Polyspecific organic cation transporters in the liver, kidney, intestine, and other organs are critical for elimination of many endogenous small organic cations as well as a wide array of drugs and environmental toxins. This gene is one of three similar cation transporter genes located in a cluster on chromosome 6. The encoded protein contains twelve putative transmembrane doma... See more...

Aliases for SLC22A2 Gene

Aliases for SLC22A2 Gene

  • Solute Carrier Family 22 Member 2 2 3 4 5
  • Organic Cation Transporter 2 2 3 4
  • Solute Carrier Family 22 (Organic Cation Transporter), Member 2 2 3
  • OCT2 3 4
  • HOCT2 4

External Ids for SLC22A2 Gene

Previous GeneCards Identifiers for SLC22A2 Gene

  • GC06M160077
  • GC06M160511
  • GC06M160547
  • GC06M160608
  • GC06M160557
  • GC06M160592
  • GC06M158107

Summaries for SLC22A2 Gene

Entrez Gene Summary for SLC22A2 Gene

  • Polyspecific organic cation transporters in the liver, kidney, intestine, and other organs are critical for elimination of many endogenous small organic cations as well as a wide array of drugs and environmental toxins. This gene is one of three similar cation transporter genes located in a cluster on chromosome 6. The encoded protein contains twelve putative transmembrane domains and is a plasma integral membrane protein. It is found primarily in the kidney, where it may mediate the first step in cation reabsorption. [provided by RefSeq, Jul 2008]

GeneCards Summary for SLC22A2 Gene

SLC22A2 (Solute Carrier Family 22 Member 2) is a Protein Coding gene. Diseases associated with SLC22A2 include Carnitine Deficiency, Systemic Primary and Mediastinal Gray Zone Lymphoma. Among its related pathways are Atenolol Pathway, Pharmacokinetics and Neurotransmitter Release Cycle. Gene Ontology (GO) annotations related to this gene include transmembrane transporter activity and ion transmembrane transporter activity. An important paralog of this gene is SLC22A1.

UniProtKB/Swiss-Prot Summary for SLC22A2 Gene

  • Mediates tubular uptake of organic compounds from circulation. Mediates the influx of agmatine, dopamine, noradrenaline (norepinephrine), serotonin, choline, famotidine, ranitidine, histamine, creatinine, amantadine, memantine, acriflavine, 4-[4-(dimethylamino)-styryl]-N-methylpyridinium ASP, amiloride, metformin, N-1-methylnicotinamide (NMN), tetraethylammonium (TEA), 1-methyl-4-phenylpyridinium (MPP), cimetidine, cisplatin and oxaliplatin. Cisplatin may develop a nephrotoxic action. Transport of creatinine is inhibited by fluoroquinolones such as DX-619 and LVFX. This transporter is a major determinant of the anticancer activity of oxaliplatin and may contribute to antitumor specificity.

Gene Wiki entry for SLC22A2 Gene

Additional gene information for SLC22A2 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for SLC22A2 Gene

Genomics for SLC22A2 Gene

GeneHancer (GH) Regulatory Elements for SLC22A2 Gene

Promoters and enhancers for SLC22A2 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH06J160258 Promoter/Enhancer 1 EPDnew Ensembl 500.4 +17.8 17837 2.8 ZSCAN5C ZIC2 TRIM28 EP300 OSR2 CEBPB KLF8 KLF17 PRDM6 FEZF1 HSALNG0054814 SLC22A2 SLC22A3 RF01045-137
GH06J160278 Enhancer 0.5 FANTOM5 Ensembl 500.7 -1.5 -1519 0.5 NR3C1 SLC22A2 LPA KY945955
GH06J160275 Enhancer 0.2 Ensembl 500.7 +1.3 1337 0.6 SLC22A2 SLC22A3 ENSG00000230234 LOC105378088
GH06J160299 Enhancer 0.9 Ensembl ENCODE 12.4 -23.1 -23080 2.2 NRF1 POLR2A ZBTB11 GABPA SAP130 GABPB1 USF1 NFE2 STAT3 MAX SLC22A3 SLC22A2 piR-37656-252
GH06J160237 Enhancer 0.9 Ensembl ENCODE 11 +38.3 38337 5 ZBTB11 REST EP300 CTBP1 GABPA CEBPG SRF FOSL2 CEBPB POLR2H piR-61126 SLC22A3 SLC22A2 RF01045-137
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around SLC22A2 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for SLC22A2

