Aliases for SLC22A10 Gene

Aliases for SLC22A10 Gene

  • Solute Carrier Family 22 Member 10 2 3 4 5
  • OAT5 2 3 4
  • Solute Carrier Family 22 (Organic Anion/Cation Transporter), Member 10 2 3
  • Organic Anion Transporter 5 3 4
  • HOAT5 2 3
  • Solute Carrier Family 22, Member 10 2
  • SLC22A10 5

External Ids for SLC22A10 Gene

Previous GeneCards Identifiers for SLC22A10 Gene

  • GC11U990606
  • GC11P062815
  • GC11P063057
  • GC11P059386
  • GC11P062905

Summaries for SLC22A10 Gene

GeneCards Summary for SLC22A10 Gene

SLC22A10 (Solute Carrier Family 22 Member 10) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include transmembrane transporter activity. An important paralog of this gene is SLC22A24.

Gene Wiki entry for SLC22A10 Gene

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for SLC22A10 Gene

Genomics for SLC22A10 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for SLC22A10 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH11J063289 Promoter 0.9 EPDnew 250.1 +152.1 152110 0.1 CEBPA HOMEZ KDM6A FOXA2 RXRA RARA THRB BCL6 JUND SOX5 SLC22A10 SLC22A9 ENSG00000256181 piR-45012-085 SLC22A25
GH11J063290 Promoter 0.3 EPDnew 250.1 +152.5 152501 0.1 SLC22A10 ENSG00000256181 piR-45012-085 SLC22A25 SLC22A9
GH11J063243 Enhancer 0.6 FANTOM5 38.7 +105.9 105864 0.7 RXRA JUND HNF4A REST MAX SP1 TAF1 YY1 ATF3 SLC22A25 CCND2P1 lnc-SLC22A25-1 SLC22A10 SLC22A9 SLC22A24
GH11J063249 Enhancer 0.9 dbSUPER 8.8 +113.0 113040 2.8 MXD4 CEBPA FOXA1 HOMEZ KDM6A THAP11 FOXA2 ZNF511 MAFF SMAD4 HSALNG0084689 LOC105369334 lnc-SLC22A9-2 TTC9C HNRNPUL2 SPINDOC SLC22A10 SLC22A25 lnc-SLC22A25-1 SLC22A9
GH11J063242 Enhancer 1 Ensembl dbSUPER 7.9 +103.5 103533 0.4 CEBPA HOMEZ THAP11 FOXA2 SAP130 RXRA RARA TEAD3 ZBTB33 BCL6 CCND2P1 SLC22A10 SLC22A25 ENSG00000256863 lnc-SLC22A25-1 SLC22A24
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around SLC22A10 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for SLC22A10

Top Transcription factor binding sites by QIAGEN in the SLC22A10 gene promoter:
  • GATA-1
  • GATA-2
  • GATA-3
  • HTF
  • Pax-6
  • YY1

Genomic Locations for SLC22A10 Gene

Latest Assembly
231,852 bases
Plus strand

Previous Assembly
(GRCh37/hg19 by Entrez Gene)
21,881 bases
Plus strand

(GRCh37/hg19 by Ensembl)
231,852 bases
Plus strand

Genomic View for SLC22A10 Gene

Genes around SLC22A10 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SLC22A10 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SLC22A10 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC22A10 Gene

Proteins for SLC22A10 Gene

  • Protein details for SLC22A10 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Solute carrier family 22 member 10
    Protein Accession:
    Secondary Accessions:
    • Q68CJ0

    Protein attributes for SLC22A10 Gene

    541 amino acids
    Molecular mass:
    60257 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for SLC22A10 Gene


neXtProt entry for SLC22A10 Gene

Post-translational modifications for SLC22A10 Gene

  • Glycosylation at Asn56 and Asn102
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for SLC22A10 Gene

Domains & Families for SLC22A10 Gene

Gene Families for SLC22A10 Gene

Human Protein Atlas (HPA):
  • Predicted membrane proteins
  • Transporters

Protein Domains for SLC22A10 Gene

Suggested Antigen Peptide Sequences for SLC22A10 Gene

GenScript: Design optimal peptide antigens:
  • cDNA FLJ60017, highly similar to Solute carrier family 22 member 10 (B4DJY8_HUMAN)
  • Organic anion transporter 5 (S22AA_HUMAN)

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the major facilitator (TC 2.A.1) superfamily. Organic cation transporter (TC 2.A.1.19) family.
  • Belongs to the major facilitator (TC 2.A.1) superfamily. Organic cation transporter (TC 2.A.1.19) family.
genes like me logo Genes that share domains with SLC22A10: view

Function for SLC22A10 Gene

Phenotypes From GWAS Catalog for SLC22A10 Gene

Gene Ontology (GO) - Molecular Function for SLC22A10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0022857 transmembrane transporter activity IEA --
genes like me logo Genes that share ontologies with SLC22A10: view
genes like me logo Genes that share phenotypes with SLC22A10: view

Animal Models for research

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SLC22A10

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for SLC22A10 Gene

Localization for SLC22A10 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC22A10 Gene

Membrane. Multi-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SLC22A10 gene
Compartment Confidence
plasma membrane 3
extracellular 1
mitochondrion 1
nucleus 1

