This gene encodes a protein, which has high sequence similarity to rat, xenopus and zebrafish proteins. The protein function is unknown. [provided by RefSeq, Jul 2008] See more...

Aliases for SLC18B1 Gene

Aliases for SLC18B1 Gene

  • Solute Carrier Family 18 Member B1 2 3 4 5
  • Solute Carrier Family 18, Subfamily B, Member 1 2 3
  • MFS-Type Transporter SLC18B1 3 4
  • C6orf192 3 4
  • Chromosome 6 Open Reading Frame 192 2
  • MFS-Type Transporter C6orf192 3
  • DJ55C23.6 3

External Ids for SLC18B1 Gene

Previous HGNC Symbols for SLC18B1 Gene

  • C6orf192

Previous GeneCards Identifiers for SLC18B1 Gene

  • GC06M133090

Summaries for SLC18B1 Gene

Entrez Gene Summary for SLC18B1 Gene

  • This gene encodes a protein, which has high sequence similarity to rat, xenopus and zebrafish proteins. The protein function is unknown. [provided by RefSeq, Jul 2008]

GeneCards Summary for SLC18B1 Gene

SLC18B1 (Solute Carrier Family 18 Member B1) is a Protein Coding gene. An important paralog of this gene is SLC18A2.

Additional gene information for SLC18B1 Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for SLC18B1 Gene

Genomics for SLC18B1 Gene

GeneHancer (GH) Regulatory Elements for SLC18B1 Gene

Promoters and enhancers for SLC18B1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH06J132812 Promoter/Enhancer 2.5 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas 525.3 -1.5 -1537 5.5 FOXK2 ZBTB40 ZNF217 EP300 ZSCAN5C TCF12 SIN3A MYC NRF1 POLR2G SLC18B1 RPS12 SNORD100 SNORD101 piR-33748 lnc-SLC18B1-1 piR-58029-006 SNORA33 LOC100421775 VNN1
GH06J132797 Promoter/Enhancer 2 EPDnew Ensembl ENCODE CraniofacialAtlas 525.4 +14.8 14798 3.1 CTCF MYC NRF1 POLR2G BCLAF1 PHB2 ZIC2 ZBTB10 POLR2A ZNF423 SLC18B1 lnc-VNN2-3 VNN2 piR-38579-039
GH06J132762 Promoter/Enhancer 1.3 EPDnew Ensembl ENCODE 14.7 +50.0 50043 2.2 POLR2A TCF12 GABPA PBX2 SPI1 BATF ELF1 RAD21 IKZF1 MTA3 RBM11P1 VNN2 lnc-RPS12-3 VNN3 SLC18B1 VNN1 ENSG00000234484
GH06J132820 Enhancer 0.7 ENCODE 24.5 -7.8 -7762 0.9 POLR2G POLR2A ZBTB17 MYNN RBM22 IKZF3 SUPT5H FOSL2 SSRP1 MEIS2 SLC18B1 SNORA33 HMGB1P13 lnc-SLC18B1-2
GH06J132821 Enhancer 0.7 ENCODE 22.5 -6.3 -6348 0.2 POLR2G BCLAF1 POLR2A KDM5B RELA MYNN FOS POLR2H RBM22 FOSL1 SLC18B1 SNORA33 HMGB1P13 lnc-SLC18B1-2
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around SLC18B1 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for SLC18B1

Genomic Locations for SLC18B1 Gene

Genomic Locations for SLC18B1 Gene
chr6:132,769,368-132,813,339
(GRCh38/hg38)
Size:
43,972 bases
Orientation:
Minus strand
chr6:133,090,507-133,119,747
(GRCh37/hg19)
Size:
29,241 bases
Orientation:
Minus strand

Genomic View for SLC18B1 Gene

Genes around SLC18B1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SLC18B1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SLC18B1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC18B1 Gene

Proteins for SLC18B1 Gene

  • Protein details for SLC18B1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6NT16-S18B1_HUMAN
    Recommended name:
    MFS-type transporter SLC18B1
    Protein Accession:
    Q6NT16
    Secondary Accessions:
    • A8K1K3
    • B3KW77
    • Q6ISF2

    Protein attributes for SLC18B1 Gene

    Size:
    456 amino acids
    Molecular mass:
    48869 Da
    Quaternary structure:
    No Data Available

neXtProt entry for SLC18B1 Gene

Post-translational modifications for SLC18B1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SLC18B1 Gene

No data available for DME Specific Peptides for SLC18B1 Gene

Domains & Families for SLC18B1 Gene

Gene Families for SLC18B1 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted membrane proteins
  • Transporters

Protein Domains for SLC18B1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for SLC18B1 Gene

GenScript: Design optimal peptide antigens:
  • cDNA FLJ50098 (B7Z1S5_HUMAN)
  • MFS-type transporter C6orf192 (CF192_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q6NT16

UniProtKB/Swiss-Prot:

S18B1_HUMAN :
  • Belongs to the major facilitator superfamily.
Family:
  • Belongs to the major facilitator superfamily.
genes like me logo Genes that share domains with SLC18B1: view

Function for SLC18B1 Gene

Phenotypes From GWAS Catalog for SLC18B1 Gene

Gene Ontology (GO) - Molecular Function for SLC18B1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0022857 transmembrane transporter activity IEA --
genes like me logo Genes that share ontologies with SLC18B1: view
genes like me logo Genes that share phenotypes with SLC18B1: view

Animal Model Products

  • Taconic Biosciences Mouse Models for SLC18B1

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SLC18B1

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SLC18B1 Gene

Localization for SLC18B1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC18B1 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SLC18B1 gene
Compartment Confidence
plasma membrane 4
cytosol 2
golgi apparatus 2
endoplasmic reticulum 1
peroxisome 0

