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Aliases for SLC25A14 Gene

Aliases for SLC25A14 Gene

  • Solute Carrier Family 25 Member 14 2 3 4 5
  • Mitochondrial Uncoupling Protein 5 3 4
  • BMCP1 3 4
  • UCP5 3 4
  • Solute Carrier Family 25 (Mitochondrial Carrier, Brain), Member 14 2
  • Brain Mitochondrial Carrier Protein 1 3
  • BMCP-1 4
  • UCP 5 4

External Ids for SLC25A14 Gene

Previous GeneCards Identifiers for SLC25A14 Gene

  • GC0XP124119
  • GC0XP126319
  • GC0XP127418
  • GC0XP128179
  • GC0XP129199
  • GC0XP129301
  • GC0XP129473
  • GC0XP118868

Summaries for SLC25A14 Gene

Entrez Gene Summary for SLC25A14 Gene

  • Mitochondrial uncoupling proteins (UCP) are members of the larger family of mitochondrial anion carrier proteins (MACP). Uncoupling proteins separate oxidative phosphorylation from ATP synthesis with energy dissipated as heat, also referred to as the mitochondrial proton leak. Uncoupling proteins facilitate the transfer of anions from the inner to the outer mitochondrial membrane and the return transfer of protons from the outer to the inner mitochondrial membrane. They also reduce the mitochondrial membrane potential in mammalian cells. This gene is widely expressed in many tissues with the greatest abundance in brain and testis. Alternative splicing results in multiple transcript variants. A pseudogene of this gene has been defined on chromosome 4. [provided by RefSeq, Aug 2013]

GeneCards Summary for SLC25A14 Gene

SLC25A14 (Solute Carrier Family 25 Member 14) is a Protein Coding gene. Among its related pathways are Metabolism and Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.. An important paralog of this gene is SLC25A30.

UniProtKB/Swiss-Prot for SLC25A14 Gene

  • Participates in the mitochondrial proton leak measured in brain mitochondria.

Gene Wiki entry for SLC25A14 Gene

Additional gene information for SLC25A14 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLC25A14 Gene

Genomics for SLC25A14 Gene

GeneHancer (GH) Regulatory Elements for SLC25A14 Gene

Promoters and enhancers for SLC25A14 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH0XJ130339 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 663.5 +0.1 113 1.6 ATF1 ARID4B SIN3A DMAP1 GLI4 ZNF2 YY1 POLR2B GLIS2 ZNF213 SLC25A14 BCORL1 GC0XM130346
GH0XJ129770 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 10.8 -560.1 -560130 17.9 HDGF PKNOX1 FOXA2 SMAD1 ZFP64 IRF4 TCF12 ZNF766 GATA2 ZNF207 SASH3 BCORL1 ZNF280C XPNPEP2 UTP14A SLC25A14 OCRL ELF4 ENSG00000240143 ZDHHC9
GH0XJ130280 Enhancer 0.4 ENCODE 12.4 -58.9 -58933 1 SP1 PRDM1 RNU6-1130P ENSG00000225046 SLC25A14 ZNF280C GC0XM130311
GH0XJ130287 Enhancer 0.4 ENCODE 11.6 -52.5 -52479 0.6 SP1 HNF4A ENSG00000225046 SLC25A14 ZNF280C GC0XM130311 RNU6-1130P
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around SLC25A14 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the SLC25A14 gene promoter:
  • GR-alpha
  • GR
  • FOXC1
  • CUTL1
  • FOXL1
  • AML1a
  • Evi-1
  • Bach1
  • AP-4
  • Sox9

Genomic Locations for SLC25A14 Gene

Genomic Locations for SLC25A14 Gene
33,474 bases
Plus strand
33,462 bases
Plus strand

Genomic View for SLC25A14 Gene

Genes around SLC25A14 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SLC25A14 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SLC25A14 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC25A14 Gene

