Aliases for SLC22A9 Gene

Aliases for SLC22A9 Gene

  • Solute Carrier Family 22 Member 9 2 3 4 5
  • OAT7 2 3 4
  • Solute Carrier Family 22 (Organic Anion Transporter), Member 9 2 3
  • Organic Anion Transporter 7 3 4
  • HOAT4 3 4
  • OAT4 2 3
  • UST3 2 4
  • Solute Carrier Family 22 (Organic Anion/Cation Transporter), Member 9 3
  • Organic Anion Transporter 4 3
  • FLJ23666 2
  • SLC22A9 5
  • UST3H 3
  • Ust3 3

External Ids for SLC22A9 Gene

Previous GeneCards Identifiers for SLC22A9 Gene

  • GC11U990605
  • GC11M064712
  • GC11P062912
  • GC11P062893
  • GC11P063137
  • GC11P059466

Summaries for SLC22A9 Gene

GeneCards Summary for SLC22A9 Gene

SLC22A9 (Solute Carrier Family 22 Member 9) is a Protein Coding gene. Diseases associated with SLC22A9 include Kidney Papillary Necrosis and Persistent Fetal Circulation Syndrome. Among its related pathways are Statin Pathway - Generalized, Pharmacokinetics. Gene Ontology (GO) annotations related to this gene include transmembrane transporter activity and sodium-independent organic anion transmembrane transporter activity. An important paralog of this gene is SLC22A25.

UniProtKB/Swiss-Prot Summary for SLC22A9 Gene

  • Sodium-independent organic anion transporter which exhibits high specificity for sulfated conjugates of xenobiotics and steroid hormones. It is also specifically activated by 3 to 5 carbons-containing short-chain fatty acids/SCFAs, including propionate, butyrate and valerate. May operate the exchange of sulfated organic components against short-chain fatty acids/SCFAs at the sinusoidal membrane of hepatocytes.

Gene Wiki entry for SLC22A9 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for SLC22A9 Gene

Genomics for SLC22A9 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for SLC22A9 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH11J063369 Promoter 0.9 EPDnew 250.7 +0.9 895 0.1 KDM6A FOXA2 RXRA TEAD3 DMAP1 JUND KAT7 CREM FOXP1 GTF2F1 SLC22A9 lnc-HRASLS5-3 PLAAT5
GH11J063289 Promoter 0.9 EPDnew 10.3 -78.9 -78894 0.1 CEBPA HOMEZ KDM6A FOXA2 RXRA RARA THRB BCL6 JUND SOX5 SLC22A10 SLC22A9 ENSG00000256181 piR-45012-085 SLC22A25
GH11J063404 Enhancer 0.8 ENCODE 11.2 +35.8 35774 0.9 CEBPA HOMEZ KDM6A FOXA2 SMAD4 SAP130 RXRA ETV4 ZBTB33 RARA SLC22A9 PLAAT3 piR-55361-094 lnc-HRASLS5-3 PLAAT5
GH11J063245 Enhancer 0.8 dbSUPER 10.5 -121.3 -121331 3.3 CEBPA FOXA1 FOXA2 MAFF SMAD4 SAP130 RXRA MIER3 RARA TEAD3 SLC22A8 SLC22A9 SLC22A25 HSALNG0084689 LOC105369334 lnc-SLC22A25-1 SLC22A10
GH11J063243 Enhancer 0.6 FANTOM5 8.3 -125.1 -125140 0.7 RXRA JUND HNF4A REST MAX SP1 TAF1 YY1 ATF3 SLC22A25 CCND2P1 lnc-SLC22A25-1 SLC22A10 SLC22A9 SLC22A24
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around SLC22A9 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for SLC22A9

Top Transcription factor binding sites by QIAGEN in the SLC22A9 gene promoter:
  • AP-2rep
  • AREB6
  • GATA-1
  • HNF-1
  • HNF-1A
  • LyF-1

Genomic Locations for SLC22A9 Gene

Latest Assembly
chr11:63,368,871-63,410,878
(GRCh38/hg38)
Size:
42,008 bases
Orientation:
Plus strand

Previous Assembly
chr11:63,137,257-63,177,766
(GRCh37/hg19 by Entrez Gene)
Size:
40,510 bases
Orientation:
Plus strand

chr11:63,137,261-63,177,766
(GRCh37/hg19 by Ensembl)
Size:
40,506 bases
Orientation:
Plus strand

Genomic View for SLC22A9 Gene

Genes around SLC22A9 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SLC22A9 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SLC22A9 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC22A9 Gene

Proteins for SLC22A9 Gene

  • Protein details for SLC22A9 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8IVM8-S22A9_HUMAN
    Recommended name:
    Solute carrier family 22 member 9
    Protein Accession:
    Q8IVM8
    Secondary Accessions:
    • A0AVB7
    • A4PB24
    • Q8TCC8
    • Q8TEC0
    • Q8WYN7

    Protein attributes for SLC22A9 Gene

    Size:
    553 amino acids
    Molecular mass:
    62169 Da
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • [Isoform 2]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.

