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Aliases for SLC22A18 Gene

Aliases for SLC22A18 Gene

  • Solute Carrier Family 22 Member 18 2 3 3 5
  • Tumor-Suppressing Subchromosomal Transferable Fragment Candidate Gene 5 Protein 3 4
  • Imprinted Multi-Membrane-Spanning Polyspecific Transporter-Related Protein 1 3 4
  • Beckwith-Wiedemann Syndrome Chromosomal Region 1 Candidate Gene A Protein 3 4
  • Organic Cation Transporter-Like Protein 2 3 4
  • Tumor-Suppressing STF CDNA 5 Protein 3 4
  • Efflux Transporter-Like Protein 3 4
  • P45-BWR1A 3 4
  • SLC22A1L 3 4
  • BWSCR1A 3 4
  • ORCTL2 3 4
  • IMPT1 3 4
  • BWR1A 3 4
  • TSSC5 3 4
  • HET 3 4
  • ITM 3 4
  • Solute Carrier Family 22 (Organic Cation Transporter), Member 1-Like 2
  • Solute Carrier Family 22 Member 1-Like 4
  • Solute Carrier Family 22, Member 18 2
  • P45-Beckwith-Wiedemann Region 1 A 4
  • P45 Beckwith-Wiedemann Region 1A 3
  • ORCTL-2 4

External Ids for SLC22A18 Gene

Previous HGNC Symbols for SLC22A18 Gene

  • ORCTL2
  • IMPT1
  • SLC22A1L

Previous GeneCards Identifiers for SLC22A18 Gene

  • GC11P002885
  • GC11P002877
  • GC11P002709

Summaries for SLC22A18 Gene

Entrez Gene Summary for SLC22A18 Gene

  • This gene is one of several tumor-suppressing subtransferable fragments located in the imprinted gene domain of 11p15.5, an important tumor-suppressor gene region. Alterations in this region have been associated with the Beckwith-Wiedemann syndrome, Wilms tumor, rhabdomyosarcoma, adrenocortical carcinoma, and lung, ovarian, and breast cancer. This gene is imprinted, with preferential expression from the maternal allele. Mutations in this gene have been found in Wilms' tumor and lung cancer. This protein may act as a transporter of organic cations, and have a role in the transport of chloroquine and quinidine-related compounds in kidney. Several alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Oct 2015]

GeneCards Summary for SLC22A18 Gene

SLC22A18 (Solute Carrier Family 22 Member 18) is a Protein Coding gene. Diseases associated with SLC22A18 include Lung Cancer and Rhabdomyosarcoma, Embryonal, 1. Among its related pathways are Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds. Gene Ontology (GO) annotations related to this gene include transporter activity and symporter activity. An important paralog of this gene is MFSD9.

UniProtKB/Swiss-Prot for SLC22A18 Gene

  • May act as a transporter of organic cations based on a proton efflux antiport mechanism. May play a role in the transport of chloroquine and quinidine-related compounds in kidney.

Gene Wiki entry for SLC22A18 Gene

Additional gene information for SLC22A18 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLC22A18 Gene

Genomics for SLC22A18 Gene

GeneHancer (GH) Regulatory Elements for SLC22A18 Gene

Promoters and enhancers for SLC22A18 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH11J002901 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE dbSUPER 693.4 +3.3 3336 4.1 PKNOX1 ATF1 ARID4B SIN3A YY1 POLR2B GLIS2 ZNF207 ATF7 SP3 SLC22A18 SLC22A18AS
GH11J002897 Promoter/Enhancer 2.1 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 665.2 -0.6 -619 2.6 SIN3A IRF4 GLIS2 FOS ATF7 RUNX3 DEK JUNB ZNF592 ATF4 SLC22A18 KCNQ1 TRPC2 SLC22A18AS CDKN1C
GH11J002986 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE dbSUPER 11.4 +90.4 90407 6.6 HDGF PKNOX1 ZFP64 ARID4B SIN3A DMAP1 YY1 POLR2B E2F8 FOS ENSG00000183562 NAP1L4 CARS NUP98 SLC22A18 TSSC4 SNORA54 PHLDA2 GC11M002982
GH11J002910 Enhancer 1.2 Ensembl ENCODE dbSUPER 19 +12.7 12725 3.4 NFIB KLF17 ZNF335 GLIS2 EGR1 FOS CREM EGR2 SP3 ELF1 SLC22A18 SLC22A18AS PHLDA2
GH11J002939 Enhancer 1.4 FANTOM5 Ensembl ENCODE dbSUPER 11.7 +41.3 41252 2 PKNOX1 MAX BMI1 RAD21 ZNF205 ZNF316 POLR2A HNF4G RCOR1 NR2F6 NAP1L4 ENSG00000183562 SLC22A18AS SNORA54 SLC22A18 KCNQ1 PHLDA2 KCNQ1-AS1 GC11M002963 GC11M002964
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around SLC22A18 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the SLC22A18 gene promoter:
  • Pax-5
  • NCX
  • SRY
  • E47
  • NF-1
  • POU6F1 (c2)

