Free for academic non-profit institutions. Other users need a Commercial license

Aliases for SLC22A14 Gene

Aliases for SLC22A14 Gene

  • Solute Carrier Family 22 Member 14 2 3 5
  • Solute Carrier Family 22 (Organic Cation Transporter), Member 14 2 3
  • Organic Cationic Transporter-Like 4 2 3
  • Organic Cation Transporter-Like 4 3 4
  • ORCTL-4 3 4
  • ORCTL4 3 4
  • OCTL2 3 4
  • Solute Carrier Family 22, Member 14 2
  • OCTL4 3

External Ids for SLC22A14 Gene

Previous HGNC Symbols for SLC22A14 Gene

  • ORCTL4

Previous GeneCards Identifiers for SLC22A14 Gene

  • GC00U912986
  • GC03P038308

Summaries for SLC22A14 Gene

Entrez Gene Summary for SLC22A14 Gene

  • This gene encodes a member of the organic-cation transporter family. It is located in a gene cluster with another member of the family, organic cation transporter like 3. The encoded protein is a transmembrane protein which is thought to transport small molecules and since this protein is conserved among several species, it is suggested to have a fundamental role in mammalian systems. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2016]

GeneCards Summary for SLC22A14 Gene

SLC22A14 (Solute Carrier Family 22 Member 14) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include transmembrane transporter activity and organic cation transmembrane transporter activity. An important paralog of this gene is SLC22A13.

Additional gene information for SLC22A14 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLC22A14 Gene

Genomics for SLC22A14 Gene

GeneHancer (GH) Regulatory Elements for SLC22A14 Gene

Promoters and enhancers for SLC22A14 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH03I037903 Enhancer 1.6 FANTOM5 Ensembl ENCODE dbSUPER 6.2 -375.5 -375540 5 PKNOX1 FOXA2 ARID4B IRF4 ATF7 RUNX3 SP5 JUNB PPARG KAT8 CTDSPL ITGA9-AS1 MIR26A1 SLC22A14 GC03P037965
GH03I038327 Enhancer 0.8 ENCODE 11.4 +46.3 46335 0.2 HDAC1 ATF1 PKNOX1 BATF ZNF280A ZNF335 ZNF766 FOS ATF7 CEBPB DLEC1P1 SLC22A14 SLC22A13 GC03M038303 RNU6-235P
GH03I038246 Enhancer 0.6 ENCODE 11.3 -33.8 -33773 1.3 CTCF JUN ZIC2 RAD21 JUND ZNF366 POLR2A GLIS1 SMC3 ZNF600 SLC22A14 ACAA1 RNU6-1227P EXOG GC03P038253 PIR62277 OXSR1 LOC101928234
GH03I038124 Enhancer 0.6 ENCODE 11.1 -156.5 -156505 0.2 PKNOX1 ZNF687 CEBPB CEBPG FOXA1 ZNF217 ATF4 CTBP1 CREB1 GC03M038125 ENSG00000201965 SLC22A14 LOC105377033 ACAA1
GH03I038001 Enhancer 1.6 FANTOM5 Ensembl ENCODE dbSUPER 3.5 -277.5 -277480 4.7 HDGF PKNOX1 CLOCK FOXA2 MLX ARID4B SIN3A ZNF2 IRF4 ZNF207 VILL ENSG00000271653 ITGA9-AS1 SLC22A14 GC03P038014
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around SLC22A14 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the SLC22A14 gene promoter:

Genomic Locations for SLC22A14 Gene

Genomic Locations for SLC22A14 Gene
chr3:38,281,430-38,318,575
(GRCh38/hg38)
Size:
37,146 bases
Orientation:
Plus strand
chr3:38,323,785-38,360,066
(GRCh37/hg19)

Genomic View for SLC22A14 Gene

Genes around SLC22A14 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SLC22A14 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SLC22A14 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC22A14 Gene

Proteins for SLC22A14 Gene

  • Protein details for SLC22A14 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y267-S22AE_HUMAN
    Recommended name:
    Solute carrier family 22 member 14
    Protein Accession:
    Q9Y267
    Secondary Accessions:
    • A0AVS9
    • A1L4H6
    • B2RCX3
    • Q6DJT3

    Protein attributes for SLC22A14 Gene

    Size:
    594 amino acids
    Molecular mass:
    66684 Da
    Quaternary structure:
    No Data Available

neXtProt entry for SLC22A14 Gene

Post-translational modifications for SLC22A14 Gene

  • Glycosylation at posLast=9999, isoforms=117, posLast=125125, and isoforms=150
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for SLC22A14 Gene

