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Aliases for SLC17A2 Gene

Aliases for SLC17A2 Gene

  • Solute Carrier Family 17 Member 2 2 3 4 5
  • Sodium/Phosphate Cotransporter 3 3 4
  • Na(+)/PI Cotransporter 3 3 4
  • NPT3 3 4
  • Solute Carrier Family 17 (Vesicular Glutamate Transporter), Member 2 3
  • Solute Carrier Family 17 (Sodium Phosphate), Member 2 2
  • Sodium-Dependent Phosphate Transport Protein 3 3
  • Solute Carrier Family 17, Member 2 2
  • Sodium Phosphate Transporter 3 3

External Ids for SLC17A2 Gene

Previous GeneCards Identifiers for SLC17A2 Gene

  • GC06M025970
  • GC06M026020
  • GC06M025856

Summaries for SLC17A2 Gene

GeneCards Summary for SLC17A2 Gene

SLC17A2 (Solute Carrier Family 17 Member 2) is a Protein Coding gene. Among its related pathways are Osteoblast Signaling. Gene Ontology (GO) annotations related to this gene include sodium:phosphate symporter activity. An important paralog of this gene is SLC17A4.

UniProtKB/Swiss-Prot for SLC17A2 Gene

  • May be involved in actively transporting phosphate into cells via Na(+) cotransport.

Additional gene information for SLC17A2 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLC17A2 Gene

Genomics for SLC17A2 Gene

GeneHancer (GH) Regulatory Elements for SLC17A2 Gene

Promoters and enhancers for SLC17A2 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH06J025930 Promoter 1.1 EPDnew 650.7 +0.0 15 0.1 ELF3 FOXA2 ARID4B DMAP1 RAD21 RARA SLC30A9 ZNF614 CREM THAP11 SLC17A2 GC06P025925 GC06P025915
GH06J025865 Enhancer 0.8 ENCODE 11.7 +64.5 64508 0.9 HDAC1 LEF1 ATF1 TEAD4 TAL1 JUN BACH1 CEBPG FOSL1 CTBP1 ENSG00000272462 SLC17A1 BTN3A2 SLC17A2 SLC17A4 SLC17A3 PIR39663
GH06J025958 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE dbSUPER 0.3 -31.2 -31196 6.5 HDGF PKNOX1 SMAD1 ARID4B FEZF1 IRF4 YY1 POLR2B ZNF207 SP3 TRIM38 ENSG00000272462 ABT1 NUP50P2 HMGN4 BTN2A3P BTN3A2 BTN2A1 SLC17A4 SLC17A2
GH06J025952 Enhancer 0.6 ENCODE dbSUPER 0.3 -22.2 -22199 1.8 MITF MEIS2 IKZF1 ENSG00000272462 TRIM38 SLC17A2 GC06P025915
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around SLC17A2 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the SLC17A2 gene promoter:
  • C/EBPalpha
  • Pax-4a
  • POU2F1a
  • POU2F1
  • IRF-7A
  • Pbx1a
  • MEF-2A
  • MEF-2
  • aMEF-2

Genomic Locations for SLC17A2 Gene

Genomic Locations for SLC17A2 Gene
17,973 bases
Minus strand
17,965 bases
Minus strand

Genomic View for SLC17A2 Gene

Genes around SLC17A2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SLC17A2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SLC17A2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC17A2 Gene

Proteins for SLC17A2 Gene

  • Protein details for SLC17A2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Sodium-dependent phosphate transport protein 3
    Protein Accession:
    Secondary Accessions:
    • A6NK81
    • A6NLD6
    • Q5TB84
    • Q76P85

    Protein attributes for SLC17A2 Gene

    439 amino acids
    Molecular mass:
    47277 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for SLC17A2 Gene


neXtProt entry for SLC17A2 Gene

Post-translational modifications for SLC17A2 Gene

  • Glycosylation at isoforms=2, 369, isoforms=2, 368, isoforms=2, 356, and posLast=4747
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for SLC17A2 Gene

