The protein encoded by this gene is a vesicle-bound, sodium-dependent phosphate transporter that is specifically expressed in the neuron-rich regions of the brain. It is preferentially associated with the membranes of synaptic vesicles and functions in glutamate transport. The protein shares 82% identity with the differentiation-associated Na-dependent inorganic phosphate cotra... See more...

Aliases for SLC17A7 Gene

Aliases for SLC17A7 Gene

  • Solute Carrier Family 17 Member 7 2 3 4 5
  • Vesicular Glutamate Transporter 1 2 3 4
  • Solute Carrier Family 17 (Sodium-Dependent Inorganic Phosphate Cotransporter), Member 7 2 3
  • Solute Carrier Family 17 (Vesicular Glutamate Transporter), Member 7 2 3
  • Brain-Specific Na(+)-Dependent Inorganic Phosphate Cotransporter 3 4
  • VGLUT1 3 4
  • BNPI 3 4
  • Brain-Specific Na-Dependent Inorganic Phosphate Cotransporter 3
  • VGluT1 4

External Ids for SLC17A7 Gene

Previous GeneCards Identifiers for SLC17A7 Gene

  • GC19M050591
  • GC19M050301
  • GC19M054608
  • GC19M054624
  • GC19M049933
  • GC19M046309
  • GC19M049934

Summaries for SLC17A7 Gene

Entrez Gene Summary for SLC17A7 Gene

  • The protein encoded by this gene is a vesicle-bound, sodium-dependent phosphate transporter that is specifically expressed in the neuron-rich regions of the brain. It is preferentially associated with the membranes of synaptic vesicles and functions in glutamate transport. The protein shares 82% identity with the differentiation-associated Na-dependent inorganic phosphate cotransporter and they appear to form a distinct class within the Na+/Pi cotransporter family. [provided by RefSeq, Jul 2008]

GeneCards Summary for SLC17A7 Gene

SLC17A7 (Solute Carrier Family 17 Member 7) is a Protein Coding gene. Diseases associated with SLC17A7 include Deafness, Autosomal Dominant 25 and Schizophrenia. Among its related pathways are Circadian entrainment and Synaptic vesicle cycle. Gene Ontology (GO) annotations related to this gene include L-glutamate transmembrane transporter activity and inorganic phosphate transmembrane transporter activity. An important paralog of this gene is SLC17A6.

UniProtKB/Swiss-Prot Summary for SLC17A7 Gene

  • Mediates the uptake of glutamate into synaptic vesicles at presynaptic nerve terminals of excitatory neural cells. May also mediate the transport of inorganic phosphate.

Gene Wiki entry for SLC17A7 Gene

Additional gene information for SLC17A7 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for SLC17A7 Gene

Genomics for SLC17A7 Gene

GeneHancer (GH) Regulatory Elements for SLC17A7 Gene

Promoters and enhancers for SLC17A7 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19J049442 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE CraniofacialAtlas 500.7 -0.7 -741 3.8 RXRA HNRNPK ZBTB40 ZNF217 CTCF SIN3A TCF12 NRF1 POLR2G SP1 SLC17A7 lnc-SLC17A7-1 ALDH16A1 NUP62 ENSG00000268047 SNRNP70 CPT1C PTOV1-AS2 PRR12 POLD1
GH19J049511 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE CraniofacialAtlas 11 -72.0 -71996 5.7 POLR2G USF1 PHF8 ZIC2 ZBTB10 ZNF423 ZBTB26 ZBTB25 TGIF2 ZBTB7A FCGRT NONHSAG026245.2 PRR12 RCN3 SNORD32A SNORD33 SNORD34 SNORD35A RPL13A PRRG2
GH19J049210 Promoter/Enhancer 1.7 Ensembl ENCODE CraniofacialAtlas 10.7 +231.5 231459 1.8 CTCF NRF1 TEAD4 CTBP1 ZBTB7A SKI SMC3 POLR2A NR2F2 NCOR1 HSALNG0126969 SNRNP70 C19orf73 PPFIA3 LIN7B NTF4 CGB7 CD37 SLC6A16 KCNA7
GH19J049567 Promoter/Enhancer 1.4 Ensembl ENCODE dbSUPER 10.2 -127.2 -127206 4.6 ZNF217 CTCF ZNF10 REST MYC CHD1 RAD21 ZNF274 TRIM22 ZKSCAN8 PRR12 NOSIP PRRG2 FCGRT MIR150 RPS11 SNORD35B RCN3 FLT3LG BCL2L12
GH19J049207 Enhancer 1.1 FANTOM5 ENCODE 10.7 +234.0 234028 1.4 CTCF RBAK AFF1 REST TOE1 RAD21 TRIM22 SMC3 RAD51 LEF1 PPP1R15A CD37 SNRNP70 C19orf73 PPFIA3 LIN7B CGB7 NTF4 SLC6A16 KCNA7
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around SLC17A7 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for SLC17A7