Proteins for SLC25A14 Gene

  • Protein details for SLC25A14 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Brain mitochondrial carrier protein 1
    Protein Accession:
    Secondary Accessions:
    • D3DTG2
    • Q0VDH7
    • Q9HC60
    • Q9HC61

    Protein attributes for SLC25A14 Gene

    325 amino acids
    Molecular mass:
    36202 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for SLC25A14 Gene


neXtProt entry for SLC25A14 Gene

Post-translational modifications for SLC25A14 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for SLC25A14 Gene

Domains & Families for SLC25A14 Gene

Gene Families for SLC25A14 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted membrane proteins
  • Predicted secreted proteins
  • Transporters

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the mitochondrial carrier (TC 2.A.29) family.
  • Belongs to the mitochondrial carrier (TC 2.A.29) family.
genes like me logo Genes that share domains with SLC25A14: view

Function for SLC25A14 Gene

Molecular function for SLC25A14 Gene

UniProtKB/Swiss-Prot Function:
Participates in the mitochondrial proton leak measured in brain mitochondria.
GENATLAS Biochemistry:
solute carrier family 25,mitochondrial,predominantly expressed in the brain,particularily in cortex,hippocampus,thalamus,amygdala,hyppothalamus

Gene Ontology (GO) - Molecular Function for SLC25A14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0022857 transmembrane transporter activity IBA --
genes like me logo Genes that share ontologies with SLC25A14: view
genes like me logo Genes that share phenotypes with SLC25A14: view

Animal Model Products

  • Taconic Biosciences Mouse Models for SLC25A14

CRISPR Products

miRNA for SLC25A14 Gene

miRTarBase miRNAs that target SLC25A14

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SLC25A14

Clone Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SLC25A14 Gene

Localization for SLC25A14 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC25A14 Gene

Mitochondrion inner membrane; Multi-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SLC25A14 gene
Compartment Confidence
plasma membrane 5
mitochondrion 5
extracellular 1
peroxisome 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for SLC25A14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion TAS 9852133
GO:0005740 mitochondrial envelope IEA --
GO:0005743 mitochondrial inner membrane TAS --
GO:0005887 integral component of plasma membrane TAS 9852133
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with SLC25A14: view

Pathways & Interactions for SLC25A14 Gene

genes like me logo Genes that share pathways with SLC25A14: view

Interacting Proteins for SLC25A14 Gene

Gene Ontology (GO) - Biological Process for SLC25A14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006839 mitochondrial transport IBA --
GO:0009060 aerobic respiration TAS 9852133
GO:0055085 transmembrane transport IEA --
genes like me logo Genes that share ontologies with SLC25A14: view

No data available for SIGNOR curated interactions for SLC25A14 Gene

Drugs & Compounds for SLC25A14 Gene

(1) Additional Compounds for SLC25A14 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with SLC25A14: view

Transcripts for SLC25A14 Gene

Unigene Clusters for SLC25A14 Gene

Solute carrier family 25 (mitochondrial carrier, brain), member 14:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SLC25A14

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for SLC25A14 Gene

ExUns: 1a · 1b ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10a · 10b ^ 11 ^ 12
SP1: - - -
SP2: - - - -
SP3: -
SP4: - - -
SP5: - - -

Relevant External Links for SLC25A14 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SLC25A14 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SLC25A14 Gene

Protein differential expression in normal tissues from HIPED for SLC25A14 Gene

This gene is overexpressed in Testis (17.1), Retina (16.4), Frontal cortex (14.6), Fetal Brain (10.4), and Fetal ovary (8.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for SLC25A14 Gene

Protein tissue co-expression partners for SLC25A14 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of SLC25A14 Gene:


SOURCE GeneReport for Unigene cluster for SLC25A14 Gene:


mRNA Expression by UniProt/SwissProt for SLC25A14 Gene:

Tissue specificity: Mainly expressed in brain. Some expression in testis and pituitary.