Gene Ontology (GO) - Cellular Components for SLC22A10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with SLC22A10: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for SLC22A10 Gene

Pathways & Interactions for SLC22A10 Gene

PathCards logo

SuperPathways for SLC22A10 Gene

No Data Available

Interacting Proteins for SLC22A10 Gene

Gene Ontology (GO) - Biological Process for SLC22A10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0015711 organic anion transport IBA 21873635
GO:0055085 transmembrane transport IEA --
genes like me logo Genes that share ontologies with SLC22A10: view

No data available for Pathways by source and SIGNOR curated interactions for SLC22A10 Gene

Drugs & Compounds for SLC22A10 Gene

(3) Drugs for SLC22A10 Gene - From: DrugBank

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
conjugated estrogens Approved Pharma Transporter, inhibitor 0
Probenecid Approved, Investigational Pharma Transporter, inhibitor 45
Salicylic acid Approved, Investigational, Vet_approved Pharma Transporter, inhibitor 331
genes like me logo Genes that share compounds with SLC22A10: view

Transcripts for SLC22A10 Gene

mRNA/cDNA for SLC22A10 Gene

8 NCBI additional mRNA sequence :
6 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SLC22A10

Alternative Splicing Database (ASD) splice patterns (SP) for SLC22A10 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11

Relevant External Links for SLC22A10 Gene

GeneLoc Exon Structure for

Expression for SLC22A10 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for SLC22A10 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

  • Liver (Hepatobiliary System)

mRNA differential expression in normal tissues according to GTEx for SLC22A10 Gene

This gene is overexpressed in Liver (x43.0).

Protein differential expression in normal tissues from HIPED for SLC22A10 Gene

This gene is overexpressed in CD8 Tcells (45.7) and NK cells (23.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for SLC22A10 Gene

Protein tissue co-expression partners for SLC22A10 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for SLC22A10

SOURCE GeneReport for Unigene cluster for SLC22A10 Gene:


mRNA Expression by UniProt/SwissProt for SLC22A10 Gene:

Tissue specificity: Detected in fetal and adult liver, and in adult kidney.

Evidence on tissue expression from TISSUES for SLC22A10 Gene

  • Liver(2.5)
genes like me logo Genes that share expression patterns with SLC22A10: view

Primer products for research

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for SLC22A10 Gene

Orthologs for SLC22A10 Gene

This gene was present in the common ancestor of mammals.

Orthologs for SLC22A10 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia SLC22A10 30 31
  • 94.72 (n)
(Canis familiaris)
Mammalia SLC22A10 30 31
  • 79.75 (n)
(Bos Taurus)
Mammalia LOC522784 30
  • 79.31 (n)
-- 31
  • 67 (a)
-- 31
  • 67 (a)
-- 31
  • 64 (a)
-- 31
  • 64 (a)
(Monodelphis domestica)
Mammalia -- 31
  • 42 (a)
-- 31
  • 37 (a)
(Mus musculus)
Mammalia Slc22a22 31
  • 38 (a)
Species where no ortholog for SLC22A10 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for SLC22A10 Gene

Gene Tree for SLC22A10 (if available)
Gene Tree for SLC22A10 (if available)
Evolutionary constrained regions (ECRs) for SLC22A10: view image

Paralogs for SLC22A10 Gene

(19) SIMAP similar genes for SLC22A10 Gene using alignment to 5 proteins:

  • E9PMM0_HUMAN Pseudogenes for SLC22A10 Gene

genes like me logo Genes that share paralogs with SLC22A10: view

Variants for SLC22A10 Gene

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for SLC22A10 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for SLC22A10 Gene

Variant ID Type Subtype PubMed ID
esv2759833 CNV loss 17122850
nsv507596 OTHER sequence alteration 20534489
nsv555177 CNV loss 21841781
nsv555178 CNV gain 21841781

Variation tolerance for SLC22A10 Gene

Residual Variation Intolerance Score: 96.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 23.47; 99.55% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SLC22A10 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for SLC22A10 Gene

Disorders for SLC22A10 Gene

Additional Disease Information for SLC22A10

No disorders were found for SLC22A10 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SLC22A10 Gene

Publications for SLC22A10 Gene

  1. Isolation of a family of organic anion transporters from human liver and kidney. (PMID: 11327718) Sun W … Erion MD (Biochemical and biophysical research communications 2001) 2 3 4
  2. Human chromosome 11 DNA sequence and analysis including novel gene identification. (PMID: 16554811) Taylor TD … Sakaki Y (Nature 2006) 3 4
  3. Novel human cDNAs homologous to Drosophila Orct and mammalian carnitine transporters. (PMID: 12372408) Eraly SA … Nigam SK (Biochemical and biophysical research communications 2002) 3 4
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. (PMID: 21873635) Gaudet P … Thomas PD (Briefings in bioinformatics 2011) 3
  5. Identification of intrahepatic cholangiocarcinoma related genes by comparison with normal liver tissues using expressed sequence tags. (PMID: 16712791) Wang AG … Kim NS (Biochemical and biophysical research communications 2006) 3

Products for SLC22A10 Gene

Sources for SLC22A10 Gene