The protein encoded by this gene is involved in the sodium-dependent transport and excretion of organic anions, some of which are potentially toxic. The encoded protein is an integral membrane protein and may be localized to the basolateral membrane. Four transcript variants encoding four different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] See more...

Aliases for SLC22A6 Gene

Aliases for SLC22A6 Gene

  • Solute Carrier Family 22 Member 6 2 3 4 5
  • OAT1 2 3 4
  • PAHT 2 3 4
  • Solute Carrier Family 22 (Organic Anion Transporter), Member 6 2 3
  • Renal Organic Anion Transporter 1 3 4
  • Organic Anion Transporter 1 3 4
  • PAH Transporter 3 4
  • HROAT1 3 4
  • HOAT1 3 4
  • ROAT1 2 3
  • HPAHT 3 4
  • Para-Aminohippurate Transporter 3
  • SLC22A6 5

External Ids for SLC22A6 Gene

Previous GeneCards Identifiers for SLC22A6 Gene

  • GC11M065256
  • GC11M064319
  • GC11M062994
  • GC11M062519
  • GC11M062500
  • GC11M062744
  • GC11M059073
  • GC11M062989
  • GC11M063004
  • GC11M063031
  • GC11M063101
  • GC11M062943
  • GC11M062961
  • GC11M063465
  • GC11M063908

Summaries for SLC22A6 Gene

Entrez Gene Summary for SLC22A6 Gene

  • The protein encoded by this gene is involved in the sodium-dependent transport and excretion of organic anions, some of which are potentially toxic. The encoded protein is an integral membrane protein and may be localized to the basolateral membrane. Four transcript variants encoding four different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for SLC22A6 Gene

SLC22A6 (Solute Carrier Family 22 Member 6) is a Protein Coding gene. Diseases associated with SLC22A6 include N-Acetylglutamate Synthase Deficiency and Gout. Among its related pathways are Atenolol Pathway, Pharmacokinetics and Statin Pathway - Generalized, Pharmacokinetics. Gene Ontology (GO) annotations related to this gene include protein homodimerization activity and ion transmembrane transporter activity. An important paralog of this gene is SLC22A8.

UniProtKB/Swiss-Prot Summary for SLC22A6 Gene

  • Involved in the renal elimination of endogenous and exogenous organic anions. Functions as organic anion exchanger when the uptake of one molecule of organic anion is coupled with an efflux of one molecule of endogenous dicarboxylic acid (glutarate, ketoglutarate, etc). Mediates the sodium-independent uptake of 2,3-dimercapto-1-propanesulfonic acid (DMPS) (By similarity). Mediates the sodium-independent uptake of p-aminohippurate (PAH), ochratoxin (OTA), acyclovir (ACV), 3'-azido-3-'deoxythymidine (AZT), cimetidine (CMD), 2,4-dichloro-phenoxyacetate (2,4-D), hippurate (HA), indoleacetate (IA), indoxyl sulfate (IS) and 3-carboxy-4-methyl-5-propyl-2-furanpropionate (CMPF), cidofovir, adefovir, 9-(2-phosphonylmethoxyethyl) guanine (PMEG), 9-(2-phosphonylmethoxyethyl) diaminopurine (PMEDAP) and edaravone sulfate. PAH uptake is inhibited by p-chloromercuribenzenesulphonate (PCMBS), diethyl pyrocarbonate (DEPC), sulindac, diclofenac, carprofen, glutarate and okadaic acid (By similarity). PAH uptake is inhibited by benzothiazolylcysteine (BTC), S-chlorotrifluoroethylcysteine (CTFC), cysteine S-conjugates S-dichlorovinylcysteine (DCVC), furosemide, steviol, phorbol 12-myristate 13-acetate (PMA), calcium ionophore A23187, benzylpenicillin, furosemide, indomethacin, bumetamide, losartan, probenecid, phenol red, urate, and alpha-ketoglutarate.