Top Transcription factor binding sites by QIAGEN in the SLC17A7 gene promoter:
  • C/EBPbeta
  • E47
  • HOXA5
  • ITF-2
  • MRF-2
  • MZF-1
  • Pax-2
  • Pax-2b
  • Pax-5
  • Tal-1beta

Genomic Locations for SLC17A7 Gene

Genomic Locations for SLC17A7 Gene
chr19:49,429,398-49,442,360
(GRCh38/hg38)
Size:
12,963 bases
Orientation:
Minus strand
chr19:49,932,655-49,945,617
(GRCh37/hg19)
Size:
12,963 bases
Orientation:
Minus strand

Genomic View for SLC17A7 Gene

Genes around SLC17A7 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SLC17A7 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SLC17A7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC17A7 Gene

Proteins for SLC17A7 Gene

  • Protein details for SLC17A7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9P2U7-VGLU1_HUMAN
    Recommended name:
    Vesicular glutamate transporter 1
    Protein Accession:
    Q9P2U7
    Secondary Accessions:
    • B4DFR9
    • B4DG46
    • Q6PCD0

    Protein attributes for SLC17A7 Gene

    Size:
    560 amino acids
    Molecular mass:
    61613 Da
    Quaternary structure:
    • Interacts with SHANK3.

    Alternative splice isoforms for SLC17A7 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SLC17A7 Gene

Post-translational modifications for SLC17A7 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SLC17A7 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SLC17A7 Gene

Domains & Families for SLC17A7 Gene

Gene Families for SLC17A7 Gene

Protein Domains for SLC17A7 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for SLC17A7 Gene

GenScript: Design optimal peptide antigens:
  • cDNA FLJ59680, highly similar to Homo sapiens solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 7, mRNA (B4DG46_HUMAN)
  • Solute carrier family 17 member 7 (VGLU1_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q9P2U7

UniProtKB/Swiss-Prot:

VGLU1_HUMAN :
  • Belongs to the major facilitator superfamily. Sodium/anion cotransporter family. VGLUT subfamily.
Family:
  • Belongs to the major facilitator superfamily. Sodium/anion cotransporter family. VGLUT subfamily.
genes like me logo Genes that share domains with SLC17A7: view

Function for SLC17A7 Gene

Molecular function for SLC17A7 Gene

UniProtKB/Swiss-Prot Function:
Mediates the uptake of glutamate into synaptic vesicles at presynaptic nerve terminals of excitatory neural cells. May also mediate the transport of inorganic phosphate.

Phenotypes From GWAS Catalog for SLC17A7 Gene

Gene Ontology (GO) - Molecular Function for SLC17A7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005313 L-glutamate transmembrane transporter activity TAS --
GO:0005315 inorganic phosphate transmembrane transporter activity IEA --
GO:0005326 neurotransmitter transporter activity IBA 21873635
GO:0008068 extracellularly glutamate-gated chloride channel activity IEA --
GO:0015293 symporter activity IEA --
genes like me logo Genes that share ontologies with SLC17A7: view
genes like me logo Genes that share phenotypes with SLC17A7: view

Animal Models for SLC17A7 Gene

MGI Knock Outs for SLC17A7:

Animal Model Products

  • Taconic Biosciences Mouse Models for SLC17A7

CRISPR Products

miRNA for SLC17A7 Gene

miRTarBase miRNAs that target SLC17A7

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SLC17A7

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for SLC17A7 Gene

Localization for SLC17A7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC17A7 Gene

Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane. Membrane; Multi-pass membrane protein. Cell junction, synapse, synaptosome.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SLC17A7 gene
Compartment Confidence
plasma membrane 5
extracellular 2
cytoskeleton 2
mitochondrion 2
nucleus 2
endoplasmic reticulum 2
endosome 2
cytosol 2
peroxisome 1
lysosome 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for SLC17A7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005623 cell IEA --
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane IEA --
GO:0008021 synaptic vesicle IEA --
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with SLC17A7: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for SLC17A7 Gene

