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Aliases for SLC22A24 Gene

Aliases for SLC22A24 Gene

  • Solute Carrier Family 22 Member 24 2 3 5
  • Solute Carrier Family 22, Member 24 2
  • NET46 3

External Ids for SLC22A24 Gene

Previous GeneCards Identifiers for SLC22A24 Gene

  • GC11M062644
  • GC11M062603
  • GC11M062847
  • GC11M059176

Summaries for SLC22A24 Gene

Entrez Gene Summary for SLC22A24 Gene

  • SLC22A24 belongs to a large family of transmembrane proteins that function as uniporters, symporters, and antiporters to transport organic ions across cell membranes (Jacobsson et al., 2007 [PubMed 17714910]).[supplied by OMIM, Mar 2008]

GeneCards Summary for SLC22A24 Gene

SLC22A24 (Solute Carrier Family 22 Member 24) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include transmembrane transporter activity. An important paralog of this gene is SLC22A10.

Additional gene information for SLC22A24 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLC22A24 Gene

Genomics for SLC22A24 Gene

GeneHancer (GH) Regulatory Elements for SLC22A24 Gene

Promoters and enhancers for SLC22A24 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH11I063144 Promoter 0.5 EPDnew 550.8 0.0 -38 0.1 SLC22A24 SLC22A10 GC11M063173
GH11I063243 Enhancer 0.7 FANTOM5 2.2 -99.5 -99510 0.7 RXRA TAF1 MAX REST YY1 JUND ATF3 HNF4A SLC22A25 CCND2P1 SLC22A10 SLC22A9 SLC22A24 LOC105369334
GH11I063179 Enhancer 0.3 ENCODE 0.3 -35.5 -35481 0.5 NFE2 SLC22A25 SLC22A24 SLC22A10 GC11M063173
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around SLC22A24 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the SLC22A24 gene promoter:

Genomic Locations for SLC22A24 Gene

Genomic Locations for SLC22A24 Gene
64,967 bases
Minus strand

Genomic View for SLC22A24 Gene

Genes around SLC22A24 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SLC22A24 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SLC22A24 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC22A24 Gene

Proteins for SLC22A24 Gene

  • Protein details for SLC22A24 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Solute carrier family 22 member 24
    Protein Accession:

    Protein attributes for SLC22A24 Gene

    322 amino acids
    Molecular mass:
    35933 Da
    Quaternary structure:
    No Data Available

neXtProt entry for SLC22A24 Gene

Post-translational modifications for SLC22A24 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SLC22A24 Gene

No data available for DME Specific Peptides for SLC22A24 Gene

Domains & Families for SLC22A24 Gene

Gene Families for SLC22A24 Gene

Human Protein Atlas (HPA):
  • Predicted membrane proteins
  • Transporters

Protein Domains for SLC22A24 Gene


Suggested Antigen Peptide Sequences for SLC22A24 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the major facilitator (TC 2.A.1) superfamily. Organic cation transporter (TC 2.A.1.19) family.
  • Belongs to the major facilitator (TC 2.A.1) superfamily. Organic cation transporter (TC 2.A.1.19) family.
genes like me logo Genes that share domains with SLC22A24: view

Function for SLC22A24 Gene

Phenotypes From GWAS Catalog for SLC22A24 Gene

Gene Ontology (GO) - Molecular Function for SLC22A24 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005452 inorganic anion exchanger activity IBA --
GO:0015143 urate transmembrane transporter activity IBA --
GO:0015347 sodium-independent organic anion transmembrane transporter activity IBA --
GO:0022857 transmembrane transporter activity IEA --
genes like me logo Genes that share ontologies with SLC22A24: view
genes like me logo Genes that share phenotypes with SLC22A24: view

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for SLC22A24 Gene

Localization for SLC22A24 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC22A24 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SLC22A24 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for SLC22A24 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005887 integral component of plasma membrane IBA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with SLC22A24: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for SLC22A24 Gene

Pathways & Interactions for SLC22A24 Gene

SuperPathways for SLC22A24 Gene

No Data Available

Interacting Proteins for SLC22A24 Gene

Gene Ontology (GO) - Biological Process for SLC22A24 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport IEA --
GO:0006811 ion transport IEA --
GO:0015698 inorganic anion transport IEA --
GO:0015747 urate transport IBA --
GO:0043252 sodium-independent organic anion transport IBA --
genes like me logo Genes that share ontologies with SLC22A24: view

