Polyspecific organic cation transporters in the liver, kidney, intestine, and other organs are critical for elimination of many endogenous small organic cations as well as a wide array of drugs and environmental toxins. This gene is one of three similar cation transporter genes located in a cluster on chromosome 6. The encoded protein contains twelve putative transmembrane doma... See more...

Aliases for SLC22A3 Gene

Aliases for SLC22A3 Gene

  • Solute Carrier Family 22 Member 3 2 3 4 5
  • Extraneuronal Monoamine Transporter 2 3 4
  • Organic Cation Transporter 3 2 3 4
  • Solute Carrier Family 22 (Extraneuronal Monoamine Transporter), Member 3 2 3
  • Solute Carrier Family 22 (Organic Cation Transporter), Member 3 2 3
  • EMTH 3 4
  • OCT3 3 4
  • EMT 3 4
  • EMT Organic Cation Transporter 3 3

External Ids for SLC22A3 Gene

Previous GeneCards Identifiers for SLC22A3 Gene

  • GC06P160208
  • GC06P160642
  • GC06P160678
  • GC06P160739
  • GC06P158244

Summaries for SLC22A3 Gene

Entrez Gene Summary for SLC22A3 Gene

  • Polyspecific organic cation transporters in the liver, kidney, intestine, and other organs are critical for elimination of many endogenous small organic cations as well as a wide array of drugs and environmental toxins. This gene is one of three similar cation transporter genes located in a cluster on chromosome 6. The encoded protein contains twelve putative transmembrane domains and is a plasma integral membrane protein. [provided by RefSeq, Jul 2008]

GeneCards Summary for SLC22A3 Gene

SLC22A3 (Solute Carrier Family 22 Member 3) is a Protein Coding gene. Diseases associated with SLC22A3 include Cerebral Palsy, Ataxic, Autosomal Recessive and Amphetamine Abuse. Among its related pathways are Synaptic vesicle cycle and Sympathetic Nerve Pathway (Neuroeffector Junction). Gene Ontology (GO) annotations related to this gene include transmembrane transporter activity and organic cation transmembrane transporter activity. An important paralog of this gene is SLC22A2.

UniProtKB/Swiss-Prot Summary for SLC22A3 Gene

  • Mediates potential-dependent transport of a variety of organic cations. May play a significant role in the disposition of cationic neurotoxins and neurotransmitters in the brain.

Gene Wiki entry for SLC22A3 Gene

Additional gene information for SLC22A3 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for SLC22A3 Gene

Genomics for SLC22A3 Gene

GeneHancer (GH) Regulatory Elements for SLC22A3 Gene

Promoters and enhancers for SLC22A3 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH06J160347 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 507.1 +0.8 820 3.6 POLR2G NCOR1 CTCF ZIC2 KDM6A TCF7 ZBTB26 TGIF2 TEAD1 HDAC2 SLC22A3 WTAP LOC729603 MAP3K4 piR-61240-258
GH06J160455 Enhancer 1 ENCODE CraniofacialAtlas 25.8 +107.5 107464 1.7 CTCF ZNF10 REST RAD21 ZBTB7A TRIM22 SMC3 ZSCAN9 ESRRA NFIC SLC22A3 WTAP LOC729603 MAP3K4 SNORA29 TCP1 piR-46847-237 piR-50444-411 lnc-LPA-6 LPAL2
GH06J160386 Enhancer 1 Ensembl ENCODE dbSUPER 22.8 +39.0 38972 1.7 TCF12 CTCF FOS FOSL2 JUN RCOR1 ATF3 NR3C1 JUND SIN3A ENSG00000287656 SLC22A3 lnc-SLC22A1-6
GH06J160254 Enhancer 1.1 Ensembl ENCODE 19.5 -94.0 -93972 4.4 TCF12 NCOR1 ZIC2 FOXA1 SKI TEAD1 TBX3 ZKSCAN8 ZSCAN9 FOXA2 RF01045-137 SLC22A3 HSALNG0054814 SLC22A2
GH06J160390 Enhancer 1.1 Ensembl ENCODE dbSUPER 19.2 +43.0 43028 2.4 TCF12 TRIM28 CREB1 FOXA2 NFIC FOS FOSL2 JUN NFE2 ATF3 SLC22A3 ENSG00000287656 lnc-SLC22A1-6
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around SLC22A3 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for SLC22A3

