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The protein encoded by this gene is involved in the sodium-dependent transport and excretion of organic anions, some of which are potentially toxic. The encoded protein is an integral membrane protein and may be localized to the basolateral membrane. Four transcript variants encoding four different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] See more...
Aliases for SLC22A6 Gene
Aliases for SLC22A6 Gene
External Ids for SLC22A6 Gene
- HGNC: 10970
- NCBI Entrez Gene: 9356
- Ensembl: ENSG00000197901
- OMIM®: 607582
- UniProtKB/Swiss-Prot: Q4U2R8
Previous GeneCards Identifiers for SLC22A6 Gene
- GC11M065256
- GC11M064319
- GC11M062994
- GC11M062519
- GC11M062500
- GC11M062744
- GC11M059073
- GC11M062989
- GC11M063004
- GC11M063031
- GC11M063101
- GC11M062943
- GC11M062961
- GC11M063465
Summaries for SLC22A6 Gene
-
The protein encoded by this gene is involved in the sodium-dependent transport and excretion of organic anions, some of which are potentially toxic. The encoded protein is an integral membrane protein and may be localized to the basolateral membrane. Four transcript variants encoding four different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
GeneCards Summary for SLC22A6 Gene
SLC22A6 (Solute Carrier Family 22 Member 6) is a Protein Coding gene. Diseases associated with SLC22A6 include N-Acetylglutamate Synthase Deficiency and Gout. Among its related pathways are Statin Pathway - Generalized, Pharmacokinetics and Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds. Gene Ontology (GO) annotations related to this gene include protein homodimerization activity and ion transmembrane transporter activity. An important paralog of this gene is SLC22A8.
UniProtKB/Swiss-Prot Summary for SLC22A6 Gene
-
Involved in the renal elimination of endogenous and exogenous organic anions. Functions as organic anion exchanger when the uptake of one molecule of organic anion is coupled with an efflux of one molecule of endogenous dicarboxylic acid (glutarate, ketoglutarate, etc). Mediates the sodium-independent uptake of 2,3-dimercapto-1-propanesulfonic acid (DMPS) (By similarity). Mediates the sodium-independent uptake of p-aminohippurate (PAH), ochratoxin (OTA), acyclovir (ACV), 3'-azido-3-'deoxythymidine (AZT), cimetidine (CMD), 2,4-dichloro-phenoxyacetate (2,4-D), hippurate (HA), indoleacetate (IA), indoxyl sulfate (IS) and 3-carboxy-4-methyl-5-propyl-2-furanpropionate (CMPF), cidofovir, adefovir, 9-(2-phosphonylmethoxyethyl) guanine (PMEG), 9-(2-phosphonylmethoxyethyl) diaminopurine (PMEDAP) and edaravone sulfate. PAH uptake is inhibited by p-chloromercuribenzenesulphonate (PCMBS), diethyl pyrocarbonate (DEPC), sulindac, diclofenac, carprofen, glutarate and okadaic acid (By similarity). PAH uptake is inhibited by benzothiazolylcysteine (BTC), S-chlorotrifluoroethylcysteine (CTFC), cysteine S-conjugates S-dichlorovinylcysteine (DCVC), furosemide, steviol, phorbol 12-myristate 13-acetate (PMA), calcium ionophore A23187, benzylpenicillin, furosemide, indomethacin, bumetamide, losartan, probenecid, phenol red, urate, and alpha-ketoglutarate.
