SLC22A12 Gene (Protein Coding)

Solute Carrier Family 22 Member 12

GC11P064609
GIFtS:
45
The protein encoded by this gene is a member of the organic anion transporter (OAT) family, and it acts as a urate transporter to regulate urate levels in blood. This protein is an integral membrane protein primarily found in epithelial cells of the proximal tubule of the kidney. An elevated level of serum urate, hyperuricemia, is associated with increased incidences of gout, a... See more...

Aliases for SLC22A12 Gene

Aliases for SLC22A12 Gene

  • Solute Carrier Family 22 Member 12 2 3 4 5
  • URAT1 2 3 4
  • RST 2 3 4
  • Solute Carrier Family 22 (Organic Anion/Cation Transporter), Member 12 2 3
  • Solute Carrier Family 22 (Organic Anion/Urate Transporter), Member 12 2 3
  • Organic Anion Transporter 4-Like Protein 3 4
  • Renal-Specific Transporter 3 4
  • Urate Anion Exchanger 1 3 4
  • OAT4L 2 3
  • Urate Transporter 1 3
  • SLC22A12 5
  • OATL4 4

External Ids for SLC22A12 Gene

Previous GeneCards Identifiers for SLC22A12 Gene

  • GC11P066873
  • GC11P066039
  • GC11P064099
  • GC11P064100
  • GC11P064115
  • GC11P064359
  • GC11P060685

Summaries for SLC22A12 Gene

Entrez Gene Summary for SLC22A12 Gene

  • The protein encoded by this gene is a member of the organic anion transporter (OAT) family, and it acts as a urate transporter to regulate urate levels in blood. This protein is an integral membrane protein primarily found in epithelial cells of the proximal tubule of the kidney. An elevated level of serum urate, hyperuricemia, is associated with increased incidences of gout, and mutations in this gene cause renal hypouricemia type 1. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2013]

GeneCards Summary for SLC22A12 Gene

SLC22A12 (Solute Carrier Family 22 Member 12) is a Protein Coding gene. Diseases associated with SLC22A12 include Hypouricemia, Renal, 1 and Hyperuricemia. Among its related pathways are Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds and Uricosurics Pathway, Pharmacodynamics. Gene Ontology (GO) annotations related to this gene include PDZ domain binding and urate transmembrane transporter activity. An important paralog of this gene is SLC22A11.

UniProtKB/Swiss-Prot Summary for SLC22A12 Gene

  • Required for efficient urate re-absorption in the kidney. Regulates blood urate levels. Mediates saturable urate uptake by facilitating the exchange of urate against organic anions.

Gene Wiki entry for SLC22A12 Gene

Additional gene information for SLC22A12 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for SLC22A12 Gene

Genomics for SLC22A12 Gene

GeneHancer (GH) Regulatory Elements Pubs

Download GeneHancer 2017 data
Promoters and enhancers for SLC22A12 Gene
GeneHancer (GH) Identifier GH Type GH
Score		 GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites		 Gene Targets
GH11J064591 Promoter 0.5 EPDnew 250.7 +0.6 560 0.1 CEBPA HLF SLC22A12 lnc-RASGRP2-2 NRXN2
GH11J064447 Promoter/Enhancer 1.6 FANTOM5 Ensembl ENCODE CraniofacialAtlas 11.1 -141.8 -141768 2.3 SP1 ZBTB10 DEK CTCF SIN3A REST FOXA2 VEZF1 IRF4 TRIM22 LINC02724 NRXN2 SLC22A12 FERMT3 TRMT112 EHD1 CCDC88B OTUB1 RASGRP2 SF1
GH11J064809 Promoter/Enhancer 2 EPDnew Ensembl ENCODE CraniofacialAtlas 6.3 +219.7 219741 2.4 TBP ZBTB10 MXD4 SIX5 NR2C1 MNT ETS1 MBD2 ZNF217 BHLHE40 MEN1 KCNK4 NRXN2 PPP2R5B FLRT1 SLC22A12 RASGRP2 lnc-MAP4K2-1 MAP4K2
GH11J064489 Enhancer 0.9 Ensembl ENCODE 11.4 -100.2 -100240 1.6 ZBTB10 MNT IKZF1 CTCF SIN3A REST MAX SMC3 RAD21 YY1 ENSG00000286816 NRXN2 LINC02724 SLC22A12 MIR1237 piR-32559-070 HSALNG0084794 SLC22A11 RPS6KA4
GH11J064500 Promoter 0.9 Ensembl 11.2 -90.1 -90140 0.2 MNT BHLHE40 RAD51 ZNF395 REST VEZF1 YY1 ZFP91 USF2 CUX1 ENSG00000232500 HSALNG0084794 SF1 ZFPL1 POLA2 ENSG00000257086 NRXN2 PLCB3 SLC22A12 NRXN2-AS1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around SLC22A12 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for SLC22A12

