Aliases for SLC1A7 Gene

Aliases for SLC1A7 Gene

  • Solute Carrier Family 1 Member 7 2 3 4 5
  • EAAT5 2 3 4
  • Solute Carrier Family 1 (Glutamate Transporter), Member 7 2 3
  • Excitatory Amino Acid Transporter 5 3 4
  • Retinal Glutamate Transporter 3 4
  • Excitatory Amino Acid Transporter 5 (Retinal Glutamate Transporter) 3
  • SLC1A7 5
  • AAAT 3

External Ids for SLC1A7 Gene

Previous GeneCards Identifiers for SLC1A7 Gene

  • GC01M053188
  • GC01M052441
  • GC01M052911
  • GC01M052922
  • GC01M053264
  • GC01M053325
  • GC01M053552
  • GC01M051668

Summaries for SLC1A7 Gene

GeneCards Summary for SLC1A7 Gene

SLC1A7 (Solute Carrier Family 1 Member 7) is a Protein Coding gene. Diseases associated with SLC1A7 include Hartnup Disorder and Extrahepatic Bile Duct Adenocarcinoma. Among its related pathways are Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds and Neurotransmitter Release Cycle. Gene Ontology (GO) annotations related to this gene include L-glutamate transmembrane transporter activity and sodium:dicarboxylate symporter activity. An important paralog of this gene is SLC1A3.

UniProtKB/Swiss-Prot Summary for SLC1A7 Gene

  • Transports L-glutamate; the L-glutamate uptake is sodium- and voltage-dependent and chloride-independent. Its associated chloride conductance may participate in visual processing.

Tocris Summary for SLC1A7 Gene

  • Glutamate transporters, also known as excitatory amino acid transporters (EAATs), are sodium- and potassium-dependent members of the solute carrier family 6 (SLC1), widely distributed throughout the brain. There are five EAAT subtypes, each with a specific distribution.

Gene Wiki entry for SLC1A7 Gene

No data available for Entrez Gene Summary , CIViC Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for SLC1A7 Gene

Genomics for SLC1A7 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for SLC1A7 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01J053142 Promoter 0.5 EPDnew 250.7 +0.0 14 0.1 RAD51 HNRNPL SLC1A7 lnc-C1orf123-2 PODN
GH01J053143 Enhancer 0.3 Ensembl dbSUPER 250.7 -1.9 -1863 0.2 SLC1A7 PODN lnc-CPT2-1 CPT2
GH01J053087 Enhancer 1.2 Ensembl ENCODE dbSUPER 18.9 +53.4 53437 7.2 ATF2 CEBPA HOMEZ KMT2B THAP11 KDM6A SMAD4 ZNF511 SAP130 ETV4 HSALNG0003667 ENSG00000235563 SLC1A7 ECHDC2 ANAPC10P1 HSALNG0003668 PODN
GH01J053120 Enhancer 1.8 VISTA FANTOM5 ENCODE CraniofacialAtlas dbSUPER 12 +19.1 19072 6.3 ZMYM3 CEBPA ZIC2 MXD4 BHLHE40 ZNF341 HOMEZ THAP11 FOXA2 KDM6A lnc-C1orf123-3 PODN SLC1A7 ENSG00000230953 ENSG00000228407 TUT4 piR-32285-004
GH01J053144 Enhancer 1.4 Ensembl ENCODE CraniofacialAtlas dbSUPER 13.3 -4.3 -4255 3.9 MYC IKZF1 JUND ZNF592 CEBPA ATF3 NFIC YY1 MXD4 HOMEZ SLC1A7 PODN GPX7 PLA2G12AP1 lnc-CPT2-1 CPT2
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around SLC1A7 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for SLC1A7

Top Transcription factor binding sites by QIAGEN in the SLC1A7 gene promoter:
  • AML1a
  • Chx10
  • Nkx2-5
  • Olf-1
  • POU2F1
  • POU2F1a
  • SRF
  • SRF (504 AA)
  • STAT3
  • STAT5A

Genomic Locations for SLC1A7 Gene

Latest Assembly
55,460 bases
Minus strand

Previous Assembly
(GRCh37/hg19 by Entrez Gene)
55,456 bases
Minus strand

(GRCh37/hg19 by Ensembl)
55,435 bases
Minus strand

Genomic View for SLC1A7 Gene

Genes around SLC1A7 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SLC1A7 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SLC1A7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC1A7 Gene

Proteins for SLC1A7 Gene

  • Protein details for SLC1A7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Excitatory amino acid transporter 5
    Protein Accession:
    Secondary Accessions:
    • Q5VVZ0
    • Q969Z8
    • Q9BW45

    Protein attributes for SLC1A7 Gene

    560 amino acids
    Molecular mass:
    60658 Da
    Quaternary structure:
    • Interacts with the PDZ domains of DLG4.

