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SLC25A18 (Solute Carrier Family 25 Member 18) is a Protein Coding gene. Diseases associated with SLC25A18 include Cat Eye Syndrome and Phencyclidine Abuse. Among its related pathways are Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds. Gene Ontology (GO) annotations related to this gene include symporter activity. An important paralog of this gene is SLC25A22.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005313 | L-glutamate transmembrane transporter activity | IBA | 21873635 |
GO:0005347 | ATP transmembrane transporter activity | IEA | -- |
GO:0005515 | protein binding | IPI | 25416956 |
GO:0015183 | L-aspartate transmembrane transporter activity | IBA | 21873635 |
GO:0015293 | symporter activity | IEA | -- |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005739 | mitochondrion | IEA | -- |
GO:0005743 | mitochondrial inner membrane | TAS | -- |
GO:0016020 | membrane | IEA | -- |
GO:0016021 | integral component of membrane | IEA | -- |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0006811 | ion transport | TAS | -- |
GO:0015810 | aspartate transmembrane transport | IBA | 21873635 |
GO:0015813 | L-glutamate transmembrane transport | IBA | 21873635 |
GO:0015867 | ATP transport | IEA | -- |
GO:0043490 | malate-aspartate shuttle | IBA | 21873635 |
Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
---|---|---|---|---|---|---|
Glutamic acid | Approved | Nutra | Agonist, Full agonist, Transporter | 304 |
ExUns: | 1a | · | 1b | · | 1c | · | 1d | · | 1e | · | 1f | · | 1g | ^ | 2 | ^ | 3a | · | 3b | · | 3c | · | 3d | · | 3e | ^ | 4a | · | 4b | · | 4c | · | 4d | · | 4e | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9a | · | 9b | ^ | 10 | ^ | 11 | ^ |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | - | - | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||
SP2: | - | - | - | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||
SP3: | - | - | - | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||
SP4: | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||
SP5: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
SP6: | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||
SP7: | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||
SP8: | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||
SP9: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
SP10: | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||||
SP11: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
SP12: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
SP13: | - | - | - |
ExUns: | 12a | · | 12b | ^ | 13a | · | 13b |
---|---|---|---|---|---|---|---|
SP1: | - | ||||||
SP2: | - | ||||||
SP3: | |||||||
SP4: | |||||||
SP5: | |||||||
SP6: | |||||||
SP7: | |||||||
SP8: | |||||||
SP9: | |||||||
SP10: | |||||||
SP11: | |||||||
SP12: | |||||||
SP13: |
This gene was present in the common ancestor of animals and fungi.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | SLC25A18 30 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | SLC25A18 30 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Slc25a18 30 |
|
||
Mouse (Mus musculus) |
Mammalia | Slc25a18 30 17 31 |
|
OneToOne | |
Platypus (Ornithorhynchus anatinus) |
Mammalia | SLC25A18 31 |
|
OneToOne | |
Oppossum (Monodelphis domestica) |
Mammalia | SLC25A18 31 |
|
OneToOne | |
Lizard (Anolis carolinensis) |
Reptilia | SLC25A18 31 |
|
OneToOne | |
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | slc25a18 30 |
|
||
Zebrafish (Danio rerio) |
Actinopterygii | slc25a18 30 31 |
|
OneToOne | |
Fruit Fly (Drosophila melanogaster) |
Insecta | CG18347 31 32 |
|
ManyToMany | |
CG12201 31 32 |
|
ManyToMany | |||
Worm (Caenorhabditis elegans) |
Secernentea | F20D1.9 31 32 |
|
ManyToMany | |
F55G1.5 31 32 |
|
ManyToMany | |||
Baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | AGC1 31 |
|
OneToMany |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
dgv1278e212 | CNV | loss | 25503493 |
dgv4464n100 | CNV | gain | 25217958 |
dgv4465n100 | CNV | gain | 25217958 |
esv2657458 | CNV | deletion | 23128226 |
esv2672971 | CNV | deletion | 23128226 |
esv3568229 | CNV | loss | 25503493 |
esv3568230 | CNV | loss | 25503493 |
esv3647223 | CNV | loss | 21293372 |
esv3647225 | CNV | loss | 21293372 |
esv3647226 | CNV | loss | 21293372 |
esv3893428 | CNV | loss | 25118596 |
nsv1065055 | CNV | gain | 25217958 |
nsv1116939 | CNV | deletion | 24896259 |
nsv3553 | CNV | deletion | 18451855 |
nsv428385 | CNV | gain+loss | 18775914 |
nsv510802 | CNV | deletion | 20534489 |
nsv526826 | CNV | gain | 19592680 |
nsv9871 | CNV | loss | 18304495 |
Disorder | Aliases | PubMed IDs |
---|---|---|
cat eye syndrome |
|
|
phencyclidine abuse |
|
|
glutaric acidemia i |
|
|