Top Transcription factor binding sites by QIAGEN in the SLC22A3 gene promoter:
  • aMEF-2
  • ATF
  • ATF6
  • Bach2
  • c-Myc
  • Ik-3
  • Max
  • MEF-2
  • MEF-2A
  • XBP-1

Genomic Locations for SLC22A3 Gene

Genomic Locations for SLC22A3 Gene
chr6:160,348,373-160,452,581
(GRCh38/hg38)
Size:
104,209 bases
Orientation:
Plus strand
chr6:160,769,300-160,876,014
(GRCh37/hg19)
Size:
106,715 bases
Orientation:
Plus strand

Genomic View for SLC22A3 Gene

Genes around SLC22A3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SLC22A3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SLC22A3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC22A3 Gene

Proteins for SLC22A3 Gene

  • Protein details for SLC22A3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O75751-S22A3_HUMAN
    Recommended name:
    Solute carrier family 22 member 3
    Protein Accession:
    O75751
    Secondary Accessions:
    • Q5SYN6
    • Q9UP02

    Protein attributes for SLC22A3 Gene

    Size:
    556 amino acids
    Molecular mass:
    61280 Da
    Quaternary structure:
    No Data Available

neXtProt entry for SLC22A3 Gene

Post-translational modifications for SLC22A3 Gene

  • Glycosylation at Asn72, Asn99, Asn119, and Asn322
  • Modification sites at PhosphoSitePlus

Other Protein References for SLC22A3 Gene

No data available for DME Specific Peptides for SLC22A3 Gene

Domains & Families for SLC22A3 Gene

Gene Families for SLC22A3 Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • Predicted membrane proteins
  • Transporters

Protein Domains for SLC22A3 Gene

Blocks:
  • Sugar transporter superfamily
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for SLC22A3 Gene

GenScript: Design optimal peptide antigens:
  • cDNA, FLJ95424, Homo sapiens solute carrier family 22 (extraneuronal monoaminetransporter), member 3 (SLC22A3), mRNA (Q5SYN6_HUMAN)
  • Extraneuronal monoamine transporter (EMT) (Q9NQC0_HUMAN)
  • Organic cation transporter 3 (S22A3_HUMAN)

Graphical View of Domain Structure for InterPro Entry

O75751

UniProtKB/Swiss-Prot:

S22A3_HUMAN :
  • Belongs to the major facilitator (TC 2.A.1) superfamily. Organic cation transporter (TC 2.A.1.19) family.
Family:
  • Belongs to the major facilitator (TC 2.A.1) superfamily. Organic cation transporter (TC 2.A.1.19) family.
genes like me logo Genes that share domains with SLC22A3: view

Function for SLC22A3 Gene

Molecular function for SLC22A3 Gene

UniProtKB/Swiss-Prot Function:
Mediates potential-dependent transport of a variety of organic cations. May play a significant role in the disposition of cationic neurotoxins and neurotransmitters in the brain.
GENATLAS Biochemistry:
solute carrier family 22,member A3,polyspecific transporter of organic cations,most abundantly expressed in the placenta and moderatly in the intestine,heart and brain,clustered with SLC22A1 and SLC22A2

Phenotypes From GWAS Catalog for SLC22A3 Gene

Gene Ontology (GO) - Molecular Function for SLC22A3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005330 dopamine:sodium symporter activity IEA --
GO:0005515 protein binding IPI 17474147
GO:0015101 organic cation transmembrane transporter activity IEA,TAS --
GO:0015651 quaternary ammonium group transmembrane transporter activity IDA 10966924
GO:0019534 toxin transmembrane transporter activity IEA --
genes like me logo Genes that share ontologies with SLC22A3: view
genes like me logo Genes that share phenotypes with SLC22A3: view

Animal Models for SLC22A3 Gene

MGI Knock Outs for SLC22A3:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SLC22A3

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for SLC22A3 Gene

Localization for SLC22A3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC22A3 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SLC22A3 gene
Compartment Confidence
plasma membrane 5
extracellular 2
mitochondrion 2
nucleus 2
cytoskeleton 1
peroxisome 1
endoplasmic reticulum 1
cytosol 1
lysosome 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Nucleoplasm (2)
  • Vesicles (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for SLC22A3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane IEA,TAS --
GO:0016020 membrane TAS 9933568
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with SLC22A3: view

