The SLC1A5 gene encodes a sodium-dependent neutral amino acid transporter that can act as a receptor for RD114/type D retrovirus (Larriba et al., 2001 [PubMed 11781704]).[supplied by OMIM, Jan 2011] See more...

Aliases for SLC1A5 Gene

Aliases for SLC1A5 Gene

  • Solute Carrier Family 1 Member 5 2 3 4 5
  • Solute Carrier Family 1 (Neutral Amino Acid Transporter), Member 5 2 3
  • Sodium-Dependent Neutral Amino Acid Transporter Type 2 3 4
  • RD114/Simian Type D Retrovirus Receptor 3 4
  • Neutral Amino Acid Transporter B(0) 3 4
  • Baboon M7 Virus Receptor 3 4
  • ATB(0) 3 4
  • ASCT2 3 4
  • M7V1 3 4
  • RDRC 3 4
  • Neutral Amino Acid Transporter B 3
  • RD114 Virus Receptor 3
  • M7VS1 3
  • AAAT 3
  • ATBO 3
  • R16 3
  • RDR 4

External Ids for SLC1A5 Gene

Previous HGNC Symbols for SLC1A5 Gene

  • RDRC
  • M7V1

Previous GeneCards Identifiers for SLC1A5 Gene

  • GC19M047922
  • GC19M047669
  • GC19M051954
  • GC19M051969
  • GC19M047278
  • GC19M043702

Summaries for SLC1A5 Gene

Entrez Gene Summary for SLC1A5 Gene

  • The SLC1A5 gene encodes a sodium-dependent neutral amino acid transporter that can act as a receptor for RD114/type D retrovirus (Larriba et al., 2001 [PubMed 11781704]).[supplied by OMIM, Jan 2011]

GeneCards Summary for SLC1A5 Gene

SLC1A5 (Solute Carrier Family 1 Member 5) is a Protein Coding gene. Diseases associated with SLC1A5 include Hartnup Disorder and Placental Choriocarcinoma. Among its related pathways are Central carbon metabolism in cancer and Glucose / Energy Metabolism. Gene Ontology (GO) annotations related to this gene include amino acid transmembrane transporter activity. An important paralog of this gene is SLC1A4.

UniProtKB/Swiss-Prot Summary for SLC1A5 Gene

  • Sodium-dependent amino acids transporter that has a broad substrate specificity, with a preference for zwitterionic amino acids. It accepts as substrates all neutral amino acids, including glutamine, asparagine, and branched-chain and aromatic amino acids, and excludes methylated, anionic, and cationic amino acids (PubMed:8702519, PubMed:29872227). Through binding of the fusogenic protein syncytin-1/ERVW-1 may mediate trophoblasts syncytialization, the spontaneous fusion of their plasma membranes, an essential process in placental development (PubMed:10708449, PubMed:23492904).
  • (Microbial infection) Acts as a cell surface receptor for Feline endogenous virus RD114.
  • (Microbial infection) Acts as a cell surface receptor for Baboon M7 endogenous virus.
  • (Microbial infection) Acts as a cell surface receptor for type D simian retroviruses.

Gene Wiki entry for SLC1A5 Gene

Additional gene information for SLC1A5 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for SLC1A5 Gene

Genomics for SLC1A5 Gene

GeneHancer (GH) Regulatory Elements for SLC1A5 Gene

Promoters and enhancers for SLC1A5 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around SLC1A5 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for SLC1A5

Top Transcription factor binding sites by QIAGEN in the SLC1A5 gene promoter:
  • GR
  • GR-alpha
  • GR-beta
  • N-Myc
  • SRF
  • SRF (504 AA)

Genomic Locations for SLC1A5 Gene

Genomic Locations for SLC1A5 Gene
chr19:46,759,698-46,788,649
(GRCh38/hg38)
Size:
28,952 bases
Orientation:
Minus strand
chr19:47,278,140-47,291,851
(GRCh37/hg19)
Size:
13,712 bases
Orientation:
Minus strand

Genomic View for SLC1A5 Gene

Genes around SLC1A5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SLC1A5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SLC1A5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC1A5 Gene

Proteins for SLC1A5 Gene

  • Protein details for SLC1A5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q15758-AAAT_HUMAN
    Recommended name:
    Neutral amino acid transporter B(0)
    Protein Accession:
    Q15758
    Secondary Accessions:
    • A8K9H5
    • B4DR77
    • B4DWS4
    • B7ZB81
    • D0EYG6
    • E9PC01
    • O95720
    • Q96RL9
    • Q9BWQ3
    • Q9UNP2

    Protein attributes for SLC1A5 Gene

    Size:
    541 amino acids
    Molecular mass:
    56598 Da
    Quaternary structure:
    • Homotrimer (Probable) (PubMed:29872227). Interacts with ERVH48-1/suppressyn; may negatively regulate syncytialization (PubMed:23492904).

