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The protein encoded by this gene is a vesicle-bound, sodium-dependent phosphate transporter that is specifically expressed in the neuron-rich regions of the brain. It is preferentially associated with the membranes of synaptic vesicles and functions in glutamate transport. The protein shares 82% identity with the differentiation-associated Na-dependent inorganic phosphate cotransporter and they appear to form a distinct class within the Na+/Pi cotransporter family. [provided by RefSeq, Jul 2008]
SLC17A7 (Solute Carrier Family 17 Member 7) is a Protein Coding gene. Diseases associated with SLC17A7 include Deafness, Autosomal Dominant 25 and Kaufman Oculocerebrofacial Syndrome. Among its related pathways are Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds and Neuroscience. Gene Ontology (GO) annotations related to this gene include L-glutamate transmembrane transporter activity and inorganic phosphate transmembrane transporter activity. An important paralog of this gene is SLC17A6.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005313 | L-glutamate transmembrane transporter activity | TAS | -- |
GO:0005315 | inorganic phosphate transmembrane transporter activity | IEA | -- |
GO:0005326 | neurotransmitter transporter activity | IBA | 21873635 |
GO:0005436 | sodium:phosphate symporter activity | TAS | 8632143 |
GO:0008068 | extracellularly glutamate-gated chloride channel activity | IEA | -- |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005623 | cell | IEA | -- |
GO:0005886 | plasma membrane | TAS | -- |
GO:0008021 | synaptic vesicle | IEA | -- |
GO:0016020 | membrane | IEA | -- |
GO:0016021 | integral component of membrane | IEA,IDA | 10820226 |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds | ||
2 | Synaptic vesicle cycle | ||
3 | Neurotransmitter Release Cycle | ||
4 | Transmission across Chemical Synapses |
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5 | Neuroscience |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0003407 | neural retina development | IEA | -- |
GO:0006811 | ion transport | TAS | -- |
GO:0006814 | sodium ion transport | IEA | -- |
GO:0006817 | phosphate ion transport | TAS,IEA | -- |
GO:0006820 | anion transport | IBA | 21873635 |
ExUns: | 1 | ^ | 2 | ^ | 3a | · | 3b | ^ | 4 | ^ | 5 | ^ | 6a | · | 6b | ^ | 7 | ^ | 8a | · | 8b | · | 8c | ^ | 9a | · | 9b | ^ | 10a | · | 10b | ^ | 11 | ^ | 12a | · | 12b | ^ | 13a | · | 13b |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | - | - | - | ||||||||||||||||||||||||||||||||||||||
SP2: | - | - | |||||||||||||||||||||||||||||||||||||||
SP3: | |||||||||||||||||||||||||||||||||||||||||
SP4: | - | - | - | ||||||||||||||||||||||||||||||||||||||
SP5: | - | - |
This gene was present in the common ancestor of eukaryotes.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | SLC17A7 30 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | SLC17A7 30 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | SLC17A7 30 31 |
|
OneToOne | |
Mouse (Mus musculus) |
Mammalia | Slc17a7 30 17 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Slc17a7 30 |
|
||
Oppossum (Monodelphis domestica) |
Mammalia | SLC17A7 31 |
|
OneToOne | |
Lizard (Anolis carolinensis) |
Reptilia | SLC17A7 31 |
|
OneToOne | |
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | slc17a7 30 |
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||
Zebrafish (Danio rerio) |
Actinopterygii | SLC17A7 (3 of 3) 31 |
|
OneToMany | |
slc17a6b 31 |
|
OneToMany | |||
slc17a7 30 31 |
|
OneToMany | |||
Fruit Fly (Drosophila melanogaster) |
Insecta | CG9887 32 |
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VGlut 31 |
|
OneToMany | |||
CG4288 32 |
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CG6978 32 |
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CG15096 32 |
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Picot 32 |
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CG3036 32 |
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CG15094 32 |
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CG9825 32 |
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CG9826 32 |
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CG9864 32 |
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l(2)08717 32 |
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CG30265 32 |
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CG30272 32 |
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CG4726 32 |
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NaPi-T 32 |
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CG3649 32 |
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CG7881 32 |
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CG8791 32 |
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CG2003 32 |
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BEST:CK02623 32 |
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Worm (Caenorhabditis elegans) |
Secernentea | eat-4 30 31 |
|
ManyToMany | |
T07A5.3 32 |
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vglu-3 31 |
|
ManyToMany | |||
vglu-2 31 |
|
ManyToMany | |||
ZK54.1 32 |
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F21F8.11 32 |
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C02C2.4 32 |
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T09B9.2 32 |
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F12B6.2a 32 |
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F12B6.2b 32 |
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R10D12.1 32 |
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K10H10.1 32 |
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Thale Cress (Arabidopsis thaliana) |
eudicotyledons | PHT4;1 30 |
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Rice (Oryza sativa) |
Liliopsida | Os01g0279700 30 |
|
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Sea Squirt (Ciona savignyi) |
Ascidiacea | -- 31 |
|
OneToMany |
SNP ID | Clinical significance and condition | Chr 19 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
714893 | Benign: not provided | 49,436,724(-) | C/T | MISSENSE_VARIANT | |
722306 | Benign: not provided | 49,434,053(-) | G/A | INTRON_VARIANT | |
727740 | Benign: not provided | 49,430,690(-) | G/A | SYNONYMOUS_VARIANT | |
730241 | Benign: not provided | 49,435,203(-) | T/C | SYNONYMOUS_VARIANT | |
738168 | Benign: not provided | 49,433,716(-) | G/T | INTRON_VARIANT |
Disorder | Aliases | PubMed IDs |
---|---|---|
deafness, autosomal dominant 25 |
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kaufman oculocerebrofacial syndrome |
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kagami-ogata syndrome |
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schizophrenia |
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neuropathy, hereditary, with liability to pressure palsies |
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