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Aliases for SLC22A31 Gene
Aliases for SLC22A31 Gene
External Ids for SLC22A31 Gene
- HGNC: 27091
- Entrez Gene: 146429
- Ensembl: ENSG00000259803
- UniProtKB: A6NKX4
Previous GeneCards Identifiers for SLC22A31 Gene
- GC16M089263
Summaries for SLC22A31 Gene
GeneCards Summary for SLC22A31 Gene
SLC22A31 (Solute Carrier Family 22 Member 31) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include transmembrane transporter activity. An important paralog of this gene is SLC22A17.
UniProtKB/Swiss-Prot Summary for SLC22A31 Gene
-
Organic anion transporter that mediates the uptake of ions.
Additional gene information for SLC22A31 Gene
- HGNC(27091)
- Entrez Gene(146429)
- Ensembl(ENSG00000259803)
- UniProtKB(A6NKX4)
- Open Targets Platform(ENSG00000259803)
- Search for SLC22A31 at DataMed
- Search for SLC22A31 at HumanCyc
No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for SLC22A31 Gene
Genomics for SLC22A31 Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for SLC22A31 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around SLC22A31 on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for SLC22A31
Genomic Locations for SLC22A31 Gene
Genomic Locations for SLC22A31 Gene
- chr16:89,195,756-89,201,673
- (GRCh38/hg38)
- Size:
- 5,918 bases
- Orientation:
- Minus strand
- chr16:89,262,169-89,268,072
- (GRCh37/hg19)
- Size:
- 5,904 bases
- Orientation:
- Minus strand
Genomic View for SLC22A31 Gene
Genes around SLC22A31 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 16q24.3 by HGNC
- 16q24.3 by Entrez Gene
- 16q24.3 by Ensembl
SLC22A31 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for SLC22A31 Gene
Proteins for SLC22A31 Gene
-
Protein details for SLC22A31 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- A6NKX4-S22AV_HUMAN
- Recommended name:
- Putative solute carrier family 22 member 31
- Protein Accession:
- A6NKX4
- S4R3Q8
Protein attributes for SLC22A31 Gene
- Size:
- 556 amino acids
- Molecular mass:
- 58815 Da
- Quaternary structure:
- No Data Available
Post-translational modifications for SLC22A31 Gene
Other Protein References for SLC22A31 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
Protein Products
- Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for SLC22A31
- Origene Custom Protein Services for SLC22A31
No data available for DME Specific Peptides for SLC22A31 Gene
Domains & Families for SLC22A31 Gene
Gene Families for SLC22A31 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Predicted membrane proteins
Protein Domains for SLC22A31 Gene
- InterPro:
- ProtoNet:
Graphical View of Domain Structure for InterPro Entry
A6NKX4UniProtKB/Swiss-Prot:
S22AV_HUMAN :- Belongs to the major facilitator (TC 2.A.1) superfamily. Organic cation transporter (TC 2.A.1.19) family.
- Family:
-
- Belongs to the major facilitator (TC 2.A.1) superfamily. Organic cation transporter (TC 2.A.1.19) family.
No data available for Suggested Antigen Peptide Sequences for SLC22A31 Gene
Function for SLC22A31 Gene
Molecular function for SLC22A31 Gene
- UniProtKB/Swiss-Prot Function:
- Organic anion transporter that mediates the uptake of ions.
Phenotypes From GWAS Catalog for SLC22A31 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0022857 | transmembrane transporter activity | IEA | -- |
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for SLC22A31 - Select products 50% OFF >
- * SLC22A31 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for SLC22A31
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for SLC22A31
-
Santa Cruz Biotechnology (SCBT) CRISPR for SLC22A31
miRNA Products
Inhibitory RNA Products
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SLC22A31
Clone Products
- Applied Biological Materials (abm): Clones for SLC22A31 - Select products 50% OFF >
- * SLC22A31 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for SLC22A31
- Addgene plasmids for SLC22A31
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for SLC22A31
Cell Line Products
-
Horizon Cell Lines for SLC22A31
No data available for Enzyme Numbers (IUBMB) , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for SLC22A31 Gene
Localization for SLC22A31 Gene
Subcellular locations from UniProtKB/Swiss-Prot for SLC22A31 Gene
- Membrane. Multi-pass membrane protein.
