SLC22A11 Gene (Protein Coding)

Solute Carrier Family 22 Member 11

GC11P064573
GIFtS:
42
The protein encoded by this gene is involved in the sodium-independent transport and excretion of organic anions, some of which are potentially toxic. The encoded protein is an integral membrane protein and is found mainly in the kidney and in the placenta, where it may act to prevent potentially harmful organic anions from reaching the fetus. Alternative splicing results in mu... See more...

Aliases for SLC22A11 Gene

Aliases for SLC22A11 Gene

  • Solute Carrier Family 22 Member 11 2 3 4 5
  • OAT4 2 3 4
  • Solute Carrier Family 22 (Organic Anion/Urate Transporter), Member 11 2 3
  • Organic Anion Transporter 4 3 4
  • Solute Carrier Family 22 (Organic Anion/Cation Transporter), Member 11 3
  • SLC22A11 5
  • HOAT4 3

External Ids for SLC22A11 Gene

Previous GeneCards Identifiers for SLC22A11 Gene

  • GC11P066839
  • GC11P066004
  • GC11P064098
  • GC11P064079
  • GC11P064324
  • GC11P060650

Summaries for SLC22A11 Gene

Entrez Gene Summary for SLC22A11 Gene

  • The protein encoded by this gene is involved in the sodium-independent transport and excretion of organic anions, some of which are potentially toxic. The encoded protein is an integral membrane protein and is found mainly in the kidney and in the placenta, where it may act to prevent potentially harmful organic anions from reaching the fetus. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2015]

GeneCards Summary for SLC22A11 Gene

SLC22A11 (Solute Carrier Family 22 Member 11) is a Protein Coding gene. Diseases associated with SLC22A11 include Danubian Endemic Familial Nephropathy and Gout. Among its related pathways are Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds and Uricosurics Pathway, Pharmacodynamics. Gene Ontology (GO) annotations related to this gene include transmembrane transporter activity and organic anion transmembrane transporter activity. An important paralog of this gene is SLC22A12.

UniProtKB/Swiss-Prot Summary for SLC22A11 Gene

  • Mediates saturable uptake of estrone sulfate, dehydroepiandrosterone sulfate and related compounds.

Gene Wiki entry for SLC22A11 Gene

Additional gene information for SLC22A11 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for SLC22A11 Gene

Genomics for SLC22A11 Gene

GeneHancer (GH) Regulatory Elements Pubs

Download GeneHancer 2017 data
Promoters and enhancers for SLC22A11 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around SLC22A11 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for SLC22A11

Top Transcription factor binding sites by QIAGEN in the SLC22A11 gene promoter:
  • c-Jun
  • E47
  • Lmo2
  • MIF-1
  • p53
  • PPAR-gamma1
  • PPAR-gamma2
  • Tal-1
  • Tal-1beta

Genomic Locations for SLC22A11 Gene

Latest Assembly
chr11:64,555,690-64,572,875
(GRCh38/hg38)
Size:
17,186 bases
Orientation:
Plus strand

Previous Assembly
chr11:64,323,413-64,340,347
(GRCh37/hg19 by Entrez Gene)
Size:
16,935 bases
Orientation:
Plus strand

chr11:64,323,098-64,340,347
(GRCh37/hg19 by Ensembl)
Size:
17,250 bases
Orientation:
Plus strand

Genomic View for SLC22A11 Gene

Genes around SLC22A11 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SLC22A11 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SLC22A11 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for SLC22A11 Gene

Proteins for SLC22A11 Gene

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  • Protein details for SLC22A11 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NSA0-S22AB_HUMAN
    Recommended name:
    Solute carrier family 22 member 11
    Protein Accession:
    Q9NSA0
    Secondary Accessions:
    • A8K426
    • Q53GR2
    • Q6ZP72
    • Q8NBU4

    Protein attributes for SLC22A11 Gene

    Size:
    550 amino acids
    Molecular mass:
    59972 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAC11483.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for SLC22A11 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SLC22A11 Gene

Protein Expression for SLC22A11 Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Post-translational modifications for SLC22A11 Gene

  • N-glycosylated. Contains several complex-type N-glycans.
  • Glycosylation at Asn39, Asn56, and Asn99
  • Modification sites at PhosphoSitePlus

Other Protein References for SLC22A11 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SLC22A11 Gene

Domains & Families for SLC22A11 Gene

Gene Families for SLC22A11 Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • FDA approved drug targets
  • Plasma proteins
  • Predicted membrane proteins
  • Transporters

Protein Domains for SLC22A11 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for SLC22A11 Gene

GenScript: Design optimal peptide antigens:
  • Organic anion transporter 4 (S22AB_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q9NSA0

UniProtKB/Swiss-Prot:

S22AB_HUMAN :
  • Belongs to the major facilitator (TC 2.A.1) superfamily. Organic cation transporter (TC 2.A.1.19) family.
Family:
  • Belongs to the major facilitator (TC 2.A.1) superfamily. Organic cation transporter (TC 2.A.1.19) family.
genes like me logo Genes that share domains with SLC22A11: view

Function for SLC22A11 Gene

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  6. Cell Lines for research

Molecular function for SLC22A11 Gene

UniProtKB/Swiss-Prot Function:
Mediates saturable uptake of estrone sulfate, dehydroepiandrosterone sulfate and related compounds.