Additional gene information for SLC22A6 Gene
- HGNC (10970)
- NCBI Entrez Gene (9356)
- Ensembl (ENSG00000197901)
- OMIM® (607582)
- UniProtKB/Swiss-Prot (Q4U2R8)
- Open Targets Platform(ENSG00000197901)
- Monarch Initiative
- Search for SLC22A6 at DataMed
- Search for SLC22A6 at HumanCyc
No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for SLC22A6 Gene
Genomics for SLC22A6 Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for SLC22A6 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around SLC22A6 on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for SLC22A6
- Top Transcription factor binding sites by QIAGEN in the SLC22A6 gene promoter:
-
- NRSF form 1
- NRSF form 2
Genomic Locations for SLC22A6 Gene
Latest Assembly
- chr11:62,936,385-62,984,967
- (GRCh38/hg38)
- Size:
- 48,583 bases
- Orientation:
- Minus strand
Previous Assembly
- chr11:62,744,069-62,752,439
- (GRCh37/hg19 by Entrez Gene)
- Size:
- 8,371 bases
- Orientation:
- Minus strand
- chr11:62,703,857-62,752,455
- (GRCh37/hg19 by Ensembl)
- Size:
- 48,599 bases
- Orientation:
- Minus strand
Genomic View for SLC22A6 Gene
Genes around SLC22A6 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 11q12.3 by HGNC
- 11q12.3 by Entrez Gene
- 11q12.3 by Ensembl
SLC22A6 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for SLC22A6 Gene
Proteins for SLC22A6 Gene
-
Protein details for SLC22A6 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q4U2R8-S22A6_HUMAN
- Recommended name:
- Solute carrier family 22 member 6
- Protein Accession:
- Q4U2R8
- A8MY93
- B2D0R6
- O95187
- O95742
- Q7LDA0
- Q8N192
- Q9NQA6
- Q9NQC2
- Q9UBG6
- Q9UEQ8
Protein attributes for SLC22A6 Gene
- Size:
- 563 amino acids
- Molecular mass:
- 61816 Da
- Quaternary structure:
- No Data Available
Protein Expression for SLC22A6 Gene
Post-translational modifications for SLC22A6 Gene
- Glycosylated. Glycosylation at Asn-113 may occur at a secondary level. Glycosylation is necessary for proper targeting of the transporter to the plasma membrane.
-
Glycosylation at Asn39, Asn56, Asn92, Asn97, and Asn113
- NX_Q4U2R8 (NX_Q4U2R8-1)
- Modification sites at PhosphoSitePlus
Other Protein References for SLC22A6 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibodies for research
- LifeSpan BioSciences SLC22A6 / OAT1 Antibody
- NSJ Bioreagents SLC22A6 Antibody
-
Custom Antibody ServicesOriGene Antibodies for SLC22A6
- Novus Biologicals Antibodies for SLC22A6
-
Abcam antibodies for SLC22A6
- Invitrogen Antibodies for SLC22A6 (AFLGC-SLC22A6)
-
Custom Antibody ServicesProSci Antibodies for SLC22A6
-
Santa Cruz Biotechnology (SCBT) Antibodies for SLC22A6
- Sino Biological Antibodies for SLC22A6
Protein products for research
-
OriGene Purified Proteins for SLC22A6
- Search Origene for MassSpec and Protein Over-expression Lysates for SLC22A6
- Origene Custom Protein Services for SLC22A6
-
Abcam proteins for SLC22A6
Assay products for research
No data available for DME Specific Peptides for SLC22A6 Gene
Domains & Families for SLC22A6 Gene
Gene Families for SLC22A6 Gene
- HGNC:
- IUPHAR :
- Human Protein Atlas (HPA):
-
- FDA approved drug targets
- Predicted membrane proteins
- Transporters
Protein Domains for SLC22A6 Gene
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for SLC22A6 Gene
- GenScript: Design optimal peptide antigens:
-
- Renal organic anion transporter 1 (S22A6_HUMAN)
Graphical View of Domain Structure for InterPro Entry
Q4U2R8UniProtKB/Swiss-Prot:
S22A6_HUMAN :- Multiple cysteine residues are necessary for proper targeting to the plasma membrane.
- Belongs to the major facilitator (TC 2.A.1) superfamily. Organic cation transporter (TC 2.A.1.19) family.
- Domain:
-
- Multiple cysteine residues are necessary for proper targeting to the plasma membrane.
- Family:
-
- Belongs to the major facilitator (TC 2.A.1) superfamily. Organic cation transporter (TC 2.A.1.19) family.
