Aliases for SLC17A2 Gene
Aliases for SLC17A2 Gene
- Solute Carrier Family 17 Member 2 2 3 4 5
- Sodium/Phosphate Cotransporter 3 3 4
- Na(+)/PI Cotransporter 3 3 4
- NPT3 3 4
- Solute Carrier Family 17 (Vesicular Glutamate Transporter), Member 2 3
- Solute Carrier Family 17 (Sodium Phosphate), Member 2 2
- Sodium-Dependent Phosphate Transport Protein 3 3
- Solute Carrier Family 17, Member 2 2
- Sodium Phosphate Transporter 3 3
External Ids for SLC17A2 Gene
- HGNC: 10930
- Entrez Gene: 10246
- Ensembl: ENSG00000112337
- OMIM: 611049
- UniProtKB: O00624
Previous GeneCards Identifiers for SLC17A2 Gene
- GC06M025970
- GC06M026020
- GC06M025856
Summaries for SLC17A2 Gene
GeneCards Summary for SLC17A2 Gene
SLC17A2 (Solute Carrier Family 17 Member 2) is a Protein Coding gene. Among its related pathways are Osteoblast Signaling. Gene Ontology (GO) annotations related to this gene include sodium:phosphate symporter activity. An important paralog of this gene is SLC17A4.
UniProtKB/Swiss-Prot for SLC17A2 Gene
-
May be involved in actively transporting phosphate into cells via Na(+) cotransport.
Additional gene information for SLC17A2 Gene
No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLC17A2 Gene
Genomics for SLC17A2 Gene
GeneHancer (GH) Regulatory Elements for SLC17A2 Gene
Promoters and enhancers for SLC17A2 Gene
| GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
|---|---|---|---|---|---|---|---|---|---|---|
| GH06J025930 | Promoter | 1.1 | EPDnew | 650.7 | +0.0 | 15 | 0.1 | ELF3 FOXA2 ARID4B DMAP1 RAD21 RARA SLC30A9 ZNF614 CREM THAP11 | SLC17A2 GC06P025925 GC06P025915 | |
| GH06J025865 | Enhancer | 0.8 | ENCODE | 11.7 | +64.5 | 64508 | 0.9 | HDAC1 LEF1 ATF1 TEAD4 TAL1 JUN BACH1 CEBPG FOSL1 CTBP1 | ENSG00000272462 SLC17A1 BTN3A2 SLC17A2 SLC17A4 SLC17A3 PIR39663 | |
| GH06J025958 | Promoter/Enhancer | 2.2 | EPDnew Ensembl ENCODE dbSUPER | 0.3 | -31.2 | -31196 | 6.5 | HDGF PKNOX1 SMAD1 ARID4B FEZF1 IRF4 YY1 POLR2B ZNF207 SP3 | TRIM38 ENSG00000272462 ABT1 NUP50P2 HMGN4 BTN2A3P BTN3A2 BTN2A1 SLC17A4 SLC17A2 | |
| GH06J025952 | Enhancer | 0.6 | ENCODE dbSUPER | 0.3 | -22.2 | -22199 | 1.8 | MITF MEIS2 IKZF1 | ENSG00000272462 TRIM38 SLC17A2 GC06P025915 |
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)
GeneHancers around SLC17A2 on UCSC Golden Path with GeneCards custom track
- Top Transcription factor binding sites by QIAGEN in the SLC17A2 gene promoter:
-
- C/EBPalpha
- Pax-4a
- POU2F1a
- POU2F1
- IRF-7A
- Pbx1a
- MEF-2A
- MEF-2
- aMEF-2
Regulatory Element Products
Genomic Locations for SLC17A2 Gene
Genomic Locations for SLC17A2 Gene
- chr6:25,912,754-25,930,726
- (GRCh38/hg38)
- Size:
- 17,973 bases
- Orientation:
- Minus strand
- chr6:25,912,982-25,930,946
- (GRCh37/hg19)
- Size:
- 17,965 bases
- Orientation:
- Minus strand
Genomic View for SLC17A2 Gene
Genes around SLC17A2 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 6p22.2 by Entrez Gene
- 6p22.2 by HGNC
- 6p22.2 by Ensembl
SLC17A2 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for SLC17A2 Gene
Proteins for SLC17A2 Gene
-
Protein details for SLC17A2 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- O00624-NPT3_HUMAN
- Recommended name:
- Sodium-dependent phosphate transport protein 3
- Protein Accession:
- O00624
- A6NK81
- A6NLD6
- Q5TB84
- Q76P85
Protein attributes for SLC17A2 Gene
- Size:
- 439 amino acids
- Molecular mass:
- 47277 Da
- Quaternary structure:
- No Data Available
Protein Expression for SLC17A2 Gene
Post-translational modifications for SLC17A2 Gene
Other Protein References for SLC17A2 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- Novus Biologicals Antibodies for SLC17A2
- Invitrogen Antibodies for SLC17A2 (AFLGC-SLC17A2)
- GeneTex SLC17A2 Antibody for SLC17A2
Protein Products
-
OriGene Purified Proteins for SLC17A2
- Search Origene for MassSpec and Protein Over-expression Lysates for SLC17A2
- Origene Custom Protein Services for SLC17A2
- Search GeneTex for Proteins for SLC17A2
Assay Products
No data available for DME Specific Peptides for SLC17A2 Gene
Domains & Families for SLC17A2 Gene
Gene Families for SLC17A2 Gene
- HGNC:
- IUPHAR :
- Human Protein Atlas (HPA):
-
- Predicted membrane proteins
- Transporters
Protein Domains for SLC17A2 Gene
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for SLC17A2 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
O00624UniProtKB/Swiss-Prot:
NPT3_HUMAN :- Belongs to the major facilitator superfamily. Sodium/anion cotransporter family.