    Alternative splice isoforms for SLC22A9 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SLC22A9 Gene

Post-translational modifications for SLC22A9 Gene

  • Glycosylation at Asn39, Asn56, and Asn102
  • Modification sites at PhosphoSitePlus

Other Protein References for SLC22A9 Gene

No data available for DME Specific Peptides for SLC22A9 Gene

Domains & Families for SLC22A9 Gene

Gene Families for SLC22A9 Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • Predicted membrane proteins
  • Transporters

Protein Domains for SLC22A9 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for SLC22A9 Gene

GenScript: Design optimal peptide antigens:
  • Organic anion transporter 7 (A4PB24_HUMAN)
  • Organic anion transporter 4 (S22A9_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q8IVM8

UniProtKB/Swiss-Prot:

S22A9_HUMAN :
  • Belongs to the major facilitator (TC 2.A.1) superfamily. Organic cation transporter (TC 2.A.1.19) family.
Family:
  • Belongs to the major facilitator (TC 2.A.1) superfamily. Organic cation transporter (TC 2.A.1.19) family.
genes like me logo Genes that share domains with SLC22A9: view

Function for SLC22A9 Gene

Molecular function for SLC22A9 Gene

UniProtKB/Swiss-Prot Function:
Sodium-independent organic anion transporter which exhibits high specificity for sulfated conjugates of xenobiotics and steroid hormones. It is also specifically activated by 3 to 5 carbons-containing short-chain fatty acids/SCFAs, including propionate, butyrate and valerate. May operate the exchange of sulfated organic components against short-chain fatty acids/SCFAs at the sinusoidal membrane of hepatocytes.

Phenotypes From GWAS Catalog for SLC22A9 Gene

Gene Ontology (GO) - Molecular Function for SLC22A9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0015301 anion:anion antiporter activity IDA 17393504
GO:0015347 sodium-independent organic anion transmembrane transporter activity IDA 17393504
GO:0015636 short-chain fatty acid transmembrane transporter activity IDA 17393504
GO:0022857 transmembrane transporter activity IEA --
genes like me logo Genes that share ontologies with SLC22A9: view
genes like me logo Genes that share phenotypes with SLC22A9: view

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SLC22A9

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SLC22A9 Gene

Localization for SLC22A9 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC22A9 Gene

Basolateral cell membrane. Multi-pass membrane protein. Note=Enriched at the sinusoidal part of the plasma membrane.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SLC22A9 gene
Compartment Confidence
plasma membrane 5
mitochondrion 3
extracellular 1
cytoskeleton 1
nucleus 1
endoplasmic reticulum 1
cytosol 1
lysosome 1

Gene Ontology (GO) - Cellular Components for SLC22A9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IEA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0016323 basolateral plasma membrane IEA,IDA 17393504
genes like me logo Genes that share ontologies with SLC22A9: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for SLC22A9 Gene

Pathways & Interactions for SLC22A9 Gene

PathCards logo

SuperPathways for SLC22A9 Gene

genes like me logo Genes that share pathways with SLC22A9: view

Pathways by source for SLC22A9 Gene

1 PharmGKB pathway for SLC22A9 Gene

Gene Ontology (GO) - Biological Process for SLC22A9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0009914 hormone transport IDA 17393504
GO:0015711 organic anion transport IBA 21873635
GO:0015912 short-chain fatty acid transport IEA --
GO:0015913 short-chain fatty acid import IDA 17393504
GO:0043252 sodium-independent organic anion transport IDA 17393504
genes like me logo Genes that share ontologies with SLC22A9: view

No data available for SIGNOR curated interactions for SLC22A9 Gene

Drugs & Compounds for SLC22A9 Gene

No Compound Related Data Available

Transcripts for SLC22A9 Gene

mRNA/cDNA for SLC22A9 Gene

1 REFSEQ mRNAs :
7 NCBI additional mRNA sequence :
2 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SLC22A9

Alternative Splicing Database (ASD) splice patterns (SP) for SLC22A9 Gene

No ASD Table

Relevant External Links for SLC22A9 Gene

GeneLoc Exon Structure for
SLC22A9

Expression for SLC22A9 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for SLC22A9 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

  • Spleen (Hematopoietic System)
  • Liver (Hepatobiliary System)

mRNA differential expression in normal tissues according to GTEx for SLC22A9 Gene

This gene is overexpressed in Liver (x39.2).