Top Transcription factor binding sites by QIAGEN in the SLC22A12 gene promoter:
  • Bach1
  • GR
  • GR-alpha
  • GR-beta

Genomic Locations for SLC22A12 Gene

Latest Assembly
chr11:64,590,641-64,603,250
(GRCh38/hg38)
Size:
12,610 bases
Orientation:
Plus strand

Previous Assembly
chr11:64,358,692-64,369,816
(GRCh37/hg19 by Entrez Gene)
Size:
11,125 bases
Orientation:
Plus strand

chr11:64,358,113-64,369,820
(GRCh37/hg19 by Ensembl)
Size:
11,708 bases
Orientation:
Plus strand

Genomic View for SLC22A12 Gene

Genes around SLC22A12 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SLC22A12 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SLC22A12 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for SLC22A12 Gene

Proteins for SLC22A12 Gene

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  • Protein details for SLC22A12 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96S37-S22AC_HUMAN
    Recommended name:
    Solute carrier family 22 member 12
    Protein Accession:
    Q96S37
    Secondary Accessions:
    • B7WPG1
    • G3XAN7
    • Q19PF7
    • Q19PF8
    • Q19PF9
    • Q19PG0
    • Q6UXW3
    • Q96DT2

    Protein attributes for SLC22A12 Gene

    Size:
    553 amino acids
    Molecular mass:
    59630 Da
    Quaternary structure:
    • Interacts with PDZK1.
    SequenceCaution:
    • Sequence=BAB68364.1; Type=Frameshift; Evidence={ECO:0000305};

    Alternative splice isoforms for SLC22A12 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SLC22A12 Gene

Protein Expression for SLC22A12 Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Post-translational modifications for SLC22A12 Gene

  • Glycosylation at Asn56 and Asn102
  • Modification sites at PhosphoSitePlus

Other Protein References for SLC22A12 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibodies for research

  • Santa Cruz Biotechnology (SCBT) Antibodies for SLC22A12

No data available for DME Specific Peptides for SLC22A12 Gene

Domains & Families for SLC22A12 Gene

Gene Families for SLC22A12 Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • Disease related genes
  • FDA approved drug targets
  • Predicted membrane proteins
  • Transporters

Protein Domains for SLC22A12 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for SLC22A12 Gene

GenScript: Design optimal peptide antigens:
  • SLC22A12 protein (Q05CF4_HUMAN)
  • URAT1 transporter protein (Q19PG1_HUMAN)
  • Urate anion exchanger 1 (S22AC_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q96S37

UniProtKB/Swiss-Prot:

S22AC_HUMAN :
  • Belongs to the major facilitator (TC 2.A.1) superfamily. Organic cation transporter (TC 2.A.1.19) family.
Family:
  • Belongs to the major facilitator (TC 2.A.1) superfamily. Organic cation transporter (TC 2.A.1.19) family.
genes like me logo Genes that share domains with SLC22A12: view

Function for SLC22A12 Gene

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  6. Cell Lines for research

Molecular function for SLC22A12 Gene

UniProtKB/Swiss-Prot Function:
Required for efficient urate re-absorption in the kidney. Regulates blood urate levels. Mediates saturable urate uptake by facilitating the exchange of urate against organic anions.