Top Transcription factor binding sites by QIAGEN in the SLC22A2 gene promoter:
  • ATF-2
  • Bach2
  • Evi-1
  • FOXO1
  • NF-kappaB
  • NF-kappaB1
  • Roaz
  • S8
  • XBP-1
  • YY1

Genomic Locations for SLC22A2 Gene

Genomic Locations for SLC22A2 Gene
chr6:160,171,061-160,277,638
(GRCh38/hg38)
Size:
106,578 bases
Orientation:
Minus strand
chr6:160,592,093-160,698,670
(GRCh37/hg19)
Size:
106,578 bases
Orientation:
Minus strand

Genomic View for SLC22A2 Gene

Genes around SLC22A2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SLC22A2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SLC22A2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC22A2 Gene

Proteins for SLC22A2 Gene

  • Protein details for SLC22A2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O15244-S22A2_HUMAN
    Recommended name:
    Solute carrier family 22 member 2
    Protein Accession:
    O15244
    Secondary Accessions:
    • Q5T7Q6
    • Q6PIQ8
    • Q8NG62
    • Q9NQB9

    Protein attributes for SLC22A2 Gene

    Size:
    555 amino acids
    Molecular mass:
    62581 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for SLC22A2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SLC22A2 Gene

Post-translational modifications for SLC22A2 Gene

  • Glycosylation at Asn72
  • Modification sites at PhosphoSitePlus

Other Protein References for SLC22A2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SLC22A2 Gene

Domains & Families for SLC22A2 Gene

Gene Families for SLC22A2 Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • Predicted membrane proteins
  • Transporters

Protein Domains for SLC22A2 Gene

Blocks:
  • Sugar transporter superfamily
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for SLC22A2 Gene

GenScript: Design optimal peptide antigens:
  • Organic cation transporter 2 (S22A2_HUMAN)

Graphical View of Domain Structure for InterPro Entry

O15244

UniProtKB/Swiss-Prot:

S22A2_HUMAN :
  • Belongs to the major facilitator (TC 2.A.1) superfamily. Organic cation transporter (TC 2.A.1.19) family.
Family:
  • Belongs to the major facilitator (TC 2.A.1) superfamily. Organic cation transporter (TC 2.A.1.19) family.
genes like me logo Genes that share domains with SLC22A2: view