Pathways & Interactions for SLC17A7 Gene

genes like me logo Genes that share pathways with SLC17A7: view

Pathways by source for SLC17A7 Gene

Gene Ontology (GO) - Biological Process for SLC17A7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003407 neural retina development IEA --
GO:0006811 ion transport TAS --
GO:0006814 sodium ion transport IEA --
GO:0006817 phosphate ion transport TAS 8632143
GO:0006836 neurotransmitter transport IEA --
genes like me logo Genes that share ontologies with SLC17A7: view

No data available for SIGNOR curated interactions for SLC17A7 Gene

Drugs & Compounds for SLC17A7 Gene

(2) Drugs for SLC17A7 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(4) Additional Compounds for SLC17A7 Gene - From: Novoseek and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
sodium
  • Na(+)
  • Na+
  • SODIUM ion
7440-23-5
genes like me logo Genes that share compounds with SLC17A7: view

Transcripts for SLC17A7 Gene

mRNA/cDNA for SLC17A7 Gene

1 REFSEQ mRNAs :
11 NCBI additional mRNA sequence :
5 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SLC17A7

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for SLC17A7 Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8a · 8b · 8c ^ 9a · 9b ^ 10a · 10b ^ 11 ^ 12a · 12b ^ 13a · 13b
SP1: - - -
SP2: - -
SP3:
SP4: - - -
SP5: - -

Relevant External Links for SLC17A7 Gene

GeneLoc Exon Structure for
SLC17A7

Expression for SLC17A7 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for SLC17A7 Gene

mRNA differential expression in normal tissues according to GTEx for SLC17A7 Gene

This gene is overexpressed in Brain - Cortex (x9.5), Brain - Anterior cingulate cortex (BA24) (x8.9), Brain - Frontal Cortex (BA9) (x8.4), Brain - Hippocampus (x7.9), Brain - Amygdala (x6.5), Brain - Cerebellum (x4.5), and Brain - Cerebellar Hemisphere (x4.5).

Protein differential expression in normal tissues from HIPED for SLC17A7 Gene

This gene is overexpressed in Frontal cortex (43.4), Brain (16.2), and Retina (6.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for SLC17A7 Gene



Protein tissue co-expression partners for SLC17A7 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for SLC17A7

SOURCE GeneReport for Unigene cluster for SLC17A7 Gene:

Hs.375616

mRNA Expression by UniProt/SwissProt for SLC17A7 Gene:

Q9P2U7-VGLU1_HUMAN
Tissue specificity: Expressed in several regions of the brain including amygdala, cerebellum, cerebral cortex, hippocampus, frontal lobe, medulla, occipital lobe, putamen and temporal lobe.

Evidence on tissue expression from TISSUES for SLC17A7 Gene

  • Nervous system(5)
  • Eye(3.3)
genes like me logo Genes that share expression patterns with SLC17A7: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for SLC17A7 Gene

