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The protein encoded by this gene is involved in the sodium-dependent transport and excretion of organic anions, some of which are potentially toxic. The encoded protein is an integral membrane protein and may be localized to the basolateral membrane. Four transcript variants encoding four different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] See more...
Aliases for SLC22A6 Gene
Aliases for SLC22A6 Gene
External Ids for SLC22A6 Gene
- HGNC: 10970
- Entrez Gene: 9356
- Ensembl: ENSG00000197901
- OMIM: 607582
- UniProtKB: Q4U2R8
Previous GeneCards Identifiers for SLC22A6 Gene
- GC11M065256
- GC11M064319
- GC11M062994
- GC11M062519
- GC11M062500
- GC11M062744
- GC11M059073
- GC11M062989
- GC11M063004
- GC11M062943
- GC11M062961
Summaries for SLC22A6 Gene
-
The protein encoded by this gene is involved in the sodium-dependent transport and excretion of organic anions, some of which are potentially toxic. The encoded protein is an integral membrane protein and may be localized to the basolateral membrane. Four transcript variants encoding four different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
GeneCards Summary for SLC22A6 Gene
SLC22A6 (Solute Carrier Family 22 Member 6) is a Protein Coding gene. Diseases associated with SLC22A6 include N-Acetylglutamate Synthase Deficiency. Among its related pathways are Tenofovir/Adefovir Pathway, Pharmacokinetics and Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds. Gene Ontology (GO) annotations related to this gene include protein homodimerization activity and ion transmembrane transporter activity. An important paralog of this gene is SLC22A8.
UniProtKB/Swiss-Prot Summary for SLC22A6 Gene
-
Involved in the renal elimination of endogenous and exogenous organic anions. Functions as organic anion exchanger when the uptake of one molecule of organic anion is coupled with an efflux of one molecule of endogenous dicarboxylic acid (glutarate, ketoglutarate, etc). Mediates the sodium-independent uptake of 2,3-dimercapto-1-propanesulfonic acid (DMPS) (By similarity). Mediates the sodium-independent uptake of p-aminohippurate (PAH), ochratoxin (OTA), acyclovir (ACV), 3'-azido-3-'deoxythymidine (AZT), cimetidine (CMD), 2,4-dichloro-phenoxyacetate (2,4-D), hippurate (HA), indoleacetate (IA), indoxyl sulfate (IS) and 3-carboxy-4-methyl-5-propyl-2-furanpropionate (CMPF), cidofovir, adefovir, 9-(2-phosphonylmethoxyethyl) guanine (PMEG), 9-(2-phosphonylmethoxyethyl) diaminopurine (PMEDAP) and edaravone sulfate. PAH uptake is inhibited by p-chloromercuribenzenesulphonate (PCMBS), diethyl pyrocarbonate (DEPC), sulindac, diclofenac, carprofen, glutarate and okadaic acid (By similarity). PAH uptake is inhibited by benzothiazolylcysteine (BTC), S-chlorotrifluoroethylcysteine (CTFC), cysteine S-conjugates S-dichlorovinylcysteine (DCVC), furosemide, steviol, phorbol 12-myristate 13-acetate (PMA), calcium ionophore A23187, benzylpenicillin, furosemide, indomethacin, bumetamide, losartan, probenecid, phenol red, urate, and alpha-ketoglutarate.
Additional gene information for SLC22A6 Gene
- Monarch Initiative
- Search for SLC22A6 at DataMed
- Search for SLC22A6 at HumanCyc
No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for SLC22A6 Gene
Genomics for SLC22A6 Gene
GeneHancer (GH) Regulatory Elements for SLC22A6 Gene
Promoters and enhancers for SLC22A6 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around SLC22A6 on UCSC Golden Path with GeneCards custom track
- Top Transcription factor binding sites by QIAGEN in the SLC22A6 gene promoter:
-
- NRSF form 1
- NRSF form 2
Genomic Locations for SLC22A6 Gene
Genomic Locations for SLC22A6 Gene
- chr11:62,936,385-62,985,023
- (GRCh38/hg38)
- Size:
- 48,639 bases
- Orientation:
- Minus strand
- chr11:62,703,857-62,752,495
- (GRCh37/hg19)
- Size:
- 48,639 bases
- Orientation:
- Minus strand
Genomic View for SLC22A6 Gene
Genes around SLC22A6 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 11q12.3 by HGNC
- 11q12.3 by Entrez Gene
- 11q12.3 by Ensembl
SLC22A6 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for SLC22A6 Gene
Proteins for SLC22A6 Gene
-
Protein details for SLC22A6 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q4U2R8-S22A6_HUMAN
- Recommended name:
- Solute carrier family 22 member 6
- Protein Accession:
- Q4U2R8
- A8MY93
- B2D0R6
- O95187
- O95742
- Q7LDA0
- Q8N192
- Q9NQA6
- Q9NQC2
- Q9UBG6
- Q9UEQ8
Protein attributes for SLC22A6 Gene
- Size:
- 563 amino acids
- Molecular mass:
- 61816 Da
- Quaternary structure:
- No Data Available
Protein Expression for SLC22A6 Gene
Post-translational modifications for SLC22A6 Gene
- Glycosylated. Glycosylation at Asn-113 may occur at a secondary level. Glycosylation is necessary for proper targeting of the transporter to the plasma membrane.
