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Aliases for SLC22A13 Gene

Aliases for SLC22A13 Gene

  • Solute Carrier Family 22 Member 13 2 3 3 5
  • Solute Carrier Family 22 (Organic Anion/Urate Transporter), Member 13 2 3
  • Solute Carrier Family 22 (Organic Anion Transporter), Member 13 2 3
  • Organic Cationic Transporter-Like 3 2 3
  • ORCTL-3 3 4
  • ORCTL3 3 4
  • OCTL1 3 4
  • Organic-Cation Transporter Like 3 3
  • Organic Cation Transporter-Like 3 4
  • OAT10 3
  • OCTL3 3

External Ids for SLC22A13 Gene

Previous HGNC Symbols for SLC22A13 Gene

  • ORCTL3

Previous GeneCards Identifiers for SLC22A13 Gene

  • GC00U912985
  • GC03P038267
  • GC03P038282

Summaries for SLC22A13 Gene

Entrez Gene Summary for SLC22A13 Gene

  • This gene encodes a member of the organic-cation transporter family. It is located in a gene cluster with another member of the family, organic cation transporter like 4. The encoded protein is a transmembrane protein involved in the transport of small molecules. This protein can function to mediate urate uptake and is a high affinity nicotinate exchanger in the kidneys and the intestine. [provided by RefSeq, Sep 2008]

GeneCards Summary for SLC22A13 Gene

SLC22A13 (Solute Carrier Family 22 Member 13) is a Protein Coding gene. Among its related pathways are Metabolism and NAD metabolism. Gene Ontology (GO) annotations related to this gene include transmembrane transporter activity and nicotinate transmembrane transporter activity. An important paralog of this gene is SLC22A7.

Additional gene information for SLC22A13 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLC22A13 Gene

Genomics for SLC22A13 Gene

GeneHancer (GH) Regulatory Elements for SLC22A13 Gene

Promoters and enhancers for SLC22A13 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH03J038265 Promoter 0.5 EPDnew 650.7 0.0 -12 0.1 SLC22A13 GC03P038253 PIR62277
GH03J038267 Enhancer 0.4 Ensembl ENCODE 650.7 +1.9 1890 0.7 SLC22A13 RNU6-235P XYLB MYD88 ACAA1 VILL LOC101409262 GC03M038270
GH03J038163 Promoter/Enhancer 2.8 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 11.1 -98.6 -98609 8 MLX ZFP64 FEZF1 DMAP1 YY1 SLC30A9 ZNF213 E2F8 ZNF143 SP3 OXSR1 LOC101928234 GORASP1 C3orf35 ACAA1 MYD88 SLC22A13 ACVR2B-AS1 VILL PLCD1
GH03J038147 Enhancer 1.4 FANTOM5 Ensembl ENCODE dbSUPER 10.4 -116.9 -116890 3 HDAC1 ZNF766 GATA2 ATF7 IKZF2 CREM GATAD2B ZEB2 MEF2D MTA1 SLC22A13 VILL MYD88 PLCD1 OXSR1
GH03J038327 Enhancer 0.8 ENCODE 10.7 +62.0 61958 0.2 HDAC1 ATF1 PKNOX1 BATF ZNF280A ZNF335 ZNF766 FOS ATF7 CEBPB DLEC1P1 SLC22A14 SLC22A13 RNU6-235P GC03M038303
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around SLC22A13 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the SLC22A13 gene promoter:
  • IRF-7A
  • GATA-1
  • Evi-1
  • HNF-1A
  • HNF-1
  • AML1a
  • USF-1
  • USF1

Genomic Locations for SLC22A13 Gene

Genomic Locations for SLC22A13 Gene
12,509 bases
Plus strand
12,509 bases
Plus strand

Genomic View for SLC22A13 Gene

Genes around SLC22A13 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SLC22A13 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SLC22A13 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC22A13 Gene

Proteins for SLC22A13 Gene

  • Protein details for SLC22A13 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Solute carrier family 22 member 13
    Protein Accession:
    Secondary Accessions:
    • B2RCV9
    • Q8IYG1