Pathways & Interactions for SLC22A3 Gene

genes like me logo Genes that share pathways with SLC22A3: view

Gene Ontology (GO) - Biological Process for SLC22A3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006811 ion transport IEA --
GO:0006855 drug transmembrane transport TAS --
GO:0015695 organic cation transport IDA,IEA 10966924
GO:0015697 quaternary ammonium group transport IDA 10966924
GO:0015844 monoamine transport IEA --
genes like me logo Genes that share ontologies with SLC22A3: view

No data available for SIGNOR curated interactions for SLC22A3 Gene

Drugs & Compounds for SLC22A3 Gene

(55) Drugs for SLC22A3 Gene - From: DrugBank, PharmGKB, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Desipramine Approved, Investigational Pharma Transporter, inhibitor 41
Dopamine Approved Pharma Full agonist, Agonist, Transporter, inhibitor 4787
Guanidine Approved Pharma Transporter, substrate, inhibitor 0
Norepinephrine Approved Pharma Transporter, substrate, inhibitor 915
Metformin Approved Pharma Transporter, substrate AMP-activated protein kinase (AMPK) activator 2154

(7) Additional Compounds for SLC22A3 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with SLC22A3: view

Transcripts for SLC22A3 Gene

mRNA/cDNA for SLC22A3 Gene

1 REFSEQ mRNAs :
10 NCBI additional mRNA sequence :
1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SLC22A3

Alternative Splicing Database (ASD) splice patterns (SP) for SLC22A3 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13 ^ 14
SP1: - - - -
SP2:
SP3:
SP4:

Relevant External Links for SLC22A3 Gene

GeneLoc Exon Structure for
SLC22A3

Expression for SLC22A3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for SLC22A3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SLC22A3 Gene

This gene is overexpressed in Artery - Aorta (x6.5), Muscle - Skeletal (x6.0), Nerve - Tibial (x4.9), and Liver (x4.4).

Protein differential expression in normal tissues from HIPED for SLC22A3 Gene

This gene is overexpressed in Seminal vesicle (19.6), Prostate (16.8), Liver (11.5), and Ovary (11.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for SLC22A3 Gene



Transcriptomic regulation report from SPP (The Signaling Pathways Project) for SLC22A3

SOURCE GeneReport for Unigene cluster for SLC22A3 Gene:

Hs.567337

mRNA Expression by UniProt/SwissProt for SLC22A3 Gene:

O75751-S22A3_HUMAN
Tissue specificity: Expressed in placenta, skeletal muscle, prostate, aorta, liver, fetal lung, salivary gland, adrenal gland, kidney and brain cortex. No expression detected in spleen.

Evidence on tissue expression from TISSUES for SLC22A3 Gene

  • Kidney(4.4)
  • Liver(2.3)
  • Nervous system(2.3)
  • Muscle(2.2)
genes like me logo Genes that share expression patterns with SLC22A3: view

No data available for Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for SLC22A3 Gene

Orthologs for SLC22A3 Gene

This gene was present in the common ancestor of animals.

Orthologs for SLC22A3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SLC22A3 31 30
  • 99.52 (n)
OneToOne
cow
(Bos Taurus)
Mammalia SLC22A3 31 30
  • 89.49 (n)
OneToOne
dog
(Canis familiaris)
Mammalia SLC22A3 31 30
  • 89.27 (n)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SLC22A3 31
  • 89 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Slc22a3 30
  • 85.48 (n)
mouse
(Mus musculus)
Mammalia Slc22a3 17 31 30
  • 85 (n)
oppossum
(Monodelphis domestica)
Mammalia SLC22A3 31
  • 84 (a)
OneToOne
chicken
(Gallus gallus)
Aves SLC22A3 31 30
  • 72.47 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SLC22A3 31
  • 66 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii zgc:175176 30
  • 54.41 (n)
SLC22A3 31
  • 44 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG8654 32
  • 38 (a)
CG6600 32
  • 33 (a)
Orct 32
  • 31 (a)
CG9317 32
  • 30 (a)
CG13610 32
  • 30 (a)
CG4630 31
  • 29 (a)
ManyToMany
CG3790 32
  • 29 (a)
CG6126 32
  • 29 (a)
CG7458 31 32
  • 27 (a)
ManyToMany
CG7442 31 32
  • 27 (a)
ManyToMany
CG17751 32
  • 27 (a)
CG5592 32
  • 27 (a)
CG6231 32
  • 26 (a)
CG17752 32
  • 26 (a)
CG14857 32
  • 25 (a)
CG7084 32
  • 24 (a)
CG16727 32
  • 24 (a)
worm
(Caenorhabditis elegans)
Secernentea oct-1 32
  • 29 (a)
F52F12.1a 32
  • 29 (a)
K05F1.6 32
  • 27 (a)
B0252.3 32
  • 27 (a)
Y82E9BR.16 32
  • 26 (a)
ZK455.8a 32
  • 26 (a)
ZK455.8b 32
  • 26 (a)
Species where no ortholog for SLC22A3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for SLC22A3 Gene