-
Glycosylation at Asn39, Asn56, Asn92, Asn97, and Asn113
- NX_Q4U2R8 (NX_Q4U2R8-1)
- Modification sites at PhosphoSitePlus
Other Protein References for SLC22A6 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- G Biosciences Immunotag™ SLC22A6 Antibody, Immunotag™ OAT1 Antibody, and Immunotag™ OAT1 Polyclonal Antibody
- NSJ Bioreagents SLC22A6 Antibody
- Atlas Antibodies Anti-SLC22A6 Antibody
- Creative Diagnostics Anti-SLC22A6 monoclonal antibody and Anti-SLC22A6 (aa 551-563) polyclonal antibody
-
Custom Antibody ServicesOriGene Antibodies for SLC22A6
- Novus Biologicals Antibodies for SLC22A6
-
Abcam antibodies for SLC22A6
- Invitrogen Antibodies for SLC22A6 (AFLGC-SLC22A6)
-
Santa Cruz Biotechnology (SCBT) Antibodies for SLC22A6
Protein Products
- Atlas Antibodies PrEST Antigen SLC22A6
-
OriGene Purified Proteins for SLC22A6
- Search Origene for MassSpec and Protein Over-expression Lysates for SLC22A6
- Origene Custom Protein Services for SLC22A6
-
Abcam proteins for SLC22A6
No data available for DME Specific Peptides for SLC22A6 Gene
Domains & Families for SLC22A6 Gene
Gene Families for SLC22A6 Gene
- HGNC:
- IUPHAR :
- Human Protein Atlas (HPA):
-
- FDA approved drug targets
- Predicted membrane proteins
- Transporters
Protein Domains for SLC22A6 Gene
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for SLC22A6 Gene
- GenScript: Design optimal peptide antigens:
-
- Renal organic anion transporter 1 (S22A6_HUMAN)
Graphical View of Domain Structure for InterPro Entry
Q4U2R8UniProtKB/Swiss-Prot:
S22A6_HUMAN :- Multiple cysteine residues are necessary for proper targeting to the plasma membrane.
- Belongs to the major facilitator (TC 2.A.1) superfamily. Organic cation transporter (TC 2.A.1.19) family.
- Domain:
-
- Multiple cysteine residues are necessary for proper targeting to the plasma membrane.
- Family:
-
- Belongs to the major facilitator (TC 2.A.1) superfamily. Organic cation transporter (TC 2.A.1.19) family.
Function for SLC22A6 Gene
Molecular function for SLC22A6 Gene
- UniProtKB/Swiss-Prot Function:
- Involved in the renal elimination of endogenous and exogenous organic anions. Functions as organic anion exchanger when the uptake of one molecule of organic anion is coupled with an efflux of one molecule of endogenous dicarboxylic acid (glutarate, ketoglutarate, etc). Mediates the sodium-independent uptake of 2,3-dimercapto-1-propanesulfonic acid (DMPS) (By similarity). Mediates the sodium-independent uptake of p-aminohippurate (PAH), ochratoxin (OTA), acyclovir (ACV), 3'-azido-3-'deoxythymidine (AZT), cimetidine (CMD), 2,4-dichloro-phenoxyacetate (2,4-D), hippurate (HA), indoleacetate (IA), indoxyl sulfate (IS) and 3-carboxy-4-methyl-5-propyl-2-furanpropionate (CMPF), cidofovir, adefovir, 9-(2-phosphonylmethoxyethyl) guanine (PMEG), 9-(2-phosphonylmethoxyethyl) diaminopurine (PMEDAP) and edaravone sulfate. PAH uptake is inhibited by p-chloromercuribenzenesulphonate (PCMBS), diethyl pyrocarbonate (DEPC), sulindac, diclofenac, carprofen, glutarate and okadaic acid (By similarity). PAH uptake is inhibited by benzothiazolylcysteine (BTC), S-chlorotrifluoroethylcysteine (CTFC), cysteine S-conjugates S-dichlorovinylcysteine (DCVC), furosemide, steviol, phorbol 12-myristate 13-acetate (PMA), calcium ionophore A23187, benzylpenicillin, furosemide, indomethacin, bumetamide, losartan, probenecid, phenol red, urate, and alpha-ketoglutarate.