    Alternative splice isoforms for SLC1A7 Gene


neXtProt entry for SLC1A7 Gene

Post-translational modifications for SLC1A7 Gene

  • Glycosylation at Asn191
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for SLC1A7 Gene

Domains & Families for SLC1A7 Gene

Gene Families for SLC1A7 Gene

Human Protein Atlas (HPA):
  • Predicted membrane proteins
  • Transporters

Protein Domains for SLC1A7 Gene

  • Sodium:dicarboxylate symporter

Suggested Antigen Peptide Sequences for SLC1A7 Gene

GenScript: Design optimal peptide antigens:
  • Solute carrier family 1 member 7 (EAA5_HUMAN)
  • Excitatory amino acid transporter 5 (F1T0D2_HUMAN)
  • Excitatory amino acid transporter 5 (F1T0D3_HUMAN)
  • Excitatory amino acid transporter 5 (F1T0D4_HUMAN)

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the dicarboxylate/amino acid:cation symporter (DAACS) (TC 2.A.23) family. SLC1A7 subfamily.
  • Belongs to the dicarboxylate/amino acid:cation symporter (DAACS) (TC 2.A.23) family. SLC1A7 subfamily.
genes like me logo Genes that share domains with SLC1A7: view

Function for SLC1A7 Gene

Molecular function for SLC1A7 Gene

UniProtKB/Swiss-Prot Function:
Transports L-glutamate; the L-glutamate uptake is sodium- and voltage-dependent and chloride-independent. Its associated chloride conductance may participate in visual processing.

Phenotypes From GWAS Catalog for SLC1A7 Gene

Gene Ontology (GO) - Molecular Function for SLC1A7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005313 L-glutamate transmembrane transporter activity TAS 9108121
GO:0015293 symporter activity IEA --
genes like me logo Genes that share ontologies with SLC1A7: view
genes like me logo Genes that share phenotypes with SLC1A7: view

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SLC1A7

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SLC1A7 Gene

Localization for SLC1A7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC1A7 Gene

Membrane. Multi-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SLC1A7 gene
Compartment Confidence
plasma membrane 5
extracellular 3
cytoskeleton 2
mitochondrion 2
peroxisome 2
nucleus 2
endoplasmic reticulum 2
endosome 2
cytosol 2
lysosome 2
golgi apparatus 2

Gene Ontology (GO) - Cellular Components for SLC1A7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0098793 presynapse IEA --
genes like me logo Genes that share ontologies with SLC1A7: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for SLC1A7 Gene

Pathways & Interactions for SLC1A7 Gene

genes like me logo Genes that share pathways with SLC1A7: view

Interacting Proteins for SLC1A7 Gene

STRING Interaction Network Preview (showing top 5 STRING interactants - click image to see top 25)
STRING Interaction Network
Selected Interacting proteins: ENSP00000478639 O00341-EAA5_HUMAN for SLC1A7 Gene via STRING IID

Gene Ontology (GO) - Biological Process for SLC1A7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001504 neurotransmitter uptake IMP 9108121
GO:0006811 ion transport TAS --
GO:0006835 dicarboxylic acid transport TAS 9108121
GO:0014047 glutamate secretion TAS --
GO:0015813 L-glutamate transmembrane transport IEA --
genes like me logo Genes that share ontologies with SLC1A7: view

No data available for SIGNOR curated interactions for SLC1A7 Gene

Drugs & Compounds for SLC1A7 Gene

(9) Drugs for SLC1A7 Gene - From: DrugBank, DGIdb, IUPHAR, HMDB, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Glutamic acid Approved Nutra Target 324
Chloride ion Experimental Pharma 0
[<sup>3</sup>H]D-aspartic acid Pharma 0
[<sup>3</sup>H]L-aspartic acid Pharma 0
DL-TBOA Pharma Inhibitor, Inhibition inhibitor of excitatory amino acid transporters 0

(5) Additional Compounds for SLC1A7 Gene - From: IUPHAR, Novoseek, HMDB, and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
  • Na(+)
  • Na+
  • SODIUM ion
  • Sodium(1+)
Chicago Sky Blue 6B

