Aliases for SLC25A11 Gene
External Ids for SLC25A11 Gene
Previous HGNC Symbols for SLC25A11 Gene
Previous GeneCards Identifiers for SLC25A11 Gene
The oxoglutarate/malate carrier transports 2-oxoglutarate across the inner membranes of mitochondria in an electroneutral exchange for malate or other dicarboxylic acids (summary by Iacobazzi et al., 1992 [PubMed 1457818]).[supplied by OMIM, Jan 2011]
GeneCards Summary for SLC25A11 Gene
SLC25A11 (Solute Carrier Family 25 Member 11) is a Protein Coding gene. Diseases associated with SLC25A11 include Breast Leiomyosarcoma and Oculogyric Crisis. Among its related pathways are Glucose metabolism and Metabolism. Gene Ontology (GO) annotations related to this gene include oxoglutarate:malate antiporter activity. An important paralog of this gene is SLC25A14.
UniProtKB/Swiss-Prot for SLC25A11 Gene
Catalyzes the transport of 2-oxoglutarate across the inner mitochondrial membrane in an electroneutral exchange for malate or other dicarboxylic acids, and plays an important role in several metabolic processes, including the malate-aspartate shuttle, the oxoglutarate/isocitrate shuttle, in gluconeogenesis from lactate, and in nitrogen metabolism (By similarity). Maintains mitochondrial fusion and fission events, and the organization and morphology of cristae (PubMed:21448454). Involved in the regulation of apoptosis (By similarity).