ENSEMBL:
Gene Tree for SLC22A3 (if available)
TreeFam:
Gene Tree for SLC22A3 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for SLC22A3: view image

Paralogs for SLC22A3 Gene

(14) SIMAP similar genes for SLC22A3 Gene using alignment to 3 proteins:

  • S22A3_HUMAN
  • Q96KH7_HUMAN
  • Q9NQC0_HUMAN

Pseudogenes.org Pseudogenes for SLC22A3 Gene

genes like me logo Genes that share paralogs with SLC22A3: view

Variants for SLC22A3 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for SLC22A3 Gene

SNP ID Clinical significance and condition Chr 06 pos Variation AA Info Type
739756 Likely Benign: not provided 160,348,677(+) C/G SYNONYMOUS_VARIANT
rs8187715 - p.Thr44Met
rs8187717 - p.Ala116Ser

Additional dbSNP identifiers (rs#s) for SLC22A3 Gene

Structural Variations from Database of Genomic Variants (DGV) for SLC22A3 Gene

Variant ID Type Subtype PubMed ID
esv2759484 CNV gain+loss 17122850
esv35098 CNV gain 17911159
esv3611428 CNV gain 21293372
nsv1020357 CNV loss 25217958
nsv1026543 CNV gain 25217958
nsv818463 CNV gain 17921354
nsv969462 CNV duplication 23825009

Variation tolerance for SLC22A3 Gene

Residual Variation Intolerance Score: 11.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.49; 28.97% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SLC22A3 Gene

Human Gene Mutation Database (HGMD)
SLC22A3
SNPedia medical, phenotypic, and genealogical associations of SNPs for
SLC22A3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SLC22A3 Gene

Disorders for SLC22A3 Gene

MalaCards: The human disease database

(4) MalaCards diseases for SLC22A3 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
cerebral palsy, ataxic, autosomal recessive
  • acp
amphetamine abuse
  • amphetamine-related disorders
obsessive-compulsive disorder
  • ocd
asthma
  • asthma, susceptibility to
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for SLC22A3

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with SLC22A3: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SLC22A3 Gene

Publications for SLC22A3 Gene

  1. Structure, function, and regional distribution of the organic cation transporter OCT3 in the kidney. (PMID: 10966924) Wu X … Ganapathy V (American journal of physiology. Renal physiology 2000) 3 4 23 26 54
  2. Expression of organic cation transporters OCT1 (SLC22A1) and OCT3 (SLC22A3) is affected by genetic factors and cholestasis in human liver. (PMID: 19591196) Nies AT … Schaeffeler E (Hepatology (Baltimore, Md.) 2009) 3 23 41 54
  3. Association between gene polymorphisms of SLC22A3 and methamphetamine use disorder. (PMID: 17010131) Aoyama N … Ozaki N (Alcoholism, clinical and experimental research 2006) 3 23 41 54
  4. Cloning of the mouse and human solute carrier 22a3 (Slc22a3/SLC22A3) identifies a conserved cluster of three organic cation transporters on mouse chromosome 17 and human 6q26-q27. (PMID: 9933568) Verhaagh S … Zwart R (Genomics 1999) 2 3 4 54
  5. Cloning and functional characterization of a potential-sensitive, polyspecific organic cation transporter (OCT3) most abundantly expressed in placenta. (PMID: 9632645) Kekuda R … Ganapathy V (The Journal of biological chemistry 1998) 2 3 26 54

Products for SLC22A3 Gene

Sources for SLC22A3 Gene