Function for SLC22A6 Gene
Molecular function for SLC22A6 Gene
- UniProtKB/Swiss-Prot Function:
- Involved in the renal elimination of endogenous and exogenous organic anions. Functions as organic anion exchanger when the uptake of one molecule of organic anion is coupled with an efflux of one molecule of endogenous dicarboxylic acid (glutarate, ketoglutarate, etc). Mediates the sodium-independent uptake of 2,3-dimercapto-1-propanesulfonic acid (DMPS) (By similarity). Mediates the sodium-independent uptake of p-aminohippurate (PAH), ochratoxin (OTA), acyclovir (ACV), 3'-azido-3-'deoxythymidine (AZT), cimetidine (CMD), 2,4-dichloro-phenoxyacetate (2,4-D), hippurate (HA), indoleacetate (IA), indoxyl sulfate (IS) and 3-carboxy-4-methyl-5-propyl-2-furanpropionate (CMPF), cidofovir, adefovir, 9-(2-phosphonylmethoxyethyl) guanine (PMEG), 9-(2-phosphonylmethoxyethyl) diaminopurine (PMEDAP) and edaravone sulfate. PAH uptake is inhibited by p-chloromercuribenzenesulphonate (PCMBS), diethyl pyrocarbonate (DEPC), sulindac, diclofenac, carprofen, glutarate and okadaic acid (By similarity). PAH uptake is inhibited by benzothiazolylcysteine (BTC), S-chlorotrifluoroethylcysteine (CTFC), cysteine S-conjugates S-dichlorovinylcysteine (DCVC), furosemide, steviol, phorbol 12-myristate 13-acetate (PMA), calcium ionophore A23187, benzylpenicillin, furosemide, indomethacin, bumetamide, losartan, probenecid, phenol red, urate, and alpha-ketoglutarate.
- UniProtKB/Swiss-Prot BiophysicochemicalProperties:
- Kinetic parameters: KM=9.3 uM for PAH (isoform 1) {ECO:0000269|PubMed:10462545, ECO:0000269|PubMed:10964714, ECO:0000269|PubMed:12538807, ECO:0000269|PubMed:15846473}; KM=4 uM for PAH (isoform 2) {ECO:0000269|PubMed:10462545, ECO:0000269|PubMed:10964714, ECO:0000269|PubMed:12538807, ECO:0000269|PubMed:15846473}; KM=11 uM for edaravone {ECO:0000269|PubMed:10462545, ECO:0000269|PubMed:10964714, ECO:0000269|PubMed:12538807, ECO:0000269|PubMed:15846473}; KM=46 uM for cidofovir {ECO:0000269|PubMed:10462545, ECO:0000269|PubMed:10964714, ECO:0000269|PubMed:12538807, ECO:0000269|PubMed:15846473}; KM=30 uM for adefovir {ECO:0000269|PubMed:10462545, ECO:0000269|PubMed:10964714, ECO:0000269|PubMed:12538807, ECO:0000269|PubMed:15846473}; KM=5.77 uM for 2,4-D {ECO:0000269|PubMed:10462545, ECO:0000269|PubMed:10964714, ECO:0000269|PubMed:12538807, ECO:0000269|PubMed:15846473}; KM=23.5 uM for HA {ECO:0000269|PubMed:10462545, ECO:0000269|PubMed:10964714, ECO:0000269|PubMed:12538807, ECO:0000269|PubMed:15846473}; KM=14 uM for IA {ECO:0000269|PubMed:10462545, ECO:0000269|PubMed:10964714, ECO:0000269|PubMed:12538807, ECO:0000269|PubMed:15846473}; KM=20.5 uM for IS {ECO:0000269|PubMed:10462545, ECO:0000269|PubMed:10964714, ECO:0000269|PubMed:12538807, ECO:0000269|PubMed:15846473}; KM=141 uM for CMPF {ECO:0000269|PubMed:10462545, ECO:0000269|PubMed:10964714, ECO:0000269|PubMed:12538807, ECO:0000269|PubMed:15846473}; Vmax=534 pmol/min/mg enzyme for 2,4-D uptake {ECO:0000269|PubMed:10462545, ECO:0000269|PubMed:10964714, ECO:0000269|PubMed:12538807, ECO:0000269|PubMed:15846473}; Vmax=430 pmol/min/mg enzyme for HA uptake {ECO:0000269|PubMed:10462545, ECO:0000269|PubMed:10964714, ECO:0000269|PubMed:12538807, ECO:0000269|PubMed:15846473}; Vmax=110 pmol/min/mg enzyme for IA uptake {ECO:0000269|PubMed:10462545, ECO:0000269|PubMed:10964714, ECO:0000269|PubMed:12538807, ECO:0000269|PubMed:15846473}; Vmax=216 pmol/min/mg enzyme for IS uptake {ECO:0000269|PubMed:10462545, ECO:0000269|PubMed:10964714, ECO:0000269|PubMed:12538807, ECO:0000269|PubMed:15846473}; Vmax=801 pmol/min/mg enzyme for CMPF uptake {ECO:0000269|PubMed:10462545, ECO:0000269|PubMed:10964714, ECO:0000269|PubMed:12538807, ECO:0000269|PubMed:15846473};