    Protein attributes for SLC22A13 Gene

    551 amino acids
    Molecular mass:
    60862 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for SLC22A13 Gene


neXtProt entry for SLC22A13 Gene

Post-translational modifications for SLC22A13 Gene

  • Glycosylation at posLast=104104, isoforms=292, isoforms=261, and isoforms=257
  • Modification sites at PhosphoSitePlus

Other Protein References for SLC22A13 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SLC22A13 Gene

Domains & Families for SLC22A13 Gene

Gene Families for SLC22A13 Gene

Human Protein Atlas (HPA):
  • Predicted membrane proteins
  • Transporters

Protein Domains for SLC22A13 Gene

Suggested Antigen Peptide Sequences for SLC22A13 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the major facilitator (TC 2.A.1) superfamily. Organic cation transporter (TC 2.A.1.19) family.
  • Belongs to the major facilitator (TC 2.A.1) superfamily. Organic cation transporter (TC 2.A.1.19) family.
genes like me logo Genes that share domains with SLC22A13: view

Function for SLC22A13 Gene

Gene Ontology (GO) - Molecular Function for SLC22A13 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005452 inorganic anion exchanger activity IBA --
GO:0008514 organic anion transmembrane transporter activity IBA --
GO:0015101 organic cation transmembrane transporter activity NAS 10072596
GO:0015347 sodium-independent organic anion transmembrane transporter activity IBA --
GO:0022857 transmembrane transporter activity IEA --
genes like me logo Genes that share ontologies with SLC22A13: view
genes like me logo Genes that share phenotypes with SLC22A13: view

Animal Model Products

  • Taconic Biosciences Mouse Models for SLC22A13

CRISPR Products

miRNA for SLC22A13 Gene

miRTarBase miRNAs that target SLC22A13

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SLC22A13

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SLC22A13 Gene

Localization for SLC22A13 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC22A13 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SLC22A13 gene
Compartment Confidence
plasma membrane 5
extracellular 5

Gene Ontology (GO) - Cellular Components for SLC22A13 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane NAS,IBA 10072596
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IBA,IEA --
GO:0016324 apical plasma membrane IDA 18411268
genes like me logo Genes that share ontologies with SLC22A13: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for SLC22A13 Gene

Pathways & Interactions for SLC22A13 Gene

genes like me logo Genes that share pathways with SLC22A13: view

Pathways by source for SLC22A13 Gene

Interacting Proteins for SLC22A13 Gene

Gene Ontology (GO) - Biological Process for SLC22A13 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0015695 organic cation transport NAS 10072596
GO:0015698 inorganic anion transport IEA --
GO:0015711 organic anion transport IBA --
GO:0015747 urate transport IDA 10072596
GO:0034356 NAD biosynthesis via nicotinamide riboside salvage pathway TAS --
genes like me logo Genes that share ontologies with SLC22A13: view

No data available for SIGNOR curated interactions for SLC22A13 Gene

Drugs & Compounds for SLC22A13 Gene

No Compound Related Data Available

Transcripts for SLC22A13 Gene

mRNA/cDNA for SLC22A13 Gene

(2) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(11) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for SLC22A13 Gene

Solute carrier family 22 (organic anion transporter), member 13:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SLC22A13

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for SLC22A13 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10
SP2: -

Relevant External Links for SLC22A13 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SLC22A13 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SLC22A13 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SLC22A13 Gene

This gene is overexpressed in Kidney - Cortex (x17.6).

Protein differential expression in normal tissues from HIPED for SLC22A13 Gene

This gene is overexpressed in Urine (46.1) and Kidney (22.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for SLC22A13 Gene

Protein tissue co-expression partners for SLC22A13 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of SLC22A13 Gene:


SOURCE GeneReport for Unigene cluster for SLC22A13 Gene:


mRNA Expression by UniProt/SwissProt for SLC22A13 Gene:

Tissue specificity: Ubiquitous, expressed at low levels.

