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The protein encoded by this gene is involved in the sodium-dependent transport and excretion of organic anions, some of which are potentially toxic. The encoded protein is an integral membrane protein and may be localized to the basolateral membrane. Four transcript variants encoding four different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
SLC22A6 (Solute Carrier Family 22 Member 6) is a Protein Coding gene. Diseases associated with SLC22A6 include N-Acetylglutamate Synthase Deficiency and Gout. Among its related pathways are Statin Pathway - Generalized, Pharmacokinetics and Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds. Gene Ontology (GO) annotations related to this gene include protein homodimerization activity and ion transmembrane transporter activity. An important paralog of this gene is SLC22A8.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005452 | inorganic anion exchanger activity | IDA | 15037815 |
GO:0005515 | protein binding | IPI | 16189514 |
GO:0008514 | organic anion transmembrane transporter activity | IMP | 22169006 |
GO:0015301 | anion:anion antiporter activity | IEA | -- |
GO:0015347 | sodium-independent organic anion transmembrane transporter activity | IBA | 21873635 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005886 | plasma membrane | TAS | -- |
GO:0005887 | integral component of plasma membrane | IDA | 14749323 |
GO:0005901 | caveola | IEA | -- |
GO:0016020 | membrane | IEA | -- |
GO:0016021 | integral component of membrane | IEA | -- |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0006820 | anion transport | IEA | -- |
GO:0015698 | inorganic anion transport | IEA | -- |
GO:0015711 | organic anion transport | IBA,IMP | 22169006 |
GO:0015742 | alpha-ketoglutarate transport | IDA | 9950961 |
GO:0031427 | response to methotrexate | IEA | -- |
Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
---|---|---|---|---|---|---|
Probenecid | Approved, Investigational | Pharma | Target, Transporter, inhibitor, substrate, blocker | 45 | ||
Amoxicillin | Approved, Vet_approved | Pharma | Transporter, inhibitor | 692 | ||
Cefazolin | Approved | Pharma | Transporter, substrate, inhibitor | 171 | ||
Cefotiam | Approved, Investigational | Pharma | Transporter, substrate, inhibitor | 2 | ||
Cidofovir | Approved | Pharma | Transporter, substrate, inhibitor | 38 |
Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
---|---|---|---|---|---|---|
2-Hydroxychlorpropamide |
|
36892-36-1 | ||||
3-Hydroxymethylantipyrine |
|
18125-49-0 | ||||
4-ene-Valproic acid |
|
|||||
4'-Hydroxydiclofenac |
|
64118-84-9 | ||||
5'-Hydroxypiroxicam |
|
77459-78-0 |
ExUns: | 1a | · | 1b | · | 1c | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9a | · | 9b | · | 9c | ^ | 10a | · | 10b |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | - | ||||||||||||||||||||||||||||
SP2: | |||||||||||||||||||||||||||||
SP3: | - | - | |||||||||||||||||||||||||||
SP4: | - |
This gene was present in the common ancestor of animals.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | SLC22A6 30 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | SLC22A6 30 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | SLC22A6 30 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Slc22a6 30 |
|
||
Mouse (Mus musculus) |
Mammalia | Slc22a6 30 17 31 |
|
OneToOne | |
Oppossum (Monodelphis domestica) |
Mammalia | SLC22A6 31 |
|
OneToOne | |
Platypus (Ornithorhynchus anatinus) |
Mammalia | -- 31 |
|
ManyToMany | |
Lizard (Anolis carolinensis) |
Reptilia | -- 31 |
|
ManyToMany | |
-- 31 |
|
ManyToMany | |||
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | LOC100490266 30 |
|
||
African clawed frog (Xenopus laevis) |
Amphibia | Xl.23285 30 |
|
||
Zebrafish (Danio rerio) |
Actinopterygii | oatx 30 |
|
||
slc22a6l 31 |
|
OneToMany | |||
Rainbow Trout (Oncorhynchus mykiss) |
Actinopterygii | Omy.9767 30 |
|
||
Fruit Fly (Drosophila melanogaster) |
Insecta | CG3790 32 |
|
|
|
CG8654 32 |
|
|
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CG13610 32 |
|
|
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CG6356 32 |
|
|
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CG6126 32 |
|
|
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CG6600 32 |
|
|
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CG5592 32 |
|
|
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CG14857 32 |
|
|
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CG6231 32 |
|
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CG14855 32 |
|
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CG16727 32 |
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CG17751 32 |
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CG17752 32 |
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Worm (Caenorhabditis elegans) |
Secernentea | oct-1 32 |
|
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F52F12.1a 32 |
|
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ZK455.8a 32 |
|
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ZK455.8b 32 |
|
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K05F1.6 32 |
|
|
SNP ID | Clinical significance and condition | Chr 11 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
rs11568635 | Benign: not provided | 62,977,279(-) |
G/A NM_153276.3(SLC22A6):c.1470C>T (p.Tyr490=) |
SYNONYMOUS_VARIANT,INTRON | |
rs11568626 | - |
p.Arg50His |
|||
rs11568627 | - |
p.Pro104Leu |
|||
rs1415632329 | - |
p.Leu7Pro |
|||
rs45607933 | - |
p.Arg293Trp |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
dgv204e214 | CNV | gain | 21293372 |
esv34011 | CNV | loss | 18971310 |
Disorder | Aliases | PubMed IDs |
---|---|---|
n-acetylglutamate synthase deficiency |
|
|
gout |
|
|
fanconi-like syndrome |
|
|
acute kidney failure |
|
|
methotrexate toxicity |
|
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