Phenotypes From GWAS Catalog for SLC22A12 Gene

Gene Ontology (GO) - Molecular Function for SLC22A12 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0015143 urate transmembrane transporter activity TAS --
GO:0022857 transmembrane transporter activity IEA --
GO:0030165 PDZ domain binding IPI 15304510
genes like me logo Genes that share ontologies with SLC22A12: view
genes like me logo Genes that share phenotypes with SLC22A12: view

Human Phenotype Ontology for SLC22A12 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for SLC22A12 Gene

MGI Knock Outs for SLC22A12:

Animal Models for research

  • Taconic Biosciences Mouse Models for SLC22A12

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SLC22A12

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for SLC22A12 Gene

Localization for SLC22A12 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC22A12 Gene

Cell membrane. Multi-pass membrane protein. Note=Detected in the luminal membrane of the epithelium of renal proximal tubules.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SLC22A12 gene
Compartment Confidence
plasma membrane 5
extracellular 4
cytosol 2
cytoskeleton 1
mitochondrion 1
peroxisome 1
nucleus 1
endoplasmic reticulum 1
endosome 1
lysosome 1

Gene Ontology (GO) - Cellular Components for SLC22A12 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IDA 12024214
GO:0016324 apical plasma membrane IDA 12024214
GO:0031526 brush border membrane NAS 12024214
genes like me logo Genes that share ontologies with SLC22A12: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for SLC22A12 Gene

Pathways & Interactions for SLC22A12 Gene

genes like me logo Genes that share pathways with SLC22A12: view

Gene Ontology (GO) - Biological Process for SLC22A12 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006811 ion transport IEA --
GO:0015711 organic anion transport IBA 21873635
GO:0015747 urate transport IDA 12024214
GO:0019725 cellular homeostasis NAS 15772301
GO:0042493 response to drug IDA 12024214
genes like me logo Genes that share ontologies with SLC22A12: view

No data available for SIGNOR curated interactions for SLC22A12 Gene

Drugs & Compounds for SLC22A12 Gene

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(16) Drugs for SLC22A12 Gene - From: DrugBank, PharmGKB, ApexBio, DGIdb, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Lesinurad Approved, Investigational Pharma Target, inhibitor URAT1 inhibitor 22
Losartan Approved Pharma Transporter, inhibitor 362
Probenecid Approved, Investigational Pharma Transporter, inhibitor 45
Favipiravir Approved, Investigational Pharma Transporter, inhibitor 0
Sulfinpyrazone Approved Pharma Target, inhibitor 0

(1) ApexBio Compounds for SLC22A12 Gene

Compound Action Cas Number
Lesinurad URAT1 inhibitor 878672-00-5
genes like me logo Genes that share compounds with SLC22A12: view

Drug products for research

Transcripts for SLC22A12 Gene

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mRNA/cDNA for SLC22A12 Gene

4 REFSEQ mRNAs :
13 NCBI additional mRNA sequence :
5 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SLC22A12

Alternative Splicing Database (ASD) splice patterns (SP) for SLC22A12 Gene

ExUns: 1 ^ 2a · 2b · 2c · 2d ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12
SP1: - -
SP2:
SP3: - -
SP4: - -

Relevant External Links for SLC22A12 Gene

GeneLoc Exon Structure for
SLC22A12

Expression for SLC22A12 Gene

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  1. Primer products for research
  2. Gene Expression Assays for research

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for SLC22A12 Gene

mRNA expression in normal human tissues for SLC22A12 Gene
mRNA expression by BioGPS for SLC22A12 GenemRNA expression by GTEx for SLC22A12 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SLC22A12 Gene

This gene is overexpressed in Kidney - Cortex (x52.6).

