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Aliases for SLC17A6 Gene

Aliases for SLC17A6 Gene

  • Solute Carrier Family 17 Member 6 2 3 4 5
  • Solute Carrier Family 17 (Sodium-Dependent Inorganic Phosphate Cotransporter), Member 6 2 3
  • Differentiation-Associated Na(+)-Dependent Inorganic Phosphate Cotransporter 3 4
  • Differentiation-Associated Na-Dependent Inorganic Phosphate Cotransporter 2 3
  • Solute Carrier Family 17 (Vesicular Glutamate Transporter), Member 6 2 3
  • Vesicular Glutamate Transporter 2 2 3
  • Differentiation-Associated BNPI 3 4
  • VGLUT2 3 4
  • DNPI 3 4
  • VGluT2 4

External Ids for SLC17A6 Gene

Previous GeneCards Identifiers for SLC17A6 Gene

  • GC11P023776
  • GC11P023161
  • GC11P022398
  • GC11P022323
  • GC11P022316
  • GC11P022042

Summaries for SLC17A6 Gene

GeneCards Summary for SLC17A6 Gene

SLC17A6 (Solute Carrier Family 17 Member 6) is a Protein Coding gene. Diseases associated with SLC17A6 include Gnathodiaphyseal Dysplasia and Tendinosis. Among its related pathways are Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds and Synaptic vesicle cycle. Gene Ontology (GO) annotations related to this gene include symporter activity and L-glutamate transmembrane transporter activity. An important paralog of this gene is SLC17A7.

UniProtKB/Swiss-Prot for SLC17A6 Gene

  • Mediates the uptake of glutamate into synaptic vesicles at presynaptic nerve terminals of excitatory neural cells. May also mediate the transport of inorganic phosphate.

Additional gene information for SLC17A6 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLC17A6 Gene

Genomics for SLC17A6 Gene

GeneHancer (GH) Regulatory Elements for SLC17A6 Gene

Promoters and enhancers for SLC17A6 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH11J022337 Promoter/Enhancer 1.3 EPDnew ENCODE dbSUPER 650.7 -0.3 -337 0.2 KLF6 SIN3A MIER2 REST ZSCAN9 TGIF2 KLF16 ZNF143 EHMT2 SLC17A6 ENSG00000254768 GC11M022326
GH11J022339 Promoter/Enhancer 1.1 EPDnew dbSUPER 650.7 -0.2 -194 0.1 TGIF2 KLF6 ZNF143 SIN3A EHMT2 MIER2 REST ZSCAN9 SLC17A6 ENSG00000254768 GC11M022326
GH11J022338 Promoter/Enhancer 1 EPDnew ENCODE dbSUPER 650.7 +0.5 549 0.6 POLR2A ENSG00000254768 SLC17A6 ANO5 ENSG00000254540
GH11J022665 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE dbSUPER 10.1 +329.9 329926 4.6 HDGF ARID4B DMAP1 ZNF48 ZNF335 IKZF2 RUNX3 ZHX2 KAT8 SP1 GAS2 ENSG00000254768 SLC17A6 RNA5SP338 FANCF
GH11J022792 Enhancer 1.2 FANTOM5 Ensembl ENCODE 11.1 +454.5 454504 1.1 FOXA2 RARA CHAMP1 ZNF614 FOS THAP11 ZNF592 NFIL3 KLF16 RCOR2 SVIP ENSG00000254768 SLC17A6 ENSG00000246225 GC11P022744 GAS2
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around SLC17A6 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the SLC17A6 gene promoter:
  • HOXA5
  • E2F-5
  • E2F
  • E2F-1
  • E2F-2
  • E2F-3a
  • E2F-4
  • c-Myb
  • Pax-2a
  • Pax-2

Genomic Locations for SLC17A6 Gene

Genomic Locations for SLC17A6 Gene
41,407 bases
Plus strand
41,407 bases
Plus strand

Genomic View for SLC17A6 Gene

Genes around SLC17A6 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SLC17A6 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SLC17A6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC17A6 Gene

Proteins for SLC17A6 Gene

  • Protein details for SLC17A6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Vesicular glutamate transporter 2
    Protein Accession:
    Secondary Accessions:
    • A6NKS2

    Protein attributes for SLC17A6 Gene

    582 amino acids
    Molecular mass:
    64392 Da
    Quaternary structure:
    No Data Available

neXtProt entry for SLC17A6 Gene

Post-translational modifications for SLC17A6 Gene

  • Glycosylation at posLast=470470, posLast=101101, and isoforms=100
  • Modification sites at PhosphoSitePlus

