Free for academic non-profit institutions. Other users need a Commercial license

Aliases for SLC17A7 Gene

Aliases for SLC17A7 Gene

  • Solute Carrier Family 17 Member 7 2 3 4 5
  • Solute Carrier Family 17 (Sodium-Dependent Inorganic Phosphate Cotransporter), Member 7 2 3
  • Solute Carrier Family 17 (Vesicular Glutamate Transporter), Member 7 2 3
  • Brain-Specific Na(+)-Dependent Inorganic Phosphate Cotransporter 3 4
  • Vesicular Glutamate Transporter 1 2 3
  • VGLUT1 3 4
  • BNPI 3 4
  • Brain-Specific Na-Dependent Inorganic Phosphate Cotransporter 3
  • VGluT1 4

External Ids for SLC17A7 Gene

Previous GeneCards Identifiers for SLC17A7 Gene

  • GC19M050591
  • GC19M050301
  • GC19M054608
  • GC19M054624
  • GC19M049933
  • GC19M046309
  • GC19M049934

Summaries for SLC17A7 Gene

Entrez Gene Summary for SLC17A7 Gene

  • The protein encoded by this gene is a vesicle-bound, sodium-dependent phosphate transporter that is specifically expressed in the neuron-rich regions of the brain. It is preferentially associated with the membranes of synaptic vesicles and functions in glutamate transport. The protein shares 82% identity with the differentiation-associated Na-dependent inorganic phosphate cotransporter and they appear to form a distinct class within the Na+/Pi cotransporter family. [provided by RefSeq, Jul 2008]

GeneCards Summary for SLC17A7 Gene

SLC17A7 (Solute Carrier Family 17 Member 7) is a Protein Coding gene. Diseases associated with SLC17A7 include Spinocerebellar Ataxia 27 and Deafness, Autosomal Dominant 25. Among its related pathways are Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds and Synaptic vesicle cycle. Gene Ontology (GO) annotations related to this gene include L-glutamate transmembrane transporter activity and inorganic phosphate transmembrane transporter activity. An important paralog of this gene is SLC17A6.

UniProtKB/Swiss-Prot for SLC17A7 Gene

  • Mediates the uptake of glutamate into synaptic vesicles at presynaptic nerve terminals of excitatory neural cells. May also mediate the transport of inorganic phosphate.

Gene Wiki entry for SLC17A7 Gene

Additional gene information for SLC17A7 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLC17A7 Gene

Genomics for SLC17A7 Gene

GeneHancer (GH) Regulatory Elements for SLC17A7 Gene

Promoters and enhancers for SLC17A7 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19J049441 Promoter/Enhancer 1.8 Ensembl ENCODE 650.7 -0.8 -841 2.8 HDGF ARNT ARID4B SIN3A DMAP1 YBX1 ZNF2 ZBTB7B IRF4 YY1 GC19M049443 SLC17A7 ALDH16A1 PRR12 GRWD1 SNORD35A SNORD35B SNRNP70 POLD1 PIH1D1
GH19J049442 Promoter/Enhancer 1.3 EPDnew ENCODE 650.7 +0.7 715 0.3 GLI4 ZEB1 ZNF335 ZNF366 KLF7 KLF13 EGR2 SP3 ZBTB11 GATAD2B SLC17A7 ALDH16A1 CPT1C PRR12 SNRNP70 PIH1D1 GRWD1 RASIP1 PTH2
GH19J049511 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 11 -72.0 -71996 5.7 HDGF PKNOX1 MLX ARID4B SIN3A ZNF48 TCF12 ZNF121 GLIS2 RUNX3 FCGRT PRR12 RCN3 SNORD35A SNORD34 SNORD33 SNORD32A RPL13A PRRG2 NOSIP
GH19J049567 Enhancer 1.4 Ensembl ENCODE dbSUPER 10.2 -127.2 -127206 4.6 PKNOX1 FOXA2 ARNT ARID4B SIN3A FEZF1 ZNF2 IRF4 YY1 ZNF121 PRR12 NOSIP SNORD35B PRRG2 POLD1 NUP62 PTOV1-AS2 SNORD35A FCGRT MIR150
GH19J049207 Enhancer 1.3 FANTOM5 Ensembl ENCODE 10.7 +234.0 234028 1.4 PKNOX1 ATF1 ARNT ARID4B SIN3A ZNF2 ZNF48 ARID2 FOS ATF7 SNRNP70 PPP1R15A PRR12 CD37 PPFIA3 C19orf73 LIN7B CGB7 NTF4 SLC6A16
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around SLC17A7 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the SLC17A7 gene promoter:
  • Tal-1beta
  • ITF-2
  • HOXA5
  • MRF-2
  • Pax-5
  • C/EBPbeta
  • E47
  • MZF-1
  • Pax-2b
  • Pax-2