Phenotypes From GWAS Catalog for SLC22A11 Gene

Gene Ontology (GO) - Molecular Function for SLC22A11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005452 inorganic anion exchanger activity IDA 15037815
GO:0005515 protein binding IPI 16236806
GO:0008514 organic anion transmembrane transporter activity IDA 15102942
GO:0015347 sodium-independent organic anion transmembrane transporter activity IDA 10660625
GO:0022857 transmembrane transporter activity IEA --
genes like me logo Genes that share ontologies with SLC22A11: view
genes like me logo Genes that share phenotypes with SLC22A11: view

Animal Models for research

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SLC22A11

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for SLC22A11 Gene

Localization for SLC22A11 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC22A11 Gene

Cell membrane. Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SLC22A11 gene
Compartment Confidence
plasma membrane 5
extracellular 4
cytoskeleton 1
mitochondrion 1
nucleus 1
endoplasmic reticulum 1
cytosol 1
lysosome 1

Gene Ontology (GO) - Cellular Components for SLC22A11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane IDA 10660625
GO:0009897 external side of plasma membrane IDA 15102942
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with SLC22A11: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for SLC22A11 Gene

Pathways & Interactions for SLC22A11 Gene

genes like me logo Genes that share pathways with SLC22A11: view

Gene Ontology (GO) - Biological Process for SLC22A11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006811 ion transport IEA --
GO:0015698 inorganic anion transport IEA --
GO:0015711 organic anion transport IBA,IDA 10660625
GO:0046415 urate metabolic process IMP 19503597
GO:0055085 transmembrane transport IEA --
genes like me logo Genes that share ontologies with SLC22A11: view

No data available for SIGNOR curated interactions for SLC22A11 Gene

Drugs & Compounds for SLC22A11 Gene

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(47) Drugs for SLC22A11 Gene - From: DrugBank, PharmGKB, DGIdb, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Probenecid Approved, Investigational Pharma Target, Transporter, inhibitor, blocker 45
Methotrexate Approved Pharma Transporter, substrate Folate antagonist,inhibits DFHR 1874
Bumetanide Approved Pharma Transporter, inhibitor NKCC cotransporter inhibitor, Na+/2Cl-/K+ (NKCC) symporter inhibitor 29
Cefalotin Approved, Investigational, Vet_approved Pharma Transporter, inhibitor 0
Cefamandole Approved, Experimental Pharma Transporter, inhibitor 2

(2) Additional Compounds for SLC22A11 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
4'-Hydroxydiclofenac
  • (O-(2,6-Dichloro-4-hydroxyanilino)phenyl)acetic acid
  • 4'-Hydroxy diclofenac
  • 4'-OH DCF
  • (O-(2,6-Dichloro-4-hydroxyanilino)phenyl)acetate
  • {2-[(2,6-dichloro-4-hydroxyphenyl)amino]phenyl}acetic acid
 64118-84-9
5'-Hydroxypiroxicam
  • 5-Hydroxypiroxicam
  • 4-Hydroxy-N-(5-hydroxypyridin-2-yl)-2-methyl-1,1-dioxo-2H-1λ⁶,2-benzothiazine-3-carboximidate
  • 5'-Hydroxypiroxicam
 77459-78-0
genes like me logo Genes that share compounds with SLC22A11: view

Transcripts for SLC22A11 Gene

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mRNA/cDNA for SLC22A11 Gene

2 REFSEQ mRNAs :
13 NCBI additional mRNA sequence :
8 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SLC22A11

Alternative Splicing Database (ASD) splice patterns (SP) for SLC22A11 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7a · 7b · 7c ^ 8a · 8b ^ 9 ^ 10 ^ 11
SP1: - - - -
SP2: - - - - - -
SP3: - - - -
SP4:
SP5:
SP6: - -

Relevant External Links for SLC22A11 Gene

GeneLoc Exon Structure for
SLC22A11

Expression for SLC22A11 Gene

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  1. Primer products for research
  2. Gene Expression Assays for research

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for SLC22A11 Gene

mRNA expression in normal human tissues for SLC22A11 Gene
mRNA expression by GTEx for SLC22A11 GenemRNA expression by BioGPS for SLC22A11 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SLC22A11 Gene

This gene is overexpressed in Kidney - Cortex (x51.0).

Protein differential expression in normal tissues from HIPED for SLC22A11 Gene

This gene is overexpressed in Urine (47.7) and Placenta (17.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for SLC22A11 Gene



Protein tissue co-expression partners for SLC22A11 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for SLC22A11

SOURCE GeneReport for Unigene cluster for SLC22A11 Gene:

Hs.220844

mRNA Expression by UniProt/SwissProt for SLC22A11 Gene:

Q9NSA0-S22AB_HUMAN
Tissue specificity: Detected in placenta and kidney.