(4) Tocris Compounds for SLC1A7 Gene

Compound Action Cas Number
7-Chlorokynurenic acid Potent competitive inhibitor of L-glutamate uptake 18000-24-3
7-Chlorokynurenic acid sodium salt Potent competitive inhibitor of L-glutamate uptake. Sodium salt of 7-Chlorokynurenic acid (Cat. No. 0237) 1263094-00-3
Chicago Sky Blue 6B Potent inhibitor of L-glutamate uptake into synaptic vesicles; also inhibits MIF 2610-05-1
Evans Blue tetrasodium salt Potent inhibitor of L-glutamate uptake into synaptic vesicles 314-13-6
genes like me logo Genes that share compounds with SLC1A7: view

Transcripts for SLC1A7 Gene

mRNA/cDNA for SLC1A7 Gene

11 NCBI additional mRNA sequence :
7 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SLC1A7

Alternative Splicing Database (ASD) splice patterns (SP) for SLC1A7 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10a · 10b ^ 11 ^ 12a · 12b ^ 13a · 13b
SP1: - - -
SP3: -

Relevant External Links for SLC1A7 Gene

GeneLoc Exon Structure for

Expression for SLC1A7 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for SLC1A7 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for SLC1A7 Gene

This gene is overexpressed in Fetal Liver (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for SLC1A7 Gene

Protein tissue co-expression partners for SLC1A7 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for SLC1A7

SOURCE GeneReport for Unigene cluster for SLC1A7 Gene:


mRNA Expression by UniProt/SwissProt for SLC1A7 Gene:

Tissue specificity: Expressed primarily in retina. Detectable in liver, heart, muscle and brain.

Evidence on tissue expression from TISSUES for SLC1A7 Gene

  • Eye(4.6)
  • Kidney(2.8)
  • Nervous system(2.8)
  • Intestine(2.5)
  • Pancreas(2.4)
  • Liver(2.4)
  • Muscle(2.3)
  • Blood(2.3)
  • Heart(2.3)
  • Skin(2.2)
  • Lymph node(2.2)
genes like me logo Genes that share expression patterns with SLC1A7: view

Primer products for research

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for SLC1A7 Gene

Orthologs for SLC1A7 Gene

This gene was present in the common ancestor of animals.

Orthologs for SLC1A7 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia SLC1A7 29 30
  • 99.09 (n)
(Ornithorhynchus anatinus)
Mammalia SLC1A7 30
  • 91 (a)
(Bos Taurus)
Mammalia SLC1A7 29 30
  • 88.93 (n)
(Monodelphis domestica)
Mammalia SLC1A7 30
  • 88 (a)
(Canis familiaris)
Mammalia SLC1A7 29 30
  • 87.86 (n)
(Rattus norvegicus)
Mammalia Slc1a7 29
  • 86.67 (n)
(Mus musculus)
Mammalia Slc1a7 29 16 30
  • 85.45 (n)
(Gallus gallus)
Aves SLC1A7 29 30
  • 72.62 (n)
(Anolis carolinensis)
Reptilia SLC1A7 30
  • 82 (a)
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia slc1a7 29
  • 71.5 (n)
(Danio rerio)
Actinopterygii slc1a7b 30
  • 72 (a)
slc1a7a 29 30
  • 70.3 (n)
Fruit Fly
(Drosophila melanogaster)
Insecta Eaat1 31
  • 44 (a)
(Caenorhabditis elegans)
Secernentea glt-2 31
  • 53 (a)
Y53C12A.2 31
  • 46 (a)
K08F4.4 31
  • 43 (a)
T22E5.2 31
  • 43 (a)
R05G6.6 31
  • 41 (a)
W03G1.1 31
  • 36 (a)
Species where no ortholog for SLC1A7 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for SLC1A7 Gene

Gene Tree for SLC1A7 (if available)
Gene Tree for SLC1A7 (if available)
Evolutionary constrained regions (ECRs) for SLC1A7: view image
Alliance of Genome Resources:
Additional Orthologs for SLC1A7

Paralogs for SLC1A7 Gene

Paralogs for SLC1A7 Gene

(6) SIMAP similar genes for SLC1A7 Gene using alignment to 6 proteins:

  • F1T0D2_HUMAN
  • F1T0D3_HUMAN
  • F1T0D4_HUMAN
  • L0C9Y3_HUMAN
  • Q9BW45_HUMAN
genes like me logo Genes that share paralogs with SLC1A7: view

Variants for SLC1A7 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for SLC1A7 Gene