    Three dimensional structures from OCA and Proteopedia for SLC1A5 Gene

    Alternative splice isoforms for SLC1A5 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SLC1A5 Gene

Post-translational modifications for SLC1A5 Gene

  • Glycosylation at Asn212 and Asn163
  • Ubiquitination at Lys372, Lys502, Lys522, and Lys537
  • Modification sites at PhosphoSitePlus
  • Glycosylation from GlyConnect

Other Protein References for SLC1A5 Gene

No data available for DME Specific Peptides for SLC1A5 Gene

Domains & Families for SLC1A5 Gene

Gene Families for SLC1A5 Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • FDA approved drug targets
  • Plasma proteins
  • Predicted intracellular proteins
  • Predicted membrane proteins
  • Transporters

Protein Domains for SLC1A5 Gene

Blocks:
  • Sodium:dicarboxylate symporter
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for SLC1A5 Gene

GenScript: Design optimal peptide antigens:
  • Solute carrier family 1 member 5 (AAAT_HUMAN)
  • cDNA FLJ57638, highly similar to Neutral amino acid transporter B(0) (B4DWS4_HUMAN)
  • Neutral amino acid transporter (Q71UA6_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q15758

UniProtKB/Swiss-Prot:

AAAT_HUMAN :
  • Belongs to the dicarboxylate/amino acid:cation symporter (DAACS) (TC 2.A.23) family. SLC1A5 subfamily.
Family:
  • Belongs to the dicarboxylate/amino acid:cation symporter (DAACS) (TC 2.A.23) family. SLC1A5 subfamily.
genes like me logo Genes that share domains with SLC1A5: view

Function for SLC1A5 Gene

Molecular function for SLC1A5 Gene

UniProtKB/Swiss-Prot Function:
Sodium-dependent amino acids transporter that has a broad substrate specificity, with a preference for zwitterionic amino acids. It accepts as substrates all neutral amino acids, including glutamine, asparagine, and branched-chain and aromatic amino acids, and excludes methylated, anionic, and cationic amino acids (PubMed:8702519, PubMed:29872227). Through binding of the fusogenic protein syncytin-1/ERVW-1 may mediate trophoblasts syncytialization, the spontaneous fusion of their plasma membranes, an essential process in placental development (PubMed:10708449, PubMed:23492904).
UniProtKB/Swiss-Prot Function:
(Microbial infection) Acts as a cell surface receptor for Feline endogenous virus RD114.
UniProtKB/Swiss-Prot Function:
(Microbial infection) Acts as a cell surface receptor for Baboon M7 endogenous virus.
UniProtKB/Swiss-Prot Function:
(Microbial infection) Acts as a cell surface receptor for type D simian retroviruses.
GENATLAS Biochemistry:
solute carrier family 1 (glutamate/neutral amino acid transport),member 5

Phenotypes From GWAS Catalog for SLC1A5 Gene

Gene Ontology (GO) - Molecular Function for SLC1A5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001618 virus receptor activity IEA --
GO:0005515 protein binding IPI 23492904
GO:0015171 amino acid transmembrane transporter activity TAS --
GO:0015175 neutral amino acid transmembrane transporter activity TAS 10051606
GO:0015186 L-glutamine transmembrane transporter activity IDA,TAS 21757002
genes like me logo Genes that share ontologies with SLC1A5: view
genes like me logo Genes that share phenotypes with SLC1A5: view

Animal Models for SLC1A5 Gene

MGI Knock Outs for SLC1A5:

Animal Model Products

  • Taconic Biosciences Mouse Models for SLC1A5

CRISPR Products

miRNA for SLC1A5 Gene

miRTarBase miRNAs that target SLC1A5

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for SLC1A5 Gene

Localization for SLC1A5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC1A5 Gene