Domains & Families for SLC22A14 Gene

Gene Families for SLC22A14 Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • Predicted membrane proteins
  • Transporters

Protein Domains for SLC22A14 Gene

Suggested Antigen Peptide Sequences for SLC22A14 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9Y267

UniProtKB/Swiss-Prot:

S22AE_HUMAN :
  • Belongs to the major facilitator (TC 2.A.1) superfamily. Organic cation transporter (TC 2.A.1.19) family.
Family:
  • Belongs to the major facilitator (TC 2.A.1) superfamily. Organic cation transporter (TC 2.A.1.19) family.
genes like me logo Genes that share domains with SLC22A14: view

Function for SLC22A14 Gene

Phenotypes From GWAS Catalog for SLC22A14 Gene

Gene Ontology (GO) - Molecular Function for SLC22A14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005452 inorganic anion exchanger activity IBA --
GO:0015101 organic cation transmembrane transporter activity NAS 10072596
GO:0015347 sodium-independent organic anion transmembrane transporter activity IBA --
GO:0022857 transmembrane transporter activity IEA --
genes like me logo Genes that share ontologies with SLC22A14: view

Phenotypes for SLC22A14 Gene

GenomeRNAi human phenotypes for SLC22A14:
genes like me logo Genes that share phenotypes with SLC22A14: view

Animal Model Products

  • Taconic Biosciences Mouse Models for SLC22A14

CRISPR Products

miRNA for SLC22A14 Gene

miRTarBase miRNAs that target SLC22A14

Inhibitory RNA Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SLC22A14 Gene

Localization for SLC22A14 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC22A14 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SLC22A14 gene
Compartment Confidence
plasma membrane 5
peroxisome 2
nucleus 2
cytosol 2

Gene Ontology (GO) - Cellular Components for SLC22A14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005887 integral component of plasma membrane IBA,NAS 10072596
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with SLC22A14: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for SLC22A14 Gene

Pathways & Interactions for SLC22A14 Gene

SuperPathways for SLC22A14 Gene

No Data Available

Interacting Proteins for SLC22A14 Gene

Selected Interacting proteins: Q9Y267-S22AE_HUMAN for SLC22A14 Gene via IID

Gene Ontology (GO) - Biological Process for SLC22A14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0015695 organic cation transport NAS 10072596
GO:0015698 inorganic anion transport IEA --
GO:0043252 sodium-independent organic anion transport IBA --
GO:0055085 transmembrane transport IEA --
genes like me logo Genes that share ontologies with SLC22A14: view

No data available for Pathways by source and SIGNOR curated interactions for SLC22A14 Gene

Drugs & Compounds for SLC22A14 Gene

No Compound Related Data Available

Transcripts for SLC22A14 Gene

mRNA/cDNA for SLC22A14 Gene

Unigene Clusters for SLC22A14 Gene

Solute carrier family 22, member 14:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for SLC22A14 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10
SP1: -
SP2:

Relevant External Links for SLC22A14 Gene

GeneLoc Exon Structure for
SLC22A14
ECgene alternative splicing isoforms for
SLC22A14

Expression for SLC22A14 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SLC22A14 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SLC22A14 Gene

This gene is overexpressed in Testis (x23.8).

Protein differential expression in normal tissues from HIPED for SLC22A14 Gene

This gene is overexpressed in Heart (68.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for SLC22A14 Gene



Protein tissue co-expression partners for SLC22A14 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of SLC22A14 Gene:

SLC22A14

SOURCE GeneReport for Unigene cluster for SLC22A14 Gene:

Hs.165559

mRNA Expression by UniProt/SwissProt for SLC22A14 Gene:

Q9Y267-S22AE_HUMAN
Tissue specificity: Ubiquitous.

Evidence on tissue expression from TISSUES for SLC22A14 Gene

  • Nervous system(4.1)
genes like me logo Genes that share expression patterns with SLC22A14: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for SLC22A14 Gene

Orthologs for SLC22A14 Gene

This gene was present in the common ancestor of animals.