- GENATLAS Biochemistry:
- solute carrier protein family 22,member A6,polyspecific transporter for organic cations,mediating the coupled exchange of alpha-ketoglutarate with multiple organic ions,including p-aminohippurate (PAH),expressed strongly in kidney,weakly in brain
Phenotypes From GWAS Catalog for SLC22A6 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005452 | inorganic anion exchanger activity | IDA | 15037815 |
| GO:0005515 | protein binding | IPI | 16189514 |
| GO:0008514 | organic anion transmembrane transporter activity | IMP | 22169006 |
| GO:0015301 | anion:anion antiporter activity | IEA | -- |
| GO:0015347 | sodium-independent organic anion transmembrane transporter activity | IBA | 21873635 |
Phenotypes for SLC22A6 Gene
- MGI mutant phenotypes for SLC22A6:
- inferred from 1 alleles
- GenomeRNAi human phenotypes for SLC22A6:
-
- no effect
- shRNA abundance <= 50%
- Decreased viability
- Resistant to vaccinia virus (VACV-A4L) infection
- Increased hepcidin::fluc mRNA expression
- Inconclusive
- Decreased shRNA abundance
- Decreased influenza A/WSN/33 replication
- Increased nuclear migration speed
- Decreased influenza A H1N1 (A/Hamburg/04/2009) virus numbers
Animal Models for SLC22A6 Gene
- MGI Knock Outs for SLC22A6:
-
- Slc22a6 Slc22a6<tm1Dgen>
Animal Models for research
-
Taconic Biosciences Mouse Models for SLC22A6
CRISPR products for research
- Applied Biological Materials (abm): CRISPR Clones for SLC22A6 - Starting at $85 >
- * SLC22A6 CRISPR as ready-to-use vector or virus: Non-viral | Lenti- | Adeno- | AAV- | siRNA - Browse All
- * Cas9 Nucleases, Nickases, Null Mutants, and GFP tag also available.
-
OriGene CRISPR knockouts for SLC22A6
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for SLC22A6
-
Santa Cruz Biotechnology (SCBT) CRISPR for SLC22A6
miRNA for SLC22A6 Gene
- miRTarBase miRNAs that target SLC22A6
-
- mmu-let-7b-5p (MIRT012170)
- hsa-miR-1238-3p (MIRT646367)
- hsa-miR-670-3p (MIRT646368)
- hsa-miR-147a (MIRT646369)
- hsa-miR-6818-5p (MIRT646370)
- hsa-miR-6759-5p (MIRT646371)
- hsa-miR-6881-3p (MIRT646372)
- hsa-miR-6780a-3p (MIRT646373)
- hsa-miR-7111-3p (MIRT646374)
- hsa-miR-6749-3p (MIRT646375)
- hsa-miR-6792-3p (MIRT646376)
- hsa-miR-4691-5p (MIRT646377)
- hsa-miR-644a (MIRT646378)
- hsa-miR-3911 (MIRT646379)
- hsa-miR-6793-5p (MIRT646380)
- hsa-miR-6748-5p (MIRT646381)
- hsa-miR-581 (MIRT646382)
- hsa-miR-1236-3p (MIRT646383)
- hsa-miR-877-3p (MIRT646384)
- hsa-miR-660-3p (MIRT646385)
- hsa-miR-5193 (MIRT646386)
- hsa-miR-2909 (MIRT646387)
- hsa-miR-211-5p (MIRT646388)
- hsa-miR-204-5p (MIRT646389)
- hsa-miR-642a-5p (MIRT646390)
- hsa-miR-8065 (MIRT646391)
- hsa-miR-659-5p (MIRT646392)
- hsa-miR-4287 (MIRT646393)
- hsa-miR-4685-3p (MIRT646394)
- hsa-miR-6734-3p (MIRT646395)
- hsa-miR-6832-3p (MIRT646396)
- hsa-miR-4667-3p (MIRT646397)
- hsa-miR-1470 (MIRT646398)
- hsa-miR-296-3p (MIRT646399)
miRNA products for research
Inhibitory RNAs for research
- Origene shrna, sirna, and RNAi products in human, mouse, rat for SLC22A6
- Browse OriGene Inhibitory RNA Products For SLC22A6
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SLC22A6
Clone products for research
- Applied Biological Materials (abm): Clones for SLC22A6 - Starting at $45 >
- * SLC22A6 as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Retro- | Protein Vector - Browse All
- * Viral Packaging Services and High Titer Production Services also available.
