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This gene encodes a protein involved in the sodium-independent transport and excretion of organic anions, some of which are potentially toxic. The encoded protein is an integral membrane protein and appears to be localized to the basolateral membrane of the kidney. Multiple alternatively spliced transcript variants that encode different protein isoforms have been described for this gene. [provided by RefSeq, May 2010]
SLC22A8 (Solute Carrier Family 22 Member 8) is a Protein Coding gene. Among its related pathways are Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds and Blood-Brain Barrier Pathway: Anatomy. Gene Ontology (GO) annotations related to this gene include transmembrane transporter activity and ion transmembrane transporter activity. An important paralog of this gene is SLC22A6.
GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
---|---|---|---|---|---|---|---|---|---|---|
GH11J063015 | Promoter/Enhancer | 0.7 | EPDnew Ensembl | 750.6 | -0.2 | -156 | 1.6 | NR2F6 HLF | SLC22A8 lnc-SLC22A8-2 ENSG00000256041 | |
GH11J063017 | Enhancer | 0.4 | Ensembl | 750.6 | -1.9 | -1856 | 1 | ZBTB8A PRDM10 RCOR1 | SLC22A8 lnc-SLC22A8-2 ENSG00000256041 | |
GH11J063245 | Enhancer | 0.8 | dbSUPER | 10.7 | -231.7 | -231695 | 3.3 | NR2F6 CREB1 SP1 HNF1A SP5 ZNF384 ZNF644 CEBPA GATAD2A RXRB | SLC22A8 SLC22A9 SLC22A25 LOC105369334 lnc-SLC22A25-1 SLC22A10 | |
GH11J062896 | Enhancer | 0.4 | Ensembl dbSUPER | 11 | +119.2 | 119244 | 0.4 | NR2F2 | SLC22A8 ROM1 HSALNG0084674 ENSG00000257002 | |
GH11J062895 | Enhancer | 0.4 | Ensembl dbSUPER | 11 | +120.0 | 120044 | 0.4 | GLIS1 | SLC22A8 TMEM223 HSALNG0084674 ENSG00000257002 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005452 | inorganic anion exchanger activity | IDA | 15037815 |
GO:0022857 | transmembrane transporter activity | IEA | -- |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005886 | plasma membrane | IBA,TAS | -- |
GO:0016020 | membrane | IEA | -- |
GO:0016021 | integral component of membrane | IEA | -- |
GO:0016323 | basolateral plasma membrane | IEA,IDA | 15037815 |
GO:0070062 | extracellular exosome | HDA | 19056867 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0006811 | ion transport | IEA | -- |
GO:0009636 | response to toxic substance | IEA | -- |
GO:0015698 | inorganic anion transport | IEA | -- |
GO:0055085 | transmembrane transport | IEA | -- |
Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
---|---|---|---|---|---|---|
Probenecid | Approved, Investigational | Pharma | Inhibition, Inhibitor, Activator, Target, Transporter, inhibitor, blocker | 40 | ||
Cefotaxime | Approved | Pharma | Target, Transporter, inhibitor | 45 | ||
Dabrafenib | Approved, Investigational | Pharma | Transporter, inhibitor | BRAF kinase inhibitor, Kinase Inhibitors, Mutant BRAF Kinase | 108 | |
Dolutegravir | Approved | Pharma | Transporter, inhibitor | 215 | ||
Rucaparib | Approved, Investigational | Pharma | Transporter, inhibitor | PARP inhibitor, PARP Inhibitors, Other | 48 |
Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs |
---|
ExUns: | 1a | · | 1b | ^ | 2a | · | 2b | · | 2c | ^ | 3 | ^ | 4a | · | 4b | ^ | 5a | · | 5b | ^ | 6a | · | 6b | · | 6c | · | 6d | ^ | 7a | · | 7b | · | 7c | ^ | 8 | ^ | 9a | · | 9b | ^ | 10 | ^ | 11 | ^ | 12a | · | 12b | · | 12c |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||
SP2: | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||
SP3: | - | - | |||||||||||||||||||||||||||||||||||||||||||||||
SP4: | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||
SP5: | - | ||||||||||||||||||||||||||||||||||||||||||||||||
SP6: | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||
SP7: | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||
SP8: | |||||||||||||||||||||||||||||||||||||||||||||||||
SP9: |
This gene was present in the common ancestor of animals and fungi.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
chimpanzee (Pan troglodytes) |
Mammalia | SLC22A8 33 32 |
|
OneToOne | |
cow (Bos Taurus) |
Mammalia | SLC22A8 32 |
|
||
OAT3 33 |
|
OneToOne | |||
dog (Canis familiaris) |
Mammalia | SLC22A8 33 32 |
|
OneToOne | |
rat (Rattus norvegicus) |
Mammalia | Slc22a8 32 |
|
||
mouse (Mus musculus) |
Mammalia | Slc22a8 17 33 32 |
|
||
platypus (Ornithorhynchus anatinus) |
Mammalia | SLC22A8 33 |
|
OneToOne | |
oppossum (Monodelphis domestica) |
Mammalia | -- 33 |
|
ManyToMany | |
lizard (Anolis carolinensis) |
Reptilia | -- 33 |
|
ManyToMany | |
-- 33 |
|
ManyToMany | |||
-- 33 |
|
ManyToMany | |||
-- 33 |
|
ManyToMany | |||
zebrafish (Danio rerio) |
Actinopterygii | slc22a6l 33 |
|
OneToMany | |
baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | MPH3 35 |
|
|
SNP ID | Clin | Chr 11 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
rs1000192624 | -- | 63,005,576(-) | T/C | genic_upstream_transcript_variant, intron_variant | |
rs1000234719 | -- | 63,017,156(-) | T/C | upstream_transcript_variant | |
rs1000242749 | -- | 63,010,530(-) | C/A | genic_upstream_transcript_variant, intron_variant | |
rs1000358390 | -- | 63,010,288(-) | C/T | genic_upstream_transcript_variant, intron_variant | |
rs1000396503 | -- | 63,010,800(-) | C/T | genic_upstream_transcript_variant, intron_variant |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
dgv204e214 | CNV | gain | 21293372 |
esv34011 | CNV | loss | 18971310 |
No disorders were found for SLC22A8 Gene.