- UniProtKB/Swiss-Prot BiophysicochemicalProperties:
- Kinetic parameters: KM=9.3 uM for PAH (isoform 1) {ECO:0000269 PubMed:10462545, ECO:0000269 PubMed:10964714, ECO:0000269 PubMed:12538807, ECO:0000269 PubMed:15846473}; KM=4 uM for PAH (isoform 2) {ECO:0000269 PubMed:10462545, ECO:0000269 PubMed:10964714, ECO:0000269 PubMed:12538807, ECO:0000269 PubMed:15846473}; KM=11 uM for edaravone {ECO:0000269 PubMed:10462545, ECO:0000269 PubMed:10964714, ECO:0000269 PubMed:12538807, ECO:0000269 PubMed:15846473}; KM=46 uM for cidofovir {ECO:0000269 PubMed:10462545, ECO:0000269 PubMed:10964714, ECO:0000269 PubMed:12538807, ECO:0000269 PubMed:15846473}; KM=30 uM for adefovir {ECO:0000269 PubMed:10462545, ECO:0000269 PubMed:10964714, ECO:0000269 PubMed:12538807, ECO:0000269 PubMed:15846473}; KM=5.77 uM for 2,4-D {ECO:0000269 PubMed:10462545, ECO:0000269 PubMed:10964714, ECO:0000269 PubMed:12538807, ECO:0000269 PubMed:15846473}; KM=23.5 uM for HA {ECO:0000269 PubMed:10462545, ECO:0000269 PubMed:10964714, ECO:0000269 PubMed:12538807, ECO:0000269 PubMed:15846473}; KM=14 uM for IA {ECO:0000269 PubMed:10462545, ECO:0000269 PubMed:10964714, ECO:0000269 PubMed:12538807, ECO:0000269 PubMed:15846473}; KM=20.5 uM for IS {ECO:0000269 PubMed:10462545, ECO:0000269 PubMed:10964714, ECO:0000269 PubMed:12538807, ECO:0000269 PubMed:15846473}; KM=141 uM for CMPF {ECO:0000269 PubMed:10462545, ECO:0000269 PubMed:10964714, ECO:0000269 PubMed:12538807, ECO:0000269 PubMed:15846473}; Vmax=534 pmol/min/mg enzyme for 2,4-D uptake {ECO:0000269 PubMed:10462545, ECO:0000269 PubMed:10964714, ECO:0000269 PubMed:12538807, ECO:0000269 PubMed:15846473}; Vmax=430 pmol/min/mg enzyme for HA uptake {ECO:0000269 PubMed:10462545, ECO:0000269 PubMed:10964714, ECO:0000269 PubMed:12538807, ECO:0000269 PubMed:15846473}; Vmax=110 pmol/min/mg enzyme for IA uptake {ECO:0000269 PubMed:10462545, ECO:0000269 PubMed:10964714, ECO:0000269 PubMed:12538807, ECO:0000269 PubMed:15846473}; Vmax=216 pmol/min/mg enzyme for IS uptake {ECO:0000269 PubMed:10462545, ECO:0000269 PubMed:10964714, ECO:0000269 PubMed:12538807, ECO:0000269 PubMed:15846473}; Vmax=801 pmol/min/mg enzyme for CMPF uptake {ECO:0000269 PubMed:10462545, ECO:0000269 PubMed:10964714, ECO:0000269 PubMed:12538807, ECO:0000269 PubMed:15846473};
- GENATLAS Biochemistry:
- solute carrier protein family 22,member A6,polyspecific transporter for organic cations,mediating the coupled exchange of alpha-ketoglutarate with multiple organic ions,including p-aminohippurate (PAH),expressed strongly in kidney,weakly in brain
Phenotypes From GWAS Catalog for SLC22A6 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005452 | inorganic anion exchanger activity | IDA | 15037815 |
| GO:0005515 | protein binding | IPI | 16189514 |
| GO:0008514 | organic anion transmembrane transporter activity | IMP | 22169006 |
| GO:0015301 | anion:anion antiporter activity | IEA | -- |
| GO:0015347 | sodium-independent organic anion transmembrane transporter activity | IBA | 21873635 |
Phenotypes for SLC22A6 Gene
- MGI mutant phenotypes for SLC22A6:
- inferred from 1 alleles
- GenomeRNAi human phenotypes for SLC22A6:
-
- Dynamic nuclei (hole, folded or small irregular)
- Decreased viability
- no effect
- Resistant to vaccinia virus (VACV-A4L) infection
- Decreased hepcidin::fluc mRNA expression
- Decreased NF-kappaB reporter expression
- Decreased influenza A H1N1 (A/Hamburg/04/2009) virus numbers
- Decreased influenza A/WSN/33 replication
- shRNA abundance <= 50%