No data available for Pathways by source and SIGNOR curated interactions for SLC22A24 Gene

Drugs & Compounds for SLC22A24 Gene

No Compound Related Data Available

Transcripts for SLC22A24 Gene

mRNA/cDNA for SLC22A24 Gene

(3) REFSEQ mRNAs :
(1) Additional mRNA sequences :
(5) Selected AceView cDNA sequences:
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for SLC22A24 Gene

Solute carrier family 22, member 24:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for SLC22A24 Gene

No ASD Table

Relevant External Links for SLC22A24 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SLC22A24 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SLC22A24 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SLC22A24 Gene

This gene is overexpressed in Kidney - Cortex (x34.1) and Liver (x14.1).

NURSA nuclear receptor signaling pathways regulating expression of SLC22A24 Gene:


SOURCE GeneReport for Unigene cluster for SLC22A24 Gene:

genes like me logo Genes that share expression patterns with SLC22A24: view

No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for SLC22A24 Gene

Orthologs for SLC22A24 Gene

This gene was present in the common ancestor of mammals.

Orthologs for SLC22A24 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia SLC22A24 34
  • 98 (a)
(Canis familiaris)
Mammalia SLC22A9 33
  • 74.52 (n)
(Bos Taurus)
Mammalia SLC22A9 33
  • 73.67 (n)
-- 34
  • 64 (a)
(Rattus norvegicus)
Mammalia Slc22a24 33
  • 67.51 (n)
(Mus musculus)
Mammalia Slc22a19 33 16
  • 67.15 (n)
Slc22a27 34
  • 53 (a)
(Monodelphis domestica)
Mammalia -- 34
  • 42 (a)
-- 34
  • 39 (a)
Species where no ortholog for SLC22A24 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for SLC22A24 Gene

Gene Tree for SLC22A24 (if available)
Gene Tree for SLC22A24 (if available)

Paralogs for SLC22A24 Gene

(15) SIMAP similar genes for SLC22A24 Gene using alignment to 2 proteins: Pseudogenes for SLC22A24 Gene

genes like me logo Genes that share paralogs with SLC22A24: view

Variants for SLC22A24 Gene

Sequence variations from dbSNP and Humsavar for SLC22A24 Gene

SNP ID Clin Chr 11 pos Variation AA Info Type
rs1000036229 -- 63,122,294(-) C/A genic_downstream_transcript_variant, intron_variant
rs1000069082 -- 63,131,385(-) C/T intron_variant
rs1000113970 -- 63,099,015(-) A/T genic_downstream_transcript_variant, intron_variant
rs1000153748 -- 63,136,294(-) C/T intron_variant
rs1000160257 -- 63,108,775(-) G/T genic_downstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for SLC22A24 Gene

Variant ID Type Subtype PubMed ID
dgv663n106 CNV deletion 24896259
esv1159693 CNV deletion 17803354
esv1629652 CNV insertion 17803354
esv2744607 CNV deletion 23290073
esv34011 CNV loss 18971310
esv3547889 CNV deletion 23714750
nsv1046221 CNV gain 25217958
nsv1070463 CNV deletion 25765185
nsv1120086 OTHER inversion 24896259
nsv468587 CNV loss 19166990
nsv472906 CNV novel sequence insertion 20440878
nsv517447 CNV loss 19592680
nsv522971 CNV loss 19592680
nsv555176 CNV loss 21841781
nsv555177 CNV loss 21841781
nsv957227 CNV deletion 24416366

Variation tolerance for SLC22A24 Gene

Gene Damage Index Score: 11.00; 92.06% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SLC22A24 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SLC22A24 Gene

Disorders for SLC22A24 Gene

Additional Disease Information for SLC22A24

No disorders were found for SLC22A24 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SLC22A24 Gene

Publications for SLC22A24 Gene

  1. Identification of six putative human transporters with structural similarity to the drug transporter SLC22 family. (PMID: 17714910) Jacobsson JA … Fredriksson R (Genomics 2007) 2 3 4 58
  2. Genome-wide association study of maternal and inherited loci for conotruncal heart defects. (PMID: 24800985) Agopian AJ … Goldmuntz E (PloS one 2014) 3 58
  3. Towards a proteome-scale map of the human protein-protein interaction network. (PMID: 16189514) Rual JF … Vidal M (Nature 2005) 3 58
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 4 58
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 3 58

Products for SLC22A24 Gene

Sources for SLC22A24 Gene

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