Aliases for SLC22A25 Gene

Aliases for SLC22A25 Gene

  • Solute Carrier Family 22 Member 25 2 3 4 5
  • UST6 2 3 4
  • MGI:2442751, MGI:2385316, MGI:3042283, MGI:3645714, MGI:3605624, MGI:2442750 2 3
  • Organic Anion Transporter UST6 3 4
  • HIMTP 2 3
  • Putative UST1-Like Organic Anion Transporter 3
  • Solute Carrier Family 22, Member 25 2
  • MGC120420 2
  • SLC22A25 5

External Ids for SLC22A25 Gene

Previous GeneCards Identifiers for SLC22A25 Gene

  • GC11M062688
  • GC11M062931
  • GC11M059260
  • GC11M063163
  • GC11M063492

Summaries for SLC22A25 Gene

GeneCards Summary for SLC22A25 Gene

SLC22A25 (Solute Carrier Family 22 Member 25) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include transmembrane transporter activity. An important paralog of this gene is SLC22A9.

Gene Wiki entry for SLC22A25 Gene

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for SLC22A25 Gene

Genomics for SLC22A25 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for SLC22A25 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH11J063243 Enhancer 0.6 FANTOM5 271.2 -0.2 -208 0.7 RXRA JUND HNF4A REST MAX SP1 TAF1 YY1 ATF3 SLC22A25 CCND2P1 lnc-SLC22A25-1 SLC22A10 SLC22A9 SLC22A24
GH11J063241 Enhancer 0.6 Ensembl ENCODE dbSUPER 250.7 +1.6 1622 0.2 ZNF652 CCND2P1 SLC22A25 ENSG00000256863 lnc-SLC22A25-1 SLC22A24 SLC22A10
GH11J063244 Enhancer 0.3 Ensembl dbSUPER 250.7 +0.9 922 0.8 CCND2P1 SLC22A25 ENSG00000256863 lnc-SLC22A25-1 SLC22A24 SLC22A10
GH11J063179 Enhancer 0.6 Ensembl ENCODE 17.1 +62.8 62823 2.6 ETS1 NFE2 ATF2 SLC22A25 SLC22A10 piR-33605-079 SLC22A24
GH11J063245 Enhancer 0.8 dbSUPER 9.5 -4.0 -4017 3.3 CEBPA FOXA1 FOXA2 MAFF SMAD4 SAP130 RXRA MIER3 RARA TEAD3 SLC22A8 SLC22A9 SLC22A25 HSALNG0084689 LOC105369334 lnc-SLC22A25-1 SLC22A10
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around SLC22A25 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for SLC22A25

Top Transcription factor binding sites by QIAGEN in the SLC22A25 gene promoter:
  • E4BP4
  • FAC1
  • GCNF
  • GCNF-1
  • GCNF-2
  • Pax-3
  • Pax-5
  • Pax-6
  • PPAR-gamma1
  • PPAR-gamma2

Genomic Locations for SLC22A25 Gene

Latest Assembly
chr11:63,162,264-63,243,523
(GRCh38/hg38)
Size:
81,260 bases
Orientation:
Minus strand

Previous Assembly
chr11:62,930,642-62,997,124
(GRCh37/hg19 by Entrez Gene)
Size:
66,483 bases
Orientation:
Minus strand

chr11:62,931,248-62,997,124
(GRCh37/hg19 by Ensembl)
Size:
65,877 bases
Orientation:
Minus strand

Genomic View for SLC22A25 Gene

Genes around SLC22A25 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SLC22A25 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SLC22A25 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC22A25 Gene

Proteins for SLC22A25 Gene

  • Protein details for SLC22A25 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6T423-S22AP_HUMAN
    Recommended name:
    Solute carrier family 22 member 25
    Protein Accession:
    Q6T423
    Secondary Accessions:
    • A4FU27