- Increased viability
- Decreased shRNA abundance
Animal Models for SLC22A6 Gene
- MGI Knock Outs for SLC22A6:
-
- Slc22a6 Slc22a6<tm1Dgen>
Animal Model Products
-
Taconic Biosciences Mouse Models for SLC22A6
CRISPR Products
-
OriGene CRISPR knockouts for SLC22A6
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for SLC22A6
- genomics-online: gRNA clones - Search results for available SLC22A6 gene related products
- Applied Biological Materials (abm): CRISPR Clones for SLC22A6 - Select products 50% OFF >
- * SLC22A6 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * SLC22A6 CRISPR applications: KO, Activation, Repression, and more - Browse All
-
Santa Cruz Biotechnology (SCBT) CRISPR for SLC22A6
miRNA for SLC22A6 Gene
- miRTarBase miRNAs that target SLC22A6
-
- hsa-mir-1238-3p (MIRT646367)
- hsa-mir-670-3p (MIRT646368)
- hsa-mir-147a (MIRT646369)
- hsa-mir-6818-5p (MIRT646370)
- hsa-mir-6759-5p (MIRT646371)
- hsa-mir-6881-3p (MIRT646372)
- hsa-mir-6780a-3p (MIRT646373)
- hsa-mir-7111-3p (MIRT646374)
- hsa-mir-6749-3p (MIRT646375)
- hsa-mir-6792-3p (MIRT646376)
- hsa-mir-4691-5p (MIRT646377)
- hsa-mir-644a (MIRT646378)
- hsa-mir-3911 (MIRT646379)
- hsa-mir-6793-5p (MIRT646380)
- hsa-mir-6748-5p (MIRT646381)
- hsa-mir-581 (MIRT646382)
- hsa-mir-1236-3p (MIRT646383)
- hsa-mir-877-3p (MIRT646384)
- hsa-mir-660-3p (MIRT646385)
- hsa-mir-5193 (MIRT646386)
- hsa-mir-2909 (MIRT646387)
- hsa-mir-211-5p (MIRT646388)
- hsa-mir-204-5p (MIRT646389)
- hsa-mir-642a-5p (MIRT646390)
- hsa-mir-8065 (MIRT646391)
- hsa-mir-659-5p (MIRT646392)
- hsa-mir-4287 (MIRT646393)
- hsa-mir-4685-3p (MIRT646394)
- hsa-mir-6734-3p (MIRT646395)
- hsa-mir-6832-3p (MIRT646396)
- hsa-mir-4667-3p (MIRT646397)
- hsa-mir-1470 (MIRT646398)
- hsa-mir-296-3p (MIRT646399)
miRNA Products
Inhibitory RNA Products
- Origene sirna, shrna, and RNAi products in human, mouse, rat for SLC22A6
- Browse OriGene Inhibitory RNA Products For SLC22A6
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SLC22A6
- genomics-online: shRNA clones - Search results for available SLC22A6 gene related products
Clone Products
-
- MG208683
- MR208683
- MR208683L3
- MR208683L3V
- MR208683L4
- MR208683L4V
- RC207579
- RC207579L1
- RC207579L1V
- RC207579L2
- RC207579L2V
- RC207579L3
- RC207579L3V
- RC207579L4
- RC207579L4V
- RC212431
- RC212431L3
- RC212431L3V
- RC212431L4
- RC212431L4V
- RC215313
- RC215313L3
- RC215313L3V
- RC215313L4
- RC215313L4V
- RC218568
- RC218568L1
- RC218568L1V
- RC218568L2
- RC218568L2V
- RC218568L3
- RC218568L3V
- RC218568L4
- RC218568L4V
- RG207579
- RG212431
- RG215313
- RG218568
- RR211439
- RR211439L1
- RR211439L1V
- RR211439L2
- RR211439L2V
- RR211439L3
- RR211439L3V
- RR211439L4
- RR211439L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for SLC22A6
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for SLC22A6
- genomics-online: cdna clones - Search results for available SLC22A6 gene related products
- orf clones - Search results for available SLC22A6 gene related products
- Applied Biological Materials (abm): Clones for SLC22A6 - Select products 50% OFF >
- * SLC22A6 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * SLC22A6 tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All
Cell Line Products
-
Horizon Cell Lines for SLC22A6
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for SLC22A6 Gene
Localization for SLC22A6 Gene
Subcellular locations from UniProtKB/Swiss-Prot for SLC22A6 Gene
- Cell membrane; Multi-pass membrane protein.