Genomic Locations for SLC17A7 Gene

Genomic Locations for SLC17A7 Gene
12,963 bases
Minus strand
12,963 bases
Minus strand

Genomic View for SLC17A7 Gene

Genes around SLC17A7 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SLC17A7 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SLC17A7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC17A7 Gene

Proteins for SLC17A7 Gene

  • Protein details for SLC17A7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Vesicular glutamate transporter 1
    Protein Accession:
    Secondary Accessions:
    • B4DFR9
    • B4DG46
    • Q6PCD0

    Protein attributes for SLC17A7 Gene

    560 amino acids
    Molecular mass:
    61613 Da
    Quaternary structure:
    • Interacts with SHANK3.

    Alternative splice isoforms for SLC17A7 Gene


neXtProt entry for SLC17A7 Gene

Post-translational modifications for SLC17A7 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SLC17A7 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • R&D Systems Antibodies for SLC17A7 (VGLUT1/SLC17A7)
  • Abcam antibodies for SLC17A7
  • Boster Bio Antibodies for SLC17A7
  • Santa Cruz Biotechnology (SCBT) Antibodies for SLC17A7

No data available for DME Specific Peptides for SLC17A7 Gene

Domains & Families for SLC17A7 Gene

Gene Families for SLC17A7 Gene

Human Protein Atlas (HPA):
  • Predicted membrane proteins
  • Transporters

Protein Domains for SLC17A7 Gene


Graphical View of Domain Structure for InterPro Entry



  • Belongs to the major facilitator superfamily. Sodium/anion cotransporter family. VGLUT subfamily.
  • Belongs to the major facilitator superfamily. Sodium/anion cotransporter family. VGLUT subfamily.
genes like me logo Genes that share domains with SLC17A7: view

Function for SLC17A7 Gene

Molecular function for SLC17A7 Gene

UniProtKB/Swiss-Prot Function:
Mediates the uptake of glutamate into synaptic vesicles at presynaptic nerve terminals of excitatory neural cells. May also mediate the transport of inorganic phosphate.

Phenotypes From GWAS Catalog for SLC17A7 Gene

Gene Ontology (GO) - Molecular Function for SLC17A7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005313 L-glutamate transmembrane transporter activity TAS --
GO:0005315 inorganic phosphate transmembrane transporter activity IEA --
GO:0005326 neurotransmitter transporter activity IBA --
GO:0008068 extracellularly glutamate-gated chloride channel activity IEA --
GO:0015293 symporter activity IEA --
genes like me logo Genes that share ontologies with SLC17A7: view
genes like me logo Genes that share phenotypes with SLC17A7: view

Animal Models for SLC17A7 Gene

MGI Knock Outs for SLC17A7:

Animal Model Products

  • Taconic Biosciences Mouse Models for SLC17A7

CRISPR Products

miRNA for SLC17A7 Gene

miRTarBase miRNAs that target SLC17A7

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SLC17A7

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for SLC17A7 Gene

Localization for SLC17A7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC17A7 Gene

Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane. Membrane; Multi-pass membrane protein. Cell junction, synapse, synaptosome.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SLC17A7 gene
Compartment Confidence
plasma membrane 5
nucleus 2
extracellular 1
cytoskeleton 1
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for SLC17A7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0008021 synaptic vesicle IEA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IDA,IEA 10820226
GO:0030054 cell junction IEA --
genes like me logo Genes that share ontologies with SLC17A7: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for SLC17A7 Gene