Evidence on tissue expression from TISSUES for SLC25A14 Gene

  • Nervous system(4)
genes like me logo Genes that share expression patterns with SLC25A14: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for SLC25A14 Gene

Orthologs for SLC25A14 Gene

This gene was present in the common ancestor of animals.

Orthologs for SLC25A14 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia SLC25A14 34 33
  • 99.81 (n)
(Monodelphis domestica)
Mammalia SLC25A14 34
  • 94 (a)
(Bos Taurus)
Mammalia SLC25A14 34 33
  • 92.44 (n)
(Canis familiaris)
Mammalia SLC25A14 34 33
  • 92.13 (n)
(Mus musculus)
Mammalia Slc25a14 16 34 33
  • 89.44 (n)
(Rattus norvegicus)
Mammalia Slc25a14 33
  • 88.92 (n)
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 79 (a)
(Gallus gallus)
Aves SLC25A14 34 33
  • 77.18 (n)
(Anolis carolinensis)
Reptilia SLC25A14 34
  • 85 (a)
(Danio rerio)
Actinopterygii slc25a14 34 33
  • 71.21 (n)
fruit fly
(Drosophila melanogaster)
Insecta Bmcp 34 35
  • 54 (a)
Species where no ortholog for SLC25A14 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SLC25A14 Gene

Gene Tree for SLC25A14 (if available)
Gene Tree for SLC25A14 (if available)
Evolutionary constrained regions (ECRs) for SLC25A14: view image

Paralogs for SLC25A14 Gene

(10) SIMAP similar genes for SLC25A14 Gene using alignment to 4 proteins:

  • Q5JY88_HUMAN Pseudogenes for SLC25A14 Gene

genes like me logo Genes that share paralogs with SLC25A14: view

Variants for SLC25A14 Gene

Sequence variations from dbSNP and Humsavar for SLC25A14 Gene

SNP ID Clin Chr 0X pos Variation AA Info Type
rs1000082474 -- 130,359,528(+) T/C 3_prime_UTR_variant, intron_variant
rs1000198001 -- 130,354,654(+) A/G intron_variant
rs1000220450 -- 130,360,989(+) A/G genic_downstream_transcript_variant, intron_variant
rs1000275855 -- 130,343,481(+) A/G genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1000352631 -- 130,365,443(+) G/T genic_downstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for SLC25A14 Gene

Variant ID Type Subtype PubMed ID
nsv528290 CNV gain 19592680
nsv510559 OTHER sequence alteration 20534489

Variation tolerance for SLC25A14 Gene

Residual Variation Intolerance Score: 17.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.35; 7.63% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SLC25A14 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SLC25A14 Gene

Disorders for SLC25A14 Gene

Additional Disease Information for SLC25A14

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for SLC25A14 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SLC25A14 Gene

Publications for SLC25A14 Gene

  1. BMCP1, a novel mitochondrial carrier with high expression in the central nervous system of humans and rodents, and respiration uncoupling activity in recombinant yeast. (PMID: 9852133) Sanchis D … Ricquier D (The Journal of biological chemistry 1998) 2 3 4 22 58
  2. Characterization of novel UCP5/BMCP1 isoforms and differential regulation of UCP4 and UCP5 expression through dietary or temperature manipulation. (PMID: 10928996) Yu XX … Pan G (FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2000) 3 4 22 58
  3. Amplified expression of uncoupling proteins in human brain ischemic lesions. (PMID: 18018477) Nakase T … Nagata K (Neuropathology : official journal of the Japanese Society of Neuropathology 2007) 3 22 58
  4. Synergistic association of mitochondrial uncoupling protein (UCP) genes with schizophrenia. (PMID: 17066476) Yasuno K … Tamiya G (American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics 2007) 3 44 58
  5. The DNA sequence of the human X chromosome. (PMID: 15772651) Ross MT … Bentley DR (Nature 2005) 3 4 58

Products for SLC25A14 Gene

Sources for SLC25A14 Gene

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