    Protein attributes for SLC22A25 Gene

    Size:
    547 amino acids
    Molecular mass:
    61008 Da
    Quaternary structure:
    No Data Available

neXtProt entry for SLC22A25 Gene

Post-translational modifications for SLC22A25 Gene

  • Glycosylation at Asn56 and Asn102
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for SLC22A25 Gene

Domains & Families for SLC22A25 Gene

Gene Families for SLC22A25 Gene

Protein Domains for SLC22A25 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for SLC22A25 Gene

GenScript: Design optimal peptide antigens:
  • UST6 protein (A4IF28_HUMAN)
  • UST6 protein (A4IF29_HUMAN)
  • UST6 protein (Q494Y1_HUMAN)
  • Organic anion transporter UST6 (S22AP_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q6T423

UniProtKB/Swiss-Prot:

S22AP_HUMAN :
  • Belongs to the major facilitator (TC 2.A.1) superfamily. Organic cation transporter (TC 2.A.1.19) family.
Family:
  • Belongs to the major facilitator (TC 2.A.1) superfamily. Organic cation transporter (TC 2.A.1.19) family.
genes like me logo Genes that share domains with SLC22A25: view

Function for SLC22A25 Gene

Phenotypes From GWAS Catalog for SLC22A25 Gene

Gene Ontology (GO) - Molecular Function for SLC22A25 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0022857 transmembrane transporter activity IEA --
genes like me logo Genes that share ontologies with SLC22A25: view
genes like me logo Genes that share phenotypes with SLC22A25: view

Animal Models for research

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SLC22A25

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for SLC22A25 Gene

Localization for SLC22A25 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC22A25 Gene

Membrane. Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SLC22A25 gene
Compartment Confidence
plasma membrane 3
endoplasmic reticulum 0

Gene Ontology (GO) - Cellular Components for SLC22A25 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with SLC22A25: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for SLC22A25 Gene

Pathways & Interactions for SLC22A25 Gene

PathCards logo

SuperPathways for SLC22A25 Gene

No Data Available

Interacting Proteins for SLC22A25 Gene

Gene Ontology (GO) - Biological Process for SLC22A25 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0015711 organic anion transport IBA 21873635
GO:0055085 transmembrane transport IEA --
genes like me logo Genes that share ontologies with SLC22A25: view

No data available for Pathways by source and SIGNOR curated interactions for SLC22A25 Gene

Drugs & Compounds for SLC22A25 Gene

No Compound Related Data Available

Transcripts for SLC22A25 Gene

mRNA/cDNA for SLC22A25 Gene

1 REFSEQ mRNAs :
10 NCBI additional mRNA sequence :
4 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SLC22A25

Alternative Splicing Database (ASD) splice patterns (SP) for SLC22A25 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b · 9c ^ 10
SP1:
SP2: - - - - -
SP3: - -
SP4: - - - - - - -

Relevant External Links for SLC22A25 Gene

GeneLoc Exon Structure for
SLC22A25

Expression for SLC22A25 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for SLC22A25 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

  • Spleen (Hematopoietic System)
  • Liver (Hepatobiliary System)

mRNA differential expression in normal tissues according to GTEx for SLC22A25 Gene

This gene is overexpressed in Liver (x50.1).

Protein differential expression in normal tissues from HIPED for SLC22A25 Gene

This gene is overexpressed in Adipocyte (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for SLC22A25 Gene



Protein tissue co-expression partners for SLC22A25 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for SLC22A25

SOURCE GeneReport for Unigene cluster for SLC22A25 Gene:

Hs.332119

mRNA Expression by UniProt/SwissProt for SLC22A25 Gene:

Q6T423-S22AP_HUMAN
Tissue specificity: Expressed exclusively in liver in both embryo and adult.

Evidence on tissue expression from TISSUES for SLC22A25 Gene

  • Liver(2.8)
genes like me logo Genes that share expression patterns with SLC22A25: view

Primer products for research

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for SLC22A25 Gene

Orthologs for SLC22A25 Gene

This gene was present in the common ancestor of mammals.