Other Protein References for SLC17A6 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SLC17A6 Gene

Domains & Families for SLC17A6 Gene

Gene Families for SLC17A6 Gene

Human Protein Atlas (HPA):
  • Predicted membrane proteins
  • Transporters

Protein Domains for SLC17A6 Gene


Graphical View of Domain Structure for InterPro Entry



  • Belongs to the major facilitator superfamily. Sodium/anion cotransporter family. VGLUT subfamily.
  • Belongs to the major facilitator superfamily. Sodium/anion cotransporter family. VGLUT subfamily.
genes like me logo Genes that share domains with SLC17A6: view

Function for SLC17A6 Gene

Molecular function for SLC17A6 Gene

UniProtKB/Swiss-Prot Function:
Mediates the uptake of glutamate into synaptic vesicles at presynaptic nerve terminals of excitatory neural cells. May also mediate the transport of inorganic phosphate.

Phenotypes From GWAS Catalog for SLC17A6 Gene

Gene Ontology (GO) - Molecular Function for SLC17A6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005313 L-glutamate transmembrane transporter activity TAS --
GO:0005326 neurotransmitter transporter activity IBA --
GO:0015293 symporter activity IEA --
GO:0022857 transmembrane transporter activity IBA --
genes like me logo Genes that share ontologies with SLC17A6: view
genes like me logo Genes that share phenotypes with SLC17A6: view

Animal Models for SLC17A6 Gene

MGI Knock Outs for SLC17A6:

Animal Model Products

  • Taconic Biosciences Mouse Models for SLC17A6

CRISPR Products

miRNA for SLC17A6 Gene

miRTarBase miRNAs that target SLC17A6

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SLC17A6

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for SLC17A6 Gene

Localization for SLC17A6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC17A6 Gene

Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane. Membrane; Multi-pass membrane protein. Cell junction, synapse, synaptosome.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SLC17A6 gene
Compartment Confidence
plasma membrane 4
nucleus 2
extracellular 1
cytoskeleton 1
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for SLC17A6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IBA --
GO:0030054 cell junction IEA --
GO:0030285 integral component of synaptic vesicle membrane IBA --
GO:0030672 synaptic vesicle membrane TAS --
genes like me logo Genes that share ontologies with SLC17A6: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for SLC17A6 Gene

Pathways & Interactions for SLC17A6 Gene

genes like me logo Genes that share pathways with SLC17A6: view

Pathways by source for SLC17A6 Gene

Gene Ontology (GO) - Biological Process for SLC17A6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006811 ion transport TAS --
GO:0006814 sodium ion transport IEA --
GO:0006820 anion transport IBA --
GO:0006836 neurotransmitter transport IEA --
GO:0015813 L-glutamate transmembrane transport IEA --
genes like me logo Genes that share ontologies with SLC17A6: view

No data available for SIGNOR curated interactions for SLC17A6 Gene

Drugs & Compounds for SLC17A6 Gene

(2) Drugs for SLC17A6 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(5) Additional Compounds for SLC17A6 Gene - From: Novoseek and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
  • Na(+)
  • Na+
  • SODIUM ion
genes like me logo Genes that share compounds with SLC17A6: view

Transcripts for SLC17A6 Gene

mRNA/cDNA for SLC17A6 Gene

(1) REFSEQ mRNAs :
(6) Additional mRNA sequences :
(25) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for SLC17A6 Gene

Solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 6:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SLC17A6

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for SLC17A6 Gene

No ASD Table

Relevant External Links for SLC17A6 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SLC17A6 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SLC17A6 Gene

mRNA differential expression in normal tissues according to GTEx for SLC17A6 Gene

This gene is overexpressed in Brain - Hypothalamus (x16.7), Brain - Amygdala (x7.1), Brain - Substantia nigra (x6.7), Brain - Frontal Cortex (BA9) (x5.9), and Pituitary (x4.6).