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0016020 | membrane | IEA | -- |
| GO:0016021 | integral component of membrane | IEA | -- |
No data available for Subcellular locations from COMPARTMENTS and Subcellular locations from the Human Protein Atlas (HPA) for SLC22A31 Gene
Pathways & Interactions for SLC22A31 Gene
Interacting Proteins for SLC22A31 Gene
GPS-Prot Interaction Network for SLC22A31
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006811 | ion transport | IEA | -- |
| GO:0055085 | transmembrane transport | IEA | -- |
No data available for Pathways by source and SIGNOR curated interactions for SLC22A31 Gene
Transcripts for SLC22A31 Gene
mRNA/cDNA for SLC22A31 Gene
- 2 REFSEQ mRNAs :
- 1 NCBI additional mRNA sequence :
- 6 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000562855 1945 nts (view in UCSC)
- ENST00000562916 692 nts (view in UCSC)
- ENST00000563595 780 nts (view in UCSC)
- ENST00000568161 651 nts (view in UCSC)
- ENST00000603735 791 nts (view in UCSC)
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for SLC22A31 - Select products 50% OFF >
- * SLC22A31 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for SLC22A31
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for SLC22A31
-
Santa Cruz Biotechnology (SCBT) CRISPR for SLC22A31
miRNA Products
Inhibitory RNA Products
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SLC22A31
Clone Products
- Applied Biological Materials (abm): Clones for SLC22A31 - Select products 50% OFF >
- * SLC22A31 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for SLC22A31
- Addgene plasmids for SLC22A31
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for SLC22A31
Relevant External Links for SLC22A31 Gene
- GeneLoc Exon Structure for
- SLC22A31
Expression for SLC22A31 Gene
mRNA differential expression in normal tissues according to GTEx for SLC22A31 Gene
This gene is overexpressed in Brain - Cerebellum (x19.2), Brain - Cerebellar Hemisphere (x15.5), Lung (x7.8), and Pancreas (x5.1).
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for SLC22A31
SOURCE GeneReport for Unigene cluster for SLC22A31 Gene:
Hs.447544Primer Products
Gene Expression Assay Products
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for SLC22A31 Gene
Orthologs for SLC22A31 Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | SLC22A31 30 |
|
||
| Dog (Canis familiaris) |
Mammalia | SLC22A31 30 31 |
|
OneToOne | |
| Oppossum (Monodelphis domestica) |
Mammalia | SLC22A31 31 |
|
OneToOne | |
| Cow (Bos Taurus) |
Mammalia | MGC157263 31 |
|
OneToOne | |
| Platypus (Ornithorhynchus anatinus) |
Mammalia | SLC22A31 31 |
|
OneToOne | |
| Chicken (Gallus gallus) |
Aves | SLC22A31 30 |
|
||
| Lizard (Anolis carolinensis) |
Reptilia | SLC22A31 31 |
|
OneToOne | |
| Zebrafish (Danio rerio) |
Actinopterygii | SLC22A31 31 |
|
OneToOne |
- Species where no ortholog for SLC22A31 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Baker's yeast (Saccharomyces cerevisiae)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Fruit Fly (Drosophila melanogaster)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Mouse (Mus musculus)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rainbow Trout (Oncorhynchus mykiss)
