Aliases for SLC1A5 Gene
- Solute Carrier Family 1 Member 5 2 3 4 5
- Solute Carrier Family 1 (Neutral Amino Acid Transporter), Member 5 2 3
- Sodium-Dependent Neutral Amino Acid Transporter Type 2 3 4
- RD114/Simian Type D Retrovirus Receptor 3 4
- Neutral Amino Acid Transporter B(0) 3 4
- Baboon M7 Virus Receptor 3 4
- ATB(0) 3 4
- ASCT2 3 4
External Ids for SLC1A5 Gene
Previous HGNC Symbols for SLC1A5 Gene
Previous GeneCards Identifiers for SLC1A5 Gene
The SLC1A5 gene encodes a sodium-dependent neutral amino acid transporter that can act as a receptor for RD114/type D retrovirus (Larriba et al., 2001 [PubMed 11781704]).[supplied by OMIM, Jan 2011]
GeneCards Summary for SLC1A5 Gene
SLC1A5 (Solute Carrier Family 1 Member 5) is a Protein Coding gene. Diseases associated with SLC1A5 include Hartnup Disorder and Placental Choriocarcinoma. Among its related pathways are Central carbon metabolism in cancer and Glucose / Energy Metabolism. Gene Ontology (GO) annotations related to this gene include amino acid transmembrane transporter activity. An important paralog of this gene is SLC1A4.
UniProtKB/Swiss-Prot Summary for SLC1A5 Gene
Sodium-dependent amino acids transporter that has a broad substrate specificity, with a preference for zwitterionic amino acids. It accepts as substrates all neutral amino acids, including glutamine, asparagine, and branched-chain and aromatic amino acids, and excludes methylated, anionic, and cationic amino acids (PubMed:8702519, PubMed:29872227). Through binding of the fusogenic protein syncytin-1/ERVW-1 may mediate trophoblasts syncytialization, the spontaneous fusion of their plasma membranes, an essential process in placental development (PubMed:10708449, PubMed:23492904).
(Microbial infection) Acts as a cell surface receptor for Feline endogenous virus RD114.
(Microbial infection) Acts as a cell surface receptor for Baboon M7 endogenous virus.
(Microbial infection) Acts as a cell surface receptor for type D simian retroviruses.