Aliases for SLC25A11 Gene
External Ids for SLC25A11 Gene
Previous HGNC Symbols for SLC25A11 Gene
Previous GeneCards Identifiers for SLC25A11 Gene
The oxoglutarate/malate carrier transports 2-oxoglutarate across the inner membranes of mitochondria in an electroneutral exchange for malate or other dicarboxylic acids (summary by Iacobazzi et al., 1992 [PubMed 1457818]).[supplied by OMIM, Jan 2011]
GeneCards Summary for SLC25A11 Gene
SLC25A11 (Solute Carrier Family 25 Member 11) is a Protein Coding gene. Diseases associated with SLC25A11 include Paragangliomas 6 and Hereditary Paraganglioma-Pheochromocytoma Syndromes. Among its related pathways are Glucose metabolism and Glycosaminoglycan metabolism. Gene Ontology (GO) annotations related to this gene include oxoglutarate:malate antiporter activity. An important paralog of this gene is SLC25A35.
UniProtKB/Swiss-Prot Summary for SLC25A11 Gene
Catalyzes the transport of 2-oxoglutarate across the inner mitochondrial membrane in an electroneutral exchange for malate or other dicarboxylic acids, and plays an important role in several metabolic processes, including the malate-aspartate shuttle, the oxoglutarate/isocitrate shuttle, in gluconeogenesis from lactate, and in nitrogen metabolism. Maintains mitochondrial fusion and fission events, and the organization and morphology of cristae (PubMed:21448454). Involved in the regulation of apoptosis (By similarity). Acts as a tumor-suppressor gene implicated in the predisposition to metastatic paraganglioma.