Protein differential expression in normal tissues from HIPED for SLC22A12 Gene

This gene is overexpressed in Urine (55.8) and Liver, secretome (8.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for SLC22A12 Gene



Protein tissue co-expression partners for SLC22A12 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for SLC22A12

SOURCE GeneReport for Unigene cluster for SLC22A12 Gene:

Hs.174424

mRNA Expression by UniProt/SwissProt for SLC22A12 Gene:

Q96S37-S22AC_HUMAN
Tissue specificity: Detected in kidney (at protein level). Detected in fetal and adult kidney. Detected in epithelial cells of proximal tubules in renal cortex.

Evidence on tissue expression from TISSUES for SLC22A12 Gene

  • Kidney(4.7)
  • Intestine(4.3)
  • Urine(2.2)

Phenotype-based relationships between genes and organs from Gene ORGANizer for SLC22A12 Gene

Germ Layers:
  • ectoderm
  • endoderm
  • mesoderm
Systems:
  • cardiovascular
  • digestive
  • nervous
  • skeletal muscle
  • skeleton
  • urinary
Regions:
Head and neck:
  • brain
  • ear
  • head
Thorax:
  • heart
Abdomen:
  • duodenum
  • intestine
  • kidney
  • large intestine
  • pancreas
  • small intestine
  • stomach
Pelvis:
  • rectum
genes like me logo Genes that share expression patterns with SLC22A12: view

Primer products for research

Orthologs for SLC22A12 Gene

This gene was present in the common ancestor of animals.

Orthologs for SLC22A12 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
 Mammalia SLC22A12 30 31
  • 99.04 (n)
 OneToOne
Dog
(Canis familiaris)
 Mammalia SLC22A12 30 31
  • 85.81 (n)
 OneToOne
Cow
(Bos Taurus)
 Mammalia SLC22A12 30 31
  • 79.99 (n)
 OneToOne
Rat
(Rattus norvegicus)
 Mammalia Slc22a12 30
  • 78.24 (n)
Mouse
(Mus musculus)
 Mammalia Slc22a12 30 17 31
  • 78.06 (n)
 OneToOne
Oppossum
(Monodelphis domestica)
 Mammalia -- 31
  • 49 (a)
 OneToMany
Fruit Fly
(Drosophila melanogaster)
 Insecta CG8654 32
  • 34 (a)
CG6126 32
  • 28 (a)
Species where no ortholog for SLC22A12 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for SLC22A12 Gene

ENSEMBL:
Gene Tree for SLC22A12 (if available)
TreeFam:
Gene Tree for SLC22A12 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for SLC22A12: view image

Paralogs for SLC22A12 Gene

Paralogs for SLC22A12 Gene

(18) SIMAP similar genes for SLC22A12 Gene using alignment to 5 proteins:

  • S22AC_HUMAN
  • B5ME56_HUMAN
  • G3XAN7_HUMAN
  • Q05CF4_HUMAN
  • Q19PG1_HUMAN
genes like me logo Genes that share paralogs with SLC22A12: view

Variants for SLC22A12 Gene

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Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for SLC22A12 Gene

SNP ID Clinical significance and condition Chr 11 pos Variation AA Info Type
858904 Uncertain Significance: not provided 64,599,876(+) C/T
NM_144585.4(SLC22A12):c.1271C>T (p.Thr424Met) 		MISSENSE
871581 Pathogenic: not provided 64,599,701(+) G/C
NM_144585.4(SLC22A12):c.1096G>C (p.Gly366Arg) 		MISSENSE
877259 Uncertain Significance: Familial renal hypouricemia 64,593,703(+) G/A
NM_144585.4(SLC22A12):c.730G>A (p.Gly244Ser) 		MISSENSE_VARIANT,INTRON
877260 Uncertain Significance: Familial renal hypouricemia 64,593,771(+) G/A
NM_144585.4(SLC22A12):c.798G>A (p.Ser266=) 		SYNONYMOUS_VARIANT,INTRON
877261 Uncertain Significance: Familial renal hypouricemia 64,598,897(+) C/T
NM_144585.4(SLC22A12):c.1044C>T (p.Phe348=) 		SYNONYMOUS

