Aliases for SLC18A2 Gene
External Ids for SLC18A2 Gene
Previous HGNC Symbols for SLC18A2 Gene
Previous GeneCards Identifiers for SLC18A2 Gene
The vesicular monoamine transporter acts to accumulate cytosolic monoamines into synaptic vesicles, using the proton gradient maintained across the synaptic vesicular membrane. Its proper function is essential to the correct activity of the monoaminergic systems that have been implicated in several human neuropsychiatric disorders. The transporter is a site of action of important drugs, including reserpine and tetrabenazine (summary by Peter et al., 1993 [PubMed 7905859]). See also SLC18A1 (MIM 193002).[supplied by OMIM, Jan 2011]
GeneCards Summary for SLC18A2 Gene
SLC18A2 (Solute Carrier Family 18 Member A2) is a Protein Coding gene. Diseases associated with SLC18A2 include Brain Dopamine-Serotonin Vesicular Transport Disease and Cocaine Abuse. Among its related pathways are Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds and Transmission across Chemical Synapses. Gene Ontology (GO) annotations related to this gene include enzyme binding and transmembrane transporter activity. An important paralog of this gene is SLC18A1.
UniProtKB/Swiss-Prot for SLC18A2 Gene
Involved in the ATP-dependent vesicular transport of biogenic amine neurotransmitters. Pumps cytosolic monoamines including dopamine, norepinephrine, serotonin, and histamine into synaptic vesicles. Requisite for vesicular amine storage prior to secretion via exocytosis.