Evidence on tissue expression from TISSUES for SLC22A13 Gene

  • Kidney(4.6)
genes like me logo Genes that share expression patterns with SLC22A13: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for SLC22A13 Gene

Orthologs for SLC22A13 Gene

This gene was present in the common ancestor of chordates.

Orthologs for SLC22A13 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia SLC22A13 34 33
  • 99.46 (n)
(Canis familiaris)
Mammalia SLC22A13 34 33
  • 83.18 (n)
(Mus musculus)
Mammalia Slc22a13 16 34 33
  • 79.13 (n)
Slc22a13b-ps 34
  • 74 (a)
(Rattus norvegicus)
Mammalia Slc22a13 33
  • 77.98 (n)
(Bos Taurus)
Mammalia SLC22A13 34 33
  • 77.82 (n)
(Monodelphis domestica)
Mammalia SLC22A13 34
  • 64 (a)
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 54 (a)
-- 34
  • 53 (a)
(Gallus gallus)
Aves SLC22A13 33
  • 58.74 (n)
-- 34
  • 48 (a)
-- 34
  • 47 (a)
(Anolis carolinensis)
Reptilia -- 34
  • 49 (a)
-- 34
  • 46 (a)
(Danio rerio)
Actinopterygii zgc:153639 33
  • 53.74 (n)
SLC22A13 34
  • 48 (a)
Species where no ortholog for SLC22A13 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SLC22A13 Gene

Gene Tree for SLC22A13 (if available)
Gene Tree for SLC22A13 (if available)
Evolutionary constrained regions (ECRs) for SLC22A13: view image

Paralogs for SLC22A13 Gene

(20) SIMAP similar genes for SLC22A13 Gene using alignment to 3 proteins:

  • H0Y4Y1_HUMAN
genes like me logo Genes that share paralogs with SLC22A13: view

Variants for SLC22A13 Gene

Sequence variations from dbSNP and Humsavar for SLC22A13 Gene

SNP ID Clin Chr 03 pos Variation AA Info Type
rs1000074773 -- 38,276,836(+) G/A intron_variant
rs1000285368 -- 38,263,878(+) T/C upstream_transcript_variant
rs1000295155 -- 38,274,444(+) C/G intron_variant
rs1000325737 -- 38,274,180(+) CTCCT/CT intron_variant
rs1000338587 -- 38,264,319(+) G/A upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for SLC22A13 Gene

Variant ID Type Subtype PubMed ID
esv3595905 OTHER inversion 21293372
esv3595908 CNV loss 21293372
nsv3769 CNV insertion 18451855
nsv528237 CNV loss 19592680
nsv999852 CNV loss 25217958

Variation tolerance for SLC22A13 Gene

Residual Variation Intolerance Score: 58.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.55; 44.44% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SLC22A13 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SLC22A13 Gene

Disorders for SLC22A13 Gene

Additional Disease Information for SLC22A13

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for SLC22A13 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SLC22A13 Gene

Publications for SLC22A13 Gene

  1. Molecular cloning, mapping, and characterization of two novel human genes, ORCTL3 and ORCTL4, bearing homology to organic-cation transporters. (PMID: 10072596) Nishiwaki T … Nakamura Y (Cytogenetics and cell genetics 1998) 2 3 4 22 58
  2. Identification of a new urate and high affinity nicotinate transporter, hOAT10 (SLC22A13). (PMID: 18411268) Bahn A … Burckhardt G (The Journal of biological chemistry 2008) 2 3 22 58
  3. Characterization of a 1200-kb genomic segment of chromosome 3p22-p21.3. (PMID: 10231028) Daigo Y … Nakamura Y (DNA research : an international journal for rapid publication of reports on genes and genomes 1999) 3 4 22 58
  4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 44 58
  5. Isolation of ORCTL3 in a novel genetic screen for tumor-specific apoptosis inducers. (PMID: 19282870) Irshad S … Grimm S (Cell death and differentiation 2009) 3 22 58

Products for SLC22A13 Gene

Sources for SLC22A13 Gene

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