Genomic Locations for SLC22A18 Gene

Genomic Locations for SLC22A18 Gene
25,526 bases
Plus strand
25,526 bases
Plus strand

Genomic View for SLC22A18 Gene

Genes around SLC22A18 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SLC22A18 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SLC22A18 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC22A18 Gene

Proteins for SLC22A18 Gene

  • Protein details for SLC22A18 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Solute carrier family 22 member 18
    Protein Accession:
    Secondary Accessions:
    • O14906
    • O43562
    • O60485
    • O60680
    • Q7LDS5
    • Q7LGF7

    Protein attributes for SLC22A18 Gene

    424 amino acids
    Molecular mass:
    44846 Da
    Quaternary structure:
    • Interacts with RNF167.
    • Sequence=AAB82727.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAA32779.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for SLC22A18 Gene

Post-translational modifications for SLC22A18 Gene

  • Ubiquitination at isoforms=229
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for SLC22A18 Gene

Domains & Families for SLC22A18 Gene

Gene Families for SLC22A18 Gene

Human Protein Atlas (HPA):
  • Disease related genes
  • Potential drug targets
  • Predicted membrane proteins
  • Transporters

Protein Domains for SLC22A18 Gene

Suggested Antigen Peptide Sequences for SLC22A18 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the major facilitator (TC 2.A.1) superfamily. Organic cation transporter (TC 2.A.1.19) family.
  • Belongs to the major facilitator (TC 2.A.1) superfamily. Organic cation transporter (TC 2.A.1.19) family.
genes like me logo Genes that share domains with SLC22A18: view

Function for SLC22A18 Gene

Molecular function for SLC22A18 Gene

UniProtKB/Swiss-Prot Function:
May act as a transporter of organic cations based on a proton efflux antiport mechanism. May play a role in the transport of chloroquine and quinidine-related compounds in kidney.

Phenotypes From GWAS Catalog for SLC22A18 Gene

Gene Ontology (GO) - Molecular Function for SLC22A18 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0015238 drug transmembrane transporter activity IDA 9744804
GO:0015293 symporter activity IEA --
GO:0015307 drug:proton antiporter activity TAS --
GO:0031625 ubiquitin protein ligase binding IPI 16314844
genes like me logo Genes that share ontologies with SLC22A18: view
genes like me logo Genes that share phenotypes with SLC22A18: view

Human Phenotype Ontology for SLC22A18 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Model Products

  • Taconic Biosciences Mouse Models for SLC22A18

CRISPR Products

miRNA for SLC22A18 Gene

miRTarBase miRNAs that target SLC22A18

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SLC22A18

Clone Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for SLC22A18 Gene

Localization for SLC22A18 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC22A18 Gene

Apical cell membrane; Multi-pass membrane protein. Note=Localized at the apical membrane surface of renal proximal tubules. {ECO:0000269 PubMed:9744804}.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SLC22A18 gene
Compartment Confidence
plasma membrane 5
nucleus 5
extracellular 1
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for SLC22A18 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005635 nuclear envelope IDA 16314844
GO:0005737 cytoplasm IDA 16314844
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA,HDA 19946888
GO:0016021 integral component of membrane NAS,IEA 9499412
genes like me logo Genes that share ontologies with SLC22A18: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for SLC22A18 Gene