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (3)
  • Golgi apparatus (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for SLC18B1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005887 integral component of plasma membrane IEA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with SLC18B1: view

Pathways & Interactions for SLC18B1 Gene

PathCards logo

SuperPathways for SLC18B1 Gene

No Data Available

Interacting Proteins for SLC18B1 Gene

STRING Interaction Network Preview (showing top 5 STRING interactants - click image to see top 22)
STRING Interaction Network
Selected Interacting proteins: ENSP00000275227 Q6NT16-S18B1_HUMAN for SLC18B1 Gene via STRING IID

;

Gene Ontology (GO) - Biological Process for SLC18B1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0055085 transmembrane transport IEA --
genes like me logo Genes that share ontologies with SLC18B1: view

No data available for Pathways by source and SIGNOR curated interactions for SLC18B1 Gene

Drugs & Compounds for SLC18B1 Gene

No Compound Related Data Available

Transcripts for SLC18B1 Gene

mRNA/cDNA for SLC18B1 Gene

1 REFSEQ mRNAs :
8 NCBI additional mRNA sequence :
7 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SLC18B1

Alternative Splicing Database (ASD) splice patterns (SP) for SLC18B1 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9a · 9b ^ 10a · 10b ^ 11a · 11b ^ 12 ^ 13a · 13b ^ 14a · 14b ^ 15a · 15b · 15c
SP1: - - - - -
SP2: - - - -
SP3: - - - -
SP4: - - -
SP5: - -
SP6: -

Relevant External Links for SLC18B1 Gene

GeneLoc Exon Structure for
SLC18B1

Expression for SLC18B1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for SLC18B1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for SLC18B1 Gene

This gene is overexpressed in CD8 Tcells (25.1), Frontal cortex (20.9), and Blymphocyte (14.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for SLC18B1 Gene



Protein tissue co-expression partners for SLC18B1 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for SLC18B1

SOURCE GeneReport for Unigene cluster for SLC18B1 Gene:

Hs.347144

Evidence on tissue expression from TISSUES for SLC18B1 Gene

  • Nervous system(4.2)
genes like me logo Genes that share expression patterns with SLC18B1: view

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for SLC18B1 Gene

Orthologs for SLC18B1 Gene

This gene was present in the common ancestor of animals.

Orthologs for SLC18B1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SLC18B1 31 30
  • 99.63 (n)
OneToOne
dog
(Canis familiaris)
Mammalia SLC18B1 31 30
  • 86.29 (n)
OneToOne
cow
(Bos Taurus)
Mammalia SLC18B1 31 30
  • 85.71 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Slc18b1 17 31 30
  • 81.01 (n)
rat
(Rattus norvegicus)
Mammalia Slc18b1 30
  • 81.01 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 31
  • 81 (a)
OneToMany
-- 31
  • 74 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia SLC18B1 31
  • 71 (a)
OneToOne
chicken
(Gallus gallus)
Aves C6ORF192 31 30
  • 68 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SLC18B1 31
  • 70 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia slc18b1 30
  • 64.95 (n)
Str.18211 30
zebrafish
(Danio rerio)
Actinopterygii slc18b1 31 30
  • 60.55 (n)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP001980 30
  • 45.84 (n)
fruit fly
(Drosophila melanogaster)
Insecta prt 31
  • 15 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea F55A4.8 31 30
  • 47.28 (n)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 32 (a)
OneToOne
Species where no ortholog for SLC18B1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SLC18B1 Gene

ENSEMBL:
Gene Tree for SLC18B1 (if available)
TreeFam:
Gene Tree for SLC18B1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for SLC18B1: view image

Paralogs for SLC18B1 Gene

Paralogs for SLC18B1 Gene

genes like me logo Genes that share paralogs with SLC18B1: view

Variants for SLC18B1 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for SLC18B1 Gene

SNP ID Clinical significance and condition Chr 06 pos Variation AA Info Type
rs41286192 - p.Ser30Pro
rs59989552 - p.Arg11Leu
rs6926101 - p.Val204Ile

Additional dbSNP identifiers (rs#s) for SLC18B1 Gene

Structural Variations from Database of Genomic Variants (DGV) for SLC18B1 Gene

Variant ID Type Subtype PubMed ID
esv3307672 CNV mobile element insertion 20981092
esv3334490 CNV insertion 20981092

Variation tolerance for SLC18B1 Gene

Residual Variation Intolerance Score: 27.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.92; 67.82% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SLC18B1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SLC18B1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SLC18B1 Gene

Disorders for SLC18B1 Gene

Additional Disease Information for SLC18B1

No disorders were found for SLC18B1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SLC18B1 Gene

Publications for SLC18B1 Gene

  1. C6ORF192 forms a unique evolutionary branch among solute carriers (SLC16, SLC17, and SLC18) and is abundantly expressed in several brain regions. (PMID: 19697161) Jacobsson JA … Fredriksson R (Journal of molecular neuroscience : MN 2010) 2 3 54
  2. Toward a comprehensive characterization of a human cancer cell phosphoproteome. (PMID: 23186163) Zhou H … Mohammed S (Journal of proteome research 2013) 4 54
  3. N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB. (PMID: 22814378) Van Damme P … Aldabe R (Proceedings of the National Academy of Sciences of the United States of America 2012) 4 54
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. (PMID: 21873635) Gaudet P … Thomas PD (Briefings in bioinformatics 2011) 3 54
  5. Ubiquitin-mediated proteolysis of HuR by heat shock. (PMID: 19322201) Abdelmohsen K … Gorospe M (The EMBO journal 2009) 3 54

Products for SLC18B1 Gene

Sources for SLC18B1 Gene