Function for SLC22A2 Gene

Molecular function for SLC22A2 Gene

UniProtKB/Swiss-Prot Function:
Mediates tubular uptake of organic compounds from circulation. Mediates the influx of agmatine, dopamine, noradrenaline (norepinephrine), serotonin, choline, famotidine, ranitidine, histamine, creatinine, amantadine, memantine, acriflavine, 4-[4-(dimethylamino)-styryl]-N-methylpyridinium ASP, amiloride, metformin, N-1-methylnicotinamide (NMN), tetraethylammonium (TEA), 1-methyl-4-phenylpyridinium (MPP), cimetidine, cisplatin and oxaliplatin. Cisplatin may develop a nephrotoxic action. Transport of creatinine is inhibited by fluoroquinolones such as DX-619 and LVFX. This transporter is a major determinant of the anticancer activity of oxaliplatin and may contribute to antitumor specificity.
UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: KM=1 mM for agmatine {ECO:0000269 PubMed:11758759, ECO:0000269 PubMed:12089365, ECO:0000269 PubMed:12538837, ECO:0000269 PubMed:15783073, ECO:0000269 PubMed:16006492, ECO:0000269 PubMed:16272756, ECO:0000269 PubMed:16394027, ECO:0000269 PubMed:9687576}; KM=95 uM for amiloride {ECO:0000269 PubMed:11758759, ECO:0000269 PubMed:12089365, ECO:0000269 PubMed:12538837, ECO:0000269 PubMed:15783073, ECO:0000269 PubMed:16006492, ECO:0000269 PubMed:16272756, ECO:0000269 PubMed:16394027, ECO:0000269 PubMed:9687576}; KM=24 uM for ASP {ECO:0000269 PubMed:11758759, ECO:0000269 PubMed:12089365, ECO:0000269 PubMed:12538837, ECO:0000269 PubMed:15783073, ECO:0000269 PubMed:16006492, ECO:0000269 PubMed:16272756, ECO:0000269 PubMed:16394027, ECO:0000269 PubMed:9687576}; KM=34 uM for memantine {ECO:0000269 PubMed:11758759, ECO:0000269 PubMed:12089365, ECO:0000269 PubMed:12538837, ECO:0000269 PubMed:15783073, ECO:0000269 PubMed:16006492, ECO:0000269 PubMed:16272756, ECO:0000269 PubMed:16394027, ECO:0000269 PubMed:9687576}; KM=27 uM for amantadine {ECO:0000269 PubMed:11758759, ECO:0000269 PubMed:12089365, ECO:0000269 PubMed:12538837, ECO:0000269 PubMed:15783073, ECO:0000269 PubMed:16006492, ECO:0000269 PubMed:16272756, ECO:0000269 PubMed:16394027, ECO:0000269 PubMed:9687576}; KM=1.38 mM for metformin {ECO:0000269 PubMed:11758759, ECO:0000269 PubMed:12089365, ECO:0000269 PubMed:12538837, ECO:0000269 PubMed:15783073, ECO:0000269 PubMed:16006492, ECO:0000269 PubMed:16272756, ECO:0000269 PubMed:16394027, ECO:0000269 PubMed:9687576}; KM=1.9 mM for noradrenaline {ECO:0000269 PubMed:11758759, ECO:0000269 PubMed:12089365, ECO:0000269 PubMed:12538837, ECO:0000269 PubMed:15783073, ECO:0000269 PubMed:16006492, ECO:0000269 PubMed:16272756, ECO:0000269 PubMed:16394027, ECO:0000269 PubMed:9687576}; KM=1.9 mM for norepinephrine {ECO:0000269 PubMed:11758759, ECO:0000269 PubMed:12089365, ECO:0000269 PubMed:12538837, ECO:0000269 PubMed:15783073, ECO:0000269 PubMed:16006492, ECO:0000269 PubMed:16272756, ECO:0000269 PubMed:16394027, ECO:0000269 PubMed:9687576}; KM=1.3 mM for histamine {ECO:0000269 PubMed:11758759, ECO:0000269 PubMed:12089365, ECO:0000269 PubMed:12538837, ECO:0000269 PubMed:15783073, ECO:0000269 PubMed:16006492, ECO:0000269 PubMed:16272756, ECO:0000269 PubMed:16394027, ECO:0000269 PubMed:9687576}; KM=0.39 mM for dopamine {ECO:0000269 PubMed:11758759, ECO:0000269 PubMed:12089365, ECO:0000269 PubMed:12538837, ECO:0000269 PubMed:15783073, ECO:0000269 PubMed:16006492, ECO:0000269 PubMed:16272756, ECO:0000269 PubMed:16394027, ECO:0000269 PubMed:9687576}; KM=0.08 mM for serotonin {ECO:0000269 PubMed:11758759, ECO:0000269 