Gene Wiki entry for SLC22A6 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for SLC22A6 Gene

Genomics for SLC22A6 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for SLC22A6 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH11J062984 Promoter/Enhancer 0.5 EPDnew Ensembl 250.7 +0.2 158 0.4 SLC22A6 BSCL2 HSALNG0084681 CHRM1
GH11J062887 Enhancer 1.1 ENCODE dbSUPER 10.1 +95.2 95208 4 NCOR1 IKZF1 SSRP1 POLR2A CEBPA NFIC NONO DEK NFATC3 NBN BSCL2 TAF6L SNHG1 TUT1 GANAB NXF1 INTS5 CSKMT EML3 STX5-DT
GH11J062906 Enhancer 1 ENCODE dbSUPER 11 +78.8 78823 0.2 ZNF207 MYC NCOR1 ZNF654 IKZF1 ZNF223 ZNF10 CTCF REST ZNF592 SLC22A6 TMEM223 LOC105369333 CHRM1 HSALNG0084674 SLC3A2
GH11J062922 Enhancer 0.8 ENCODE dbSUPER 10.9 +62.7 62676 0.5 NFIC ZIC2 CEBPB ZEB1 MAX SIN3A BHLHE40 ZNF189 PKNOX1 GLIS1 CHRM1 SLC22A6 HSALNG0084677 LOC105369333
GH11J062930 Enhancer 0.6 Ensembl 11.6 +54.0 53967 2.4 MAX RAD21 SMC3 ZNF189 ZFP37 SP7 ZNF366 ZBTB8A ZNF660 FOS BSCL2 SLC22A6 LBHD1 B3GAT3 HSALNG0084677 lnc-SLC3A2-4 CHRM1 LOC105369333
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around SLC22A6 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for SLC22A6

Top Transcription factor binding sites by QIAGEN in the SLC22A6 gene promoter:
  • NRSF form 1
  • NRSF form 2

Genomic Locations for SLC22A6 Gene

Latest Assembly
chr11:62,936,385-62,984,967
(GRCh38/hg38)
Size:
48,583 bases
Orientation:
Minus strand

Previous Assembly
chr11:62,744,069-62,752,439
(GRCh37/hg19 by Entrez Gene)
Size:
8,371 bases
Orientation:
Minus strand

chr11:62,703,857-62,752,455
(GRCh37/hg19 by Ensembl)
Size:
48,599 bases
Orientation:
Minus strand

Genomic View for SLC22A6 Gene

Genes around SLC22A6 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SLC22A6 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SLC22A6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC22A6 Gene

Proteins for SLC22A6 Gene

  • Protein details for SLC22A6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q4U2R8-S22A6_HUMAN
    Recommended name:
    Solute carrier family 22 member 6
    Protein Accession:
    Q4U2R8
    Secondary Accessions:
    • A8MY93
    • B2D0R6
    • O95187
    • O95742
    • Q7LDA0
    • Q8N192
    • Q9NQA6
    • Q9NQC2
    • Q9UBG6
    • Q9UEQ8

    Protein attributes for SLC22A6 Gene

    Size:
    563 amino acids
    Molecular mass:
    61816 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for SLC22A6 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SLC22A6 Gene

Post-translational modifications for SLC22A6 Gene

  • Glycosylated. Glycosylation at Asn-113 may occur at a secondary level. Glycosylation is necessary for proper targeting of the transporter to the plasma membrane.
  • Glycosylation at Asn39, Asn56, Asn92, Asn97, and Asn113
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for SLC22A6 Gene

Domains & Families for SLC22A6 Gene

Gene Families for SLC22A6 Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • FDA approved drug targets
  • Predicted membrane proteins
  • Transporters

Protein Domains for SLC22A6 Gene

Suggested Antigen Peptide Sequences for SLC22A6 Gene

GenScript: Design optimal peptide antigens:
  • Renal organic anion transporter 1 (S22A6_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q4U2R8

UniProtKB/Swiss-Prot:

S22A6_HUMAN :
  • Multiple cysteine residues are necessary for proper targeting to the plasma membrane.
  • Belongs to the major facilitator (TC 2.A.1) superfamily. Organic cation transporter (TC 2.A.1.19) family.
Domain:
  • Multiple cysteine residues are necessary for proper targeting to the plasma membrane.
Family:
  • Belongs to the major facilitator (TC 2.A.1) superfamily. Organic cation transporter (TC 2.A.1.19) family.
genes like me logo Genes that share domains with SLC22A6: view