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for SLC22A12 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for SLC22A12 Gene

Variant ID Type Subtype PubMed ID
dgv1965n54 CNV loss 21841781
esv2422214 CNV deletion 17116639
esv2744627 CNV deletion 23290073
nsv1113399 CNV deletion 24896259
nsv1122630 CNV deletion 24896259
nsv1142115 CNV tandem duplication 24896259
nsv1149041 CNV insertion 26484159
nsv528506 CNV loss 19592680
nsv555197 CNV loss 21841781
nsv818842 CNV gain 17921354
nsv832188 CNV gain 17160897

Variation tolerance for SLC22A12 Gene

Residual Variation Intolerance Score: 50.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.14; 38.86% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SLC22A12 Gene

Human Gene Mutation Database (HGMD)
SLC22A12
SNPedia medical, phenotypic, and genealogical associations of SNPs for
SLC22A12

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SLC22A12 Gene

Disorders for SLC22A12 Gene

MalaCards: The human disease database

(15) MalaCards diseases for SLC22A12 Gene - From: OMI, CVR, GTR, ORP, SWI, COP, and GCD

Disorder Aliases PubMed IDs
hypouricemia, renal, 1
  • rhuc1
hyperuricemia
  • blood urate raized
gout
  • articular gout
nephrolithiasis, uric acid
  • nephrolithiasis, uric acid, susceptibility to
nephrolithiasis
  • kidney stones
- elite association - COSMIC cancer census association via MalaCards

UniProtKB/Swiss-Prot

S22AC_HUMAN
  • Hypouricemia renal 1 (RHUC1) [MIM:220150]: A disorder characterized by impaired uric acid reabsorption at the apical membrane of proximal renal tubule cells, and high urinary urate excretion. Patients often appear asymptomatic, but may be subject to exercise-induced acute renal failure, chronic renal dysfunction and nephrolithiasis. {ECO:0000269 PubMed:12024214, ECO:0000269 PubMed:14694169, ECO:0000269 PubMed:15327384, ECO:0000269 PubMed:15634722, ECO:0000269 PubMed:15912381, ECO:0000269 PubMed:16837472, ECO:0000269 PubMed:26418379}. Note=The disease is caused by variants affecting the gene represented in this entry.

Additional Disease Information for SLC22A12

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform
genes like me logo Genes that share disorders with SLC22A12: view

No data available for Genatlas for SLC22A12 Gene

Publications for SLC22A12 Gene

  1. Molecular analysis of the SLC22A12 (URAT1) gene in patients with primary gout. (PMID: 16837472) Vázquez-Mellado J … Burgos-Vargas R (Rheumatology (Oxford, England) 2007) 3 4 23 41
  2. Association of the human urate transporter 1 with reduced renal uric acid excretion and hyperuricemia in a German Caucasian population. (PMID: 16385546) Graessler J … Schroeder HE (Arthritis and rheumatism 2006) 3 4 23 41
  3. Molecular identification of a renal urate anion exchanger that regulates blood urate levels. (PMID: 12024214) Enomoto A … Endou H (Nature 2002) 2 3 4 74
  4. Common polymorphisms influencing serum uric acid levels contribute to susceptibility to gout, but not to coronary artery disease. (PMID: 19890391) Stark K … Hengstenberg C (PloS one 2009) 3 23 41
  5. Prevalence of hypouricaemia and SLC22A12 mutations in healthy Korean subjects. (PMID: 19019168) Lee JH … Cheong HI (Nephrology (Carlton, Vic.) 2008) 3 23 41

ExternalLinks

View latest publications for SLC22A12 gene in Mastermind

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