Protein differential expression in normal tissues from HIPED for SLC22A9 Gene

This gene is overexpressed in Fetal Liver (24.0), Liver (19.5), and Fetal heart (12.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for SLC22A9 Gene



Protein tissue co-expression partners for SLC22A9 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for SLC22A9

SOURCE GeneReport for Unigene cluster for SLC22A9 Gene:

Hs.502772

mRNA Expression by UniProt/SwissProt for SLC22A9 Gene:

Q8IVM8-S22A9_HUMAN
Tissue specificity: Specifically expressed in liver by hepatocytes (at protein level).

Evidence on tissue expression from TISSUES for SLC22A9 Gene

  • Liver(4.6)
  • Kidney(4.5)
  • Nervous system(4.3)
genes like me logo Genes that share expression patterns with SLC22A9: view

Primer products for research

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for SLC22A9 Gene

Orthologs for SLC22A9 Gene

This gene was present in the common ancestor of mammals.

Orthologs for SLC22A9 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia SLC22A9 30 31
  • 98.98 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia LOC517475 30
  • 76.04 (n)
-- 31
  • 68 (a)
ManyToMany
-- 31
  • 62 (a)
ManyToMany
Rat
(Rattus norvegicus)
Mammalia Slc22a25 30
  • 69.87 (n)
Dog
(Canis familiaris)
Mammalia -- 31
  • 61 (a)
OneToMany
Mouse
(Mus musculus)
Mammalia Slc22a19 31
  • 55 (a)
ManyToMany
Slc22a27 31
  • 54 (a)
ManyToMany
Slc22a29 31
  • 54 (a)
ManyToMany
Slc22a28 31
  • 53 (a)
ManyToMany
Slc22a26 31
  • 53 (a)
ManyToMany
Slc22a30 31
  • 53 (a)
ManyToMany
Oppossum
(Monodelphis domestica)
Mammalia -- 31
  • 41 (a)
ManyToMany
-- 31
  • 36 (a)
ManyToMany
Species where no ortholog for SLC22A9 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for SLC22A9 Gene

ENSEMBL:
Gene Tree for SLC22A9 (if available)
TreeFam:
Gene Tree for SLC22A9 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for SLC22A9: view image

Paralogs for SLC22A9 Gene

(13) SIMAP similar genes for SLC22A9 Gene using alignment to 1 proteins:

  • S22A9_HUMAN
genes like me logo Genes that share paralogs with SLC22A9: view

Variants for SLC22A9 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for SLC22A9 Gene

SNP ID Clinical significance and condition Chr 11 pos Variation AA Info Type
rs770073076 A colorectal cancer sample p.Asn521Lys
VAR_036403 A breast cancer sample p.Ala393Val
VAR_036404 A breast cancer sample p.Met487Val

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for SLC22A9 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for SLC22A9 Gene

Variant ID Type Subtype PubMed ID
esv2653139 CNV insertion 19546169
esv3303992 CNV mobile element insertion 20981092
esv3437215 CNV insertion 20981092
nsv1053627 CNV loss 25217958
nsv555178 CNV gain 21841781

Variation tolerance for SLC22A9 Gene

Residual Variation Intolerance Score: 81.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.58; 44.77% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SLC22A9 Gene

Human Gene Mutation Database (HGMD)
SLC22A9
SNPedia medical, phenotypic, and genealogical associations of SNPs for
SLC22A9

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SLC22A9 Gene

Disorders for SLC22A9 Gene

MalaCards: The human disease database

(2) MalaCards diseases for SLC22A9 Gene - From: COP

Disorder Aliases PubMed IDs
kidney papillary necrosis
  • necrotizing renal papillitis
persistent fetal circulation syndrome
  • congenital alveolar capillary dysplasia with misalignment of pulmonary veins
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for SLC22A9

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform
genes like me logo Genes that share disorders with SLC22A9: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SLC22A9 Gene

Publications for SLC22A9 Gene

  1. Novel liver-specific organic anion transporter OAT7 that operates the exchange of sulfate conjugates for short chain fatty acid butyrate. (PMID: 17393504) Shin HJ … Kanai Y (Hepatology (Baltimore, Md.) 2007) 2 3 4
  2. Isolation of a family of organic anion transporters from human liver and kidney. (PMID: 11327718) Sun W … Erion MD (Biochemical and biophysical research communications 2001) 2 3 4
  3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 41
  4. Functional differences in steroid sulfate uptake of organic anion transporter 4 (OAT4) and organic anion transporting polypeptide 2B1 (OATP2B1) in human placenta. (PMID: 18501590) Ugele B … Rex-Haffner M (The Journal of steroid biochemistry and molecular biology 2008) 3 23
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4

Products for SLC22A9 Gene

  • Biorbyt antibodies for SLC22A9

Sources for SLC22A9 Gene