This gene encodes a member of a family of proteins that translocate small metabolites across the mitochondrial membrane. The encoded protein exchanges dicarboxylates, such as malate and succinate, for phosphate, sulfate, and other small molecules, thereby providing substrates for metabolic processes including the Krebs cycle and fatty acid synthesis. Alternatively spliced trans... See more...

Aliases for SLC25A10 Gene

Aliases for SLC25A10 Gene

  • Solute Carrier Family 25 Member 10 2 3 4 5
  • Solute Carrier Family 25 (Mitochondrial Carrier; Dicarboxylate Transporter), Member 10 2 3
  • Mitochondrial Dicarboxylate Carrier 3 4
  • DIC 3 4
  • Dicarboxylate Ion Carrier 3
  • SLC25A10 5

External Ids for SLC25A10 Gene

Previous HGNC Symbols for SLC25A10 Gene

  • DIC

Previous GeneCards Identifiers for SLC25A10 Gene

  • GC17U990019
  • GC17P080239
  • GC17P080375
  • GC17P077289
  • GC17P079679
  • GC17P075125
  • GC17P079674

Summaries for SLC25A10 Gene

Entrez Gene Summary for SLC25A10 Gene

  • This gene encodes a member of a family of proteins that translocate small metabolites across the mitochondrial membrane. The encoded protein exchanges dicarboxylates, such as malate and succinate, for phosphate, sulfate, and other small molecules, thereby providing substrates for metabolic processes including the Krebs cycle and fatty acid synthesis. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Aug 2012]

GeneCards Summary for SLC25A10 Gene

SLC25A10 (Solute Carrier Family 25 Member 10) is a Protein Coding gene. Diseases associated with SLC25A10 include Encephalopathy, Ethylmalonic and Retinitis Pigmentosa. Among its related pathways are Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds and Sulfur amino acid metabolism. Gene Ontology (GO) annotations related to this gene include antiporter activity and phosphate ion transmembrane transporter activity. An important paralog of this gene is ENSG00000262660.

UniProtKB/Swiss-Prot Summary for SLC25A10 Gene

  • Involved in translocation of malonate, malate and succinate in exchange for phosphate, sulfate, sulfite or thiosulfate across mitochondrial inner membrane.

Gene Wiki entry for SLC25A10 Gene

Additional gene information for SLC25A10 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for SLC25A10 Gene

Genomics for SLC25A10 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for SLC25A10 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around SLC25A10 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for SLC25A10

Top Transcription factor binding sites by QIAGEN in the SLC25A10 gene promoter:
  • AP-4
  • HEN1
  • HSF2
  • LCR-F1
  • Nkx2-5
  • NRSF form 1
  • NRSF form 2
  • Roaz
  • RORalpha1

Genomic Locations for SLC25A10 Gene

Genomic Locations for SLC25A10 Gene
chr17:81,712,236-81,721,016
(GRCh38/hg38)
Size:
8,781 bases
Orientation:
Plus strand
chr17:79,670,404-79,688,042
(GRCh37/hg19)
Size:
17,639 bases
Orientation:
Plus strand

Genomic View for SLC25A10 Gene

Genes around SLC25A10 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SLC25A10 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SLC25A10 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC25A10 Gene

Proteins for SLC25A10 Gene

  • Protein details for SLC25A10 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UBX3-DIC_HUMAN
    Recommended name:
    Mitochondrial dicarboxylate carrier
    Protein Accession:
    Q9UBX3
    Secondary Accessions:
    • Q542Z3
    • Q96BA1
    • Q96IP1

    Protein attributes for SLC25A10 Gene

    Size:
    287 amino acids
    Molecular mass:
    31282 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for SLC25A10 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SLC25A10 Gene

Post-translational modifications for SLC25A10 Gene

  • Ubiquitination at Lys254
  • Modification sites at PhosphoSitePlus

Other Protein References for SLC25A10 Gene

No data available for DME Specific Peptides for SLC25A10 Gene

Domains & Families for SLC25A10 Gene

Gene Families for SLC25A10 Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted membrane proteins
  • Transporters

Protein Domains for SLC25A10 Gene

Suggested Antigen Peptide Sequences for SLC25A10 Gene

GenScript: Design optimal peptide antigens:
  • cDNA FLJ60124, highly similar to Mitochondrial dicarboxylate carrier (B4DLN1_HUMAN)
  • cDNA FLJ61034, highly similar to Mitochondrial dicarboxylate carrier (B4E1E9_HUMAN)
  • Solute carrier family 25 member 10 (DIC_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q9UBX3

UniProtKB/Swiss-Prot:

DIC_HUMAN :
  • Belongs to the mitochondrial carrier (TC 2.A.29) family.
Family:
  • Belongs to the mitochondrial carrier (TC 2.A.29) family.
genes like me logo Genes that share domains with SLC25A10: view

Function for SLC25A10 Gene

Molecular function for SLC25A10 Gene

UniProtKB/Swiss-Prot Function:
Involved in translocation of malonate, malate and succinate in exchange for phosphate, sulfate, sulfite or thiosulfate across mitochondrial inner membrane.