- Family:
-
- Belongs to the major facilitator superfamily. Sodium/anion cotransporter family.
Function for SLC17A2 Gene
Molecular function for SLC17A2 Gene
- UniProtKB/Swiss-Prot Function:
- May be involved in actively transporting phosphate into cells via Na(+) cotransport.
- GENATLAS Biochemistry:
- solute carrier family 17 (sodium/phosphate cotransport) member 2,predominantly expressed in muscle and heart
Phenotypes From GWAS Catalog for SLC17A2 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005436 | sodium:phosphate symporter activity | TAS | 9149941 |
| GO:0015293 | symporter activity | IEA | -- |
| GO:0022857 | transmembrane transporter activity | IBA | -- |
Phenotypes for SLC17A2 Gene
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-
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-
CRISPR Products
-
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- Applied Biological Materials CRISPR for SLC17A2
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for SLC17A2
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miRNA for SLC17A2 Gene
- miRTarBase miRNAs that target SLC17A2
miRNA Products
Inhibitory RNA Products
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Clone Products
- Sino Biological Human cDNA Clone for SLC17A2
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-
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Cell Line Products
-
Horizon Cell Lines for SLC17A2
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SLC17A2 Gene
Localization for SLC17A2 Gene
Subcellular locations from UniProtKB/Swiss-Prot for SLC17A2 Gene
- Membrane; Multi-pass membrane protein.
| Compartment | Confidence |
|---|---|
| plasma membrane | 5 |
| endoplasmic reticulum | 1 |
| golgi apparatus | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005887 | integral component of plasma membrane | TAS | 9149941 |
| GO:0016020 | membrane | TAS | 9149941 |
| GO:0016021 | integral component of membrane | IBA,IEA | -- |
No data available for Subcellular locations from the Human Protein Atlas (HPA) for SLC17A2 Gene
Pathways & Interactions for SLC17A2 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Osteoblast Signaling | ||
Pathways by source for SLC17A2 Gene
1 BioSystems pathway for SLC17A2 Gene
Interacting Proteins for SLC17A2 Gene
GPS-Prot Interaction Network for SLC17A2
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006796 | phosphate-containing compound metabolic process | TAS | 9149941 |
| GO:0006811 | ion transport | IEA | -- |
| GO:0006814 | sodium ion transport | TAS | 9149941 |
| GO:0006820 | anion transport | IBA | -- |
| GO:0035725 | sodium ion transmembrane transport | IEA | -- |
No data available for SIGNOR curated interactions for SLC17A2 Gene
Transcripts for SLC17A2 Gene
mRNA/cDNA for SLC17A2 Gene
- (9) REFSEQ mRNAs :
- (7) Additional mRNA sequences :
- (17) Selected AceView cDNA sequences:
- (3) Ensembl transcripts including schematic representations, and UCSC links where relevant :
-
- ENST00000360488 2270 bps (uc003nfl.5)
- ENST00000265425 1493 bps (uc063mfy.1)
- ENST00000377850 2524 bps (uc063mfx.1)
Unigene Clusters for SLC17A2 Gene
- Solute carrier family 17 (sodium phosphate), member 2:
- Representative Sequences:
CRISPR Products
-
OriGene CRISPR knockouts for SLC17A2
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- Applied Biological Materials CRISPR for SLC17A2
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for SLC17A2
- GenScript: Design CRISPR guide RNA sequences for SLC17A2
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for SLC17A2
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- genomics-online: shRNA clones - Search results for 103 available SLC17A2 gene related products
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Clone Products
- Sino Biological Human cDNA Clone for SLC17A2
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- Applied Biological Materials Clones for SLC17A2
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
| ExUns: | 1a | · | 1b | · | 1c | · | 1d | ^ | 2 | ^ | 3 | ^ | 4a | · | 4b | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11a | · | 11b | ^ | 12a | · | 12b |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | |||||||||||||||||||||||||||||||||
| SP2: | |||||||||||||||||||||||||||||||||||
| SP3: | - | - | |||||||||||||||||||||||||||||||||
| SP4: | |||||||||||||||||||||||||||||||||||
| SP5: | - |
Expression for SLC17A2 Gene
mRNA differential expression in normal tissues according to GTEx for SLC17A2 Gene
This gene is overexpressed in Liver (x52.3).
