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Aliases for SLC22A11 Gene

Aliases for SLC22A11 Gene

  • Solute Carrier Family 22 Member 11 2 3 5
  • Solute Carrier Family 22 (Organic Anion/Urate Transporter), Member 11 2 3
  • Organic Anion Transporter 4 3 4
  • OAT4 3 4
  • Solute Carrier Family 22 (Organic Anion/Cation Transporter), Member 11 3
  • HOAT4 3

External Ids for SLC22A11 Gene

Previous GeneCards Identifiers for SLC22A11 Gene

  • GC11P066839
  • GC11P066004
  • GC11P064098
  • GC11P064079
  • GC11P064324
  • GC11P060650

Summaries for SLC22A11 Gene

Entrez Gene Summary for SLC22A11 Gene

  • The protein encoded by this gene is involved in the sodium-independent transport and excretion of organic anions, some of which are potentially toxic. The encoded protein is an integral membrane protein and is found mainly in the kidney and in the placenta, where it may act to prevent potentially harmful organic anions from reaching the fetus. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2015]

GeneCards Summary for SLC22A11 Gene

SLC22A11 (Solute Carrier Family 22 Member 11) is a Protein Coding gene. Diseases associated with SLC22A11 include Gout and Persistent Fetal Circulation Syndrome. Among its related pathways are Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds and Zidovudine Pathway, Pharmacokinetics/Pharmacodynamics. Gene Ontology (GO) annotations related to this gene include transmembrane transporter activity and organic anion transmembrane transporter activity. An important paralog of this gene is SLC22A12.

UniProtKB/Swiss-Prot for SLC22A11 Gene

  • Mediates saturable uptake of estrone sulfate, dehydroepiandrosterone sulfate and related compounds.

Gene Wiki entry for SLC22A11 Gene

Additional gene information for SLC22A11 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLC22A11 Gene

Genomics for SLC22A11 Gene

GeneHancer (GH) Regulatory Elements for SLC22A11 Gene

Promoters and enhancers for SLC22A11 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH11I064553 Promoter/Enhancer 1.8 EPDnew FANTOM5 Ensembl ENCODE 550.8 -0.7 -728 3.2 HDAC1 RB1 ARID4B ZNF48 ZSCAN9 RAD21 RARA ARID2 ZNF366 ZNF143 SLC22A11 PYGM MEN1 NRXN2 MAJIN GC11P064541
GH11I064629 Enhancer 1 FANTOM5 ENCODE dbSUPER 12.1 +73.9 73917 1.1 SMARCE1 CTCF AFF1 DPF2 ZNF148 HDAC2 SMARCA4 IKZF1 CREM NRXN2 SLC22A11 RASGRP2 GC11M064637 GC11M064638 SLC22A12
GH11I064438 Enhancer 0.8 FANTOM5 ENCODE 11.3 -116.5 -116513 1.3 SMARCE1 ZNF217 ZNF121 CTBP1 MTA1 ESR1 DPF2 HNF4A SLC22A12 NRXN2 SLC22A11 MIR1237 OTUB1 GC11P064445 ENSG00000231492
GH11I064501 Enhancer 0.8 ENCODE 11.1 -53.4 -53405 1.9 HDAC1 HDGF ZFP64 RARA TCF12 RCOR1 THAP11 SP5 NCOA1 ZEB2 LOC105369342 ENSG00000237410 NRXN2 SLC22A11 SLC22A12 MIR1237 LOC100996455 ENSG00000237363
GH11I064630 Enhancer 0.7 ENCODE 12.1 +74.6 74598 0.2 CTCF SIN3A CTBP1 MTA3 EGR1 CREM SMARCE1 AFF1 RNF2 L3MBTL2 NRXN2 SLC22A11 GC11M064637 GC11M064638 SLC22A12
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around SLC22A11 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the SLC22A11 gene promoter:

Genomic Locations for SLC22A11 Gene

Genomic Locations for SLC22A11 Gene
17,250 bases
Plus strand

Genomic View for SLC22A11 Gene

Genes around SLC22A11 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SLC22A11 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SLC22A11 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC22A11 Gene

Proteins for SLC22A11 Gene

  • Protein details for SLC22A11 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Solute carrier family 22 member 11
    Protein Accession:
    Secondary Accessions:
    • A8K426
    • Q53GR2
    • Q6ZP72
    • Q8NBU4

