Aliases for SLC22A11 Gene
External Ids for SLC22A11 Gene
Previous GeneCards Identifiers for SLC22A11 Gene
The protein encoded by this gene is involved in the sodium-independent transport and excretion of organic anions, some of which are potentially toxic. The encoded protein is an integral membrane protein and is found mainly in the kidney and in the placenta, where it may act to prevent potentially harmful organic anions from reaching the fetus. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2015]
GeneCards Summary for SLC22A11 Gene
SLC22A11 (Solute Carrier Family 22 Member 11) is a Protein Coding gene. Diseases associated with SLC22A11 include Danubian Endemic Familial Nephropathy and Gout. Among its related pathways are Allopurinol Pathway, Pharmacokinetics and Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds. Gene Ontology (GO) annotations related to this gene include transmembrane transporter activity and organic anion transmembrane transporter activity. An important paralog of this gene is SLC22A12.
UniProtKB/Swiss-Prot Summary for SLC22A11 Gene
Mediates saturable uptake of estrone sulfate, dehydroepiandrosterone sulfate and related compounds.