PubMed:12089365, ECO:0000269 PubMed:12538837, ECO:0000269 PubMed:15783073, ECO:0000269 PubMed:16006492, ECO:0000269 PubMed:16272756, ECO:0000269 PubMed:16394027, ECO:0000269 PubMed:9687576}; KM=72.6 uM for cimetidine (at pH 7.4 and 37 degrees Celsius) {ECO:0000269 PubMed:11758759, ECO:0000269 PubMed:12089365, ECO:0000269 PubMed:12538837, ECO:0000269 PubMed:15783073, ECO:0000269 PubMed:16006492, ECO:0000269 PubMed:16272756, ECO:0000269 PubMed:16394027, ECO:0000269 PubMed:9687576}; KM=56.1 uM for famotidine {ECO:0000269 PubMed:11758759, ECO:0000269 PubMed:12089365, ECO:0000269 PubMed:12538837, ECO:0000269 PubMed:15783073, ECO:0000269 PubMed:16006492, ECO:0000269 PubMed:16272756, ECO:0000269 PubMed:16394027, ECO:0000269 PubMed:9687576}; KM=65.2 uM for ranitidine {ECO:0000269 PubMed:11758759, ECO:0000269 PubMed:12089365, ECO:0000269 PubMed:12538837, ECO:0000269 PubMed:15783073, ECO:0000269 PubMed:16006492, ECO:0000269 PubMed:16272756, ECO:0000269 PubMed:16394027, ECO:0000269 PubMed:9687576}; KM=431 uM for TEA (isoform 1) {ECO:0000269 PubMed:11758759, ECO:0000269 PubMed:12089365, ECO:0000269 PubMed:12538837, ECO:0000269 PubMed:15783073, ECO:0000269 PubMed:16006492, ECO:0000269 PubMed:16272756, ECO:0000269 PubMed:16394027, ECO:0000269 PubMed:9687576}; KM=63 uM for TEA (isoform 2) {ECO:0000269 PubMed:11758759, ECO:0000269 PubMed:12089365, ECO:0000269 PubMed:12538837, ECO:0000269 PubMed:15783073, ECO:0000269 PubMed:16006492, ECO:0000269 PubMed:16272756, ECO:0000269 PubMed:16394027, ECO:0000269 PubMed:9687576}; Vmax=3770 pmol/min/mg enzyme for TEA uptake (isoform 1) {ECO:0000269 PubMed:11758759, ECO:0000269 PubMed:12089365, ECO:0000269 PubMed:12538837, ECO:0000269 PubMed:15783073, ECO:0000269 PubMed:16006492, ECO:0000269 PubMed:16272756, ECO:0000269 PubMed:16394027, ECO:0000269 PubMed:9687576}; Vmax=314 pmol/min/mg enzyme for TEA uptake (isoform 2) {ECO:0000269 PubMed:11758759, ECO:0000269 PubMed:12089365, ECO:0000269 PubMed:12538837, ECO:0000269 PubMed:15783073, ECO:0000269 PubMed:16006492, ECO:0000269 PubMed:16272756, ECO:0000269 PubMed:16394027, ECO:0000269 PubMed:9687576}; Vmax=11.9 nmol/min/mg enzyme for metformin uptake {ECO:0000269 PubMed:11758759, ECO:0000269 PubMed:12089365, ECO:0000269 PubMed:12538837, ECO:0000269 PubMed:15783073, ECO:0000269 PubMed:16006492, ECO:0000269 PubMed:16272756, ECO:0000269 PubMed:16394027, ECO:0000269 PubMed:9687576}; Vmax=2170 pmol/min/mg enzyme for cimetidine uptake {ECO:0000269 PubMed:11758759, ECO:0000269 PubMed:12089365, ECO:0000269 PubMed:12538837, ECO:0000269 PubMed:15783073, ECO:0000269 PubMed:16006492, ECO:0000269 PubMed:16272756, ECO:0000269 PubMed:16394027, ECO:0000269 PubMed:9687576}; Vmax=204 pmol/min/mg enzyme for famotidine uptake {ECO:0000269 PubMed:11758759, ECO:0000269 PubMed:12089365, ECO:0000269 PubMed:12538837, ECO:0000269 PubMed:15783073, ECO:0000269 PubMed:16006492, ECO:0000269 PubMed:16272756, ECO:0000269 PubMed:16394027, ECO:0000269 PubMed:9687576}; Vmax=265 pmol/min/mg enzyme for ranitidine uptake {ECO:0000269 PubMed:11758759, ECO:0000269 PubMed:12089365, ECO:0000269 PubMed:12538837, ECO:0000269 PubMed:15783073, ECO:0000269 PubMed:16006492, ECO:0000269 PubMed:16272756, ECO:0000269 PubMed:16394027, ECO:0000269 PubMed:9687576};
UniProtKB/Swiss-Prot Induction:
May be down-regulated in diabetic patients.
GENATLAS Biochemistry:
solute carrier family 22,member A2,polyspecific transporter oforganic cations,mainly expressed in kidney (luminal membrane of distal tube)