Evidence on tissue expression from TISSUES for SLC22A11 Gene

  • Kidney(4.7)
  • Intestine(4.4)
  • Liver(4.3)
genes like me logo Genes that share expression patterns with SLC22A11: view

Primer products for research

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for SLC22A11 Gene

Orthologs for SLC22A11 Gene

This gene was present in the common ancestor of animals.

Orthologs for SLC22A11 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
 Mammalia SLC22A11 30 31
  • 99.64 (n)
 OneToOne
Dog
(Canis familiaris)
 Mammalia SLC22A11 30 31
  • 80.72 (n)
 OneToOne
Cow
(Bos Taurus)
 Mammalia SLC22A11 30 31
  • 79.24 (n)
 OneToOne
Platypus
(Ornithorhynchus anatinus)
 Mammalia SLC22A11 31
  • 48 (a)
 OneToOne
Oppossum
(Monodelphis domestica)
 Mammalia -- 31
  • 45 (a)
 OneToMany
Fruit Fly
(Drosophila melanogaster)
 Insecta CG8654 32
  • 33 (a)
Worm
(Caenorhabditis elegans)
 Secernentea ZK455.8a 32
  • 29 (a)
ZK455.8b 32
  • 28 (a)
K05F1.6 32
  • 27 (a)
Species where no ortholog for SLC22A11 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Mouse (Mus musculus)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Zebrafish (Danio rerio)

Evolution for SLC22A11 Gene

ENSEMBL:
Gene Tree for SLC22A11 (if available)
TreeFam:
Gene Tree for SLC22A11 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for SLC22A11: view image

Paralogs for SLC22A11 Gene

Paralogs for SLC22A11 Gene

(18) SIMAP similar genes for SLC22A11 Gene using alignment to 4 proteins:

  • S22AB_HUMAN
  • A6NCG2_HUMAN
  • H7C0B7_HUMAN
  • H7C3R9_HUMAN
genes like me logo Genes that share paralogs with SLC22A11: view

Variants for SLC22A11 Gene

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Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for SLC22A11 Gene

SNP ID Clinical significance and condition Chr 11 pos Variation AA Info Type
rs72559736 Benign: not provided 64,556,035(+) C/T
NM_018484.4(SLC22A11):c.36C>T (p.Gly12=) 		SYNONYMOUS
rs77872171 Benign: not provided 64,556,062(+) G/A
NM_018484.4(SLC22A11):c.63G>A (p.Val21=) 		SYNONYMOUS
rs12785832 - p.Val155Gly

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for SLC22A11 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for SLC22A11 Gene

Variant ID Type Subtype PubMed ID
dgv1965n54 CNV loss 21841781
esv2422214 CNV deletion 17116639
nsv825945 CNV gain 20364138
nsv832188 CNV gain 17160897

Variation tolerance for SLC22A11 Gene

Residual Variation Intolerance Score: 37.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.95; 36.24% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SLC22A11 Gene

Human Gene Mutation Database (HGMD)
SLC22A11
SNPedia medical, phenotypic, and genealogical associations of SNPs for
SLC22A11

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SLC22A11 Gene

Disorders for SLC22A11 Gene

MalaCards: The human disease database

(6) MalaCards diseases for SLC22A11 Gene - From: COP and GCD

Disorder Aliases PubMed IDs
danubian endemic familial nephropathy
  • defn
gout
  • articular gout
nephrolithiasis, uric acid
  • nephrolithiasis, uric acid, susceptibility to
persistent fetal circulation syndrome
  • congenital alveolar capillary dysplasia with misalignment of pulmonary veins
tubulointerstitial kidney disease, autosomal dominant, 1
  • adtkd1
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for SLC22A11

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform
genes like me logo Genes that share disorders with SLC22A11: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SLC22A11 Gene

Publications for SLC22A11 Gene

  1. Molecular cloning and characterization of multispecific organic anion transporter 4 expressed in the placenta. (PMID: 10660625) Cha SH … Endou H (The Journal of biological chemistry 2000) 2 3 4 26
  2. Identification and characterization of single nucleotide polymorphisms of SLC22A11 (hOAT4) in Korean women osteoporosis patients. (PMID: 18414001) Lee WK … Cha SH (Molecules and cells 2008) 3 23 41
  3. The role of N-linked glycosylation in protein folding, membrane targeting, and substrate binding of human organic anion transporter hOAT4. (PMID: 15576633) Zhou F … You G (Molecular pharmacology 2005) 2 3 4
  4. Human organic anion transporters mediate the transport of tetracycline. (PMID: 11855680) Babu E … Endou H (Japanese journal of pharmacology 2002) 3 23 26
  5. Replication of the five novel loci for uric acid concentrations and potential mediating mechanisms. (PMID: 19861489) van der Harst P … Navis G (Human molecular genetics 2010) 3 41

ExternalLinks

View latest publications for SLC22A11 gene in Mastermind

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