-
- MG208683
- MR208683
- MR208683L3
- MR208683L4
- RC207579
- RC207579L1
- RC207579L2
- RC207579L3
- RC207579L4
- RC212431
- RC212431L3
- RC212431L4
- RC215313
- RC215313L3
- RC215313L4
- RC218568
- RC218568L1
- RC218568L2
- RC218568L3
- RC218568L4
- RG207579
- RG212431
- RG215313
- RG218568
- RR211439
- RR211439L3
- RR211439L4
- MR208683L3V
- MR208683L4V
- RC207579L1V
- RC207579L2V
- RC207579L3V
- RC207579L4V
- RC212431L3V
- RC212431L4V
- RC215313L3V
- RC215313L4V
- RC218568L1V
- RC218568L2V
- RC218568L3V
- RC218568L4V
- RR211439L3V
- RR211439L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for SLC22A6
- Addgene plasmids for SLC22A6
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for SLC22A6
Cell Lines for research
-
Horizon Cell Lines for SLC22A6
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for SLC22A6 Gene
Localization for SLC22A6 Gene
Subcellular locations from UniProtKB/Swiss-Prot for SLC22A6 Gene
- Cell membrane. Multi-pass membrane protein.
| Compartment | Confidence |
|---|---|
| plasma membrane | 5 |
| extracellular | 4 |
| mitochondrion | 2 |
| cytoskeleton | 1 |
| nucleus | 1 |
| endoplasmic reticulum | 1 |
| endosome | 1 |
| cytosol | 1 |
| lysosome | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005886 | plasma membrane | TAS | -- |
| GO:0005887 | integral component of plasma membrane | IDA | 14749323 |
| GO:0005901 | caveola | IEA | -- |
| GO:0016020 | membrane | IEA | -- |
| GO:0016021 | integral component of membrane | IEA | -- |
No data available for Subcellular locations from the Human Protein Atlas (HPA) for SLC22A6 Gene
Pathways & Interactions for SLC22A6 Gene
Pathways by source for SLC22A6 Gene
Interacting Proteins for SLC22A6 Gene
Selected Interacting proteins:
Q4U2R8-S22A6_HUMAN
ENSP00000367102
for SLC22A6 Gene via
UniProtKB
STRING
IID
GPS-Prot Interaction Network for SLC22A6
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006820 | anion transport | IEA | -- |
| GO:0015698 | inorganic anion transport | IEA | -- |
| GO:0015711 | organic anion transport | IBA,IMP | 22169006 |
| GO:0015742 | alpha-ketoglutarate transport | IDA | 9950961 |
| GO:0031427 | response to methotrexate | IEA | -- |
No data available for SIGNOR curated interactions for SLC22A6 Gene
Drugs & Compounds for SLC22A6 Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| Probenecid | Approved, Investigational | Pharma | Target, Transporter, inhibitor, substrate, blocker | 45 | ||
| Amoxicillin | Approved, Vet_approved | Pharma | Transporter, inhibitor | 692 | ||
| Cefazolin | Approved | Pharma | Transporter, substrate, inhibitor | 171 | ||
| Cefotiam | Approved, Investigational | Pharma | Transporter, substrate, inhibitor | 2 | ||
| Cidofovir | Approved | Pharma | Transporter, substrate, inhibitor | 38 |
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
|---|---|---|---|---|---|---|
| 2-Hydroxychlorpropamide |
|
36892-36-1 | ||||
| 3-Hydroxymethylantipyrine |
|
18125-49-0 | ||||
| 4-ene-Valproic acid |
|
|||||
| 4'-Hydroxydiclofenac |
|
64118-84-9 | ||||
| 5'-Hydroxypiroxicam |
|
77459-78-0 |
Transcripts for SLC22A6 Gene
mRNA/cDNA for SLC22A6 Gene
- 5 REFSEQ mRNAs :
- 16 NCBI additional mRNA sequence :
- 6 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000360421 2127 nts (view in UCSC)
- ENST00000377871 2151 nts (view in UCSC)
- ENST00000421062 1560 nts (view in UCSC)
- ENST00000458333 1521 nts (view in UCSC)
- ENST00000537349 768 nts (view in UCSC)
CRISPR products for research
- Applied Biological Materials (abm): CRISPR Clones for SLC22A6 - Starting at $85 >
- * SLC22A6 CRISPR as ready-to-use vector or virus: Non-viral | Lenti- | Adeno- | AAV- | siRNA - Browse All
- * Cas9 Nucleases, Nickases, Null Mutants, and GFP tag also available.