Orthologs for SLC17A7 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for SLC17A7 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SLC17A7 31 30
  • 98.44 (n)
OneToOne
dog
(Canis familiaris)
Mammalia SLC17A7 31 30
  • 93.69 (n)
OneToOne
cow
(Bos Taurus)
Mammalia SLC17A7 31 30
  • 93.33 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Slc17a7 17 31 30
  • 90.24 (n)
rat
(Rattus norvegicus)
Mammalia Slc17a7 30
  • 89.82 (n)
oppossum
(Monodelphis domestica)
Mammalia SLC17A7 31
  • 83 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SLC17A7 31
  • 81 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia slc17a7 30
  • 73.26 (n)
zebrafish
(Danio rerio)
Actinopterygii SLC17A7 (3 of 3) 31
  • 75 (a)
OneToMany
slc17a6b 31
  • 75 (a)
OneToMany
slc17a7 31 30
  • 73.05 (n)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta CG9887 32
  • 48 (a)
VGlut 31
  • 41 (a)
OneToMany
CG4288 32
  • 41 (a)
CG6978 32
  • 35 (a)
Picot 32
  • 34 (a)
CG15096 32
  • 34 (a)
CG3036 32
  • 33 (a)
CG15094 32
  • 32 (a)
CG9864 32
  • 31 (a)
l(2)08717 32
  • 31 (a)
CG9826 32
  • 31 (a)
CG9825 32
  • 31 (a)
NaPi-T 32
  • 30 (a)
CG30272 32
  • 30 (a)
CG4726 32
  • 30 (a)
CG30265 32
  • 30 (a)
CG3649 32
  • 29 (a)
CG7881 32
  • 29 (a)
CG8791 32
  • 29 (a)
CG2003 32
  • 28 (a)
BEST:CK02623 32
  • 28 (a)
worm
(Caenorhabditis elegans)
Secernentea eat-4 31 30
  • 51.8 (n)
ManyToMany
T07A5.3 32
  • 43 (a)
vglu-3 31
  • 37 (a)
ManyToMany
vglu-2 31
  • 35 (a)
ManyToMany
ZK54.1 32
  • 35 (a)
F21F8.11 32
  • 26 (a)
C02C2.4 32
  • 26 (a)
F12B6.2b 32
  • 25 (a)
R10D12.1 32
  • 25 (a)
T09B9.2 32
  • 25 (a)
F12B6.2a 32
  • 25 (a)
K10H10.1 32
  • 24 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons PHT4;1 30
  • 45.85 (n)
rice
(Oryza sativa)
Liliopsida Os01g0279700 30
  • 46.49 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 58 (a)
OneToMany
Species where no ortholog for SLC17A7 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SLC17A7 Gene

ENSEMBL:
Gene Tree for SLC17A7 (if available)
TreeFam:
Gene Tree for SLC17A7 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for SLC17A7: view image

Paralogs for SLC17A7 Gene

(8) SIMAP similar genes for SLC17A7 Gene using alignment to 5 proteins:

  • VGLU1_HUMAN
  • B4DFR9_HUMAN
  • B4DG46_HUMAN
  • L8EA60_HUMAN
  • M0R1S5_HUMAN
genes like me logo Genes that share paralogs with SLC17A7: view

Variants for SLC17A7 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for SLC17A7 Gene

SNP ID Clinical significance and condition Chr 19 pos Variation AA Info Type
rs17855709 - p.Pro431Arg

Additional dbSNP identifiers (rs#s) for SLC17A7 Gene

Structural Variations from Database of Genomic Variants (DGV) for SLC17A7 Gene

Variant ID Type Subtype PubMed ID
dgv52n68 CNV loss 17160897
nsv953599 CNV deletion 24416366
nsv9739 CNV gain+loss 18304495

Variation tolerance for SLC17A7 Gene

Residual Variation Intolerance Score: 22% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.74; 32.93% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SLC17A7 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SLC17A7

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SLC17A7 Gene

Disorders for SLC17A7 Gene

MalaCards: The human disease database

(8) MalaCards diseases for SLC17A7 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
deafness, autosomal dominant 25
  • dfna25
schizophrenia
  • sczd
neuropathy, hereditary, with liability to pressure palsies
  • hnpp
bipolar disorder
  • major affective disorder 1
pervasive developmental disorder
  • pervasive development disorder
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for SLC17A7

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with SLC17A7: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SLC17A7 Gene

Publications for SLC17A7 Gene

  1. Molecular cloning of a novel brain-type Na(+)-dependent inorganic phosphate cotransporter. (PMID: 10820226) Aihara Y … Takeda J (Journal of neurochemistry 2000) 2 3 4 23 54
  2. Resequencing and association study of vesicular glutamate transporter 1 gene (VGLUT1) with schizophrenia. (PMID: 19720501) Shen YC … Chen CH (Schizophrenia research 2009) 3 23 41 54
  3. Identification of new putative susceptibility genes for several psychiatric disorders by association analysis of regulatory and non-synonymous SNPs of 306 genes involved in neurotransmission and neurodevelopment. (PMID: 19086053) Gratacòs M … Psychiatric Genetics Network Group (American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics 2009) 3 41 54
  4. Pharmacogenetics of antipsychotic response in the CATIE trial: a candidate gene analysis. (PMID: 19156168) Need AC … Goldstein DB (European journal of human genetics : EJHG 2009) 3 41 54
  5. Loss of VGLUT1 and VGLUT2 in the prefrontal cortex is correlated with cognitive decline in Alzheimer disease. (PMID: 17531353) Kashani A … El Mestikawy S (Neurobiology of aging 2008) 3 23 54

Products for SLC17A7 Gene

Sources for SLC17A7 Gene