Aliases for SLC18A2 Gene
External Ids for SLC18A2 Gene
Previous HGNC Symbols for SLC18A2 Gene
Previous GeneCards Identifiers for SLC18A2 Gene
This gene encodes an transmembrane protein that functions as an ATP-dependent transporter of monoamines, such as dopamine, norepinephrine, serotonin, and histamine. This protein transports amine neurotransmitters into synaptic vesicles. Polymorphisms in this gene may be associated with schizophrenia, bipolar disorder, and other neurological/psychiatric ailments. [provided by RefSeq, Jun 2018]
GeneCards Summary for SLC18A2 Gene
SLC18A2 (Solute Carrier Family 18 Member A2) is a Protein Coding gene. Diseases associated with SLC18A2 include Parkinsonism-Dystonia, Infantile, 2 and Brain Dopamine-Serotonin Vesicular Transport Disease. Among its related pathways are Neurotransmitter Release Cycle and Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3. Gene Ontology (GO) annotations related to this gene include enzyme binding and transmembrane transporter activity. An important paralog of this gene is SLC18A1.
UniProtKB/Swiss-Prot Summary for SLC18A2 Gene
Involved in the ATP-dependent vesicular transport of biogenic amine neurotransmitters. Pumps cytosolic monoamines including dopamine, norepinephrine, serotonin, and histamine into synaptic vesicles (PubMed:23363473). Requisite for vesicular amine storage prior to secretion via exocytosis.