-
OriGene CRISPR knockouts for SLC22A6
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for SLC22A6
-
Santa Cruz Biotechnology (SCBT) CRISPR for SLC22A6
miRNA products for research
Inhibitory RNAs for research
- Origene shrna, sirna, and RNAi products in human, mouse, rat for SLC22A6
- Browse OriGene Inhibitory RNA Products For SLC22A6
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SLC22A6
Clone products for research
- Applied Biological Materials (abm): Clones for SLC22A6 - Starting at $45 >
- * SLC22A6 as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Retro- | Protein Vector - Browse All
- * Viral Packaging Services and High Titer Production Services also available.
-
- MG208683
- MR208683
- MR208683L3
- MR208683L4
- RC207579
- RC207579L1
- RC207579L2
- RC207579L3
- RC207579L4
- RC212431
- RC212431L3
- RC212431L4
- RC215313
- RC215313L3
- RC215313L4
- RC218568
- RC218568L1
- RC218568L2
- RC218568L3
- RC218568L4
- RG207579
- RG212431
- RG215313
- RG218568
- RR211439
- RR211439L3
- RR211439L4
- MR208683L3V
- MR208683L4V
- RC207579L1V
- RC207579L2V
- RC207579L3V
- RC207579L4V
- RC212431L3V
- RC212431L4V
- RC215313L3V
- RC215313L4V
- RC218568L1V
- RC218568L2V
- RC218568L3V
- RC218568L4V
- RR211439L3V
- RR211439L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for SLC22A6
- Addgene plasmids for SLC22A6
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for SLC22A6
| ExUns: | 1a | · | 1b | · | 1c | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9a | · | 9b | · | 9c | ^ | 10a | · | 10b |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | ||||||||||||||||||||||||||||
| SP2: | |||||||||||||||||||||||||||||
| SP3: | - | - | |||||||||||||||||||||||||||
| SP4: | - |
Relevant External Links for SLC22A6 Gene
- GeneLoc Exon Structure for
- SLC22A6
Expression for SLC22A6 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Kidney (Urinary System)
- Proximal Tubule Cells Proximal Tubule
- Proximal Tubule
- Epithelial Tubule
- Metanephros
-
Epithelial Cells
- Proximal Tubule Cells Proximal Tubule
- Eye (Sensory Organs)
mRNA differential expression in normal tissues according to GTEx for SLC22A6 Gene
This gene is overexpressed in Kidney - Cortex (x47.1).
This gene is overexpressed in Urine (41.5), Plasma (18.5), and Kidney (9.0).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for SLC22A6 Gene
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for SLC22A6
SOURCE GeneReport for Unigene cluster for SLC22A6 Gene:
Hs.369252mRNA Expression by UniProt/SwissProt for SLC22A6 Gene:
Q4U2R8-S22A6_HUMAN
Tissue specificity:
Strongly expressed in kidney and to a lower extent in liver, skeletal muscle, brain and placenta. Found at the basolateral membrane of the proximal tubule.