    Protein attributes for SLC22A11 Gene

    550 amino acids
    Molecular mass:
    59972 Da
    Quaternary structure:
    No Data Available
    • Sequence=BAC11483.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for SLC22A11 Gene


neXtProt entry for SLC22A11 Gene

Post-translational modifications for SLC22A11 Gene

  • N-glycosylated. Contains several complex-type N-glycans.
  • Glycosylation at posLast=3939, posLast=5656, and posLast=9999

Other Protein References for SLC22A11 Gene

No data available for DME Specific Peptides for SLC22A11 Gene

Domains & Families for SLC22A11 Gene

Gene Families for SLC22A11 Gene

Human Protein Atlas (HPA):
  • FDA approved drug targets
  • Plasma proteins
  • Predicted membrane proteins
  • Transporters

Protein Domains for SLC22A11 Gene

Suggested Antigen Peptide Sequences for SLC22A11 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the major facilitator (TC 2.A.1) superfamily. Organic cation transporter (TC 2.A.1.19) family.
  • Belongs to the major facilitator (TC 2.A.1) superfamily. Organic cation transporter (TC 2.A.1.19) family.
genes like me logo Genes that share domains with SLC22A11: view

Function for SLC22A11 Gene

Molecular function for SLC22A11 Gene

UniProtKB/Swiss-Prot Function:
Mediates saturable uptake of estrone sulfate, dehydroepiandrosterone sulfate and related compounds.

Phenotypes From GWAS Catalog for SLC22A11 Gene

Gene Ontology (GO) - Molecular Function for SLC22A11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005452 inorganic anion exchanger activity IDA 15037815
GO:0005515 protein binding IPI 16236806
GO:0008514 organic anion transmembrane transporter activity IDA 15102942
GO:0015143 urate transmembrane transporter activity IBA --
GO:0015347 sodium-independent organic anion transmembrane transporter activity TAS --
genes like me logo Genes that share ontologies with SLC22A11: view
genes like me logo Genes that share phenotypes with SLC22A11: view

Animal Model Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for SLC22A11 Gene

Localization for SLC22A11 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC22A11 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SLC22A11 gene
Compartment Confidence
plasma membrane 5
extracellular 5

Gene Ontology (GO) - Cellular Components for SLC22A11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane IDA 10660625
GO:0009897 external side of plasma membrane IDA 15102942
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with SLC22A11: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for SLC22A11 Gene

Pathways & Interactions for SLC22A11 Gene

genes like me logo Genes that share pathways with SLC22A11: view

Gene Ontology (GO) - Biological Process for SLC22A11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport IEA --
GO:0006811 ion transport IEA --
GO:0015698 inorganic anion transport IEA --
GO:0015711 organic anion transport IDA 10660625
GO:0015747 urate transport IBA --
genes like me logo Genes that share ontologies with SLC22A11: view

No data available for SIGNOR curated interactions for SLC22A11 Gene

Drugs & Compounds for SLC22A11 Gene

(40) Drugs for SLC22A11 Gene - From: DrugBank, PharmGKB, DGIdb, FDA Approved Drugs, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Probenecid Approved, Investigational Pharma Inhibition, Inhibitor, Target, Transporter, inhibitor, blocker 35
Methotrexate Approved Pharma Transporter, substrate Folate antagonist,inhibits DFHR 1603
Bumetanide Approved Pharma Agonist, Transporter, inhibitor NKCC cotransporter inhibitor, Na+/2Cl-/K+ (NKCC) symporter inhibitor 19
Caprylic acid Approved, Experimental, Investigational Pharma Transporter, inhibitor 0
Cefalotin Approved, Vet_approved Pharma Transporter, inhibitor 0

(2) Additional Compounds for SLC22A11 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
  • (O-(2,6-Dichloro-4-hydroxyanilino)phenyl)acetic acid
  • 4'-Hydroxy diclofenac
  • 4'-OH DCF
  • {2-[(2,6-dichloro-4-hydroxyphenyl)amino]phenyl}acetic acid
genes like me logo Genes that share compounds with SLC22A11: view

Transcripts for SLC22A11 Gene

Unigene Clusters for SLC22A11 Gene

Solute carrier family 22 (organic anion/urate transporter), member 11:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for SLC22A11 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7a · 7b · 7c ^ 8a · 8b ^ 9 ^ 10 ^ 11
SP1: - - - -
SP2: - - - - - -
SP3: - - - -
SP6: - -

Relevant External Links for SLC22A11 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SLC22A11 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SLC22A11 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SLC22A11 Gene

This gene is overexpressed in Kidney - Cortex (x51.0).

