Aliases for SLC22A18AS Gene

Aliases for SLC22A18AS Gene

  • Solute Carrier Family 22 Member 18 Antisense 2 3 5
  • P27-BWR1B 2 3 4
  • BWR1B 2 3 4
  • Solute Carrier Family 22 (Organic Cation Transporter), Member 1-Like Antisense 2 3
  • Solute Carrier Family 22 (Organic Cation Transporter), Member 18 Antisense 2 3
  • Beckwith-Wiedemann Syndrome Chromosomal Region 1 Candidate Gene B Protein 3 4
  • Organic Cation Transporter-Like Protein 2 Antisense Protein 3 4
  • Solute Carrier Family 22 Member 1-Like Antisense Protein 3 4
  • Solute Carrier Family 22 Member 18 Antisense Protein 3 4
  • P27-Beckwith-Wiedemann Region 1 B 3 4
  • SLC22A1LS 3 4
  • BWSCR1B 3 4
  • ORCTL2S 3 4
  • Beckwith-Wiedemann Syndrome Chromosome Region 1, Candidate B 3
  • Organic Cation Transporter-Like 2 Antisense 3
  • Beckwith-Wiedemann Region 1B 3
  • SLC22A18AS 5

External Ids for SLC22A18AS Gene

Previous HGNC Symbols for SLC22A18AS Gene

  • BWSCR1B
  • ORCTL2S
  • SLC22A1LS

Previous GeneCards Identifiers for SLC22A18AS Gene

  • GC11M002866
  • GC11M002697
  • GC11M002910
  • GC11M002911
  • GC11M002915
  • GC11M002920

Summaries for SLC22A18AS Gene

GeneCards Summary for SLC22A18AS Gene

SLC22A18AS (Solute Carrier Family 22 Member 18 Antisense) is a Protein Coding gene. Diseases associated with SLC22A18AS include Beckwith-Wiedemann Syndrome.

Additional gene information for SLC22A18AS Gene

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for SLC22A18AS Gene

Genomics for SLC22A18AS Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for SLC22A18AS Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around SLC22A18AS on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for SLC22A18AS

Top Transcription factor binding sites by QIAGEN in the SLC22A18AS gene promoter:
  • AP-1
  • c-Fos
  • c-Jun
  • MZF-1
  • NRSF form 2
  • Pax-5
  • RFX1
  • RP58
  • YY1
  • Zic1

Genomic Locations for SLC22A18AS Gene

Genomic Locations for SLC22A18AS Gene
chr11:2,887,344-2,905,504
(GRCh38/hg38)
Size:
18,161 bases
Orientation:
Minus strand
chr11:2,909,010-2,925,175
(GRCh37/hg19)
Size:
16,166 bases
Orientation:
Minus strand

Genomic View for SLC22A18AS Gene

Genes around SLC22A18AS on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SLC22A18AS Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SLC22A18AS Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC22A18AS Gene

Proteins for SLC22A18AS Gene

  • Protein details for SLC22A18AS Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N1D0-BWR1B_HUMAN
    Recommended name:
    Beckwith-Wiedemann syndrome chromosomal region 1 candidate gene B protein
    Protein Accession:
    Q8N1D0
    Secondary Accessions:
    • E9PLK8
    • O43563

    Protein attributes for SLC22A18AS Gene

    Size:
    253 amino acids
    Molecular mass:
    27061 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for SLC22A18AS Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SLC22A18AS Gene

Post-translational modifications for SLC22A18AS Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for SLC22A18AS Gene

Domains & Families for SLC22A18AS Gene

Gene Families for SLC22A18AS Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for SLC22A18AS Gene

ProtoNet:

Suggested Antigen Peptide Sequences for SLC22A18AS Gene

GenScript: Design optimal peptide antigens:
  • p27-Beckwith-Wiedemann region 1 B (BWR1B_HUMAN)
genes like me logo Genes that share domains with SLC22A18AS: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for SLC22A18AS Gene

Function for SLC22A18AS Gene

Phenotypes From GWAS Catalog for SLC22A18AS Gene

Gene Ontology (GO) - Molecular Function for SLC22A18AS Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
genes like me logo Genes that share ontologies with SLC22A18AS: view
genes like me logo Genes that share phenotypes with SLC22A18AS: view

Animal Model Products

CRISPR Products

miRNA for SLC22A18AS Gene

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SLC22A18AS

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SLC22A18AS Gene

Localization for SLC22A18AS Gene

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for SLC22A18AS Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
genes like me logo Genes that share ontologies with SLC22A18AS: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from COMPARTMENTS for SLC22A18AS Gene

Pathways & Interactions for SLC22A18AS Gene

PathCards logo

SuperPathways for SLC22A18AS Gene

No Data Available

Interacting Proteins for SLC22A18AS Gene

Gene Ontology (GO) - Biological Process for SLC22A18AS Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008150 biological_process ND --
genes like me logo Genes that share ontologies with SLC22A18AS: view

No data available for Pathways by source and SIGNOR curated interactions for SLC22A18AS Gene

Drugs & Compounds for SLC22A18AS Gene

No Compound Related Data Available

Transcripts for SLC22A18AS Gene

mRNA/cDNA for SLC22A18AS Gene

2 REFSEQ mRNAs :
4 NCBI additional mRNA sequence :
3 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SLC22A18AS

Alternative Splicing Database (ASD) splice patterns (SP) for SLC22A18AS Gene

No ASD Table

Relevant External Links for SLC22A18AS Gene

GeneLoc Exon Structure for
SLC22A18AS

Expression for SLC22A18AS Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for SLC22A18AS Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

  • Colon (Gastrointestinal Tract)

mRNA differential expression in normal tissues according to GTEx for SLC22A18AS Gene

This gene is overexpressed in Colon - Transverse (x11.7), Kidney - Cortex (x6.8), and Liver (x5.7).