Function for SLC22A6 Gene

Molecular function for SLC22A6 Gene

UniProtKB/Swiss-Prot Function:
Involved in the renal elimination of endogenous and exogenous organic anions. Functions as organic anion exchanger when the uptake of one molecule of organic anion is coupled with an efflux of one molecule of endogenous dicarboxylic acid (glutarate, ketoglutarate, etc). Mediates the sodium-independent uptake of 2,3-dimercapto-1-propanesulfonic acid (DMPS) (By similarity). Mediates the sodium-independent uptake of p-aminohippurate (PAH), ochratoxin (OTA), acyclovir (ACV), 3'-azido-3-'deoxythymidine (AZT), cimetidine (CMD), 2,4-dichloro-phenoxyacetate (2,4-D), hippurate (HA), indoleacetate (IA), indoxyl sulfate (IS) and 3-carboxy-4-methyl-5-propyl-2-furanpropionate (CMPF), cidofovir, adefovir, 9-(2-phosphonylmethoxyethyl) guanine (PMEG), 9-(2-phosphonylmethoxyethyl) diaminopurine (PMEDAP) and edaravone sulfate. PAH uptake is inhibited by p-chloromercuribenzenesulphonate (PCMBS), diethyl pyrocarbonate (DEPC), sulindac, diclofenac, carprofen, glutarate and okadaic acid (By similarity). PAH uptake is inhibited by benzothiazolylcysteine (BTC), S-chlorotrifluoroethylcysteine (CTFC), cysteine S-conjugates S-dichlorovinylcysteine (DCVC), furosemide, steviol, phorbol 12-myristate 13-acetate (PMA), calcium ionophore A23187, benzylpenicillin, furosemide, indomethacin, bumetamide, losartan, probenecid, phenol red, urate, and alpha-ketoglutarate.
UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: KM=9.3 uM for PAH (isoform 1) {ECO:0000269|PubMed:10462545, ECO:0000269|PubMed:10964714, ECO:0000269|PubMed:12538807, ECO:0000269|PubMed:15846473}; KM=4 uM for PAH (isoform 2) {ECO:0000269|PubMed:10462545, ECO:0000269|PubMed:10964714, ECO:0000269|PubMed:12538807, ECO:0000269|PubMed:15846473}; KM=11 uM for edaravone {ECO:0000269|PubMed:10462545, ECO:0000269|PubMed:10964714, ECO:0000269|PubMed:12538807, ECO:0000269|PubMed:15846473}; KM=46 uM for cidofovir {ECO:0000269|PubMed:10462545, ECO:0000269|PubMed:10964714, ECO:0000269|PubMed:12538807, ECO:0000269|PubMed:15846473}; KM=30 uM for adefovir {ECO:0000269|PubMed:10462545, ECO:0000269|PubMed:10964714, ECO:0000269|PubMed:12538807, ECO:0000269|PubMed:15846473}; KM=5.77 uM for 2,4-D {ECO:0000269|PubMed:10462545, ECO:0000269|PubMed:10964714, ECO:0000269|PubMed:12538807, ECO:0000269|PubMed:15846473}; KM=23.5 uM for HA {ECO:0000269|PubMed:10462545, ECO:0000269|PubMed:10964714, ECO:0000269|PubMed:12538807, ECO:0000269|PubMed:15846473}; KM=14 uM for IA {ECO:0000269|PubMed:10462545, ECO:0000269|PubMed:10964714, ECO:0000269|PubMed:12538807, ECO:0000269|PubMed:15846473}; KM=20.5 uM for IS {ECO:0000269|PubMed:10462545, ECO:0000269|PubMed:10964714, ECO:0000269|PubMed:12538807, ECO:0000269|PubMed:15846473}; KM=141 uM for CMPF {ECO:0000269|PubMed:10462545, ECO:0000269|PubMed:10964714, ECO:0000269|PubMed:12538807, ECO:0000269|PubMed:15846473}; Vmax=534 pmol/min/mg enzyme for 2,4-D uptake {ECO:0000269|PubMed:10462545, ECO:0000269|PubMed:10964714, ECO:0000269|PubMed:12538807, ECO:0000269|PubMed:15846473}; Vmax=430 pmol/min/mg enzyme for HA uptake {ECO:0000269|PubMed:10462545, ECO:0000269|PubMed:10964714, ECO:0000269|PubMed:12538807, ECO:0000269|PubMed:15846473}; Vmax=110 pmol/min/mg enzyme for IA uptake {ECO:0000269|PubMed:10462545, ECO:0000269|PubMed:10964714, ECO:0000269|PubMed:12538807, ECO:0000269|PubMed:15846473}; Vmax=216 pmol/min/mg enzyme for IS uptake {ECO:0000269|PubMed:10462545, ECO:0000269|PubMed:10964714, ECO:0000269|PubMed:12538807, ECO:0000269|PubMed:15846473}; Vmax=801 pmol/min/mg enzyme for CMPF uptake {ECO:0000269|PubMed:10462545, ECO:0000269|PubMed:10964714, ECO:0000269|PubMed:12538807, ECO:0000269|PubMed:15846473};
GENATLAS Biochemistry:
solute carrier protein family 22,member A6,polyspecific transporter for organic cations,mediating the coupled exchange of alpha-ketoglutarate with multiple organic ions,including p-aminohippurate (PAH),expressed strongly in kidney,weakly in brain