| Compartment | Confidence |
|---|---|
| plasma membrane | 5 |
| extracellular | 1 |
| nucleus | 1 |
| endoplasmic reticulum | 0 |
| lysosome | 0 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005886 | plasma membrane | IBA,TAS | -- |
| GO:0005887 | integral component of plasma membrane | IDA | 14749323 |
| GO:0005901 | caveola | IEA | -- |
| GO:0016020 | membrane | IEA | -- |
| GO:0016021 | integral component of membrane | IEA | -- |
No data available for Subcellular locations from the Human Protein Atlas (HPA) for SLC22A6 Gene
Pathways & Interactions for SLC22A6 Gene
Pathways by source for SLC22A6 Gene
Interacting Proteins for SLC22A6 Gene
Selected Interacting proteins:
Q4U2R8-S22A6_HUMAN
ENSP00000367102
for SLC22A6 Gene via
UniProtKB
STRING
IID
GPS-Prot Interaction Network for SLC22A6
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006820 | anion transport | IEA | -- |
| GO:0015698 | inorganic anion transport | IEA | -- |
| GO:0015711 | organic anion transport | IBA,IMP | 22169006 |
| GO:0015742 | alpha-ketoglutarate transport | IDA | 9950961 |
| GO:0031427 | response to methotrexate | IEA | -- |
No data available for SIGNOR curated interactions for SLC22A6 Gene
Drugs & Compounds for SLC22A6 Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| Probenecid | Approved, Investigational | Pharma | Inhibition, Inhibitor, Activator, Target, Transporter, inhibitor, substrate, blocker | 40 | ||
| Amoxicillin | Approved, Vet_approved | Pharma | Transporter, inhibitor | 613 | ||
| Cefazolin | Approved | Pharma | Transporter, substrate, inhibitor | 147 | ||
| Cefotiam | Approved, Investigational | Pharma | Transporter, substrate, inhibitor | 2 | ||
| Cidofovir | Approved | Pharma | Transporter, substrate, inhibitor | 35 |
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
|---|---|---|---|---|---|---|
| 2-Hydroxychlorpropamide |
|
36892-36-1 |
|
|||
| 3-Hydroxymethylantipyrine |
|
18125-49-0 | ||||
| 4-ene-Valproic acid |
|
|||||
| 4'-Hydroxydiclofenac |
|
64118-84-9 | ||||
| 5'-Hydroxypiroxicam |
|
77459-78-0 |
Transcripts for SLC22A6 Gene
mRNA/cDNA for SLC22A6 Gene
- (5) REFSEQ mRNAs :
- (16) Additional mRNA sequences :
- (40) Selected AceView cDNA sequences:
- (6) Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000360421 2143 bps (ENST00000360421.8)
- ENST00000377871 2151 bps (ENST00000377871.7)
- ENST00000421062 1560 bps (ENST00000421062.2)
- ENST00000458333 1521 bps (ENST00000458333.6)
- ENST00000537349 768 bps (ENST00000537349.1)
CRISPR Products
-
OriGene CRISPR knockouts for SLC22A6
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for SLC22A6
- genomics-online: gRNA clones - Search results for available SLC22A6 gene related products
- Applied Biological Materials (abm): CRISPR Clones for SLC22A6 - Select products 50% OFF >