Pathways & Interactions for SLC22A18 Gene

genes like me logo Genes that share pathways with SLC22A18: view

Interacting Proteins for SLC22A18 Gene

Gene Ontology (GO) - Biological Process for SLC22A18 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006811 ion transport IEA --
GO:0006855 drug transmembrane transport IEA --
GO:0007588 excretion NAS 9744804
GO:0015695 organic cation transport NAS 9744804
GO:0015893 drug transport IDA 9744804
genes like me logo Genes that share ontologies with SLC22A18: view

No data available for SIGNOR curated interactions for SLC22A18 Gene

Drugs & Compounds for SLC22A18 Gene

No Compound Related Data Available

Transcripts for SLC22A18 Gene

Unigene Clusters for SLC22A18 Gene

Solute carrier family 22, member 18:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SLC22A18

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for SLC22A18 Gene

ExUns: 1 ^ 2 ^ 3a · 3b · 3c ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11a · 11b ^ 12a · 12b ^ 13a · 13b
SP1: - - - -
SP2: - - -
SP3: -
SP4: - - -
SP5: -

Relevant External Links for SLC22A18 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SLC22A18 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SLC22A18 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SLC22A18 Gene

This gene is overexpressed in Liver (x7.8), Colon - Transverse (x5.3), and Kidney - Cortex (x4.2).

Protein differential expression in normal tissues from HIPED for SLC22A18 Gene

This gene is overexpressed in Nasal epithelium (60.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for SLC22A18 Gene

Protein tissue co-expression partners for SLC22A18 Gene

NURSA nuclear receptor signaling pathways regulating expression of SLC22A18 Gene:


SOURCE GeneReport for Unigene cluster for SLC22A18 Gene:


mRNA Expression by UniProt/SwissProt for SLC22A18 Gene:

Tissue specificity: Expressed at high levels in adult and fetal kidney and liver, and adult colon. Expressed in fetal renal proximal tubules (at protein level). Expressed at lower levels in heart, brain and lung.

Evidence on tissue expression from TISSUES for SLC22A18 Gene

  • Kidney(2)

Phenotype-based relationships between genes and organs from Gene ORGANizer for SLC22A18 Gene

Germ Layers:
  • ectoderm
  • endoderm
  • mesoderm
  • integumentary
  • reproductive
  • respiratory
  • skeletal muscle
  • breast
  • lung
genes like me logo Genes that share expression patterns with SLC22A18: view

Orthologs for SLC22A18 Gene

This gene was present in the common ancestor of animals.

Orthologs for SLC22A18 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia SLC22A18 34 33
  • 96.57 (n)
(Bos Taurus)
Mammalia SLC22A18 34
  • 79 (a)
(Mus musculus)
Mammalia Slc22a18 16 34 33
  • 78.51 (n)
(Rattus norvegicus)
Mammalia Slc22a18 33
  • 77.78 (n)
(Canis familiaris)
Mammalia SLC22A18 34 33
  • 77.38 (n)
(Monodelphis domestica)
Mammalia SLC22A18 34
  • 69 (a)
(Ornithorhynchus anatinus)
Mammalia SLC22A18 34
  • 54 (a)
(Gallus gallus)
Aves SLC22A18 34 33
  • 59.54 (n)
(Anolis carolinensis)
Reptilia SLC22A18 34
  • 50 (a)
(Danio rerio)
Actinopterygii slc22a18 34 33
  • 56.88 (n)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.11050 33
(Caenorhabditis elegans)
Secernentea C53B4.3 34 33
  • 39.24 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 39 (a)
Species where no ortholog for SLC22A18 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for SLC22A18 Gene

Gene Tree for SLC22A18 (if available)
Gene Tree for SLC22A18 (if available)
Evolutionary constrained regions (ECRs) for SLC22A18: view image

Paralogs for SLC22A18 Gene

Paralogs for SLC22A18 Gene

(1) SIMAP similar genes for SLC22A18 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with SLC22A18: view

Variants for SLC22A18 Gene

Sequence variations from dbSNP and Humsavar for SLC22A18 Gene

SNP ID Clin Chr 11 pos Variation AA Info Type
rs121909071 pathogenic, Lung cancer, Lung cancer (LNCR) [MIM:211980] 2,918,030(+) C/T coding_sequence_variant, missense_variant
rs78838117 pathogenic, Rhabdomyosarcoma, somatic 2,909,210(+) G/A coding_sequence_variant, intron_variant, missense_variant
VAR_024061 A rhabdomyosarcoma sample p.Arg86Cys
rs1000233303 -- 2,911,235(+) A/T intron_variant
rs1000438831 -- 2,905,479(+) C/T intron_variant