- Rat (Rattus norvegicus)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Squirt (Ciona savignyi)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Tropical Clawed Frog (Silurana tropicalis)
- Wheat (Triticum aestivum)
- Worm (Caenorhabditis elegans)
Evolution for SLC22A31 Gene
- ENSEMBL:
- Gene Tree for SLC22A31 (if available)
- TreeFam:
- Gene Tree for SLC22A31 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for SLC22A31: view image
Paralogs for SLC22A31 Gene
Paralogs for SLC22A31 Gene
(4) SIMAP similar genes for SLC22A31 Gene using alignment to 2 proteins:
- S22AV_HUMAN
- S4R3Q8_HUMAN
Variants for SLC22A31 Gene
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| dgv3066n100 | CNV | gain | 25217958 |
| dgv5320n54 | CNV | loss | 21841781 |
| esv1002217 | CNV | deletion | 20482838 |
| esv1613886 | CNV | deletion | 17803354 |
| esv2715127 | CNV | deletion | 23290073 |
| esv2715128 | CNV | deletion | 23290073 |
| esv2715130 | CNV | deletion | 23290073 |
| esv2763149 | CNV | gain | 21179565 |
| nsv1063024 | CNV | gain | 25217958 |
| nsv457621 | CNV | loss | 19166990 |
| nsv471115 | CNV | loss | 18288195 |
| nsv482951 | CNV | loss | 15286789 |
| nsv509638 | CNV | insertion | 20534489 |
| nsv519104 | CNV | loss | 19592680 |
| nsv573674 | CNV | gain | 21841781 |
| nsv573724 | CNV | loss | 21841781 |
| nsv952072 | CNV | deletion | 24416366 |
Gene Damage Index Score:
13.04;
95.03% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for SLC22A31 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- SLC22A31
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for SLC22A31 Gene
Disorders for SLC22A31 Gene
Additional Disease Information for SLC22A31
No disorders were found for SLC22A31 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SLC22A31 Gene
Publications for SLC22A31 Gene
- The sequence and analysis of duplication-rich human chromosome 16. (PMID: 15616553) Martin J … Pennacchio LA (Nature 2004) 3 4
ExternalLinks
Products for SLC22A31 Gene
- Browse OriGene Antibodies
- Custom Antibody Services
- Browse OriGene ELISA Kits
- Custom Assay Services
- Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for SLC22A31
- Origene Custom Protein Services for SLC22A31
- Browse OriGene Inhibitory RNA Products For SLC22A31
- Browse OriGene qPCR primer pairs and template standards
- OriGene CRISPR knockouts for SLC22A31
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For SLC22A31
- Sino Biological Human cDNA Clone for SLC22A31
- Browse Sino Biological Recombinant Proteins
- Browse Sino Biological Cell Lysates
- Browse Sino Biological Antibodies
- Browse Sino Biological Assays
- Browse cDNA Clones
- Browse ELISA Kits
- Browse CRO Services
- High-throughput Antibody Production Service
- Protein Production Service
- Epitope Tag Antibodies & Reporter Protein Antibodies
- Lentiviral ORF Clones
- VectorBuilder Custom and pre-made DNA vectors for SLC22A31 (ie. gene expression, shRNA knockdown, CRISPR)
- VectorBuilder Viral vectors for SLC22A31 (ie. lentivirus, AAV, adenovirus)
- VectorBuilder CRISPR vectors for SLC22A31 (ie. knockout, knockin, CRISPRa, CRISPRi)
- VectorBuilder Virus packaging for SLC22A31 CRISPR vectors (ie. lentivirus, AAV, adenovirus)