- * SLC22A6 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * SLC22A6 CRISPR applications: KO, Activation, Repression, and more - Browse All
-
Santa Cruz Biotechnology (SCBT) CRISPR for SLC22A6
miRNA Products
Inhibitory RNA Products
- Origene sirna, shrna, and RNAi products in human, mouse, rat for SLC22A6
- Browse OriGene Inhibitory RNA Products For SLC22A6
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SLC22A6
- genomics-online: shRNA clones - Search results for available SLC22A6 gene related products
Clone Products
-
- MG208683
- MR208683
- MR208683L3
- MR208683L3V
- MR208683L4
- MR208683L4V
- RC207579
- RC207579L1
- RC207579L1V
- RC207579L2
- RC207579L2V
- RC207579L3
- RC207579L3V
- RC207579L4
- RC207579L4V
- RC212431
- RC212431L3
- RC212431L3V
- RC212431L4
- RC212431L4V
- RC215313
- RC215313L3
- RC215313L3V
- RC215313L4
- RC215313L4V
- RC218568
- RC218568L1
- RC218568L1V
- RC218568L2
- RC218568L2V
- RC218568L3
- RC218568L3V
- RC218568L4
- RC218568L4V
- RG207579
- RG212431
- RG215313
- RG218568
- RR211439
- RR211439L1
- RR211439L1V
- RR211439L2
- RR211439L2V
- RR211439L3
- RR211439L3V
- RR211439L4
- RR211439L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for SLC22A6
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for SLC22A6
- genomics-online: cdna clones - Search results for available SLC22A6 gene related products
- orf clones - Search results for available SLC22A6 gene related products
- Applied Biological Materials (abm): Clones for SLC22A6 - Select products 50% OFF >
- * SLC22A6 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * SLC22A6 tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All
| ExUns: | 1a | · | 1b | · | 1c | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9a | · | 9b | · | 9c | ^ | 10a | · | 10b |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | ||||||||||||||||||||||||||||
| SP2: | |||||||||||||||||||||||||||||
| SP3: | - | - | |||||||||||||||||||||||||||
| SP4: | - |
Expression for SLC22A6 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Kidney (Urinary System)
- Proximal Tubule Cells Proximal Tubule
- Proximal Tubule
- Epithelial Tubule
- Metanephros
-
Epithelial Cells
- Proximal Tubule Cells Proximal Tubule
- Eye (Sensory Organs)
mRNA differential expression in normal tissues according to GTEx for SLC22A6 Gene
This gene is overexpressed in Kidney - Cortex (x47.1).
This gene is overexpressed in Urine (41.5), Plasma (18.5), and Kidney (9.0).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for SLC22A6 Gene
NURSA nuclear receptor signaling pathways regulating expression of SLC22A6 Gene:
SLC22A6SOURCE GeneReport for Unigene cluster for SLC22A6 Gene:
Hs.369252mRNA Expression by UniProt/SwissProt for SLC22A6 Gene:
Q4U2R8-S22A6_HUMAN
Tissue specificity:
Strongly expressed in kidney and to a lower extent in liver, skeletal muscle, brain and placenta. Found at the basolateral membrane of the proximal tubule.
