Aliases for SLC20A1 Gene
External Ids for SLC20A1 Gene
Previous HGNC Symbols for SLC20A1 Gene
Previous GeneCards Identifiers for SLC20A1 Gene
The protein encoded by this gene is a sodium-phosphate symporter that absorbs phosphate from interstitial fluid for use in cellular functions such as metabolism, signal transduction, and nucleic acid and lipid synthesis. The encoded protein is also a retroviral receptor, causing human cells to be susceptible to infection by gibbon ape leukemia virus, simian sarcoma-associated virus, feline leukemia virus subgroup B, and 10A1 murine leukemia virus.[provided by RefSeq, Mar 2011]
GeneCards Summary for SLC20A1 Gene
SLC20A1 (Solute Carrier Family 20 Member 1) is a Protein Coding gene. Diseases associated with SLC20A1 include Leukemia. Among its related pathways are Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds and Glucose / Energy Metabolism. Gene Ontology (GO) annotations related to this gene include signal transducer activity and sodium:phosphate symporter activity. An important paralog of this gene is SLC20A2.
UniProtKB/Swiss-Prot for SLC20A1 Gene
Sodium-phosphate symporter which plays a fundamental housekeeping role in phosphate transport, such as absorbing phosphate from interstitial fluid for normal cellular functions such as cellular metabolism, signal transduction, and nucleic acid and lipid synthesis. May play a role in extracellular matrix and cartilage calcification as well as in vascular calcification.
(Microbial infection) May function as a retroviral receptor as it confers human cells susceptibility to infection to Gibbon Ape Leukemia Virus (GaLV), Simian sarcoma-associated virus (SSAV) and Feline leukemia virus subgroup B (FeLV-B) as well as 10A1 murine leukemia virus (10A1 MLV).