Organic ion transporters, such as SLC22A15, transport various medically and physiologically important compounds, including pharmaceuticals, toxins, hormones, neurotransmitters, and cellular metabolites. These transporters are also referred to as amphiphilic solute facilitators (ASFs).[supplied by OMIM, Apr 2004] See more...

Aliases for SLC22A15 Gene

Aliases for SLC22A15 Gene

  • Solute Carrier Family 22 Member 15 2 3 4 5
  • Solute Carrier Family 22 (Organic Cation Transporter), Member 15 2 3
  • Fly-Like Putative Transporter 1 3 4
  • Flipt 1 3 4
  • FLIPT1 3 4
  • Fly-Like Putative Organic Ion Transporter 1 3
  • Solute Carrier Family 22, Member 15 2
  • Trans-Like Protein 3
  • PRO34686 3

External Ids for SLC22A15 Gene

Previous GeneCards Identifiers for SLC22A15 Gene

  • GC01P115666
  • GC01P115865
  • GC01P116231
  • GC01P116520
  • GC01P114392

Summaries for SLC22A15 Gene

Entrez Gene Summary for SLC22A15 Gene

  • Organic ion transporters, such as SLC22A15, transport various medically and physiologically important compounds, including pharmaceuticals, toxins, hormones, neurotransmitters, and cellular metabolites. These transporters are also referred to as amphiphilic solute facilitators (ASFs).[supplied by OMIM, Apr 2004]

GeneCards Summary for SLC22A15 Gene

SLC22A15 (Solute Carrier Family 22 Member 15) is a Protein Coding gene. Among its related pathways are Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds. Gene Ontology (GO) annotations related to this gene include transmembrane transporter activity. An important paralog of this gene is SLC22A4.

UniProtKB/Swiss-Prot Summary for SLC22A15 Gene

  • Probably transports organic cations (By similarity). Appears not to be the agmatine transporter.

Additional gene information for SLC22A15 Gene

No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for SLC22A15 Gene

Genomics for SLC22A15 Gene

GeneHancer (GH) Regulatory Elements for SLC22A15 Gene

Promoters and enhancers for SLC22A15 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01J115975 Promoter/Enhancer 2.4 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 526.9 +0.9 882 4 ZNF217 ZSCAN5C NRF1 GTF2E2 ZFX POLR2A ZBTB11 AFF1 ZBTB26 TRIM28 SLC22A15 LOC101928977 ENSG00000237993 ATP1A1-AS1 CASQ2 MAB21L3 IGSF3 ATP1A1
GH01J115924 Promoter/Enhancer 0.9 EPDnew Ensembl ENCODE 529.1 -51.9 -51869 2.5 EP300 NANOG POLR2A SMARCA4 TAF1 SLC22A15 CASQ2 IGSF3 L13713-013 piR-50443-026 LINC01649 LOC101928977
GH01J116002 Enhancer 0.9 Ensembl ENCODE dbSUPER 31.6 +26.6 26602 3 ZIC2 TRIM28 RFX1 ESR1 ZNF366 PRDM10 ZNF629 ZNF692 FOXA1 SLC22A15 MAB21L3 ENSG00000237993 LOC101928977
GH01J115827 Promoter/Enhancer 1.4 FANTOM5 ENCODE CraniofacialAtlas 13 -147.1 -147096 2.6 USF1 JUND FOS ZNF10 TRIM28 ZBTB17 TCF7L2 CTCF PHF8 POLR2A lnc-VANGL1-5 lnc-NHLH2-6 SLC22A15 CASQ2 ENSG00000237993 ATP1A1 NHLH2
GH01J115929 Enhancer 0.5 Ensembl 28.5 -46.4 -46397 1.8 JUND GATA3 FOS RCOR1 CHD2 GATA2 ZNF24 ATF3 FOSL2 POLR2A L13713-013 SLC22A15 ENSG00000237993 IGSF3 LINC01649 lnc-SLC22A15-3 LOC101928977
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around SLC22A15 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for SLC22A15

Top Transcription factor binding sites by QIAGEN in the SLC22A15 gene promoter:
  • C/EBPbeta
  • Evi-1
  • GATA-1
  • GCNF
  • GCNF-1
  • GCNF-2
  • HEN1
  • Lhx3a
  • LHX3b
  • Pbx1a

