Aliases for SLC22A2 Gene
External Ids for SLC22A2 Gene
Previous GeneCards Identifiers for SLC22A2 Gene
Polyspecific organic cation transporters in the liver, kidney, intestine, and other organs are critical for elimination of many endogenous small organic cations as well as a wide array of drugs and environmental toxins. This gene is one of three similar cation transporter genes located in a cluster on chromosome 6. The encoded protein contains twelve putative transmembrane domains and is a plasma integral membrane protein. It is found primarily in the kidney, where it may mediate the first step in cation reabsorption. [provided by RefSeq, Jul 2008]
GeneCards Summary for SLC22A2 Gene
SLC22A2 (Solute Carrier Family 22 Member 2) is a Protein Coding gene. Diseases associated with SLC22A2 include Carnitine Deficiency, Systemic Primary and Mediastinal Gray Zone Lymphoma. Among its related pathways are Atenolol Pathway, Pharmacokinetics and PEDF Induced Signaling. Gene Ontology (GO) annotations related to this gene include transmembrane transporter activity and ion transmembrane transporter activity. An important paralog of this gene is SLC22A1.
UniProtKB/Swiss-Prot Summary for SLC22A2 Gene
Mediates tubular uptake of organic compounds from circulation. Mediates the influx of agmatine, dopamine, noradrenaline (norepinephrine), serotonin, choline, famotidine, ranitidine, histamine, creatinine, amantadine, memantine, acriflavine, 4-[4-(dimethylamino)-styryl]-N-methylpyridinium ASP, amiloride, metformin, N-1-methylnicotinamide (NMN), tetraethylammonium (TEA), 1-methyl-4-phenylpyridinium (MPP), cimetidine, cisplatin and oxaliplatin. Cisplatin may develop a nephrotoxic action. Transport of creatinine is inhibited by fluoroquinolones such as DX-619 and LVFX. This transporter is a major determinant of the anticancer activity of oxaliplatin and may contribute to antitumor specificity.