Protein differential expression in normal tissues from HIPED for SLC22A18AS Gene

This gene is overexpressed in Urine (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for SLC22A18AS Gene



Protein tissue co-expression partners for SLC22A18AS Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for SLC22A18AS

SOURCE GeneReport for Unigene cluster for SLC22A18AS Gene:

Hs.300076

mRNA Expression by UniProt/SwissProt for SLC22A18AS Gene:

Q8N1D0-BWR1B_HUMAN
Tissue specificity: Most abundantly expressed in gastrointestinal tissues. Expressed at lower levels in kidney and placenta. Expressed in fetal brain, liver, placenta, kidney and lung.
genes like me logo Genes that share expression patterns with SLC22A18AS: view

No data available for Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for SLC22A18AS Gene

Orthologs for SLC22A18AS Gene

This gene was present in the common ancestor of human and chimp.

Orthologs for SLC22A18AS Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia SLC22A18AS 30 31
  • 98.81 (n)
OneToOne
Species where no ortholog for SLC22A18AS was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • Cow (Bos Taurus)
  • Dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Mouse (Mus musculus)
  • Oppossum (Monodelphis domestica)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for SLC22A18AS Gene

ENSEMBL:
Gene Tree for SLC22A18AS (if available)
TreeFam:
Gene Tree for SLC22A18AS (if available)
Aminode:
Evolutionary constrained regions (ECRs) for SLC22A18AS: view image

Paralogs for SLC22A18AS Gene

No data available for Paralogs for SLC22A18AS Gene

Variants for SLC22A18AS Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for SLC22A18AS Gene

SNP ID Clinical significance and condition Chr 11 pos Variation AA Info Type
768417 Benign: not provided 2,902,596(-) A/G INITIATIOR_CODON_VARIANT,MISSENSE_VARIANT,FIVE_PRIME_UTR_VARIANT,INTRON_VARIANT
789206 Benign: not provided 2,903,410(-) G/A MISSENSE_VARIANT,INTRON_VARIANT
rs365605 - p.Gly89Asp
rs441071 - p.Gly133Arg

Additional dbSNP identifiers (rs#s) for SLC22A18AS Gene

Structural Variations from Database of Genomic Variants (DGV) for SLC22A18AS Gene

Variant ID Type Subtype PubMed ID
dgv1574n54 CNV loss 21841781
dgv1575n54 CNV loss 21841781
dgv1576n54 CNV loss 21841781
esv2181696 CNV deletion 18987734
esv2744015 CNV deletion 23290073
esv2759795 CNV gain 17122850
nsv1070931 CNV deletion 25765185
nsv467655 CNV loss 19166990
nsv467657 CNV loss 19166990
nsv467658 CNV loss 19166990
nsv469930 CNV loss 18288195
nsv553111 CNV loss 21841781
nsv553119 CNV loss 21841781
nsv553120 CNV loss 21841781
nsv825715 CNV gain 20364138
nsv832050 CNV loss 17160897
nsv951292 CNV deletion 24416366

Variation tolerance for SLC22A18AS Gene

Gene Damage Index Score: 2.41; 42.58% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SLC22A18AS Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SLC22A18AS

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SLC22A18AS Gene

Disorders for SLC22A18AS Gene

MalaCards: The human disease database

(1) MalaCards diseases for SLC22A18AS Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
beckwith-wiedemann syndrome
  • bws
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for SLC22A18AS

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
genes like me logo Genes that share disorders with SLC22A18AS: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SLC22A18AS Gene

Publications for SLC22A18AS Gene

  1. Paternal imprinting of the SLC22A1LS gene located in the human chromosome segment 11p15.5. (PMID: 15175115) Bajaj V … Kumar A (BMC genetics 2004) 2 3 4 23
  2. Divergently transcribed overlapping genes expressed in liver and kidney and located in the 11p15.5 imprinted domain. (PMID: 9570947) Cooper PR … Higgins MJ (Genomics 1998) 2 3 4 23
  3. Transcriptional map of 170-kb region at chromosome 11p15.5: identification and mutational analysis of the BWR1A gene reveals the presence of mutations in tumor samples. (PMID: 9520460) Schwienbacher C … Negrini M (Proceedings of the National Academy of Sciences of the United States of America 1998) 2 3 4
  4. Promoter characterization and regulation of expression of an imprinted gene SLC22A18AS. (PMID: 18721868) Bajaj V … Kumar A (Gene 2008) 3 23
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4

Products for SLC22A18AS Gene

Sources for SLC22A18AS Gene