Phenotypes From GWAS Catalog for SLC22A2 Gene

Gene Ontology (GO) - Molecular Function for SLC22A2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0015101 organic cation transmembrane transporter activity TAS,IDA 16024787
GO:0022857 transmembrane transporter activity IEA --
genes like me logo Genes that share ontologies with SLC22A2: view
genes like me logo Genes that share phenotypes with SLC22A2: view

Animal Models for SLC22A2 Gene

MGI Knock Outs for SLC22A2:

Animal Model Products

CRISPR Products

miRNA for SLC22A2 Gene

miRTarBase miRNAs that target SLC22A2

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SLC22A2

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for SLC22A2 Gene

Localization for SLC22A2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC22A2 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SLC22A2 gene
Compartment Confidence
plasma membrane 5
extracellular 2
mitochondrion 2
nucleus 2
cytoskeleton 1
peroxisome 1
endoplasmic reticulum 1
endosome 1
cytosol 1
lysosome 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for SLC22A2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane TAS 9260930
GO:0016020 membrane IEA,TAS 9260930
GO:0016021 integral component of membrane IEA --
GO:0070062 extracellular exosome HDA 19056867
genes like me logo Genes that share ontologies with SLC22A2: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for SLC22A2 Gene

Pathways & Interactions for SLC22A2 Gene

genes like me logo Genes that share pathways with SLC22A2: view

Interacting Proteins for SLC22A2 Gene

;

Gene Ontology (GO) - Biological Process for SLC22A2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006811 ion transport IEA --
GO:0006812 cation transport IEA --
GO:0006855 drug transmembrane transport TAS --
GO:0007269 neurotransmitter secretion TAS --
GO:0007589 body fluid secretion TAS 9260930
genes like me logo Genes that share ontologies with SLC22A2: view

No data available for SIGNOR curated interactions for SLC22A2 Gene

Drugs & Compounds for SLC22A2 Gene

(117) Drugs for SLC22A2 Gene - From: DrugBank, PharmGKB, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Cisplatin Approved Pharma Transporter, substrate, inhibitor Inhibits DNA synthesis,chemotherapy drug, Potent pro-apoptotic anticancer agent; activates caspase-3, Platinum 3311
Metformin Approved Pharma Transporter, substrate, inhibitor AMP-activated protein kinase (AMPK) activator 2154
Cimetidine Approved, Investigational Pharma Inhibition, Inhibitor, Transporter, substrate, inhibitor H2 receptor antagonist 100
Desipramine Approved, Investigational Pharma Transporter, inhibitor 41
Dopamine Approved Pharma Full agonist, Agonist, Transporter, substrate, inhibitor 4787

(15) Additional Compounds for SLC22A2 Gene - From: HMDB and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
N-desmethylimatinib
  • CGP74588
genes like me logo Genes that share compounds with SLC22A2: view

Transcripts for SLC22A2 Gene

mRNA/cDNA for SLC22A2 Gene

2 REFSEQ mRNAs :
5 NCBI additional mRNA sequence :
6 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SLC22A2

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for SLC22A2 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b
SP1: -
SP2: -
SP3:

Relevant External Links for SLC22A2 Gene

GeneLoc Exon Structure for
SLC22A2

Expression for SLC22A2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for SLC22A2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SLC22A2 Gene

This gene is overexpressed in Kidney - Cortex (x47.3).