Protein differential expression in normal tissues from HIPED for SLC17A6 Gene

This gene is overexpressed in Fetal Brain (33.2), Brain (20.8), and Frontal cortex (12.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for SLC17A6 Gene

Protein tissue co-expression partners for SLC17A6 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of SLC17A6 Gene:


SOURCE GeneReport for Unigene cluster for SLC17A6 Gene:


mRNA Expression by UniProt/SwissProt for SLC17A6 Gene:

Tissue specificity: Predominantly expressed in adult brain. Expressed in amygdala, caudate nucleus, cerebral cortex, frontal lobe, hippocampus, medulla, occipital lobe, putamen, spinal cord, substantia nigra, subthalamic nucleus, temporal lobe and thalamus.

Evidence on tissue expression from TISSUES for SLC17A6 Gene

  • Nervous system(4.8)
genes like me logo Genes that share expression patterns with SLC17A6: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for SLC17A6 Gene

Orthologs for SLC17A6 Gene

This gene was present in the common ancestor of animals.

Orthologs for SLC17A6 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia SLC17A6 34 33
  • 99.83 (n)
(Monodelphis domestica)
Mammalia SLC17A6 34
  • 97 (a)
(Ornithorhynchus anatinus)
Mammalia SLC17A6 34
  • 96 (a)
(Bos Taurus)
Mammalia SLC17A6 34 33
  • 94.79 (n)
(Canis familiaris)
Mammalia SLC17A6 34 33
  • 93.99 (n)
(Mus musculus)
Mammalia Slc17a6 16 34 33
  • 88.77 (n)
(Rattus norvegicus)
Mammalia Slc17a6 33
  • 87.63 (n)
(Gallus gallus)
Aves SLC17A6 34 33
  • 84.28 (n)
(Anolis carolinensis)
Reptilia SLC17A6 34
  • 95 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia slc17a6 33
  • 76.76 (n)
African clawed frog
(Xenopus laevis)
Amphibia LOC398748 33
(Danio rerio)
Actinopterygii slc17a6a 34 33
  • 74.39 (n)
fruit fly
(Drosophila melanogaster)
Insecta VGlut 34 33
  • 55.97 (n)
CG9887 35
  • 51 (a)
CG4288 35
  • 41 (a)
CG15096 35
  • 34 (a)
Picot 35
  • 34 (a)
CG3036 35
  • 34 (a)
CG15094 35
  • 33 (a)
l(2)08717 35
  • 31 (a)
CG9864 35
  • 31 (a)
CG9826 35
  • 31 (a)
NaPi-T 35
  • 31 (a)
CG3649 35
  • 30 (a)
CG9825 35
  • 30 (a)
CG4726 35
  • 30 (a)
CG30272 35
  • 29 (a)
CG30265 35
  • 29 (a)
CG8791 35
  • 28 (a)
CG7881 35
  • 28 (a)
CG2003 35
  • 28 (a)
BEST:CK02623 35
  • 26 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP007992 33
  • 53.92 (n)
(Caenorhabditis elegans)
Secernentea eat-4 34
  • 44 (a)
T07A5.3 35
  • 41 (a)
vglu-3 34
  • 38 (a)
ZK54.1 34 35
  • 36 (a)
vglu-2 34
  • 36 (a)
C38C10.2 34
  • 33 (a)
F12B6.2a 35
  • 25 (a)
F12B6.2b 35
  • 25 (a)
K10H10.1 35
  • 24 (a)
T09B9.2 34 35
  • 23 (a)
Y4C6B.3 34
  • 22 (a)
R10D12.1 34 35
  • 22 (a)
Y15E3A.4 34
  • 22 (a)
F25G6.7 34
  • 22 (a)
cima-1 34
  • 22 (a)
F21F8.11 34 35
  • 22 (a)
ZK682.2 34
  • 21 (a)
T28F3.4 34
  • 21 (a)
F12B6.2 34
  • 20 (a)
Y4C6B.4 34
  • 20 (a)
H11E01.2 34
  • 20 (a)
M162.5 34
  • 20 (a)
F44E7.7 34
  • 20 (a)
T27D12.1 34
  • 20 (a)
C02C2.4 34 35
  • 20 (a)
C01B4.8 34
  • 19 (a)
T22F3.7 34
  • 19 (a)
Y19D10A.5 34
  • 19 (a)
Y19D10A.8 34
  • 19 (a)
T22F3.10 34
  • 19 (a)
T19D12.9 34
  • 19 (a)
F56A4.10 34
  • 18 (a)
C01B4.7 34
  • 18 (a)
T19D12.10 34
  • 18 (a)
C35A5.3 34
  • 18 (a)
C18D1.2 34
  • 18 (a)
Y19D10A.4 34
  • 18 (a)
Y51B9A.6 34
  • 18 (a)
K11G9.5 34
  • 18 (a)
F59A1.13 34
  • 18 (a)
T22F3.11 34
  • 18 (a)
M117.1 34
  • 18 (a)
T22F3.8 34
  • 18 (a)
K08C7.1 34
  • 17 (a)
F56A4.12 34
  • 17 (a)
C18H9.5 34
  • 17 (a)
T02B11.6 34
  • 17 (a)
Y19D10A.11 34
  • 17 (a)
F10C2.7 34
  • 17 (a)
F11A5.9 34
  • 16 (a)
F41C3.2 34
  • 15 (a)
W04C9.6 34
  • 15 (a)
T28H11.8 34
  • 14 (a)
T01H3.3 34
  • 13 (a)
C39E9.7 34
  • 12 (a)
Y19D10A.10 34
  • 12 (a)
F56A4.11 34
  • 11 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 60 (a)
Species where no ortholog for SLC17A6 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SLC17A6 Gene