Cell membrane; Multi-pass membrane protein. Melanosome. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SLC1A5 gene
Compartment Confidence
plasma membrane 5
golgi apparatus 3
extracellular 2
cytoskeleton 2
mitochondrion 2
nucleus 2
endoplasmic reticulum 2
cytosol 2
lysosome 2
peroxisome 1
endosome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Plasma membrane (4)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for SLC1A5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane TAS 8702519
GO:0016020 membrane HDA,IEA 19946888
GO:0016021 integral component of membrane IDA,IEA 29872227
GO:0042470 melanosome IEA --
genes like me logo Genes that share ontologies with SLC1A5: view

Pathways & Interactions for SLC1A5 Gene

genes like me logo Genes that share pathways with SLC1A5: view

Gene Ontology (GO) - Biological Process for SLC1A5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006865 amino acid transport TAS --
GO:0006868 glutamine transport TAS,IDA 21757002
GO:0010585 glutamine secretion IEA --
GO:0015804 neutral amino acid transport TAS 10051606
GO:0015825 L-serine transport IEA --
genes like me logo Genes that share ontologies with SLC1A5: view

No data available for SIGNOR curated interactions for SLC1A5 Gene

Drugs & Compounds for SLC1A5 Gene

(8) Drugs for SLC1A5 Gene - From: DrugBank, DGIdb, IUPHAR, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
asparagine Approved, Investigational Nutra Target 0
L-Glutamine Approved, Investigational Nutra Full agonist, Agonist, Transporter, substrate 0
Fluciclovine (18F) Approved Pharma Target, binder 0
benzylcysteine Experimental Pharma Inhibition, Inhibitor 0
benzylserine Pharma Inhibition, Inhibitor 0

(3) Additional Compounds for SLC1A5 Gene - From: IUPHAR, Novoseek, and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
p-nitrophenyl glutamyl anilide
Inhibition, Inhibitor
sodium
  • Na(+)
  • Na+
  • SODIUM ion
7440-23-5
genes like me logo Genes that share compounds with SLC1A5: view

Transcripts for SLC1A5 Gene

mRNA/cDNA for SLC1A5 Gene

3 REFSEQ mRNAs :
16 NCBI additional mRNA sequence :
6 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for SLC1A5 Gene

ExUns: 1 ^ 2 ^ 3a · 3b · 3c ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9a · 9b · 9c ^ 10a · 10b ^ 11a · 11b
SP1: - - -
SP2:
SP3: - - - -
SP4: -
SP5: -
SP6:

Relevant External Links for SLC1A5 Gene

GeneLoc Exon Structure for
SLC1A5

Expression for SLC1A5 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for SLC1A5 Gene

Protein differential expression in normal tissues from HIPED for SLC1A5 Gene

This gene is overexpressed in Nasal epithelium (29.9), Bone (11.7), and Liver (11.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for SLC1A5 Gene



Protein tissue co-expression partners for SLC1A5 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for SLC1A5

SOURCE GeneReport for Unigene cluster for SLC1A5 Gene:

Hs.631582

mRNA Expression by UniProt/SwissProt for SLC1A5 Gene:

Q15758-AAAT_HUMAN
Tissue specificity: Placenta, lung, skeletal muscle, kidney, pancreas, and intestine.

Evidence on tissue expression from TISSUES for SLC1A5 Gene

  • Kidney(4.5)
  • Intestine(4.3)
  • Nervous system(3.5)
  • Lung(3.3)
  • Eye(2.8)
  • Liver(2.4)
  • Skin(2.4)
  • Blood(2.2)
  • Pancreas(2.2)
genes like me logo Genes that share expression patterns with SLC1A5: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for SLC1A5 Gene

Orthologs for SLC1A5 Gene

This gene was present in the common ancestor of animals.

Orthologs for SLC1A5 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SLC1A5 31 30
  • 99.5 (n)
OneToOne
dog
(Canis familiaris)
Mammalia SLC1A5 31 30
  • 86.17 (n)
OneToOne
cow
(Bos Taurus)
Mammalia SLC1A5 31 30
  • 84.88 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Slc1a5 17 31 30
  • 81.29 (n)
rat
(Rattus norvegicus)
Mammalia Slc1a5 30
  • 79.38 (n)
oppossum
(Monodelphis domestica)
Mammalia SLC1A5 31
  • 66 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SLC1A5 31
  • 52 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SLC1A5