Protein differential expression in normal tissues from HIPED for SLC22A2 Gene

This gene is overexpressed in Urine (48.6), Kidney (9.6), and Heart (7.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for SLC22A2 Gene



Protein tissue co-expression partners for SLC22A2 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for SLC22A2

SOURCE GeneReport for Unigene cluster for SLC22A2 Gene:

Hs.436385

mRNA Expression by UniProt/SwissProt for SLC22A2 Gene:

O15244-S22A2_HUMAN
Tissue specificity: Mainly expressed in kidney. Localized at the luminal membrane and basolateral membrane of kidney distal tubule and proximal tubules. To a lower extent, expressed in neurons of the cerebral cortex and in various subcortical nuclei (at protein levels). Also detected in secretory phase endometrium; in scattered cells in the stroma.

Evidence on tissue expression from TISSUES for SLC22A2 Gene

  • Kidney(4.8)
  • Intestine(4.2)
genes like me logo Genes that share expression patterns with SLC22A2: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for SLC22A2 Gene

Orthologs for SLC22A2 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for SLC22A2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SLC22A2 31 30
  • 99.44 (n)
OneToOne
cow
(Bos Taurus)
Mammalia SLC22A2 31 30
  • 84.58 (n)
OneToOne
dog
(Canis familiaris)
Mammalia SLC22A2 31 30
  • 84.37 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Slc22a2 17 31 30
  • 83.06 (n)
rat
(Rattus norvegicus)
Mammalia Slc22a2 30
  • 81.51 (n)
oppossum
(Monodelphis domestica)
Mammalia SLC22A2 31
  • 72 (a)
OneToOne
chicken
(Gallus gallus)
Aves SLC22A2 30
  • 71.31 (n)
-- 31
  • 69 (a)
ManyToMany
-- 31
  • 67 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia -- 31
  • 68 (a)
ManyToMany
-- 31
  • 62 (a)
ManyToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100487774 30
  • 62.66 (n)
African clawed frog
(Xenopus laevis)
Amphibia MGC68647 30
zebrafish
(Danio rerio)
Actinopterygii slc22a2 31 30
  • 56.23 (n)
OneToMany
Dr.13231 30
fruit fly
(Drosophila melanogaster)
Insecta Orct 32
  • 33 (a)
CG13610 32
  • 32 (a)
CG6600 32
  • 31 (a)
CG9317 32
  • 31 (a)
CG8654 32
  • 30 (a)
CG3790 32
  • 30 (a)
CG5592 32
  • 29 (a)
CG4630 31 32
  • 28 (a)
ManyToMany
CG6126 32
  • 28 (a)
CG7442 31 32
  • 27 (a)
ManyToMany
CG16727 32
  • 27 (a)
CG17751 32
  • 27 (a)
CG17752 32
  • 26 (a)
CG7084 32
  • 26 (a)
CG6231 32
  • 26 (a)
CG7458 31 32
  • 25 (a)
ManyToMany
CG7333 32
  • 25 (a)
CG6356 32
  • 25 (a)
worm
(Caenorhabditis elegans)
Secernentea oct-1 32
  • 31 (a)
F52F12.1a 32
  • 31 (a)
ZK455.8b 32
  • 27 (a)
B0252.3 32
  • 27 (a)
Y82E9BR.16 32
  • 27 (a)
ZK455.8a 32
  • 26 (a)
K05F1.6 32
  • 24 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes PHO84 33
Species where no ortholog for SLC22A2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SLC22A2 Gene

ENSEMBL:
Gene Tree for SLC22A2 (if available)
TreeFam:
Gene Tree for SLC22A2 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for SLC22A2: view image

