Aliases for SLC22A7 Gene
External Ids for SLC22A7 Gene
Previous GeneCards Identifiers for SLC22A7 Gene
The protein encoded by this gene is involved in the sodium-independent transport and excretion of organic anions, some of which are potentially toxic. The encoded protein is an integral membrane protein and appears to be localized to the basolateral membrane of the kidney. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008]
GeneCards Summary for SLC22A7 Gene
SLC22A7 (Solute Carrier Family 22 Member 7) is a Protein Coding gene. Diseases associated with SLC22A7 include Bilirubin Metabolic Disorder. Among its related pathways are Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds and Bile secretion. Gene Ontology (GO) annotations related to this gene include transmembrane transporter activity and sodium-independent organic anion transmembrane transporter activity. An important paralog of this gene is SLC22A6.
UniProtKB/Swiss-Prot for SLC22A7 Gene
Mediates sodium-independent multispecific organic anion transport. Transport of prostaglandin E2, prostaglandin F2, tetracycline, bumetanide, estrone sulfate, glutarate, dehydroepiandrosterone sulfate, allopurinol, 5-fluorouracil, paclitaxel, L-ascorbic acid, salicylate, ethotrexate, and alpha-ketoglutarate.