Aliases for SLC1A6 Gene
External Ids for SLC1A6 Gene
Previous GeneCards Identifiers for SLC1A6 Gene
GeneCards Summary for SLC1A6 Gene
SLC1A6 (Solute Carrier Family 1 Member 6) is a Protein Coding gene. Diseases associated with SLC1A6 include Spinocerebellar Ataxia 5 and Episodic Ataxia, Type 6. Among its related pathways are Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds and Synaptic vesicle cycle. Gene Ontology (GO) annotations related to this gene include L-glutamate transmembrane transporter activity and L-aspartate transmembrane transporter activity. An important paralog of this gene is SLC1A3.
UniProtKB/Swiss-Prot Summary for SLC1A6 Gene
Sodium-dependent, high-affinity amino acid transporter that mediates the uptake of L-glutamate and also L-aspartate and D-aspartate (PubMed:7791878). Functions as a symporter that transports one amino acid molecule together with two or three Na(+) ions and one proton, in parallel with the counter-transport of one K(+) ion. Mediates Cl(-) flux that is not coupled to amino acid transport; this avoids the accumulation of negative charges due to aspartate and Na(+) symport (By similarity). Plays a redundant role in the rapid removal of released glutamate from the synaptic cleft, which is essential for terminating the postsynaptic action of glutamate (Probable).
Glutamate transporters, also known as excitatory amino acid transporters (EAATs), are sodium- and potassium-dependent members of the solute carrier family 6 (SLC1), widely distributed throughout the brain. There are five EAAT subtypes, each with a specific distribution.