Orthologs for SLC22A14 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SLC22A14 33 34
  • 97.25 (n)
dog
(Canis familiaris)
Mammalia SLC22A14 33 34
  • 79.94 (n)
cow
(Bos Taurus)
Mammalia SLC22A14 33 34
  • 76.45 (n)
rat
(Rattus norvegicus)
Mammalia Slc22a14 33
  • 76.25 (n)
mouse
(Mus musculus)
Mammalia Slc22a14 33 16 34
  • 72.66 (n)
oppossum
(Monodelphis domestica)
Mammalia SLC22A14 34
  • 43 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 24 (a)
OneToMany
-- 34
  • 18 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia SLC22A14 34
  • 20 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii SLC22A14 34
  • 30 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG5592 34
  • 24 (a)
OneToMany
CG16727 34
  • 21 (a)
OneToMany
CG17752 34
  • 21 (a)
OneToMany
CG6006 34
  • 21 (a)
OneToMany
CG17751 34
  • 20 (a)
OneToMany
CG6356 34
  • 20 (a)
OneToMany
CG7342 34
  • 20 (a)
OneToMany
CG42269 34
  • 19 (a)
OneToMany
CG7333 34
  • 19 (a)
OneToMany
CG14855 34
  • 18 (a)
OneToMany
CG7084 34
  • 18 (a)
OneToMany
CG8925 34
  • 18 (a)
OneToMany
CG10486 34
  • 17 (a)
OneToMany
CG14856 34
  • 17 (a)
OneToMany
CG14857 34
  • 17 (a)
OneToMany
CG6231 34
  • 17 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea C06H5.6 34
  • 20 (a)
OneToMany
B0252.3 34
  • 19 (a)
OneToMany
T22F7.1 34
  • 18 (a)
OneToMany
B0361.11 34
  • 17 (a)
OneToMany
T05A1.5 34
  • 17 (a)
OneToMany
oct-2 34
  • 15 (a)
OneToMany
K05F1.6 34
  • 14 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 24 (a)
OneToMany
-- 34
  • 22 (a)
OneToMany
-- 34
  • 21 (a)
OneToMany
-- 34
  • 21 (a)
OneToMany
-- 34
  • 20 (a)
OneToMany
-- 34
  • 20 (a)
OneToMany
-- 34
  • 19 (a)
OneToMany
-- 34
  • 19 (a)
OneToMany
-- 34
  • 19 (a)
OneToMany
-- 34
  • 18 (a)
OneToMany
-- 34
  • 12 (a)
OneToMany
Species where no ortholog for SLC22A14 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for SLC22A14 Gene

ENSEMBL:
Gene Tree for SLC22A14 (if available)
TreeFam:
Gene Tree for SLC22A14 (if available)

Paralogs for SLC22A14 Gene

(4) SIMAP similar genes for SLC22A14 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with SLC22A14: view

Variants for SLC22A14 Gene

Sequence variations from dbSNP and Humsavar for SLC22A14 Gene

SNP ID Clin Chr 03 pos Variation AA Info Type
rs1000014884 -- 38,283,361(+) C/A genic_upstream_transcript_variant, intron_variant
rs1000120469 -- 38,292,214(+) T/A genic_upstream_transcript_variant, intron_variant
rs1000195292 -- 38,312,053(+) C/T intron_variant
rs1000223755 -- 38,290,641(+) T/A genic_upstream_transcript_variant, intron_variant
rs1000237301 -- 38,308,698(+) G/C intron_variant

Structural Variations from Database of Genomic Variants (DGV) for SLC22A14 Gene

Variant ID Type Subtype PubMed ID
esv3595908 CNV loss 21293372
nsv999852 CNV loss 25217958

Variation tolerance for SLC22A14 Gene

Residual Variation Intolerance Score: 98.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 12.85; 94.82% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SLC22A14 Gene

Human Gene Mutation Database (HGMD)
SLC22A14
SNPedia medical, phenotypic, and genealogical associations of SNPs for
SLC22A14

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SLC22A14 Gene

Disorders for SLC22A14 Gene

Additional Disease Information for SLC22A14

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for SLC22A14 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SLC22A14 Gene

Publications for SLC22A14 Gene

  1. Molecular cloning, mapping, and characterization of two novel human genes, ORCTL3 and ORCTL4, bearing homology to organic-cation transporters. (PMID: 10072596) Nishiwaki T … Nakamura Y (Cytogenetics and cell genetics 1998) 2 3 4 22 58
  2. Characterization of a 1200-kb genomic segment of chromosome 3p22-p21.3. (PMID: 10231028) Daigo Y … Nakamura Y (DNA research : an international journal for rapid publication of reports on genes and genomes 1999) 3 4 22 58
  3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 44 58
  4. L-type voltage-dependent calcium channel alpha subunit 1C is a novel candidate gene associated with secondary hyperparathyroidism: an application of haplotype-based analysis for multiple linked single nucleotide polymorphisms. (PMID: 20424473) Yokoyama K … Hosoya T (Nephron. Clinical practice 2010) 3 44 58
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58

Products for SLC22A14 Gene

Sources for SLC22A14 Gene

Content
Loading form....