Genomic Locations for SLC22A15 Gene

Genomic Locations for SLC22A15 Gene
chr1:115,976,498-116,070,054
(GRCh38/hg38)
Size:
93,557 bases
Orientation:
Plus strand
chr1:116,519,119-116,612,675
(GRCh37/hg19)
Size:
93,557 bases
Orientation:
Plus strand

Genomic View for SLC22A15 Gene

Genes around SLC22A15 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SLC22A15 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SLC22A15 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC22A15 Gene

Proteins for SLC22A15 Gene

  • Protein details for SLC22A15 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8IZD6-S22AF_HUMAN
    Recommended name:
    Solute carrier family 22 member 15
    Protein Accession:
    Q8IZD6
    Secondary Accessions:
    • A8MUR3
    • Q6UXP5
    • Q8TAL9
    • Q9NSH5

    Protein attributes for SLC22A15 Gene

    Size:
    547 amino acids
    Molecular mass:
    60540 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH26358.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305}; Sequence=AAH26358.1; Type=Frameshift; Evidence={ECO:0000305};

    Alternative splice isoforms for SLC22A15 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SLC22A15 Gene

Post-translational modifications for SLC22A15 Gene

  • Glycosylation at Asn58, Asn63, Asn80, and Asn106
  • Modification sites at PhosphoSitePlus

Other Protein References for SLC22A15 Gene

No data available for DME Specific Peptides for SLC22A15 Gene

Domains & Families for SLC22A15 Gene

Gene Families for SLC22A15 Gene

Protein Domains for SLC22A15 Gene

Suggested Antigen Peptide Sequences for SLC22A15 Gene

GenScript: Design optimal peptide antigens:
  • Fly-like putative transporter 1 (S22AF_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q8IZD6

UniProtKB/Swiss-Prot:

S22AF_HUMAN :
  • Belongs to the major facilitator (TC 2.A.1) superfamily. Organic cation transporter (TC 2.A.1.19) family.
Family:
  • Belongs to the major facilitator (TC 2.A.1) superfamily. Organic cation transporter (TC 2.A.1.19) family.
genes like me logo Genes that share domains with SLC22A15: view

Function for SLC22A15 Gene

Molecular function for SLC22A15 Gene

UniProtKB/Swiss-Prot Function:
Probably transports organic cations (By similarity). Appears not to be the agmatine transporter.

Phenotypes From GWAS Catalog for SLC22A15 Gene

Gene Ontology (GO) - Molecular Function for SLC22A15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0022857 transmembrane transporter activity IEA --
genes like me logo Genes that share ontologies with SLC22A15: view
genes like me logo Genes that share phenotypes with SLC22A15: view

Animal Model Products

  • Taconic Biosciences Mouse Models for SLC22A15

miRNA for SLC22A15 Gene

miRTarBase miRNAs that target SLC22A15

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SLC22A15 Gene

Localization for SLC22A15 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC22A15 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SLC22A15 gene
Compartment Confidence
plasma membrane 3
extracellular 1
cytoskeleton 1
mitochondrion 1
nucleus 1
lysosome 0

Gene Ontology (GO) - Cellular Components for SLC22A15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with SLC22A15: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for SLC22A15 Gene

Pathways & Interactions for SLC22A15 Gene

genes like me logo Genes that share pathways with SLC22A15: view

Interacting Proteins for SLC22A15 Gene

;

Gene Ontology (GO) - Biological Process for SLC22A15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006811 ion transport IEA --
GO:0055085 transmembrane transport IEA --
genes like me logo Genes that share ontologies with SLC22A15: view

No data available for SIGNOR curated interactions for SLC22A15 Gene

Drugs & Compounds for SLC22A15 Gene

(1) Drugs for SLC22A15 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
agmatine Experimental Pharma Activator 0
genes like me logo Genes that share compounds with SLC22A15: view

Transcripts for SLC22A15 Gene

mRNA/cDNA for SLC22A15 Gene

1 REFSEQ mRNAs :
14 NCBI additional mRNA sequence :
3 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for SLC22A15 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b · 6c ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12
SP1: -
SP2: -

Relevant External Links for SLC22A15 Gene

GeneLoc Exon Structure for
SLC22A15

Expression for SLC22A15 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for SLC22A15 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for SLC22A15

SOURCE GeneReport for Unigene cluster for SLC22A15 Gene:

Hs.125482

mRNA Expression by UniProt/SwissProt for SLC22A15 Gene:

Q8IZD6-S22AF_HUMAN
Tissue specificity: Expressed at highest levels in kidney and brain. Expressed at high levels in skeletal muscle, heart, liver, placenta and white blood cells. Expressed at moderate levels in lung and spleen. Expressed at low levels in thymus, small intestine and colon. Expressed in several intestinal tumor cell lines.