Protein differential expression in normal tissues from HIPED for SLC22A11 Gene

This gene is overexpressed in Urine (47.7) and Placenta (17.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for SLC22A11 Gene

Protein tissue co-expression partners for SLC22A11 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of SLC22A11 Gene:


SOURCE GeneReport for Unigene cluster for SLC22A11 Gene:


mRNA Expression by UniProt/SwissProt for SLC22A11 Gene:

Tissue specificity: Detected in placenta and kidney.

Evidence on tissue expression from TISSUES for SLC22A11 Gene

  • Kidney(4.7)
  • Intestine(4.2)
  • Liver(4.1)
genes like me logo Genes that share expression patterns with SLC22A11: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for SLC22A11 Gene

Orthologs for SLC22A11 Gene

This gene was present in the common ancestor of animals.

Orthologs for SLC22A11 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia SLC22A11 33 34
  • 99.64 (n)
(Canis familiaris)
Mammalia SLC22A11 33 34
  • 80.72 (n)
(Bos Taurus)
Mammalia SLC22A11 33 34
  • 79.24 (n)
(Ornithorhynchus anatinus)
Mammalia SLC22A11 34
  • 48 (a)
(Monodelphis domestica)
Mammalia -- 34
  • 45 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG8654 35
  • 33 (a)
(Caenorhabditis elegans)
Secernentea ZK455.8a 35
  • 29 (a)
ZK455.8b 35
  • 28 (a)
K05F1.6 35
  • 27 (a)
Species where no ortholog for SLC22A11 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • zebrafish (Danio rerio)

Evolution for SLC22A11 Gene

Gene Tree for SLC22A11 (if available)
Gene Tree for SLC22A11 (if available)

Paralogs for SLC22A11 Gene

Variants for SLC22A11 Gene

Sequence variations from dbSNP and Humsavar for SLC22A11 Gene

SNP ID Clin Chr 11 pos Variation AA Info Type
rs1000150332 -- 64,562,957(+) G/A intron_variant
rs1000261909 -- 64,559,781(+) G/A intron_variant
rs1000431353 -- 64,565,072(+) C/T intron_variant
rs1000651835 -- 64,560,002(+) C/G/T intron_variant
rs1001223455 -- 64,571,487(+) C/A/T 3_prime_UTR_variant

Structural Variations from Database of Genomic Variants (DGV) for SLC22A11 Gene

Variant ID Type Subtype PubMed ID
nsv832188 CNV gain 17160897
nsv825945 CNV gain 20364138
esv2422214 CNV deletion 17116639
dgv1965n54 CNV loss 21841781

Variation tolerance for SLC22A11 Gene

Residual Variation Intolerance Score: 37.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.95; 36.24% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SLC22A11 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SLC22A11 Gene

Disorders for SLC22A11 Gene

MalaCards: The human disease database

(2) MalaCards diseases for SLC22A11 Gene - From: HGMD, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
  • articular gout
persistent fetal circulation syndrome
  • congenital alveolar capillary dysplasia with misalignment of pulmonary veins
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for SLC22A11

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with SLC22A11: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SLC22A11 Gene

Publications for SLC22A11 Gene

  1. Molecular cloning and characterization of multispecific organic anion transporter 4 expressed in the placenta. (PMID: 10660625) Cha SH … Endou H (The Journal of biological chemistry 2000) 2 3 4 25 58
  2. Identification and characterization of single nucleotide polymorphisms of SLC22A11 (hOAT4) in Korean women osteoporosis patients. (PMID: 18414001) Lee WK … Cha SH (Molecules and cells 2008) 3 22 44 58
  3. The role of N-linked glycosylation in protein folding, membrane targeting, and substrate binding of human organic anion transporter hOAT4. (PMID: 15576633) Zhou F … You G (Molecular pharmacology 2005) 2 3 4 58
  4. Human organic anion transporters mediate the transport of tetracycline. (PMID: 11855680) Babu E … Endou H (Japanese journal of pharmacology 2002) 3 22 25 58
  5. Multiple genetic loci influence serum urate levels and their relationship with gout and cardiovascular disease risk factors. (PMID: 20884846) Yang Q … Coresh J (Circulation. Cardiovascular genetics 2010) 3 44 58

Products for SLC22A11 Gene

Sources for SLC22A11 Gene

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