Phenotypes From GWAS Catalog for SLC22A6 Gene

Gene Ontology (GO) - Molecular Function for SLC22A6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005452 inorganic anion exchanger activity IDA 15037815
GO:0005515 protein binding IPI 16189514
GO:0008514 organic anion transmembrane transporter activity IMP 22169006
GO:0015301 anion:anion antiporter activity IEA --
GO:0015347 sodium-independent organic anion transmembrane transporter activity IBA 21873635
genes like me logo Genes that share ontologies with SLC22A6: view
genes like me logo Genes that share phenotypes with SLC22A6: view

Animal Models for SLC22A6 Gene

MGI Knock Outs for SLC22A6:

Animal Models for research

  • Taconic Biosciences Mouse Models for SLC22A6

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SLC22A6

Clone products for research

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for SLC22A6 Gene

Localization for SLC22A6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC22A6 Gene

Cell membrane. Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SLC22A6 gene
Compartment Confidence
plasma membrane 5
extracellular 4
mitochondrion 2
cytoskeleton 1
nucleus 1
endoplasmic reticulum 1
endosome 1
cytosol 1
lysosome 1

Gene Ontology (GO) - Cellular Components for SLC22A6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane IDA 14749323
GO:0005901 caveola IEA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with SLC22A6: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for SLC22A6 Gene

Pathways & Interactions for SLC22A6 Gene

genes like me logo Genes that share pathways with SLC22A6: view

Gene Ontology (GO) - Biological Process for SLC22A6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006820 anion transport IEA --
GO:0015698 inorganic anion transport IEA --
GO:0015711 organic anion transport IBA,IMP 22169006
GO:0015742 alpha-ketoglutarate transport IDA 9950961
GO:0031427 response to methotrexate IEA --
genes like me logo Genes that share ontologies with SLC22A6: view

No data available for SIGNOR curated interactions for SLC22A6 Gene

Drugs & Compounds for SLC22A6 Gene

(158) Drugs for SLC22A6 Gene - From: DrugBank, PharmGKB, DGIdb, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Cidofovir Approved Pharma Transporter, substrate, inhibitor 38
Probenecid Approved, Investigational Pharma Target, Transporter, inhibitor, substrate, blocker 45
Adefovir dipivoxil Approved, Investigational Pharma Transporter, substrate, inhibitor 98
Amoxicillin Approved, Vet_approved Pharma Transporter, inhibitor 700
Cefazolin Approved Pharma Transporter, substrate, inhibitor 175