Structural Variations from Database of Genomic Variants (DGV) for SLC22A18 Gene

Variant ID Type Subtype PubMed ID
dgv133e201 CNV deletion 23290073
dgv134e201 CNV deletion 23290073
esv2744016 CNV deletion 23290073
esv2744017 CNV deletion 23290073
esv2744018 CNV deletion 23290073
esv2744020 CNV deletion 23290073
esv2759795 CNV gain 17122850
esv998342 CNV deletion 20482838
nsv1141122 CNV deletion 24896259
nsv1147172 CNV deletion 26484159
nsv467657 CNV loss 19166990
nsv467658 CNV loss 19166990
nsv469930 CNV loss 18288195
nsv472377 CNV novel sequence insertion 20440878
nsv553111 CNV loss 21841781
nsv553119 CNV loss 21841781
nsv553120 CNV loss 21841781
nsv553121 CNV loss 21841781
nsv832050 CNV loss 17160897
nsv951292 CNV deletion 24416366

Variation tolerance for SLC22A18 Gene

Residual Variation Intolerance Score: 86.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.82; 83.47% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SLC22A18 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SLC22A18 Gene

Disorders for SLC22A18 Gene

MalaCards: The human disease database

(10) MalaCards diseases for SLC22A18 Gene - From: OMIM, ClinVar, GTR, Orphanet, Swiss-Prot, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
lung cancer
  • lung cancer, susceptibility to
rhabdomyosarcoma, embryonal, 1
  • rmse1
breast cancer
  • breast cancer, familial
rare adenocarcinoma of the breast
breast adenocarcinoma
  • adenocarcinoma of breast
- elite association - COSMIC cancer census association via MalaCards


  • Lung cancer (LNCR) [MIM:211980]: A common malignancy affecting tissues of the lung. The most common form of lung cancer is non-small cell lung cancer (NSCLC) that can be divided into 3 major histologic subtypes: squamous cell carcinoma, adenocarcinoma, and large cell lung cancer. NSCLC is often diagnosed at an advanced stage and has a poor prognosis. {ECO:0000269 PubMed:9751628}. Note=The gene represented in this entry may be involved in disease pathogenesis.
  • Rhabdomyosarcoma, embryonal, 1 (RMSE1) [MIM:268210]: A form of rhabdomyosarcoma, a highly malignant tumor of striated muscle derived from primitive mesenchymal cells and exhibiting differentiation along rhabdomyoblastic lines. Rhabdomyosarcoma is one of the most frequently occurring soft tissue sarcomas and the most common in children. It occurs in four forms: alveolar, pleomorphic, embryonal and botryoidal rhabdomyosarcomas. Note=The disease may be caused by mutations affecting the gene represented in this entry.

Additional Disease Information for SLC22A18

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with SLC22A18: view

No data available for Genatlas for SLC22A18 Gene

Publications for SLC22A18 Gene

  1. Transcriptional map of 170-kb region at chromosome 11p15.5: identification and mutational analysis of the BWR1A gene reveals the presence of mutations in tumor samples. (PMID: 9520460) Schwienbacher C … Negrini M (Proceedings of the National Academy of Sciences of the United States of America 1998) 2 3 4 22 58
  2. IMPT1, an imprinted gene similar to polyspecific transporter and multi-drug resistance genes. (PMID: 9499412) Dao D … Tycko B (Human molecular genetics 1998) 2 3 4 22 58
  3. Tumor suppressor candidate TSSC5 is regulated by UbcH6 and a novel ubiquitin ligase RING105. (PMID: 16314844) Yamada HY … Gorbsky GJ (Oncogene 2006) 3 4 22 58
  4. Somatic mutation of TSSC5, a novel imprinted gene from human chromosome 11p15.5. (PMID: 9751628) Lee MP … Feinberg AP (Cancer research 1998) 3 4 22 58
  5. Functional characterization of ORCTL2--an organic cation transporter expressed in the renal proximal tubules. (PMID: 9744804) Reece M … Pelletier J (FEBS letters 1998) 3 4 22 58

Products for SLC22A18 Gene

Sources for SLC22A18 Gene

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