Aliases for SLC22A3 Gene
External Ids for SLC22A3 Gene
Previous GeneCards Identifiers for SLC22A3 Gene
Polyspecific organic cation transporters in the liver, kidney, intestine, and other organs are critical for elimination of many endogenous small organic cations as well as a wide array of drugs and environmental toxins. This gene is one of three similar cation transporter genes located in a cluster on chromosome 6. The encoded protein contains twelve putative transmembrane domains and is a plasma integral membrane protein. [provided by RefSeq, Jul 2008]
GeneCards Summary for SLC22A3 Gene
SLC22A3 (Solute Carrier Family 22 Member 3) is a Protein Coding gene. Diseases associated with SLC22A3 include Cerebral Palsy, Ataxic, Autosomal Recessive and Amphetamine Abuse. Among its related pathways are Atenolol Pathway, Pharmacokinetics and Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds. Gene Ontology (GO) annotations related to this gene include transmembrane transporter activity and organic cation transmembrane transporter activity. An important paralog of this gene is SLC22A2.
UniProtKB/Swiss-Prot Summary for SLC22A3 Gene
Mediates potential-dependent transport of a variety of organic cations. May play a significant role in the disposition of cationic neurotoxins and neurotransmitters in the brain.