- VectorBuilder Stable cell line generation for SLC22A31
- Addgene plasmids for SLC22A31
- Horizon Cell Lines for SLC22A31
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for SLC22A31
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for SLC22A31
- Search GeneCopoeia for miRNA 3'UTR Target clone products for SLC22A31
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SLC22A31
Sources for SLC22A31 Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) ProtoNet
- (16) Blocks
- (17) MGI
- (18) IUBMB
- (19) KEGG
- (20) MINT
- (21) STRING
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) ASD
- (28) SAGE
- (29) SOURCE
- (30) HomoloGene
- (31) PanEnsembl
- (32) euGenes
- (33) SGD
- (34) FlyBase
- (35) WormBase
- (36) Pseudogene
- (37) DGV
- (38) dbSNP
- (39) GenAtlas
- (40) HGMD
- (41) GAD
- (42) BGMUT
- (43) HuGE
- (44) Atlas
- (45) GenBank
- (46) HORDE
- (47) HUGE
- (48) IMGT
- (49) Leiden
- (50) miRBase
- (51) DME
- (52) OriGene
- (53) PubMed
- (54) R&D Systems
- (55) TGDB
- (56) Tocris
- (57) Abcam
- (58) Novus Biologicals
- (59) ProSpec
- (60) Sino Biological
- (61) GenScript
- (62) Qiagen
- (63) OCA
- (64) Proteopedia
- (65) MOPED
- (66) neXtProt
- (67) Reactome
- (68) GeneGo (Thomson Reuters)
- (69) DISEASES
- (70) SIMAP
- (71) GenomeRNAi
- (72) LifeMap
- (73) miRTarBase
- (74) MalaCards
- (75) Invitrogen
- (76) BitterDB
- (77) ESI-BIO
- (78) RefSeq
- (79) BioSystems
- (80) MaxQB
- (81) IUPHAR
- (82) BioGPS
- (83) Illumina
- (84) COMPARTMENTS
- (85) HOMER
- (86) PaxDb
- (87) ApexBio
- (88) Addgene
- (89) antibodies-online
- (90) CYP
- (91) NONCODE
- (92) TreeFam
- (93) PathCards
- (94) GeneReviews
- (95) GeneTex
- (96) Taconic Biosciences
- (97) GTEx
- (98) ProteomicsDB
- (99) SCBT
- (100) DGIdb
- (101) ClinicalTrials
- (102) RVIS
- (103) SIGNOR
- (104) diseasecard
- (105) NIH Rare Diseases
- (106) Orphanet
- (107) UMLS
- (108) GTR
- (109) Disease Ontology
- (110) Genetics Home Reference
- (111) MeSH
- (112) MedlinePlus
- (113) CDC
- (114) NINDS
- (115) NCBI Bookshelf
- (116) ClinVar
- (117) Gene Damage Index
- (118) HPO
- (119) UDN
- (120) VISTA
- (121) FANTOM5
- (122) ENCODE
- (123) ProSci
- (124) Horizon
- (125) The Signaling Pathways Project (SPP)
- (126) IID
- (127) VectorBuilder
- (128) SNPedia
- (129) BRCA Exchange
- (130) CIViC
- (131) ProteoGenix
- (132) dbSUPER
- (133) TISSUES
- (134) Gene ORGANizer
- (135) abm
- (136) Human Protein Atlas
- (137) GWAS Catalog
- (138) Monarch Initiative
- (139) DataMed
- (140) HumanCyc
- (141) UCNEbase
- (142) EPDnew
- (143) Applied Biosystems
- (144) GlyConnect
- (145) Aminode
- (146) GeneCopoeia
- (147) GPS-Prot
- (148) RNACentral
- (149) LncRNADisease
- (150) LOVD
- (151) miR2Disease
- (152) DiseaseEnhancer
- (153) Boster Bio
- (154) Biorbyt
- (155) Biocompare
- (156) Mastermind
- (157) CTD^2 Dashboard
- (158) CraniofacialAtlas
- (159) GeneImprint
- (160) Synthego
- (161) ENA
- (162) GtRNAdb
- (163) LncBase
- (164) LncBook
- (165) LNCipedia
- (166) Modomics
- (167) PDBe
- (168) Rfam
- (169) SILVA
- (170) snOPY
- (171) SRPDB
- (172) GENCODE
- (173) TarBase
- (174) Signalway Antibody
- (175) Open Targets Platform
- (176) 5SRRNADB
- (177) snoDB
- (178) MirGeneDB