SNP ID Clinical significance and condition Chr 01 pos Variation AA Info Type
rs375136400 A colorectal cancer sample p.Arg41Cys
rs1288401 -- p.Gln537Arg

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for SLC1A7 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for SLC1A7 Gene

Variant ID Type Subtype PubMed ID
dgv21e201 CNV deletion 23290073
dgv275n54 CNV loss 21841781
dgv276n54 CNV loss 21841781
dgv277n54 CNV loss 21841781
dgv42e199 CNV deletion 23128226
dgv43e199 CNV deletion 23128226
dgv83n106 CNV deletion 24896259
dgv84n106 CNV deletion 24896259
dgv88e59 CNV duplication 20981092
esv21434 CNV gain+loss 19812545
esv2306191 CNV deletion 18987734
esv2671978 CNV deletion 23128226
esv2672076 CNV deletion 23128226
esv26895 CNV loss 19812545
esv2743348 CNV deletion 23290073
esv2748163 CNV deletion 23290073
esv2748174 CNV deletion 23290073
esv2748185 CNV deletion 23290073
esv3329716 CNV duplication 20981092
esv3561970 CNV deletion 23714750
esv3561982 CNV deletion 23714750
esv3561993 CNV deletion 23714750
esv3577856 CNV loss 25503493
esv3577857 CNV loss 25503493
esv3586062 CNV loss 21293372
esv3586063 CNV loss 21293372
esv3586064 CNV loss 21293372
esv998975 CNV insertion 20482838
nsv1001535 CNV gain 25217958
nsv1003159 CNV gain 25217958
nsv1010121 CNV gain 25217958
nsv1010473 CNV loss 25217958
nsv1075923 CNV deletion 25765185
nsv1075924 CNV deletion 25765185
nsv1115343 CNV duplication 24896259
nsv1116598 CNV tandem duplication 24896259
nsv1128594 CNV duplication 24896259
nsv1133852 CNV deletion 24896259
nsv1149544 CNV duplication 26484159
nsv160120 CNV insertion 16902084
nsv516780 CNV gain+loss 19592680
nsv522862 CNV loss 19592680
nsv546239 CNV loss 21841781
nsv546240 CNV loss 21841781
nsv546241 CNV loss 21841781
nsv546256 CNV loss 21841781
nsv822587 CNV gain 20364138
nsv822598 CNV loss 20364138
nsv950739 CNV deletion 24416366
nsv958856 CNV deletion 24416366

Variation tolerance for SLC1A7 Gene

Residual Variation Intolerance Score: 84.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 12.30; 94.11% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SLC1A7 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
Leiden Open Variation Database (LOVD)

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SLC1A7 Gene

Disorders for SLC1A7 Gene

MalaCards: The human disease database

(19) MalaCards diseases for SLC1A7 Gene - From: COP

Disorder Aliases PubMed IDs
hartnup disorder
  • hnd
extrahepatic bile duct adenocarcinoma
  • adenocarcinoma of extrahepatic bile duct
dicarboxylic aminoaciduria
  • dcbxa
episodic ataxia, type 6
  • ea6
late congenital syphilis
  • juvenile neurosyphilis
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for SLC1A7

Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform
genes like me logo Genes that share disorders with SLC1A7: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SLC1A7 Gene

Publications for SLC1A7 Gene

  1. Excitatory amino acid transporter 5, a retinal glutamate transporter coupled to a chloride conductance. (PMID: 9108121) Arriza JL … Amara SG (Proceedings of the National Academy of Sciences of the United States of America 1997) 2 3 4 22 25
  2. Differential genetic associations for systemic lupus erythematosus based on anti-dsDNA autoantibody production. (PMID: 21408207) Chung SA … Criswell LA (PLoS genetics 2011) 3 40
  3. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey SD … DREAM investigators (Diabetes care 2010) 3 40
  4. L-type voltage-dependent calcium channel alpha subunit 1C is a novel candidate gene associated with secondary hyperparathyroidism: an application of haplotype-based analysis for multiple linked single nucleotide polymorphisms. (PMID: 20424473) Yokoyama K … Hosoya T (Nephron. Clinical practice 2010) 3 40
  5. Identification of new putative susceptibility genes for several psychiatric disorders by association analysis of regulatory and non-synonymous SNPs of 306 genes involved in neurotransmission and neurodevelopment. (PMID: 19086053) Gratacòs M … Psychiatric Genetics Network Group (American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics 2009) 3 40

Products for SLC1A7 Gene

Sources for SLC1A7 Gene