(27) Additional Compounds for SLC22A6 Gene - From: Novoseek and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
2-Hydroxychlorpropamide
  • N-(4-Chloro-2-hydroxybenzenesulfonyl)propane-1-carbamimidate
  • N-(4-Chloro-2-hydroxybenzenesulphonyl)propane-1-carbamimidate
  • N-(4-Chloro-2-hydroxybenzenesulphonyl)propane-1-carbamimidic acid
36892-36-1
3-Hydroxymethylantipyrine
  • 3-HMAP
  • 3-Hydroxymethylantipyrine
18125-49-0
4-ene-Valproic acid
  • 4-En-valproic acid
  • 4-Ene-vpa
  • 4-En-valproate
  • 4-Ene-valproate
  • 2-Propyl-4-pentenoic acid, (+-)-isomer
4'-Hydroxydiclofenac
  • (O-(2,6-Dichloro-4-hydroxyanilino)phenyl)acetic acid
  • 4'-Hydroxy diclofenac
  • 4'-OH DCF
  • (O-(2,6-Dichloro-4-hydroxyanilino)phenyl)acetate
  • {2-[(2,6-dichloro-4-hydroxyphenyl)amino]phenyl}acetic acid
64118-84-9
5'-Hydroxypiroxicam
  • 5-Hydroxypiroxicam
  • 4-Hydroxy-N-(5-hydroxypyridin-2-yl)-2-methyl-1,1-dioxo-2H-1λ⁶,2-benzothiazine-3-carboximidate
  • 5'-Hydroxypiroxicam
77459-78-0
genes like me logo Genes that share compounds with SLC22A6: view

Transcripts for SLC22A6 Gene

mRNA/cDNA for SLC22A6 Gene

5 REFSEQ mRNAs :
16 NCBI additional mRNA sequence :
6 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SLC22A6

Clone products for research

Alternative Splicing Database (ASD) splice patterns (SP) for SLC22A6 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b · 9c ^ 10a · 10b
SP1: -
SP2:
SP3: - -
SP4: -

Relevant External Links for SLC22A6 Gene

GeneLoc Exon Structure for
SLC22A6

Expression for SLC22A6 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for SLC22A6 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SLC22A6 Gene

This gene is overexpressed in Kidney - Cortex (x47.1).

Protein differential expression in normal tissues from HIPED for SLC22A6 Gene

This gene is overexpressed in Urine (41.5), Plasma (18.5), and Kidney (9.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for SLC22A6 Gene



Protein tissue co-expression partners for SLC22A6 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for SLC22A6

SOURCE GeneReport for Unigene cluster for SLC22A6 Gene:

Hs.369252

mRNA Expression by UniProt/SwissProt for SLC22A6 Gene:

Q4U2R8-S22A6_HUMAN
Tissue specificity: Strongly expressed in kidney and to a lower extent in liver, skeletal muscle, brain and placenta. Found at the basolateral membrane of the proximal tubule.

Evidence on tissue expression from TISSUES for SLC22A6 Gene

  • Kidney(4.9)
  • Intestine(4.3)
  • Urine(2.2)
  • Nervous system(2.2)
genes like me logo Genes that share expression patterns with SLC22A6: view

Primer products for research

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for SLC22A6 Gene

Orthologs for SLC22A6 Gene

This gene was present in the common ancestor of animals.

Orthologs for SLC22A6 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia SLC22A6 29 30
  • 99.45 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia SLC22A6 29 30
  • 89.8 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia SLC22A6 29 30
  • 88.38 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Slc22a6 29
  • 86.18 (n)
Mouse
(Mus musculus)
Mammalia Slc22a6 29 16 30
  • 85.36 (n)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia SLC22A6 30
  • 58 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia -- 30
  • 41 (a)
ManyToMany
Lizard
(Anolis carolinensis)
Reptilia -- 30
  • 54 (a)
ManyToMany
-- 30
  • 52 (a)
ManyToMany
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia LOC100490266 29
  • 56.76 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.23285 29
Zebrafish
(Danio rerio)
Actinopterygii oatx 29
  • 53.81 (n)
slc22a6l 30
  • 50 (a)
OneToMany
Rainbow Trout
(Oncorhynchus mykiss)
Actinopterygii Omy.9767 29
Fruit Fly
(Drosophila melanogaster)
Insecta CG3790 31
  • 30 (a)
CG8654 31
  • 30 (a)
CG13610 31
  • 29 (a)
CG6356 31
  • 29 (a)
CG6126 31
  • 28 (a)
CG6600 31
  • 28 (a)
CG5592 31
  • 26 (a)
CG14857 31
  • 24 (a)
CG6231 31
  • 24 (a)
CG14855 31
  • 23 (a)
CG16727 31
  • 23 (a)
CG17751 31
  • 23 (a)
CG17752 31
  • 22 (a)
Worm
(Caenorhabditis elegans)
Secernentea oct-1 31
  • 28 (a)
F52F12.1a 31
  • 28 (a)
ZK455.8a 31
  • 28 (a)
ZK455.8b 31
  • 28 (a)
K05F1.6 31
  • 26 (a)
Species where no ortholog for SLC22A6 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for SLC22A6 Gene