Domains & Families for SLC17A2 Gene

Gene Families for SLC17A2 Gene

Human Protein Atlas (HPA):
  • Predicted membrane proteins
  • Transporters

Protein Domains for SLC17A2 Gene


Suggested Antigen Peptide Sequences for SLC17A2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the major facilitator superfamily. Sodium/anion cotransporter family.
  • Belongs to the major facilitator superfamily. Sodium/anion cotransporter family.
genes like me logo Genes that share domains with SLC17A2: view

Function for SLC17A2 Gene

Molecular function for SLC17A2 Gene

UniProtKB/Swiss-Prot Function:
May be involved in actively transporting phosphate into cells via Na(+) cotransport.
GENATLAS Biochemistry:
solute carrier family 17 (sodium/phosphate cotransport) member 2,predominantly expressed in muscle and heart

Phenotypes From GWAS Catalog for SLC17A2 Gene

Gene Ontology (GO) - Molecular Function for SLC17A2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005436 sodium:phosphate symporter activity TAS 9149941
GO:0015293 symporter activity IEA --
GO:0022857 transmembrane transporter activity IBA --
genes like me logo Genes that share ontologies with SLC17A2: view
genes like me logo Genes that share phenotypes with SLC17A2: view

Animal Model Products

  • Taconic Biosciences Mouse Models for SLC17A2

miRNA for SLC17A2 Gene

miRTarBase miRNAs that target SLC17A2

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SLC17A2 Gene

Localization for SLC17A2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC17A2 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SLC17A2 gene
Compartment Confidence
plasma membrane 5
endoplasmic reticulum 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for SLC17A2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005887 integral component of plasma membrane TAS 9149941
GO:0016020 membrane TAS 9149941
GO:0016021 integral component of membrane IBA,IEA --
genes like me logo Genes that share ontologies with SLC17A2: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for SLC17A2 Gene

Pathways & Interactions for SLC17A2 Gene

SuperPathways for SLC17A2 Gene

SuperPathway Contained pathways
1 Osteoblast Signaling
genes like me logo Genes that share pathways with SLC17A2: view

Pathways by source for SLC17A2 Gene

1 BioSystems pathway for SLC17A2 Gene

Interacting Proteins for SLC17A2 Gene

Gene Ontology (GO) - Biological Process for SLC17A2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006796 phosphate-containing compound metabolic process TAS 9149941
GO:0006811 ion transport IEA --
GO:0006814 sodium ion transport TAS 9149941
GO:0006820 anion transport IBA --
GO:0035725 sodium ion transmembrane transport IEA --
genes like me logo Genes that share ontologies with SLC17A2: view

No data available for SIGNOR curated interactions for SLC17A2 Gene

Drugs & Compounds for SLC17A2 Gene

(1) Additional Compounds for SLC17A2 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
  • Na(+)
  • Na+
  • SODIUM ion
genes like me logo Genes that share compounds with SLC17A2: view

Transcripts for SLC17A2 Gene

mRNA/cDNA for SLC17A2 Gene

(9) REFSEQ mRNAs :
(7) Additional mRNA sequences :
(17) Selected AceView cDNA sequences:
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for SLC17A2 Gene

Solute carrier family 17 (sodium phosphate), member 2:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for SLC17A2 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12a · 12b
SP1: - -
SP3: - -
SP5: -

Relevant External Links for SLC17A2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SLC17A2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SLC17A2 Gene

mRNA differential expression in normal tissues according to GTEx for SLC17A2 Gene

This gene is overexpressed in Liver (x52.3).