Evidence on tissue expression from TISSUES for SLC22A6 Gene
- Kidney(4.9)
- Intestine(4.1)
Primer Products
-
OriGene qPCR primer pairs for SLC22A6
-
OriGene qPCR primer pairs and template standards for SLC22A6
- genomics-online: primer clones - Search results for available SLC22A6 gene related products
Gene Expression Assay Products
No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for SLC22A6 Gene
Orthologs for SLC22A6 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | SLC22A6 33 32 |
|
OneToOne | |
| dog (Canis familiaris) |
Mammalia | SLC22A6 33 32 |
|
OneToOne | |
| cow (Bos Taurus) |
Mammalia | SLC22A6 33 32 |
|
OneToOne | |
| rat (Rattus norvegicus) |
Mammalia | Slc22a6 32 |
|
||
| mouse (Mus musculus) |
Mammalia | Slc22a6 17 33 32 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | SLC22A6 33 |
|
OneToOne | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | -- 33 |
|
ManyToMany | |
| lizard (Anolis carolinensis) |
Reptilia | -- 33 |
|
ManyToMany | |
| -- 33 |
|
ManyToMany | |||
| tropical clawed frog (Silurana tropicalis) |
Amphibia | LOC100490266 32 |
|
||
| African clawed frog (Xenopus laevis) |
Amphibia | Xl.23285 32 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | oatx 32 |
|
||
| slc22a6l 33 |
|
OneToMany | |||
| rainbow trout (Oncorhynchus mykiss) |
Actinopterygii | Omy.9767 32 |
|
||
| fruit fly (Drosophila melanogaster) |
Insecta | CG8654 34 |
|
|
|
| CG3790 34 |
|
|
|||
| CG6356 34 |
|
|
|||
| CG13610 34 |
|
|
|||
| CG6600 34 |
|
|
|||
| CG6126 34 |
|
|
|||
| CG5592 34 |
|
|
|||
| CG14857 34 |
|
|
|||
| CG6231 34 |
|
|
|||
| CG16727 34 |
|
|
|||
| CG17751 34 |
|
|
|||
| CG14855 34 |
|
|
|||
| CG17752 34 |
|
|
|||
| worm (Caenorhabditis elegans) |
Secernentea | oct-1 34 |
|
|
|
| F52F12.1a 34 |
|
|
|||
| ZK455.8a 34 |
|
|
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| ZK455.8b 34 |
|
|
|||
| K05F1.6 34 |
|
|
- Species where no ortholog for SLC22A6 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- chicken (Gallus gallus)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
Evolution for SLC22A6 Gene
- ENSEMBL:
- Gene Tree for SLC22A6 (if available)
- TreeFam:
- Gene Tree for SLC22A6 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for SLC22A6: view image
Paralogs for SLC22A6 Gene
Paralogs for SLC22A6 Gene
(19) SIMAP similar genes for SLC22A6 Gene using alignment to 2 proteins:
- S22A6_HUMAN
- F5H0T7_HUMAN
Pseudogenes.org Pseudogenes for SLC22A6 Gene
Variants for SLC22A6 Gene
| SNP ID | Clin | Chr 11 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1000108104 | -- | 62,984,914(-) | T/C | 5_prime_UTR_variant, genic_upstream_transcript_variant, upstream_transcript_variant | |
| rs1000387451 | -- | 62,978,773(-) | G/A | intron_variant | |
| rs1000989446 | -- | 62,976,974(-) | G/A | intron_variant | |
| rs1000998373 | -- | 62,983,798(-) | T/C | intron_variant | |
| rs1001114593 | -- | 62,983,421(-) | C/G | intron_variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| dgv204e214 | CNV | gain | 21293372 |
| esv34011 | CNV | loss | 18971310 |
Residual Variation Intolerance Score:
48.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
2.62;
45.34% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for SLC22A6 Gene
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SLC22A6 Gene
Disorders for SLC22A6 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| n-acetylglutamate synthase deficiency |
|
|
Search SLC22A6 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for SLC22A6
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No data available for UniProtKB/Swiss-Prot and Genatlas for SLC22A6 Gene
Publications for SLC22A6 Gene
- Cloning of the human kidney PAH transporter: narrow substrate specificity and regulation by protein kinase C. (PMID: 9950961) Lu R … Schuster VL (The American journal of physiology 1999) 2 3 4 23 26 56
- Functional consequences of single nucleotide polymorphisms in the human organic anion transporter hOAT1 (SLC22A6). (PMID: 15914676) Bleasby K … Pritchard JB (The Journal of pharmacology and experimental therapeutics 2005) 3 4 23 43 56
- The antiviral nucleotide analogs cidofovir and adefovir are novel substrates for human and rat renal organic anion transporter 1. (PMID: 10462545) Cihlar T … Sweet DH (Molecular pharmacology 1999) 3 4 23 26 56
- Molecular cloning and functional expression of a multispecific organic anion transporter from human kidney. (PMID: 9887087) Hosoyamada M … Endou H (The American journal of physiology 1999) 3 4 23 26 56
- Molecular cloning and characterization of two novel human renal organic anion transporters (hOAT1 and hOAT3). (PMID: 10049739) Race JE … Holtzman EJ (Biochemical and biophysical research communications 1999) 3 4 23 26 56
ExternalLinks
Products for SLC22A6 Gene
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- antibodies-online: Show 30 available SLC22A6 Antibodies ranked by validation data
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- Santa Cruz Biotechnology (SCBT) Antibodies for SLC22A6
- Search Santa Cruz Biotechnology (SCBT) for SLC22A6 siRNA/shRNA
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Sources for SLC22A6 Gene
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