SLC22A23 belongs to a large family of transmembrane proteins that function as uniporters, symporters, and antiporters to transport organic ions across cell membranes (Jacobsson et al., 2007 [PubMed 17714910]).[supplied by OMIM, Mar 2008] See more...

Aliases for SLC22A23 Gene

Aliases for SLC22A23 Gene

  • Solute Carrier Family 22 Member 23 2 3 4 5
  • C6orf85 3 4
  • Solute Carrier Family 22, Member 23 2
  • Chromosome 6 Open Reading Frame 85 2
  • Ion Transporter Protein 3

External Ids for SLC22A23 Gene

Previous HGNC Symbols for SLC22A23 Gene

  • C6orf85

Previous GeneCards Identifiers for SLC22A23 Gene

  • GC06M003216
  • GC06M003147

Summaries for SLC22A23 Gene

Entrez Gene Summary for SLC22A23 Gene

  • SLC22A23 belongs to a large family of transmembrane proteins that function as uniporters, symporters, and antiporters to transport organic ions across cell membranes (Jacobsson et al., 2007 [PubMed 17714910]).[supplied by OMIM, Mar 2008]

GeneCards Summary for SLC22A23 Gene

SLC22A23 (Solute Carrier Family 22 Member 23) is a Protein Coding gene. Diseases associated with SLC22A23 include Laryngeal Benign Neoplasm and Wolf-Hirschhorn Syndrome. Gene Ontology (GO) annotations related to this gene include transmembrane transporter activity. An important paralog of this gene is SLC22A17.

Additional gene information for SLC22A23 Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for SLC22A23 Gene

Genomics for SLC22A23 Gene

GeneHancer (GH) Regulatory Elements for SLC22A23 Gene


GeneHancers around SLC22A23 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for SLC22A23

Top Transcription factor binding sites by QIAGEN in the SLC22A23 gene promoter:
  • Arnt
  • Egr-4
  • PPAR-gamma1
  • PPAR-gamma2
  • Sox5
  • SREBP-1a
  • SREBP-1b
  • SREBP-1c

Genomic Locations for SLC22A23 Gene

Genomic Locations for SLC22A23 Gene
chr6:3,268,962-3,457,022
(GRCh38/hg38)
Size:
188,061 bases
Orientation:
Minus strand
chr6:3,269,196-3,457,256
(GRCh37/hg19)
Size:
188,061 bases
Orientation:
Minus strand

Genomic View for SLC22A23 Gene

Genes around SLC22A23 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SLC22A23 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SLC22A23 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC22A23 Gene

Proteins for SLC22A23 Gene

  • Protein details for SLC22A23 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A1A5C7-S22AN_HUMAN
    Recommended name:
    Solute carrier family 22 member 23
    Protein Accession:
    A1A5C7
    Secondary Accessions:
    • A1A5C8
    • Q5T8B8
    • Q6ZMH3
    • Q8IW73

    Protein attributes for SLC22A23 Gene

    Size:
    686 amino acids
    Molecular mass:
    73748 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAD18753.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for SLC22A23 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SLC22A23 Gene

Post-translational modifications for SLC22A23 Gene

  • Glycosylation at Asn24, Thr143, and Asn279
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for SLC22A23 Gene

Domains & Families for SLC22A23 Gene

Gene Families for SLC22A23 Gene

Protein Domains for SLC22A23 Gene

Suggested Antigen Peptide Sequences for SLC22A23 Gene

GenScript: Design optimal peptide antigens:
  • Chromosome 6 open reading frame 85 (Q5JS57_HUMAN)
  • SLC22A23 protein (Q7L9D0_HUMAN)
  • Solute carrier family 22 member 23 (S22AN_HUMAN)

Graphical View of Domain Structure for InterPro Entry

A1A5C7

UniProtKB/Swiss-Prot:

S22AN_HUMAN :
  • Belongs to the major facilitator (TC 2.A.1) superfamily. Organic cation transporter (TC 2.A.1.19) family.
Family:
  • Belongs to the major facilitator (TC 2.A.1) superfamily. Organic cation transporter (TC 2.A.1.19) family.
genes like me logo Genes that share domains with SLC22A23: view

Function for SLC22A23 Gene

Phenotypes From GWAS Catalog for SLC22A23 Gene

Gene Ontology (GO) - Molecular Function for SLC22A23 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
GO:0022857 transmembrane transporter activity IEA --
genes like me logo Genes that share ontologies with SLC22A23: view
genes like me logo Genes that share phenotypes with SLC22A23: view

Animal Model Products

CRISPR Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SLC22A23 Gene

Localization for SLC22A23 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC22A23 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SLC22A23 gene
Compartment Confidence
plasma membrane 3
nucleus 2
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Nucleoplasm (2)
  • Vesicles (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for SLC22A23 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with SLC22A23: view

Pathways & Interactions for SLC22A23 Gene

PathCards logo

SuperPathways for SLC22A23 Gene

No Data Available

Gene Ontology (GO) - Biological Process for SLC22A23 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006811 ion transport IEA --
GO:0055085 transmembrane transport IEA --
genes like me logo Genes that share ontologies with SLC22A23: view

No data available for Pathways by source and SIGNOR curated interactions for SLC22A23 Gene

Drugs & Compounds for SLC22A23 Gene

No Compound Related Data Available

Transcripts for SLC22A23 Gene

mRNA/cDNA for SLC22A23 Gene

4 REFSEQ mRNAs :
17 NCBI additional mRNA sequence :
12 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for SLC22A23 Gene