Paralogs for SLC22A2 Gene

(14) SIMAP similar genes for SLC22A2 Gene using alignment to 2 proteins:

  • S22A2_HUMAN
  • Q5T7Q5_HUMAN
genes like me logo Genes that share paralogs with SLC22A2: view

Variants for SLC22A2 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for SLC22A2 Gene

SNP ID Clinical significance and condition Chr 06 pos Variation AA Info Type
739414 Likely Benign: not provided 160,243,657(-) G/A SYNONYMOUS_VARIANT
774649 Benign: not provided 160,224,731(-) G/T SYNONYMOUS_VARIANT
rs145450955 - p.Thr201Met
rs316019 - p.Ser270Ala
rs3907239 - p.Arg463Lys

Additional dbSNP identifiers (rs#s) for SLC22A2 Gene

Structural Variations from Database of Genomic Variants (DGV) for SLC22A2 Gene

Variant ID Type Subtype PubMed ID
dgv1231e214 CNV gain 21293372
esv23439 CNV loss 19812545
esv2421683 CNV deletion 20811451
esv2433457 CNV deletion 19546169
esv2660610 CNV deletion 23128226
esv2669393 CNV deletion 23128226
esv2759484 CNV gain+loss 17122850
esv3411449 CNV duplication 20981092
esv35098 CNV gain 17911159
esv3611428 CNV gain 21293372
esv3611431 CNV loss 21293372
esv3611432 CNV loss 21293372
nsv509159 CNV insertion 20534489
nsv520963 CNV loss 19592680
nsv818463 CNV gain 17921354

Variation tolerance for SLC22A2 Gene

Residual Variation Intolerance Score: 17.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.61; 45.17% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SLC22A2 Gene

Human Gene Mutation Database (HGMD)
SLC22A2
SNPedia medical, phenotypic, and genealogical associations of SNPs for
SLC22A2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SLC22A2 Gene

Disorders for SLC22A2 Gene

MalaCards: The human disease database

(9) MalaCards diseases for SLC22A2 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
carnitine deficiency, systemic primary
  • cdsp
mediastinal gray zone lymphoma
  • mediastinal b-cell lymphoma, unclassifiable, with features intermediate between diffuse large b-cell lymphoma and classical hodgkin lymphoma
placental choriocarcinoma
  • choriocarcinoma of the placenta
gray zone lymphoma
  • b-cell lymphoma, unclassifiable, with features intermediate between diffuse large b-cell lymphoma and classical hodgkin lymphoma
t-cell/histiocyte rich large b cell lymphoma
  • thrlbcl
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for SLC22A2

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with SLC22A2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SLC22A2 Gene

Publications for SLC22A2 Gene

  1. Human organic cation transporter (OCT1 and OCT2) gene polymorphisms and therapeutic effects of metformin. (PMID: 17111267) Shikata E … Ieiri I (Journal of human genetics 2007) 3 4 23 41 54
  2. Association of the SLC22A1, SLC22A2, and SLC22A3 genes encoding organic cation transporters with diabetic nephropathy and hypertension. (PMID: 20429798) Sallinen R … Finnish Diabetic Nephropathy Study Group (Annals of medicine 2010) 3 23 41 54
  3. Differential transport of platinum compounds by the human organic cation transporter hOCT2 (hSLC22A2). (PMID: 20067471) Burger H … Wiemer EA (British journal of pharmacology 2010) 3 23 26 54
  4. The effects of genetic polymorphisms in the organic cation transporters OCT1, OCT2, and OCT3 on the renal clearance of metformin. (PMID: 19536068) Tzvetkov MV … Brockmöller J (Clinical pharmacology and therapeutics 2009) 3 23 41 54
  5. Effect of genetic variation in the organic cation transporter 2 on the renal elimination of metformin. (PMID: 19483665) Chen Y … Giacomini KM (Pharmacogenetics and genomics 2009) 3 23 41 54

Products for SLC22A2 Gene

Sources for SLC22A2 Gene