Pathways & Interactions for SLC17A7 Gene

genes like me logo Genes that share pathways with SLC17A7: view

Pathways by source for SLC17A7 Gene

Gene Ontology (GO) - Biological Process for SLC17A7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003407 neural retina development IEA --
GO:0006811 ion transport TAS --
GO:0006814 sodium ion transport IEA --
GO:0006817 phosphate ion transport TAS 8632143
GO:0006820 anion transport IBA --
genes like me logo Genes that share ontologies with SLC17A7: view

No data available for SIGNOR curated interactions for SLC17A7 Gene

Drugs & Compounds for SLC17A7 Gene

(2) Drugs for SLC17A7 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(4) Additional Compounds for SLC17A7 Gene - From: Novoseek and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
  • Na(+)
  • Na+
  • SODIUM ion
genes like me logo Genes that share compounds with SLC17A7: view

Transcripts for SLC17A7 Gene

mRNA/cDNA for SLC17A7 Gene

(1) REFSEQ mRNAs :
(7) Additional mRNA sequences :
(106) Selected AceView cDNA sequences:
(5) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for SLC17A7 Gene

Solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 7:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SLC17A7

Alternative Splicing Database (ASD) splice patterns (SP) for SLC17A7 Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8a · 8b · 8c ^ 9a · 9b ^ 10a · 10b ^ 11 ^ 12a · 12b ^ 13a · 13b
SP1: - - -
SP2: - -
SP4: - - -
SP5: - -

Relevant External Links for SLC17A7 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SLC17A7 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SLC17A7 Gene

mRNA differential expression in normal tissues according to GTEx for SLC17A7 Gene

This gene is overexpressed in Brain - Cortex (x9.5), Brain - Anterior cingulate cortex (BA24) (x8.9), Brain - Frontal Cortex (BA9) (x8.4), Brain - Hippocampus (x7.9), Brain - Amygdala (x6.5), Brain - Cerebellum (x4.5), and Brain - Cerebellar Hemisphere (x4.5).

Protein differential expression in normal tissues from HIPED for SLC17A7 Gene

This gene is overexpressed in Frontal cortex (43.4), Brain (16.2), and Retina (6.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for SLC17A7 Gene

Protein tissue co-expression partners for SLC17A7 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of SLC17A7 Gene:


SOURCE GeneReport for Unigene cluster for SLC17A7 Gene:


mRNA Expression by UniProt/SwissProt for SLC17A7 Gene:

Tissue specificity: Expressed in several regions of the brain including amygdala, cerebellum, cerebral cortex, hippocampus, frontal lobe, medulla, occipital lobe, putamen and temporal lobe.

Evidence on tissue expression from TISSUES for SLC17A7 Gene

  • Nervous system(5)
  • Eye(3.3)
genes like me logo Genes that share expression patterns with SLC17A7: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for SLC17A7 Gene

Orthologs for SLC17A7 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for SLC17A7 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia SLC17A7 34 33
  • 98.44 (n)
(Canis familiaris)
Mammalia SLC17A7 34 33
  • 93.69 (n)
(Bos Taurus)
Mammalia SLC17A7 34 33
  • 93.33 (n)
(Mus musculus)
Mammalia Slc17a7 16 34 33
  • 90.24 (n)
(Rattus norvegicus)
Mammalia Slc17a7 33
  • 89.82 (n)
(Monodelphis domestica)
Mammalia SLC17A7 34
  • 83 (a)
(Anolis carolinensis)
Reptilia SLC17A7 34
  • 81 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia slc17a7 33
  • 73.26 (n)
(Danio rerio)
Actinopterygii SLC17A7 (3 of 3) 34
  • 75 (a)
slc17a6b 34
  • 75 (a)
slc17a7 34 33
  • 73.05 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG9887 35
  • 48 (a)
VGlut 34
  • 41 (a)
CG4288 35
  • 41 (a)
CG6978 35
  • 35 (a)
CG15096 35
  • 34 (a)
Picot 35
  • 34 (a)
CG3036 35
  • 33 (a)
CG15094 35
  • 32 (a)
CG9826 35
  • 31 (a)
CG9864 35
  • 31 (a)
CG9825 35
  • 31 (a)
l(2)08717 35
  • 31 (a)
NaPi-T 35
  • 30 (a)
CG4726 35
  • 30 (a)
CG30272 35
  • 30 (a)
CG30265 35
  • 30 (a)
CG7881 35
  • 29 (a)
CG8791 35
  • 29 (a)
CG3649 35
  • 29 (a)
BEST:CK02623 35
  • 28 (a)
CG2003 35
  • 28 (a)
(Caenorhabditis elegans)
Secernentea eat-4 34 33
  • 51.8 (n)
T07A5.3 35
  • 43 (a)
vglu-3 34
  • 37 (a)
vglu-2 34
  • 35 (a)
ZK54.1 35
  • 35 (a)
F21F8.11 35
  • 26 (a)
C02C2.4 35
  • 26 (a)
F12B6.2a 35
  • 25 (a)
F12B6.2b 35
  • 25 (a)
T09B9.2 35
  • 25 (a)
R10D12.1 35
  • 25 (a)
K10H10.1 35
  • 24 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons PHT4;1 33
  • 45.85 (n)
(Oryza sativa)
Liliopsida Os01g0279700 33
  • 46.49 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 58 (a)
Species where no ortholog for SLC17A7 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SLC17A7 Gene