Evidence on tissue expression from TISSUES for SLC22A6 Gene
- Kidney(4.9)
- Intestine(4.3)
- Urine(2.2)
- Nervous system(2.2)
Primer products for research
-
OriGene qPCR primer pairs for SLC22A6
-
OriGene qPCR primer pairs and template standards for SLC22A6
Gene Expression Assays for research
No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for SLC22A6 Gene
Orthologs for SLC22A6 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | SLC22A6 30 31 |
|
OneToOne | |
| Dog (Canis familiaris) |
Mammalia | SLC22A6 30 31 |
|
OneToOne | |
| Cow (Bos Taurus) |
Mammalia | SLC22A6 30 31 |
|
OneToOne | |
| Rat (Rattus norvegicus) |
Mammalia | Slc22a6 30 |
|
||
| Mouse (Mus musculus) |
Mammalia | Slc22a6 30 17 31 |
|
OneToOne | |
| Oppossum (Monodelphis domestica) |
Mammalia | SLC22A6 31 |
|
OneToOne | |
| Platypus (Ornithorhynchus anatinus) |
Mammalia | -- 31 |
|
ManyToMany | |
| Lizard (Anolis carolinensis) |
Reptilia | -- 31 |
|
ManyToMany | |
| -- 31 |
|
ManyToMany | |||
| Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | LOC100490266 30 |
|
||
| African clawed frog (Xenopus laevis) |
Amphibia | Xl.23285 30 |
|
||
| Zebrafish (Danio rerio) |
Actinopterygii | oatx 30 |
|
||
| slc22a6l 31 |
|
OneToMany | |||
| Rainbow Trout (Oncorhynchus mykiss) |
Actinopterygii | Omy.9767 30 |
|
||
| Fruit Fly (Drosophila melanogaster) |
Insecta | CG3790 32 |
|
|
|
| CG8654 32 |
|
|
|||
| CG13610 32 |
|
|
|||
| CG6356 32 |
|
|
|||
| CG6126 32 |
|
|
|||
| CG6600 32 |
|
|
|||
| CG5592 32 |
|
|
|||
| CG14857 32 |
|
|
|||
| CG6231 32 |
|
|
|||
| CG14855 32 |
|
|
|||
| CG16727 32 |
|
|
|||
| CG17751 32 |
|
|
|||
| CG17752 32 |
|
|
|||
| Worm (Caenorhabditis elegans) |
Secernentea | oct-1 32 |
|
|
|
| F52F12.1a 32 |
|
|
|||
| ZK455.8a 32 |
|
|
|||
| ZK455.8b 32 |
|
|
|||
| K05F1.6 32 |
|
|
- Species where no ortholog for SLC22A6 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Baker's yeast (Saccharomyces cerevisiae)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chicken (Gallus gallus)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Squirt (Ciona savignyi)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Wheat (Triticum aestivum)
Evolution for SLC22A6 Gene
- ENSEMBL:
- Gene Tree for SLC22A6 (if available)
- TreeFam:
- Gene Tree for SLC22A6 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for SLC22A6: view image
Paralogs for SLC22A6 Gene
Paralogs for SLC22A6 Gene
(19) SIMAP similar genes for SLC22A6 Gene using alignment to 2 proteins:
- S22A6_HUMAN
- F5H0T7_HUMAN
Pseudogenes.org Pseudogenes for SLC22A6 Gene
Variants for SLC22A6 Gene
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for SLC22A6 Gene
| SNP ID | Clinical significance and condition | Chr 11 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs11568635 | Benign: not provided | 62,977,279(-) |
G/A NM_153276.3(SLC22A6):c.1470C>T (p.Tyr490=) |
SYNONYMOUS_VARIANT,INTRON | |
| rs11568626 | - |
p.Arg50His |
|||
| rs11568627 | - |
p.Pro104Leu |
|||
| rs1415632329 | - |
p.Leu7Pro |
|||
| rs45607933 | - |
p.Arg293Trp |
All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| dgv204e214 | CNV | gain | 21293372 |
| esv34011 | CNV | loss | 18971310 |
Residual Variation Intolerance Score:
48.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
2.62;
45.34% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for SLC22A6 Gene
SNP Genotyping and Copy Number Assays for research
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SLC22A6 Gene
Disorders for SLC22A6 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| n-acetylglutamate synthase deficiency |
|
|
| gout |
|
|
| fanconi-like syndrome |
|
|
| acute kidney failure |
|
|