Phenotypes From GWAS Catalog for SLC25A10 Gene

Gene Ontology (GO) - Molecular Function for SLC25A10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005310 dicarboxylic acid transmembrane transporter activity TAS --
GO:0005515 protein binding IPI 19060904
GO:0015116 sulfate transmembrane transporter activity IBA 21873635
GO:0015117 thiosulfate transmembrane transporter activity IBA 21873635
GO:0015131 oxaloacetate transmembrane transporter activity IBA 21873635
genes like me logo Genes that share ontologies with SLC25A10: view
genes like me logo Genes that share phenotypes with SLC25A10: view

Animal Models for SLC25A10 Gene

MGI Knock Outs for SLC25A10:

Animal Model Products

  • Taconic Biosciences Mouse Models for SLC25A10

CRISPR Products

miRNA for SLC25A10 Gene

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SLC25A10

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for SLC25A10 Gene

Localization for SLC25A10 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC25A10 Gene

Mitochondrion inner membrane. Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SLC25A10 gene
Compartment Confidence
mitochondrion 5
nucleus 4
cytosol 2
plasma membrane 1
extracellular 1
cytoskeleton 1
peroxisome 1
endoplasmic reticulum 1
lysosome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Mitochondria (3)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for SLC25A10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus HDA 21630459
GO:0005654 nucleoplasm IDA --
GO:0005739 mitochondrion IDA --
GO:0005743 mitochondrial inner membrane TAS --
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with SLC25A10: view

Pathways & Interactions for SLC25A10 Gene

genes like me logo Genes that share pathways with SLC25A10: view

Pathways by source for SLC25A10 Gene

Gene Ontology (GO) - Biological Process for SLC25A10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006094 gluconeogenesis TAS --
GO:0006811 ion transport TAS --
GO:0006835 dicarboxylic acid transport TAS --
GO:0006839 mitochondrial transport IEA --
GO:0008272 sulfate transport IBA 21873635
genes like me logo Genes that share ontologies with SLC25A10: view

No data available for SIGNOR curated interactions for SLC25A10 Gene

Drugs & Compounds for SLC25A10 Gene

(1) Drugs for SLC25A10 Gene - From: DrugBank and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Succinic acid Approved Nutra Agonist, Full agonist, Transporter, ligand 0
genes like me logo Genes that share compounds with SLC25A10: view

Transcripts for SLC25A10 Gene

mRNA/cDNA for SLC25A10 Gene

3 REFSEQ mRNAs :
11 NCBI additional mRNA sequence :
8 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SLC25A10

Alternative Splicing Database (ASD) splice patterns (SP) for SLC25A10 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b · 6c ^ 7a · 7b · 7c ^ 8 ^ 9 ^ 10a · 10b · 10c · 10d ^ 11 ^ 12a · 12b · 12c
SP1: - - - - - -
SP2: - - - - - - -
SP3: - - - - -
SP4: - - - - -
SP5: - - - - - - - -
SP6: - - -
SP7: -
SP8: - - -
SP9: - -

Relevant External Links for SLC25A10 Gene

GeneLoc Exon Structure for
SLC25A10

Expression for SLC25A10 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for SLC25A10 Gene

mRNA differential expression in normal tissues according to GTEx for SLC25A10 Gene

This gene is overexpressed in Liver (x6.1) and Kidney - Cortex (x5.0).

Protein differential expression in normal tissues from HIPED for SLC25A10 Gene

This gene is overexpressed in Nasal epithelium (45.0) and Gallbladder (9.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for SLC25A10 Gene



Protein tissue co-expression partners for SLC25A10 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for SLC25A10

SOURCE GeneReport for Unigene cluster for SLC25A10 Gene:

Hs.548187

mRNA Expression by UniProt/SwissProt for SLC25A10 Gene:

Q9UBX3-DIC_HUMAN
Tissue specificity: Present in high amounts in liver and kidney, and at lower levels in all the other tissues analyzed.

Evidence on tissue expression from TISSUES for SLC25A10 Gene

  • Skin(4.3)
  • Thyroid gland(4)
genes like me logo Genes that share expression patterns with SLC25A10: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Phenotype-based relationships between genes and organs from Gene ORGANizer for SLC25A10 Gene

