data available for DME Specific Peptides for SLC25A27 Gene

Domains & Families for SLC25A27 Gene

Gene Families for SLC25A27 Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins
  • Transporters

Protein Domains for SLC25A27 Gene

Suggested Antigen Peptide Sequences for SLC25A27 Gene

GenScript: Design optimal peptide antigens:
  • cDNA, FLJ78839, highly similar to Mitochondrial uncoupling protein 4 (B4DHR4_HUMAN)
  • cDNA FLJ60996, highly similar to Mitochondrial uncoupling protein 4 (B4DZG4_HUMAN)
  • Solute carrier family 25, member 27 (Q5VTS5_HUMAN)
  • cDNA FLJ78641, highly similar to Homo sapiens uncoupling protein UCP-4 (Q5VTS9_HUMAN)
  • Solute carrier family 25 member 27 (UCP4_HUMAN)

Graphical View of Domain Structure for InterPro Entry

O95847

UniProtKB/Swiss-Prot:

UCP4_HUMAN :
  • Belongs to the mitochondrial carrier (TC 2.A.29) family.
Family:
  • Belongs to the mitochondrial carrier (TC 2.A.29) family.
genes like me logo Genes that share domains with SLC25A27: view

Function for SLC25A27 Gene

Molecular function for SLC25A27 Gene

UniProtKB/Swiss-Prot Function:
UCP are mitochondrial transporter proteins that create proton leaks across the inner mitochondrial membrane, thus uncoupling oxidative phosphorylation from ATP synthesis. As a result, energy is dissipated in the form of heat. May play a role in thermoregulatory heat production and metabolism in brain.

Phenotypes From GWAS Catalog for SLC25A27 Gene

genes like me logo Genes that share phenotypes with SLC25A27: view

Animal Model Products

CRISPR Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SLC25A27 Gene

Localization for SLC25A27 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC25A27 Gene

Mitochondrion inner membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SLC25A27 gene
Compartment Confidence
mitochondrion 5
cytosol 3
peroxisome 2
nucleus 2
plasma membrane 1
extracellular 1
cytoskeleton 1
endoplasmic reticulum 1
lysosome 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for SLC25A27 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005623 cell IEA --
GO:0005739 mitochondrion IDA 10025957
GO:0005743 mitochondrial inner membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with SLC25A27: view

Pathways & Interactions for SLC25A27 Gene

genes like me logo Genes that share pathways with SLC25A27: view

Interacting Proteins for SLC25A27 Gene

;

Gene Ontology (GO) - Biological Process for SLC25A27 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008284 positive regulation of cell proliferation IEA --
GO:0009409 response to cold IBA 21873635
GO:0010917 negative regulation of mitochondrial membrane potential IEA --
GO:0035356 cellular triglyceride homeostasis IEA --
GO:0043066 negative regulation of apoptotic process IEA --
genes like me logo Genes that share ontologies with SLC25A27: view

No data available for SIGNOR curated interactions for SLC25A27 Gene

Drugs & Compounds for SLC25A27 Gene

(2) Drugs for SLC25A27 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
genes like me logo Genes that share compounds with SLC25A27: view

Transcripts for SLC25A27 Gene

mRNA/cDNA for SLC25A27 Gene

3 REFSEQ mRNAs :
13 NCBI additional mRNA sequence :
8 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for SLC25A27 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b · 3c ^ 4a · 4b · 4c ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10a · 10b · 10c · 10d ^ 11a · 11b
SP1: - - -
SP2: - - - -
SP3: - - - - - - -
SP4: -
SP5: - - - -
SP6: - - -
SP7: - -
SP8: -

Relevant External Links for SLC25A27 Gene

GeneLoc Exon Structure for
SLC25A27

Expression for SLC25A27 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for SLC25A27 Gene

Protein differential expression in normal tissues from HIPED for SLC25A27 Gene

This gene is overexpressed in Brain (54.3) and Frontal cortex (9.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for SLC25A27 Gene



Protein tissue co-expression partners for SLC25A27 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for SLC25A27

SOURCE GeneReport for Unigene cluster for SLC25A27 Gene:

Hs.40510

mRNA Expression by UniProt/SwissProt for SLC25A27 Gene:

O95847-UCP4_HUMAN
Tissue specificity: Found in adult and fetal brain. Present in most of the brain tissues, with low levels in spinal chord, corpus callosum and substantia nigra.