Protein differential expression in normal tissues from HIPED for SLC17A2 Gene

This gene is overexpressed in Fetal Liver (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for SLC17A2 Gene

Protein tissue co-expression partners for SLC17A2 Gene

NURSA nuclear receptor signaling pathways regulating expression of SLC17A2 Gene:


SOURCE GeneReport for Unigene cluster for SLC17A2 Gene:


mRNA Expression by UniProt/SwissProt for SLC17A2 Gene:

Tissue specificity: Expressed in the small intestine, kidney, spleen and testis. Not detected in fetal brain, bone marrow, and mammary gland.

Evidence on tissue expression from TISSUES for SLC17A2 Gene

  • Liver(4.4)
genes like me logo Genes that share expression patterns with SLC17A2: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Phenotype-based relationships between genes and organs from Gene ORGANizer for SLC17A2 Gene

Orthologs for SLC17A2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for SLC17A2 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia SLC17A2 34 33
  • 98.98 (n)
(Canis familiaris)
Mammalia LOC488255 33
  • 90.17 (n)
SLC17A2 34
  • 69 (a)
(Bos Taurus)
Mammalia SLC17A2 34 33
  • 89.96 (n)
(Mus musculus)
Mammalia Slc17a2 16 34 33
  • 85.94 (n)
(Rattus norvegicus)
Mammalia Slc17a2 33
  • 85.64 (n)
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 48 (a)
-- 34
  • 38 (a)
(Monodelphis domestica)
Mammalia -- 34
  • 42 (a)
-- 34
  • 35 (a)
(Danio rerio)
Actinopterygii CU929219.1 34
  • 29 (a)
Species where no ortholog for SLC17A2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SLC17A2 Gene

Gene Tree for SLC17A2 (if available)
Gene Tree for SLC17A2 (if available)
Evolutionary constrained regions (ECRs) for SLC17A2: view image

Paralogs for SLC17A2 Gene

Paralogs for SLC17A2 Gene

(7) SIMAP similar genes for SLC17A2 Gene using alignment to 2 proteins:

  • A6NK81_HUMAN
genes like me logo Genes that share paralogs with SLC17A2: view

Variants for SLC17A2 Gene

Sequence variations from dbSNP and Humsavar for SLC17A2 Gene

SNP ID Clin Chr 06 pos Variation AA Info Type
rs1000080460 -- 25,913,069(-) G/T 3_prime_UTR_variant, downstream_transcript_variant, genic_downstream_transcript_variant
rs1000144806 -- 25,930,520(-) A/G 5_prime_UTR_variant, genic_upstream_transcript_variant, intron_variant
rs1000327892 -- 25,925,861(-) T/C 5_prime_UTR_variant, intron_variant
rs1000443996 -- 25,926,247(-) G/A genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1000603671 -- 25,932,495(-) A/T upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for SLC17A2 Gene

Variant ID Type Subtype PubMed ID
nsv1023453 CNV gain 25217958
nsv1124045 CNV deletion 24896259
nsv5229 CNV deletion 18451855

Variation tolerance for SLC17A2 Gene

Residual Variation Intolerance Score: 40.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.79; 33.82% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SLC17A2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SLC17A2 Gene

Disorders for SLC17A2 Gene

Additional Disease Information for SLC17A2

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for SLC17A2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SLC17A2 Gene

Publications for SLC17A2 Gene

  1. A 1.1-Mb transcript map of the hereditary hemochromatosis locus. (PMID: 9149941) Ruddy DA … Feder JN (Genome research 1997) 2 3 4 58
  2. Common polymorphisms influencing serum uric acid levels contribute to susceptibility to gout, but not to coronary artery disease. (PMID: 19890391) Stark K … Hengstenberg C (PloS one 2009) 3 44 58
  3. The DNA sequence and analysis of human chromosome 6. (PMID: 14574404) Mungall AJ … Beck S (Nature 2003) 3 4 58
  4. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  5. Genome-wide association study of serum iron phenotypes in premenopausal women of European descent. (PMID: 26852655) Koller DL … Foroud T (Blood cells, molecules & diseases 2016) 3 58

Products for SLC17A2 Gene

Sources for SLC17A2 Gene

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