No ASD Table

Relevant External Links for SLC22A23 Gene

GeneLoc Exon Structure for
SLC22A23

Expression for SLC22A23 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for SLC22A23 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for SLC22A23 Gene

This gene is overexpressed in Fetal Brain (49.3) and Frontal cortex (17.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for SLC22A23 Gene



Protein tissue co-expression partners for SLC22A23 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for SLC22A23

SOURCE GeneReport for Unigene cluster for SLC22A23 Gene:

Hs.713588

Evidence on tissue expression from TISSUES for SLC22A23 Gene

  • Intestine(4.2)
  • Nervous system(3.7)
genes like me logo Genes that share expression patterns with SLC22A23: view

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for SLC22A23 Gene

Orthologs for SLC22A23 Gene

This gene was present in the common ancestor of chordates.

Orthologs for SLC22A23 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SLC22A23 31 30
  • 98.3 (n)
OneToOne
dog
(Canis familiaris)
Mammalia SLC22A23 31 30
  • 91.69 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Slc22a23 30
  • 89.23 (n)
mouse
(Mus musculus)
Mammalia Slc22a23 17 31 30
  • 89.18 (n)
cow
(Bos Taurus)
Mammalia SLC22A23 31 30
  • 87.41 (n)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SLC22A23 31
  • 78 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SLC22A23 31
  • 59 (a)
OneToOne
chicken
(Gallus gallus)
Aves SLC22A23 31 30
  • 79.16 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia -- 31
  • 62 (a)
OneToMany
-- 31
  • 59 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia slc22a23 30
  • 68.41 (n)
zebrafish
(Danio rerio)
Actinopterygii SLC22A23 (2 of 3) 31
  • 60 (a)
OneToMany
SLC22A23 (3 of 3) 31
  • 47 (a)
OneToMany
SLC22A23 (1 of 3) 31
  • 38 (a)
OneToMany
Species where no ortholog for SLC22A23 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SLC22A23 Gene

ENSEMBL:
Gene Tree for SLC22A23 (if available)
TreeFam:
Gene Tree for SLC22A23 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for SLC22A23: view image

Paralogs for SLC22A23 Gene

(4) SIMAP similar genes for SLC22A23 Gene using alignment to 6 proteins:

  • S22AN_HUMAN
  • C9IZW5_HUMAN
  • C9J4Z0_HUMAN
  • F8WBC7_HUMAN
  • H7C4T9_HUMAN
  • Q7L9D0_HUMAN
genes like me logo Genes that share paralogs with SLC22A23: view

Variants for SLC22A23 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for SLC22A23 Gene

SNP ID Clinical significance and condition Chr 06 pos Variation AA Info Type
719434 Benign: not provided 3,283,860(-) C/T NON_CODING_TRANSCRIPT_VARIANT,SYNONYMOUS_VARIANT
790986 Benign: not provided 3,273,379(-) C/T NON_CODING_TRANSCRIPT_VARIANT,SYNONYMOUS_VARIANT
792031 Benign: not provided 3,273,382(-) G/A NON_CODING_TRANSCRIPT_VARIANT,SYNONYMOUS_VARIANT

Additional dbSNP identifiers (rs#s) for SLC22A23 Gene

Structural Variations from Database of Genomic Variants (DGV) for SLC22A23 Gene

Variant ID Type Subtype PubMed ID
dgv1163e214 CNV loss 21293372
dgv3257n106 CNV deletion 24896259
esv2167684 CNV deletion 18987734
esv24289 CNV loss 19812545
esv2461941 CNV insertion 19546169
esv2669587 CNV deletion 23128226
esv2678916 CNV deletion 23128226
esv2731491 CNV deletion 23290073
esv2731492 CNV deletion 23290073
esv2731493 CNV deletion 23290073
esv2731494 CNV deletion 23290073
esv3607929 CNV gain 21293372
esv3607931 CNV loss 21293372
nsv1074904 CNV deletion 25765185

Variation tolerance for SLC22A23 Gene

Residual Variation Intolerance Score: 10.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.32; 26.28% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SLC22A23 Gene

Human Gene Mutation Database (HGMD)
SLC22A23
SNPedia medical, phenotypic, and genealogical associations of SNPs for
SLC22A23

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SLC22A23 Gene

Disorders for SLC22A23 Gene

MalaCards: The human disease database

(2) MalaCards diseases for SLC22A23 Gene - From: DISEASES

Disorder Aliases PubMed IDs
laryngeal benign neoplasm
  • laryngeal tumor
wolf-hirschhorn syndrome
  • whs
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for SLC22A23

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with SLC22A23: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SLC22A23 Gene

Publications for SLC22A23 Gene

  1. Identification of six putative human transporters with structural similarity to the drug transporter SLC22 family. (PMID: 17714910) Jacobsson JA … Fredriksson R (Genomics 2007) 2 3 4 54
  2. Genome-wide association study of antipsychotic-induced QTc interval prolongation. (PMID: 20921969) Aberg K … van den Oord EJ (The pharmacogenomics journal 2012) 3 41 54
  3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 41 54
  4. Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci. (PMID: 21102463) Franke A … Parkes M (Nature genetics 2010) 3 41 54
  5. Analysis of 39 Crohn's disease risk loci in Swedish inflammatory bowel disease patients. (PMID: 19760754) Törkvist L … Pettersson S (Inflammatory bowel diseases 2010) 3 41 54

Products for SLC22A23 Gene

Sources for SLC22A23 Gene