This gene is overexpressed in Fetal Liver (69.0).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for SLC17A2 Gene
NURSA nuclear receptor signaling pathways regulating expression of SLC17A2 Gene:
SLC17A2SOURCE GeneReport for Unigene cluster for SLC17A2 Gene:
Hs.591802mRNA Expression by UniProt/SwissProt for SLC17A2 Gene:
O00624-NPT3_HUMAN
Tissue specificity:
Expressed in the small intestine, kidney, spleen and testis. Not detected in fetal brain, bone marrow, and mammary gland.
Evidence on tissue expression from TISSUES for SLC17A2 Gene
- Liver(4.4)
Primer Products
-
OriGene qPCR primer pairs for SLC17A2
-
OriGene qPCR primer pairs and template standards for SLC17A2
Gene Expression Assay Products
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Phenotype-based relationships between genes and organs from Gene ORGANizer for SLC17A2 Gene
Orthologs for SLC17A2 Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | SLC17A2 34 33 |
|
OneToOne | |
| dog (Canis familiaris) |
Mammalia | LOC488255 33 |
|
||
| SLC17A2 34 |
|
OneToOne | |||
| cow (Bos Taurus) |
Mammalia | SLC17A2 34 33 |
|
OneToOne | |
| mouse (Mus musculus) |
Mammalia | Slc17a2 16 34 33 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Slc17a2 33 |
|
||
| platypus (Ornithorhynchus anatinus) |
Mammalia | -- 34 |
|
ManyToMany | |
| -- 34 |
|
ManyToMany | |||
| oppossum (Monodelphis domestica) |
Mammalia | -- 34 |
|
ManyToMany | |
| -- 34 |
|
ManyToMany | |||
| zebrafish (Danio rerio) |
Actinopterygii | CU929219.1 34 |
|
OneToMany |
- Species where no ortholog for SLC17A2 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- chicken (Gallus gallus)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- lizard (Anolis carolinensis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- tropical clawed frog (Silurana tropicalis)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Evolution for SLC17A2 Gene
- ENSEMBL:
- Gene Tree for SLC17A2 (if available)
- TreeFam:
- Gene Tree for SLC17A2 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for SLC17A2: view image
Paralogs for SLC17A2 Gene
Paralogs for SLC17A2 Gene
(7) SIMAP similar genes for SLC17A2 Gene using alignment to 2 proteins:
- NPT3_HUMAN
- A6NK81_HUMAN
Variants for SLC17A2 Gene
| SNP ID | Clin | Chr 06 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1000080460 | -- | 25,913,069(-) | G/T | 3_prime_UTR_variant, downstream_transcript_variant, genic_downstream_transcript_variant | |
| rs1000144806 | -- | 25,930,520(-) | A/G | 5_prime_UTR_variant, genic_upstream_transcript_variant, intron_variant | |
| rs1000327892 | -- | 25,925,861(-) | T/C | 5_prime_UTR_variant, intron_variant | |
| rs1000443996 | -- | 25,926,247(-) | G/A | genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant | |
| rs1000603671 | -- | 25,932,495(-) | A/T | upstream_transcript_variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| nsv1023453 | CNV | gain | 25217958 |
| nsv1124045 | CNV | deletion | 24896259 |
| nsv5229 | CNV | deletion | 18451855 |
Residual Variation Intolerance Score:
40.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
1.79;
33.82% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for SLC17A2 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- SLC17A2
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SLC17A2 Gene
Disorders for SLC17A2 Gene
Additional Disease Information for SLC17A2
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No disorders were found for SLC17A2 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SLC17A2 Gene
Publications for SLC17A2 Gene
- A 1.1-Mb transcript map of the hereditary hemochromatosis locus. (PMID: 9149941) Ruddy DA … Feder JN (Genome research 1997) 2 3 4 58
- Common polymorphisms influencing serum uric acid levels contribute to susceptibility to gout, but not to coronary artery disease. (PMID: 19890391) Stark K … Hengstenberg C (PloS one 2009) 3 44 58
- The DNA sequence and analysis of human chromosome 6. (PMID: 14574404) Mungall AJ … Beck S (Nature 2003) 3 4 58
- Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
- Genome-wide association study of serum iron phenotypes in premenopausal women of European descent. (PMID: 26852655) Koller DL … Foroud T (Blood cells, molecules & diseases 2016) 3 58
Products for SLC17A2 Gene
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Sources for SLC17A2 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
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