Orthologs for SLC22A25 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia SLC22A25 30 31
  • 98.62 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Slc22a30 30 17 31
  • 69.53 (n)
ManyToMany
Slc22a27 17 31
  • 55 (a)
ManyToMany
Slc22a28 17 31
  • 55 (a)
ManyToMany
Slc22a29 17 31
  • 55 (a)
ManyToMany
Slc22a19 31
  • 55 (a)
ManyToMany
Slc22a26 31
  • 52 (a)
ManyToMany
Cow
(Bos Taurus)
Mammalia -- 31
  • 69 (a)
ManyToMany
-- 31
  • 62 (a)
ManyToMany
Rat
(Rattus norvegicus)
Mammalia Ust5r 30
  • 68.86 (n)
Dog
(Canis familiaris)
Mammalia -- 31
  • 63 (a)
OneToMany
Oppossum
(Monodelphis domestica)
Mammalia -- 31
  • 40 (a)
ManyToMany
-- 31
  • 36 (a)
ManyToMany
Species where no ortholog for SLC22A25 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for SLC22A25 Gene

ENSEMBL:
Gene Tree for SLC22A25 (if available)
TreeFam:
Gene Tree for SLC22A25 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for SLC22A25: view image

Paralogs for SLC22A25 Gene

(15) SIMAP similar genes for SLC22A25 Gene using alignment to 5 proteins:

  • S22AP_HUMAN
  • E9PJ86_HUMAN
  • H0YCA2_HUMAN
  • H0YCS4_HUMAN
  • H7BYX8_HUMAN

Pseudogenes.org Pseudogenes for SLC22A25 Gene

genes like me logo Genes that share paralogs with SLC22A25: view

Variants for SLC22A25 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for SLC22A25 Gene

SNP ID Clinical significance and condition Chr 11 pos Variation AA Info Type
rs11231397 - p.Arg300Thr
rs11231409 - p.Ser250Gly
rs17157907 - p.Gly448Ala
rs35722529 - p.Arg89Cys
rs6591771 - p.Met486Val

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for SLC22A25 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for SLC22A25 Gene

Variant ID Type Subtype PubMed ID
esv2744609 CNV deletion 23290073
esv33721 CNV loss 17666407
esv34011 CNV loss 18971310
esv3626627 CNV loss 21293372
esv3626629 CNV loss 21293372
nsv555177 CNV loss 21841781

Variation tolerance for SLC22A25 Gene

Residual Variation Intolerance Score: 65.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 11.76; 93.34% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SLC22A25 Gene

Human Gene Mutation Database (HGMD)
SLC22A25
SNPedia medical, phenotypic, and genealogical associations of SNPs for
SLC22A25

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SLC22A25 Gene

Disorders for SLC22A25 Gene

Additional Disease Information for SLC22A25

No disorders were found for SLC22A25 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SLC22A25 Gene

Publications for SLC22A25 Gene

  1. Identification of six putative human transporters with structural similarity to the drug transporter SLC22 family. (PMID: 17714910) Jacobsson JA … Fredriksson R (Genomics 2007) 2 3
  2. Novel slc22 transporter homologs in fly, worm, and human clarify the phylogeny of organic anion and cation transporters. (PMID: 15054140) Eraly SA … Nigam SK (Physiological genomics 2004) 3 4
  3. The midbody interactome reveals unexpected roles for PP1 phosphatases in cytokinesis. (PMID: 31586073) Capalbo L … D'Avino PP (Nature communications 2019) 3
  4. Estrogen-regulated feedback loop limits the efficacy of estrogen receptor-targeted breast cancer therapy. (PMID: 29987050) Xiao T … Brown M (Proceedings of the National Academy of Sciences of the United States of America 2018) 3
  5. Identification of TNFSF13, SPATC1L, SLC22A25 and SALL4 as novel susceptibility loci for atrial fibrillation by an exome‑wide association study. (PMID: 28849223) Yamada Y … Tanaka M (Molecular medicine reports 2017) 3

Products for SLC22A25 Gene

Sources for SLC22A25 Gene