Evidence on tissue expression from TISSUES for SLC22A15 Gene

  • Nervous system(4.4)
  • Kidney(4.1)
genes like me logo Genes that share expression patterns with SLC22A15: view

No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for SLC22A15 Gene

Orthologs for SLC22A15 Gene

This gene was present in the common ancestor of animals.

Orthologs for SLC22A15 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SLC22A15 31 30
  • 99.63 (n)
OneToOne
cow
(Bos Taurus)
Mammalia SLC22A15 31 30
  • 90.01 (n)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SLC22A15 31
  • 89 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SLC22A15 31 30
  • 88.29 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Slc22a15 17 31 30
  • 87.99 (n)
rat
(Rattus norvegicus)
Mammalia Slc22a15 30
  • 87.32 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia SLC22A15 31
  • 53 (a)
OneToOne
chicken
(Gallus gallus)
Aves SLC22A15 31 30
  • 79.43 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SLC22A15 31
  • 80 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia slc22a15.1 30
  • 62.92 (n)
Str.16656 30
African clawed frog
(Xenopus laevis)
Amphibia MGC53252 30
zebrafish
(Danio rerio)
Actinopterygii SLC22A15 31
  • 47 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Orct 31
  • 31 (a)
OneToMany
Orct2 31
  • 29 (a)
OneToMany
CG6126 31
  • 27 (a)
OneToMany
CG3790 31
  • 24 (a)
OneToMany
CG9317 31
  • 20 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea Y82E9BR.16 31
  • 25 (a)
OneToMany
oct-1 31
  • 24 (a)
OneToMany
F45E10.2 31
  • 22 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 42 (a)
OneToMany
-- 31
  • 39 (a)
OneToMany
-- 31
  • 31 (a)
OneToMany
-- 31
  • 27 (a)
OneToMany
Species where no ortholog for SLC22A15 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SLC22A15 Gene

ENSEMBL:
Gene Tree for SLC22A15 (if available)
TreeFam:
Gene Tree for SLC22A15 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for SLC22A15: view image

Paralogs for SLC22A15 Gene

(7) SIMAP similar genes for SLC22A15 Gene using alignment to 1 proteins:

  • S22AF_HUMAN
genes like me logo Genes that share paralogs with SLC22A15: view

Variants for SLC22A15 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for SLC22A15 Gene

SNP ID Clinical significance and condition Chr 01 pos Variation AA Info Type
rs17852419 - p.Pro349Gln

Additional dbSNP identifiers (rs#s) for SLC22A15 Gene

Structural Variations from Database of Genomic Variants (DGV) for SLC22A15 Gene

Variant ID Type Subtype PubMed ID
esv27976 CNV loss 19812545
nsv2522 CNV insertion 18451855
nsv528884 CNV loss 19592680
nsv831126 CNV gain 17160897

Variation tolerance for SLC22A15 Gene

Residual Variation Intolerance Score: 41.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.68; 72.96% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SLC22A15 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SLC22A15

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SLC22A15 Gene

Disorders for SLC22A15 Gene

Additional Disease Information for SLC22A15

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for SLC22A15 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SLC22A15 Gene

Publications for SLC22A15 Gene

  1. Novel human cDNAs homologous to Drosophila Orct and mammalian carnitine transporters. (PMID: 12372408) Eraly SA … Nigam SK (Biochemical and biophysical research communications 2002) 2 3 4 54
  2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 41 54
  3. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark HF … Gray A (Genome research 2003) 3 4 54
  4. Widespread Expansion of Protein Interaction Capabilities by Alternative Splicing. (PMID: 26871637) Yang X … Vidal M (Cell 2016) 3 54
  5. The full-ORF clone resource of the German cDNA Consortium. (PMID: 17974005) Bechtel S … Schupp I (BMC genomics 2007) 4 54

Products for SLC22A15 Gene

Sources for SLC22A15 Gene