Gene Tree for SLC17A7 (if available)
Gene Tree for SLC17A7 (if available)
Evolutionary constrained regions (ECRs) for SLC17A7: view image

Paralogs for SLC17A7 Gene

Paralogs for SLC17A7 Gene

(8) SIMAP similar genes for SLC17A7 Gene using alignment to 5 proteins:

  • B4DG46_HUMAN
  • L8EA60_HUMAN
  • M0R1S5_HUMAN
genes like me logo Genes that share paralogs with SLC17A7: view

Variants for SLC17A7 Gene

Sequence variations from dbSNP and Humsavar for SLC17A7 Gene

SNP ID Clin Chr 19 pos Variation AA Info Type
rs1000074421 -- 49,442,027(-) C/T upstream_transcript_variant
rs1000290915 -- 49,439,407(-) G/C intron_variant
rs1000351979 -- 49,433,722(-) G/A intron_variant
rs1000468671 -- 49,439,699(-) C/T intron_variant
rs1000529035 -- 49,440,030(-) A/T intron_variant

Structural Variations from Database of Genomic Variants (DGV) for SLC17A7 Gene

Variant ID Type Subtype PubMed ID
dgv52n68 CNV loss 17160897
nsv953599 CNV deletion 24416366
nsv9739 CNV gain+loss 18304495

Variation tolerance for SLC17A7 Gene

Residual Variation Intolerance Score: 22% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.74; 32.93% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SLC17A7 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SLC17A7 Gene

Disorders for SLC17A7 Gene

MalaCards: The human disease database

(3) MalaCards diseases for SLC17A7 Gene - From: DISEASES, Novoseek, and GeneCards

- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for SLC17A7

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with SLC17A7: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SLC17A7 Gene

Publications for SLC17A7 Gene

  1. Molecular cloning of a novel brain-type Na(+)-dependent inorganic phosphate cotransporter. (PMID: 10820226) Aihara Y … Takeda J (Journal of neurochemistry 2000) 2 3 4 22 58
  2. Resequencing and association study of vesicular glutamate transporter 1 gene (VGLUT1) with schizophrenia. (PMID: 19720501) Shen YC … Chen CH (Schizophrenia research 2009) 3 22 44 58
  3. Identification of new putative susceptibility genes for several psychiatric disorders by association analysis of regulatory and non-synonymous SNPs of 306 genes involved in neurotransmission and neurodevelopment. (PMID: 19086053) Gratacòs M … Psychiatric Genetics Network Group (American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics 2009) 3 44 58
  4. Pharmacogenetics of antipsychotic response in the CATIE trial: a candidate gene analysis. (PMID: 19156168) Need AC … Goldstein DB (European journal of human genetics : EJHG 2009) 3 44 58
  5. Loss of VGLUT1 and VGLUT2 in the prefrontal cortex is correlated with cognitive decline in Alzheimer disease. (PMID: 17531353) Kashani A … El Mestikawy S (Neurobiology of aging 2008) 3 22 58

Products for SLC17A7 Gene

Sources for SLC17A7 Gene

Loading form....