Gene Tree for SLC17A6 (if available)
Gene Tree for SLC17A6 (if available)
Evolutionary constrained regions (ECRs) for SLC17A6: view image

Paralogs for SLC17A6 Gene

Paralogs for SLC17A6 Gene

(6) SIMAP similar genes for SLC17A6 Gene using alignment to 3 proteins:

  • L0R6P3_HUMAN
genes like me logo Genes that share paralogs with SLC17A6: view

Variants for SLC17A6 Gene

Sequence variations from dbSNP and Humsavar for SLC17A6 Gene

SNP ID Clin Chr 11 pos Variation AA Info Type
VAR_038710 A breast cancer sample p.Thr40Ser
rs1000089427 -- 22,342,104(+) T/C intron_variant
rs1000131253 -- 22,336,605(+) G/A upstream_transcript_variant
rs1000139380 -- 22,345,909(+) C/T intron_variant
rs1000171777 -- 22,372,775(+) A/C intron_variant

Structural Variations from Database of Genomic Variants (DGV) for SLC17A6 Gene

Variant ID Type Subtype PubMed ID
esv3357361 CNV insertion 20981092
esv3625615 CNV gain 21293372
nsv1038630 CNV loss 25217958
nsv1041233 CNV gain 25217958
nsv1122588 CNV deletion 24896259
nsv38773 CNV deletion 16902084

Variation tolerance for SLC17A6 Gene

Residual Variation Intolerance Score: 7.57% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.25; 40.42% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SLC17A6 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SLC17A6 Gene

Disorders for SLC17A6 Gene

MalaCards: The human disease database

(4) MalaCards diseases for SLC17A6 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
gnathodiaphyseal dysplasia
  • gdd
  • colorblindness, tritanopic
  • sczd
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for SLC17A6

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with SLC17A6: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SLC17A6 Gene

Publications for SLC17A6 Gene

  1. Identification of differentiation-associated brain-specific phosphate transporter as a second vesicular glutamate transporter (VGLUT2). (PMID: 11698620) Takamori S … Jahn R (The Journal of neuroscience : the official journal of the Society for Neuroscience 2001) 3 4 22 58
  2. Molecular cloning of a novel brain-type Na(+)-dependent inorganic phosphate cotransporter. (PMID: 10820226) Aihara Y … Takeda J (Journal of neurochemistry 2000) 3 4 22 58
  3. [A study of the single nucleotide polymorphism in seven genes (GHR, IGFBP3, IGFR1, IRS1, FMN1, ANXA2, TaGLN) in ethnic Russians and in patients with prostate cancer]. (PMID: 20540360) Lisitskaia KV … Shishkin SS (Molekuliarnaia genetika, mikrobiologiia i virusologiia 2010) 3 44 58
  4. Resequencing of the vesicular glutamate transporter 2 gene (VGLUT2) reveals some rare genetic variants that may increase the genetic burden in schizophrenia. (PMID: 20541370) Shen YC … Chen CH (Schizophrenia research 2010) 3 44 58
  5. Identification of new putative susceptibility genes for several psychiatric disorders by association analysis of regulatory and non-synonymous SNPs of 306 genes involved in neurotransmission and neurodevelopment. (PMID: 19086053) Gratacòs M … Psychiatric Genetics Network Group (American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics 2009) 3 44 58

Products for SLC17A6 Gene

Sources for SLC17A6 Gene

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