| methotrexate toxicity |
|
|
Search SLC22A6 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for SLC22A6
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- Atlas
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
- Open Targets Platform
No data available for UniProtKB/Swiss-Prot and Genatlas for SLC22A6 Gene
Publications for SLC22A6 Gene
- Cloning of the human kidney PAH transporter: narrow substrate specificity and regulation by protein kinase C. (PMID: 9950961) Lu R ā¦ Schuster VL (The American journal of physiology 1999) 2 3 4 23 26
- Functional consequences of single nucleotide polymorphisms in the human organic anion transporter hOAT1 (SLC22A6). (PMID: 15914676) Bleasby K ā¦ Pritchard JB (The Journal of pharmacology and experimental therapeutics 2005) 3 4 23 41
- Molecular cloning and characterization of two novel human renal organic anion transporters (hOAT1 and hOAT3). (PMID: 10049739) Race JE ā¦ Holtzman EJ (Biochemical and biophysical research communications 1999) 3 4 23 26
- Molecular cloning and functional expression of a multispecific organic anion transporter from human kidney. (PMID: 9887087) Hosoyamada M ā¦ Endou H (The American journal of physiology 1999) 3 4 23 26
- The antiviral nucleotide analogs cidofovir and adefovir are novel substrates for human and rat renal organic anion transporter 1. (PMID: 10462545) Cihlar T ā¦ Sweet DH (Molecular pharmacology 1999) 3 4 23 26
ExternalLinks
Products for SLC22A6 Gene
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- Taconic Biosciences Mouse Models for SLC22A6
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- Genetically Engineered Models Available Immediately
- Humanized Mice
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- VectorBuilder Custom and pre-made DNA vectors for SLC22A6 (ie. gene expression, shRNA knockdown, CRISPR)
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- Addgene plasmids for SLC22A6
- antibodies-online: Show 30 available SLC22A6 Antibodies ranked by validation data
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- Search for SLC22A6 Proteins at ProSci
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Sources for SLC22A6 Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM® (Updated: 05-Mar-2021)
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) ProtoNet
- (16) Blocks
- (17) MGI
- (18) IUBMB
- (19) KEGG
- (20) MINT
- (21) STRING
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) ASD
- (28) SAGE
- (29) SOURCE
- (30) HomoloGene
- (31) PanEnsembl
- (32) euGenes
- (33) SGD
- (34) FlyBase
- (35) WormBase
- (36) Pseudogene
- (37) DGV
- (38) dbSNP
- (39) GenAtlas
- (40) HGMD
- (41) GAD
- (42) BGMUT
- (43) HuGE
- (44) Atlas
- (45) GenBank
- (46) HORDE
- (47) HUGE
- (48) IMGT
- (49) Leiden
- (50) miRBase
- (51) DME
- (52) OriGene
- (53) PubMed
- (54) R&D Systems
- (55) TGDB
- (56) Tocris
- (57) Abcam
- (58) Novus Biologicals
- (59) ProSpec
- (60) Sino Biological
- (61) GenScript
- (62) Qiagen
- (63) OCA
- (64) Proteopedia
- (65) MOPED
- (66) neXtProt
- (67) Reactome
- (68) GeneGo (Thomson Reuters)
- (69) DISEASES
- (70) SIMAP
- (71) GenomeRNAi
- (72) LifeMap
- (73) miRTarBase
- (74) MalaCards
- (75) Invitrogen
- (76) BitterDB
- (77) ESI-BIO
- (78) RefSeq
- (79) BioSystems
- (80) MaxQB
- (81) IUPHAR
- (82) BioGPS
- (83) Illumina
- (84) COMPARTMENTS
- (85) HOMER
- (86) PaxDb
- (87) ApexBio
- (88) Addgene
- (89) antibodies-online
- (90) CYP
- (91) NONCODE
- (92) TreeFam
- (93) PathCards
- (94) GeneReviews
- (95) GeneTex
- (96) Taconic Biosciences
- (97) GTEx
- (98) ProteomicsDB
- (99) SCBT
- (100) DGIdb
- (101) ClinicalTrials
- (102) RVIS
- (103) SIGNOR
- (104)