Orthologs for SLC25A10 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for SLC25A10 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia SLC25A10 30
  • 99.21 (n)
Dog
(Canis familiaris)
Mammalia SLC25A10 30
  • 88.4 (n)
-- 31
  • 54 (a)
OneToMany
Mouse
(Mus musculus)
Mammalia Slc25a10 30 17 31
  • 86.55 (n)
OneToMany
Cow
(Bos Taurus)
Mammalia SLC25A10 30
  • 86.37 (n)
MRPL12 31
  • 55 (a)
OneToMany
Rat
(Rattus norvegicus)
Mammalia Slc25a10 30
  • 84.8 (n)
Oppossum
(Monodelphis domestica)
Mammalia -- 31
  • 76 (a)
OneToMany
Platypus
(Ornithorhynchus anatinus)
Mammalia -- 31
  • 74 (a)
OneToMany
Chicken
(Gallus gallus)
Aves SLC25A10 30
  • 81.16 (n)
-- 31
  • 56 (a)
OneToMany
Lizard
(Anolis carolinensis)
Reptilia -- 31
  • 84 (a)
OneToMany
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia slc25a10 30
  • 71.58 (n)
Str.15496 30
African clawed frog
(Xenopus laevis)
Amphibia Xl.11739 30
Zebrafish
(Danio rerio)
Actinopterygii si:ch1073-100f3.2 31
  • 77 (a)
ManyToMany
CABZ01059390.1 31
  • 77 (a)
ManyToMany
LOC100332610 30
  • 71.99 (n)
zgc56614 30
Fruit Fly
(Drosophila melanogaster)
Insecta BcDNA:GH02431 32
  • 58 (a)
CG4323 32
  • 51 (a)
Dic3 31
  • 46 (a)
ManyToMany
CG11196 32
  • 45 (a)
CG18363 32
  • 38 (a)
CG6893 31
  • 37 (a)
ManyToMany
Dic4 31
  • 36 (a)
ManyToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP003073 30
  • 57.94 (n)
Worm
(Caenorhabditis elegans)
Secernentea K11G12.5 31 32
  • 57 (a)
OneToMany
Baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes DIC1 30 31 33
  • 47.83 (n)
OneToMany
Bread mold
(Neurospora crassa)
Ascomycetes NCU01514 30
  • 53.09 (n)
Sea Squirt
(Ciona savignyi)
Ascidiacea CSA.2426 31
  • 53 (a)
OneToMany
Species where no ortholog for SLC25A10 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for SLC25A10 Gene

ENSEMBL:
Gene Tree for SLC25A10 (if available)
TreeFam:
Gene Tree for SLC25A10 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for SLC25A10: view image

Paralogs for SLC25A10 Gene

(10) SIMAP similar genes for SLC25A10 Gene using alignment to 5 proteins:

  • DIC_HUMAN
  • B4DLN1_HUMAN
  • B4E1E9_HUMAN
  • I3L1E8_HUMAN
  • I3L3N9_HUMAN
genes like me logo Genes that share paralogs with SLC25A10: view

Variants for SLC25A10 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for SLC25A10 Gene

SNP ID Clinical significance and condition Chr 17 pos Variation AA Info Type
712222 Benign: not provided 81,715,736(+) C/T SYNONYMOUS_VARIANT
730939 Benign: not provided 81,716,850(+) G/A MISSENSE_VARIANT
768922 Benign: not provided 81,720,188(+) G/A MISSENSE_VARIANT,THREE_PRIME_UTR_VARIANT
771770 Benign: not provided 81,720,115(+) G/A SYNONYMOUS_VARIANT,THREE_PRIME_UTR_VARIANT
780471 Benign: not provided 81,720,313(+) G/A SYNONYMOUS_VARIANT,THREE_PRIME_UTR_VARIANT

Additional dbSNP identifiers (rs#s) for SLC25A10 Gene

Structural Variations from Database of Genomic Variants (DGV) for SLC25A10 Gene

Variant ID Type Subtype PubMed ID
esv26223 CNV gain+loss 19812545
nsv428351 CNV gain 18775914
nsv470620 CNV loss 18288195
nsv828128 CNV loss 20364138
nsv952390 CNV deletion 24416366

Variation tolerance for SLC25A10 Gene

Residual Variation Intolerance Score: 61.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.21; 24.36% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SLC25A10 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SLC25A10

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SLC25A10 Gene

Disorders for SLC25A10 Gene

MalaCards: The human disease database

(2) MalaCards diseases for SLC25A10 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
encephalopathy, ethylmalonic
  • ee
retinitis pigmentosa
  • retinitis pigmentosa 1
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for SLC25A10

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
genes like me logo Genes that share disorders with SLC25A10: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SLC25A10 Gene

Publications for SLC25A10 Gene

  1. Organization and sequence of the gene for the human mitochondrial dicarboxylate carrier: evolution of the carrier family. (PMID: 10585886) Fiermonte G … Palmieri F (The Biochemical journal 1999) 3 4 23
  2. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson SL … O'Brien SJ (PloS one 2010) 3 41
  3. Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries. (PMID: 16303743) Otsuki T … Isogai T (DNA research : an international journal for rapid publication of reports on genes and genomes 2005) 3 4
  4. Identification of dicarboxylate carrier Slc25a10 as malate transporter in de novo fatty acid synthesis. (PMID: 16027120) Mizuarai S … Kotani H (The Journal of biological chemistry 2005) 3 26
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4

Products for SLC25A10 Gene

  • Biorbyt antibodies for SLC25A10

Sources for SLC25A10 Gene