Evidence on tissue expression from TISSUES for SLC25A27 Gene

  • Nervous system(4.8)
genes like me logo Genes that share expression patterns with SLC25A27: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for SLC25A27 Gene

Orthologs for SLC25A27 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for SLC25A27 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SLC25A27 31 30
  • 99.79 (n)
OneToOne
dog
(Canis familiaris)
Mammalia SLC25A27 31 30
  • 94.63 (n)
OneToOne
cow
(Bos Taurus)
Mammalia SLC25A27 31 30
  • 92.16 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Slc25a27 17 31 30
  • 88.99 (n)
rat
(Rattus norvegicus)
Mammalia Slc25a27 30
  • 88.26 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia SLC25A27 31
  • 67 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia slc25a27 30
  • 71.68 (n)
Str.20468 30
zebrafish
(Danio rerio)
Actinopterygii slc25a27 31 30
  • 67.31 (n)
OneToOne
zgc63899 30
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP009603 30
  • 56 (n)
fruit fly
(Drosophila melanogaster)
Insecta Ucp4A 31 30
  • 55.78 (n)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea ucp-4 31 30
  • 55.25 (n)
OneToOne
thale cress
(Arabidopsis thaliana)
eudicotyledons AT1G14140 30
  • 51.34 (n)
sea squirt
(Ciona savignyi)
Ascidiacea Cin.1001 30
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.1001 30
Species where no ortholog for SLC25A27 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SLC25A27 Gene

ENSEMBL:
Gene Tree for SLC25A27 (if available)
TreeFam:
Gene Tree for SLC25A27 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for SLC25A27: view image

Paralogs for SLC25A27 Gene

(11) SIMAP similar genes for SLC25A27 Gene using alignment to 6 proteins:

  • UCP4_HUMAN
  • B4DHR4_HUMAN
  • B4DZG4_HUMAN
  • Q5VTS8_HUMAN
  • S4R300_HUMAN
  • S4R3J2_HUMAN
genes like me logo Genes that share paralogs with SLC25A27: view

Variants for SLC25A27 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for SLC25A27 Gene

SNP ID Clinical significance and condition Chr 06 pos Variation AA Info Type
718746 Benign: not provided 46,655,916(+) C/T SYNONYMOUS_VARIANT
rs17853162 - p.Ala145Val
rs35884480 - p.Ile197Thr

Additional dbSNP identifiers (rs#s) for SLC25A27 Gene

Variation tolerance for SLC25A27 Gene

Residual Variation Intolerance Score: 60% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.53; 55.65% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SLC25A27 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SLC25A27

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for SLC25A27 Gene

Disorders for SLC25A27 Gene

MalaCards: The human disease database

(1) MalaCards diseases for SLC25A27 Gene - From: LncRNADisease

Disorder Aliases PubMed IDs
hepatocellular carcinoma
  • hcc
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for SLC25A27

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with SLC25A27: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SLC25A27 Gene

Publications for SLC25A27 Gene

  1. UCP4, a novel brain-specific mitochondrial protein that reduces membrane potential in mammalian cells. (PMID: 10025957) Mao W … Pan G (FEBS letters 1999) 2 3 4 23 54
  2. A homozygous genetic variant of mitochondrial uncoupling protein 4 exerts protection against the occurrence of multiple sclerosis. (PMID: 19536655) Szolnoki Z … Somogyvari F (Neuromolecular medicine 2009) 3 23 41 54
  3. Synergistic association of mitochondrial uncoupling protein (UCP) genes with schizophrenia. (PMID: 17066476) Yasuno K … Tamiya G (American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics 2007) 3 23 41 54
  4. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson SL … O'Brien SJ (PloS one 2010) 3 41 54
  5. Oxidative stress, telomere length and biomarkers of physical aging in a cohort aged 79 years from the 1932 Scottish Mental Survey. (PMID: 18977241) Starr JM … Deary IJ (Mechanisms of ageing and development 2008) 3 41 54

Products for SLC25A27 Gene

Sources for SLC25A27 Gene