ENSEMBL:
Gene Tree for SLC22A6 (if available)
TreeFam:
Gene Tree for SLC22A6 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for SLC22A6: view image
Alliance of Genome Resources:
Additional Orthologs for SLC22A6

Paralogs for SLC22A6 Gene

(19) SIMAP similar genes for SLC22A6 Gene using alignment to 2 proteins:

  • S22A6_HUMAN
  • F5H0T7_HUMAN

Pseudogenes.org Pseudogenes for SLC22A6 Gene

genes like me logo Genes that share paralogs with SLC22A6: view

Variants for SLC22A6 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for SLC22A6 Gene

SNP ID Clinical significance and condition Chr 11 pos Variation AA Info Type
rs11568635 Benign: not provided 62,977,279(-) G/A
NM_153276.3(SLC22A6):c.1470C>T (p.Tyr490=)
SYNONYMOUS_VARIANT,INTRON
rs11568626 -- p.Arg50His
rs11568627 -- p.Pro104Leu
rs141563232 -- p.Leu7Pro
rs45607933 -- p.Arg293Trp

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for SLC22A6 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for SLC22A6 Gene

Variant ID Type Subtype PubMed ID
dgv204e214 CNV gain 21293372
esv34011 CNV loss 18971310

Variation tolerance for SLC22A6 Gene

Residual Variation Intolerance Score: 48.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.62; 45.34% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SLC22A6 Gene

Human Gene Mutation Database (HGMD)
SLC22A6
SNPedia medical, phenotypic, and genealogical associations of SNPs for
SLC22A6
Leiden Open Variation Database (LOVD)
SLC22A6

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SLC22A6 Gene

Disorders for SLC22A6 Gene

MalaCards: The human disease database

(8) MalaCards diseases for SLC22A6 Gene - From: COP and GCD

Disorder Aliases PubMed IDs
n-acetylglutamate synthase deficiency
  • nagsd
gout
  • articular gout
fanconi-like syndrome
  • fanconi like syndrome
acute kidney failure
  • acute renal failure
methotrexate toxicity
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for SLC22A6

Human Genome Epidemiology Navigator
(HuGE)
Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform
genes like me logo Genes that share disorders with SLC22A6: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SLC22A6 Gene

Publications for SLC22A6 Gene

  1. Cloning of the human kidney PAH transporter: narrow substrate specificity and regulation by protein kinase C. (PMID: 9950961) Lu R … Schuster VL (The American journal of physiology 1999) 2 3 4 22 25
  2. Functional consequences of single nucleotide polymorphisms in the human organic anion transporter hOAT1 (SLC22A6). (PMID: 15914676) Bleasby K … Pritchard JB (The Journal of pharmacology and experimental therapeutics 2005) 3 4 22 40
  3. Molecular cloning and functional expression of a multispecific organic anion transporter from human kidney. (PMID: 9887087) Hosoyamada M … Endou H (The American journal of physiology 1999) 3 4 22 25
  4. Molecular cloning and characterization of two novel human renal organic anion transporters (hOAT1 and hOAT3). (PMID: 10049739) Race JE … Holtzman EJ (Biochemical and biophysical research communications 1999) 3 4 22 25
  5. The antiviral nucleotide analogs cidofovir and adefovir are novel substrates for human and rat renal organic anion transporter 1. (PMID: 10462545) Cihlar T … Sweet DH (Molecular pharmacology 1999) 3 4 22 25

Products for SLC22A6 Gene

Sources for SLC22A6 Gene